{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:25:21Z","timestamp":1790965521386,"version":"4.1.0"},"reference-count":26,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Projects Coordination Unit of Istanbul University","award":["39751"],"award-info":[{"award-number":["39751"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The dichloromethane extract of the roots of Prangos hulusii, a recently described endemic species from Turkey, has yielded nine known and one new prenylated coumarins. The structures were elucidated by spectroscopic methods and direct comparison with the reference compounds where available. The root extract and its prenylated coumarins exhibit antimicrobial activity against nine standard and six clinically isolated strains at a concentration between 5 and 125 \u00b5g\/mL. In particular, the new coumarin, 4\u2032-senecioiloxyosthol (1), displayed 5 \u00b5g\/mL MIC (Minimum Inhibitory Concentration) value against Bacillus subtilis ATCC 9372, murraol (4) and auraptenol (5) showed 63 \u00b5g\/mL MIC value against Klebsiella pneumoniae ATCC 4352 and Bacillus subtilis ATCC 9372, and isoimperatorin (9) exhibited 16 \u00b5g\/mL MIC value.<\/jats:p>","DOI":"10.3390\/molecules22071098","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T10:27:31Z","timestamp":1499077651000},"page":"1098","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Antibacterial Activities of Pyrenylated Coumarins from the Roots of Prangos hulusii"],"prefix":"10.3390","volume":"22","author":[{"given":"Nur","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se\u00e7il","family":"Yaz\u0131c\u0131-T\u00fct\u00fcni\u015f","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Bilgin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul Yeni Yuzyil University, Istanbul 34110, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emir","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul Yeni Yuzyil University, Istanbul 34110, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmut","family":"Miski","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,7,1]]},"reference":[{"key":"ref_1","first-page":"139","article-title":"The Asian Umbelliferae biodiversity database (ASIUM) with particular feference to South-West Asian taxa","volume":"28","author":"Pimenov","year":"2004","journal-title":"Turk. 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