{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:57:21Z","timestamp":1787029041313,"version":"build-2736575974"},"reference-count":63,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T00:00:00Z","timestamp":1496188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Dodoneine (Ddn) is one of the active compounds identified from Agelanthus dodoneifolius, which is a medicinal plant used in African pharmacopeia and traditional medicine for the treatment of hypertension. In the context of a scientific program aiming at discovering new hypotensive agents through the original combination of natural product discovery and superacid chemistry diversification, and after evidencing dodoneine\u2019s vasorelaxant effect on rat aorta, superacid modifications allowed us to generate original analogues which showed selective human carbonic anhydrase III (hCA III) and L-type Ca2+ current inhibition. These derivatives can now be considered as new lead compounds for vasorelaxant therapeutics targeting these two proteins.<\/jats:p>","DOI":"10.3390\/molecules22060915","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T10:41:04Z","timestamp":1496227264000},"page":"915","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bioactive Natural Product and Superacid Chemistry for Lead Compound Identification: A Case Study of Selective hCA III and L-Type Ca2+ Current Inhibitors for Hypotensive Agent Discovery"],"prefix":"10.3390","volume":"22","author":[{"given":"H\u00e9l\u00e8ne","family":"Carreyre","sequence":"first","affiliation":[{"name":"Superacid Group\/Organic Synthesis Team, Universit\u00e9 de Poitiers, IC2MP\u2014UMR CNRS 7285, 86073 Poitiers CEDEX 09, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Carr\u00e9","sequence":"additional","affiliation":[{"name":"STIM\u2014ERL CNRS 7368 Universit\u00e9 de Poitiers, 86073 Poitiers Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Ouedraogo","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiologie Animale, Universit\u00e9 de Ouagadougou, 03 BP 7021 Ouagadougou 01, Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarisse","family":"Vandebrouck","sequence":"additional","affiliation":[{"name":"STIM\u2014ERL CNRS 7368 Universit\u00e9 de Poitiers, 86073 Poitiers Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Bescond","sequence":"additional","affiliation":[{"name":"STIM\u2014ERL CNRS 7368 Universit\u00e9 de Poitiers, 86073 Poitiers Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Department of Neurofarba, Sez, Chimica Farmaceutica e Nutraceutica, University of Florence, 50019 Sesto Fiorentino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Thibaudeau","sequence":"additional","affiliation":[{"name":"Superacid Group\/Organic Synthesis Team, Universit\u00e9 de Poitiers, IC2MP\u2014UMR CNRS 7285, 86073 Poitiers CEDEX 09, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nrd2961","article-title":"Lessons from 60 years of pharmaceutical innovation","volume":"8","author":"Munos","year":"2009","journal-title":"Nat. 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