{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:29:55Z","timestamp":1790368195059,"version":"4.1.0"},"reference-count":72,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2017,4,29]],"date-time":"2017-04-29T00:00:00Z","timestamp":1493424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Cancer comprises a collection of related diseases characterized by the existence of altered cellular pathways resulting in an abnormal tendency for uncontrolled growth. A broad spectrum, coordinated, and personalized approach focused on targeting diverse oncogenic pathways with low toxicity and economic natural compounds can provide a real benefit as a chemopreventive and\/or treatment of this complex disease. Oleuropein, a bioactive phenolic compound mainly present in olive oil and other natural sources, has been reported to modulate several oncogenic signalling pathways. This review presents and critically discusses the available literature about the anticancer and onco-suppressive activity of oleuropein and the underlying molecular mechanisms implicated in the anticarcinogenic and therapeutic effects. The existence of limitations and the promising perspectives of research on this phenolic compound are also critically analyzed and discussed.<\/jats:p>","DOI":"10.3390\/molecules22050705","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T11:37:20Z","timestamp":1493725040000},"page":"705","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Oleuropein and Cancer Chemoprevention: The Link is Hot"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-5014","authenticated-orcid":false,"given":"Ammad","family":"Ahmad Farooqi","sequence":"first","affiliation":[{"name":"Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore 54000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundas","family":"Fayyaz","sequence":"additional","affiliation":[{"name":"Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore 54000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, National Institute of Health Dr. Ricardo Jorge, I.P., Av. Padre Cruz, 1649-016 Lisbon, Portugal"},{"name":"Center for Study in Animal Science, Pra\u00e7a Gomes Teixeira, Apartado 55142, 4051-401 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8656-6838","authenticated-orcid":false,"given":"Antoni","family":"Sureda","sequence":"additional","affiliation":[{"name":"Research Group on Community Nutrition and Oxidative Stress and CIBEROBN\u2014Physiopathology of Obesity and Nutrition, University of Balearic Islands, Palma de Mallorca E-07122, Balearic Islands, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed","family":"Nabavi","sequence":"additional","affiliation":[{"name":"Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Mocan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Iuliu Ha\u021bieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"},{"name":"ICHAT and Institute for Life Sciences, University of Agricultural Sciences and Veterinary Medicine, Calea M\u0103n\u0103s\u0327tur 3-5, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed","family":"Nabavi","sequence":"additional","affiliation":[{"name":"Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9159-960X","authenticated-orcid":false,"given":"Anupam","family":"Bishayee","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL 33169, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.biotechadv.2015.08.001","article-title":"Discovery and resupply of pharmacologically active plant-derived natural products: A review","volume":"33","author":"Aanasov","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.foodchem.2016.04.111","article-title":"Antibacterial and antifungal activities of thymol: A brief review of the literature","volume":"210","author":"Marchese","year":"2016","journal-title":"Food Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.foodchem.2015.09.085","article-title":"Understanding genistein in cancer: The \u201cgood\u201d and the \u201cbad\u201d effects: A review","volume":"196","author":"Russo","year":"2016","journal-title":"Food Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.2533\/chimia.2011.400","article-title":"Advanced methods for natural product drug discovery in the field of nutraceuticals","volume":"65","author":"Wolfender","year":"2011","journal-title":"CHIMIA Int. J. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.foodchem.2014.10.042","article-title":"Plants belonging to the genus Thymus as antibacterial agents: From farm to pharmacy","volume":"173","author":"Nabavi","year":"2015","journal-title":"Food Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","article-title":"Natural products: A continuing source of novel drug leads","volume":"1830","author":"Cragg","year":"2013","journal-title":"Biochim. Biophys. Acta (BBA) Gen. Subj."},{"key":"ref_7","first-page":"189","article-title":"Discovery of natural product anticancer agents from biodiverse organisms","volume":"12","author":"Kinghorn","year":"2009","journal-title":"Curr. Opin. Drug Discov. Dev."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Waltenberger, B., Mocan, A., \u0160mejkal, K., Heiss, E.H., and Atanasov, A.G. (2016). Natural products to counteract the epidemic of cardiovascular and metabolic disorders. Molecules, 21.","DOI":"10.3390\/molecules21060807"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Bishayee, A., and Sethi, G. (2016). Bioactive Natural Products in Cancer Prevention and Therapy: Progress and Promise, Seminars in Cancer Biology, Elsevier.","DOI":"10.3390\/proceedings1100982"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nrc1189","article-title":"Cancer chemoprevention with dietary phytochemicals","volume":"3","author":"Surh","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S1470-2045(05)70425-3","article-title":"Use of cancer chemopreventive phytochemicals as antineoplastic agents","volume":"6","author":"Steward","year":"2005","journal-title":"Lancet Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tox.2009.10.010","article-title":"Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention","volume":"278","author":"Neergheen","year":"2010","journal-title":"Toxicology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.semcancer.2016.06.002","article-title":"In Food-based natural products for cancer management: Is the whole greater than the sum of the parts?","volume":"40\u201341","author":"Hussain","year":"2016","journal-title":"Semin. Cancer Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/mnfr.200800516","article-title":"The complex links between dietary phytochemicals and human health deciphered by metabolomics","volume":"53","author":"Manach","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jff.2014.09.001","article-title":"Biological activities of the natural antioxidant oleuropein: Exceeding the expectation\u2013A mini-review","volume":"18","author":"Hassen","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"31R","DOI":"10.1039\/a708920a","article-title":"Critical Review. Phenolic compounds in olives","volume":"123","author":"Ryan","year":"1998","journal-title":"Analyst"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/(SICI)1097-0010(20000515)80:7<1013::AID-JSFA571>3.0.CO;2-C","article-title":"Oleuropein and related compounds","volume":"80","author":"Wichers","year":"2000","journal-title":"J. Sci. Food Agric."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.tifs.2013.03.003","article-title":"Protective role of oleuropein and its metabolite hydroxytyrosol on cancer","volume":"31","author":"Mayas","year":"2013","journal-title":"Trends Food Sci. Technol."},{"key":"ref_19","unstructured":"(2016, November 20). ChenIDplus, A Toxnet Database, Available online: https:\/\/chem.nlm.nih.gov\/chemidplus\/name\/oleuropein."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jfda.2013.10.002","article-title":"Development and validation of a simple reversed-phase HPLC-UV method for determination of oleuropein in olive leaves","volume":"22","year":"2014","journal-title":"J. Food Drug Anal."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1021\/jf205209y","article-title":"\u03b2-Glucosidase involvement in the formation and transformation of oleuropein during the growth and development of olive fruits (Olea europaea L. cv. Arbequina) grown under different farming practices","volume":"60","author":"Romero","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Malheiro, R., Rodrigues, N., and Pereira, J.A. (2015). Olive oil phenolic composition as affected by geographic origin, olive cultivar, and cultivation systems. Olive and Olive Oil Bioactive Constituents, Academic Press and AOCS Press.","DOI":"10.1016\/B978-1-63067-041-2.50010-0"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1021\/jf970391+","article-title":"Phenolic compounds in different olive varieties","volume":"46","author":"Esti","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.trac.2005.11.007","article-title":"State-of-the-art and trends in the analysis of oleuropein and derivatives","volume":"25","year":"2006","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.indcrop.2011.12.024","article-title":"Rapid quantitative determination of oleuropein in olive leaves (Olea europaea) using mid-infrared spectroscopy combined with chemometric analyses","volume":"37","author":"Aouidi","year":"2012","journal-title":"Ind. Crops Prod."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.talanta.2016.06.021","article-title":"Determination of oleuropein using multiwalled carbon nanotube modified glassy carbon electrode by adsorptive stripping square wave voltammetry","volume":"159","author":"Cittan","year":"2016","journal-title":"Talanta"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"7984","DOI":"10.1021\/jf0617925","article-title":"Rapid quantification of the phenolic fraction of Spanish virgin olive oils by capillary electrophoresis with UV detection","volume":"54","author":"Cerretani","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1002\/elps.200500650","article-title":"Capillary electrophoresis-electrospray ionization-mass spectrometry method to determine the phenolic fraction of extra-virgin olive oil","volume":"27","year":"2006","journal-title":"Electrophoresis"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0021-9673(95)01375-X","article-title":"Characterization of phenolic and secoiridoid aglycons present in virgin olive oil by gas chromatography-chemical ionization mass spectrometry","volume":"736","author":"Angerosa","year":"1996","journal-title":"J. Chromatogr. A"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.chroma.2005.07.033","article-title":"Solid-phase extraction gas chromatography-ion trap-mass spectrometry qualitative method for evaluation of phenolic compounds in virgin olive oil and structural confirmation of oleuropein and ligstroside aglycons and their oxidation products","volume":"1093","author":"Gil","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1002\/jsfa.4085","article-title":"HPLC analysis of oleuropein, hydroxytyrosol, and tyrosol in stems and roots of Olea europaea L. cv. Picual during ripening","volume":"90","year":"2010","journal-title":"J. Sci. Food Agric."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.seppur.2016.08.003","article-title":"Oleuropein rich extract from olive leaves by combining microfiltration, ultrafiltration and nanofiltration","volume":"172","author":"Khemakhem","year":"2017","journal-title":"Sep. Purif. Technol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.foodchem.2012.01.038","article-title":"Improvement of oleuropein extractability by optimising steam blanching process as pre-treatment of olive leaf extraction via response surface methodology","volume":"133","author":"Stamatopoulos","year":"2012","journal-title":"Food Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jpba.2016.07.001","article-title":"A novel liquid chromatography method using diode-array detector for the determination of oleuropein in dietary supplements","volume":"129","author":"Bertolini","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.foodchem.2016.10.011","article-title":"Selective ultrasound-enhanced enzymatic hydrolysis of oleuropein to its aglycon in olive (Olea europaea L.) leaf extracts","volume":"220","year":"2017","journal-title":"Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/rcm.3855","article-title":"Characterization of isomers of oleuropein aglycon in olive oils by rapid-resolution liquid chromatography coupled to electrospray time-of-flight and ion trap tandem mass spectrometry","volume":"23","author":"Fu","year":"2009","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1021\/jf051647b","article-title":"Factors affecting the contents of iridoid oleuropein in olive leaves (Olea europaea L.)","volume":"54","author":"Ranalli","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/treephys\/28.1.45","article-title":"Polyphenol oxidase and its relationship with oleuropein concentration in fruits and leaves of olive (Olea europaea) cv. \u2018Picual\u2019 trees during fruit ripening","volume":"28","author":"Blanco","year":"2008","journal-title":"Tree Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.chroma.2005.12.106","article-title":"Dynamic ultrasound-assisted extraction of oleuropein and related biophenols from olive leaves","volume":"1108","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1016\/j.biortech.2009.06.059","article-title":"Assessment of phenolics-enriched extract and fractions of olive leaves and their antioxidant activities","volume":"100","author":"Lee","year":"2009","journal-title":"Bioresour. Technol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cbi.2008.08.014","article-title":"Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves","volume":"176","author":"Jemai","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0168-1656(01)00387-X","article-title":"Bioactive derivatives from oleuropein by a biotransformation on Olea europaea leaf extracts","volume":"93","author":"Briante","year":"2002","journal-title":"J. Biotechnol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0308-8146(03)00051-7","article-title":"Enhancement of phenolic compounds in olive plants (Olea europaea L.) and their influence on resistance against Phytophthora sp.","volume":"83","author":"Ortuno","year":"2003","journal-title":"Food Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.pmpp.2007.05.001","article-title":"Antifungal capacity of major phenolic compounds of Olea europaea L. against Phytophthora megasperma Drechsler and Cylindrocarpon destructans (Zinssm.) Scholten","volume":"69","year":"2006","journal-title":"Physiol. Mol. Plant Pathol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1365-2621.2011.02892.x","article-title":"Evaluation of table olive by-product as a source of natural antioxidants","volume":"47","author":"Ros","year":"2012","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.foodchem.2009.12.013","article-title":"Phenolic compounds in olive oil and olive pomace from Cilento (Campania, Italy) and their antioxidant activity","volume":"121","author":"Cioffi","year":"2010","journal-title":"Food Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/0031-9422(91)80018-V","article-title":"Biosynthesis of secoiridoid glucosides in Oleaceae","volume":"34","author":"Damtoft","year":"1993","journal-title":"Phytochemistry"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0031-9422(95)00211-O","article-title":"Biosynthesis of iridoids in Syringa and Fraxinus: Secoiridoid precursors","volume":"40","author":"Damtoft","year":"1995","journal-title":"Phytochemistry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"10048","DOI":"10.1021\/jf800694h","article-title":"Influence of the decrease in oxygen during malaxation of olive paste on the composition of volatiles and phenolic compounds in virgin olive oil","volume":"56","author":"Servili","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/jn\/132.3.409","article-title":"Olive oil phenols are absorbed in humans","volume":"132","author":"Vissers","year":"2002","journal-title":"J. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/sj.ejcn.1601917","article-title":"Bioavailability and antioxidant effects of olive oil phenols in humans: A review","volume":"58","author":"Vissers","year":"2004","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1177\/0003319714532169","article-title":"Health benefits of the Mediterranean Diet: An update of research over the last 5 years","volume":"66","author":"Gotsis","year":"2015","journal-title":"Angiology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1476-511X-10-127","article-title":"Olive oil intake is inversely related to cancer prevalence: A systematic review and a meta-analysis of 13800 patients and 23340 controls in 19 observational studies","volume":"10","author":"Saltopoulou","year":"2011","journal-title":"Lipids Health Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1001\/archinte.158.11.1181","article-title":"Mediterranean dietary pattern in a randomized trial: Prolonged survival and possible reduced cancer rate","volume":"158","author":"Salen","year":"1998","journal-title":"Arch. Intern. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1001\/jamainternmed.2015.4838","article-title":"Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED trial: A randomized clinical trial","volume":"175","author":"Toledo","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1530\/JME-12-0241","article-title":"Antioxidant and antigrowth action of peracetylated oleuropein in thyroid cancer cells","volume":"51","author":"Bulotta","year":"2013","journal-title":"J. Mol. Endocrinol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.3945\/jn.109.104992","article-title":"Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice","volume":"139","author":"Kimura","year":"2009","journal-title":"J. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/0717-6287-47-54","article-title":"Fruits and barks extracts of Zanthozyllum heitzii a spice from Cameroon induce mitochondrial dependent apoptosis and Go\/G1 phase arrest in human leukemia HL-60 cells","volume":"47","author":"Pieme","year":"2014","journal-title":"Biol. Res."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Menendez, J.A., Vazquez-Martin, A., Colomer, R., Brunet, J., Carrasco-Pancorbo, A., Garcia-Villalba, R., Fernandez-Gutierrez, A., and Segura-Carretero, A. (2007). Olive oil\u2019s bitter principle reverses acquired autoresistance to trastuzumab (Herceptin\u2122) in HER2-overexpressing breast cancer cells. BMC Cancer, 7.","DOI":"10.1186\/1471-2407-7-80"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Menendez, J.A., Vazquez-Martin, A., Garcia-Villalba, R., Carrasco-Pancorbo, A., Oliveras-Ferraros, C., Fernandez-Gutierrez, A., and Segura-Carretero, A. (2008). tabAnti-HER2 (erb B-2) oncogene effects of phenolic compounds directly isolated from commercial Extra-Virgin Olive Oil (EVOO). BMC Cancer, 8.","DOI":"10.1186\/1471-2407-8-377"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1254\/jphs.14012FP","article-title":"Oleuropein induced apoptosis in HeLa cells via a mitochondrial apoptotic cascade associated with activation of the c-Jun NH2-terminal kinase","volume":"125","author":"Yao","year":"2014","journal-title":"J. Pharmacol. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/mnfr.200900111","article-title":"Oleuropein and hydroxytyrosol inhibit MCF-7 breast cancer cell proliferation interfering with ERK1\/2 activation","volume":"54","author":"Sirianni","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/mnfr.201300323","article-title":"Oleuropein and hydroxytyrosol activate GPER\/GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells","volume":"58","author":"Chimento","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.fct.2012.12.009","article-title":"Olive oil oleuropein has anti-breast cancer properties with higher efficiency on ER-negative cells","volume":"53","author":"Elamin","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrc2694","article-title":"Signal integration by JNK and p38 MAPK pathways in cancer development","volume":"9","author":"Wagner","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1038\/sj.onc.1207556","article-title":"Mitogen-activated protein kinases in apoptosis regulation","volume":"23","author":"Wada","year":"2004","journal-title":"Oncogene"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm3722","article-title":"Control of apoptosis by the BCL-2 protein family: Implications for physiology and therapy","volume":"15","author":"Czabotar","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"6739","DOI":"10.7314\/APJCP.2013.14.11.6739","article-title":"Oleuropein induces apoptosis via the p53 pathway in breast cancer cells","volume":"14","author":"Hassan","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.3892\/mmr.2015.3266","article-title":"Oleuropein induces apoptosis via activation of caspases and suppression of phosphatidylinositol 3-kinase\/protein kinase B pathway in HepG2 human hepatoma cell line","volume":"11","author":"Yan","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_70","first-page":"31","article-title":"Antiproliferative effect of oleuropein in prostate cell lines","volume":"41","author":"Acquaviva","year":"2012","journal-title":"Int. J. Oncol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jnutbio.2014.10.013","article-title":"Extravirgin olive oil up-regulates CB\u2081 tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms","volume":"26","author":"Falconi","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_72","first-page":"1533","article-title":"Crude phenolic extracts from extra virgin olive oil circumvent de novo breast cancer resistance to HER1\/HER2-targeting drugs by inducing GADD45-sensed cellular stress, G2\/M arrest and hyperacetylation of Histone H3","volume":"38","author":"Joven","year":"2011","journal-title":"Int. J. Oncol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/22\/5\/705\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:34:16Z","timestamp":1760207656000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/22\/5\/705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,29]]},"references-count":72,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5]]}},"alternative-id":["molecules22050705"],"URL":"https:\/\/doi.org\/10.3390\/molecules22050705","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,29]]}}}