{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:12:19Z","timestamp":1760242339374,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Phosphoramidite building blocks of ribostamycin (3 and 4), that may be incorporated at any position of the oligonucleotide sequence, were synthesized. The building blocks, together with a previously described neomycin-modified solid support, were applied for the preparation of aminoglycoside-2\u2032-O-methyl oligoribonucleotide fusions. The fusions were used to clamp a single strand DNA sequence (a purine-rich strand of c-Myc promoter 1) to form triple helical 2\u2032-O-methyl RNA\/DNA-hybrid constructs. The potential of the aminoglycoside moieties to stabilize the triple helical constructs were studied by UV-melting profile analysis.<\/jats:p>","DOI":"10.3390\/molecules22050760","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T11:45:16Z","timestamp":1494243916000},"page":"760","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synthesis of Aminoglycoside-2\u2032-O-Methyl Oligoribonucleotide Fusions"],"prefix":"10.3390","volume":"22","author":[{"given":"Lotta","family":"Granqvist","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Turku, Vatselankatu 2, 20014 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Kraszewski","sequence":"additional","affiliation":[{"name":"Centre of New Technologies, University of Warsaw, Banacha 2c, 02 097 Warsaw, Poland"},{"name":"College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, Banacha 2c, 02 097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ville","family":"T\u00e4htinen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Turku, Vatselankatu 2, 20014 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasi","family":"Virta","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Turku, Vatselankatu 2, 20014 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1021\/cr0681546","article-title":"Targeting of RNA with Small Molecules","volume":"108","author":"Thomas","year":"2008","journal-title":"Chem. 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