{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:19:07Z","timestamp":1762507147478,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T00:00:00Z","timestamp":1499299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A patented organotin di-n-butyl-di-(4-chlorobenzohydroxamato)tin (DBDCT) with high a antitumor activity was designed, however, its antitumor and toxic mechanisms have not yet been clearly illustrated. Hepatic proteins of DBDCT-treated rats were identified and analyzed using LC\u2013MS\/MS with label-free quantitative technology. In total, 149 differentially expressed proteins were successfully identified. Five protein and mRNA expressions were involved in the peroxisome proliferator-activated receptor (PPAR) signaling pathway, including a scavenger receptor (CD36), adipocyte fatty acid binding protein 4 (FABP4), enoyl-CoA hydratase (EHHADH), acetyl-CoA acyltransferase 1 (ACAA1), and phosphoenolpyruvate carboxykinase (PEPCK) in DBDCT-treated Rat Liver (BRL) cells. PPAR-\u03b1 and PPAR-\u03bb were also significantly decreased at both protein and mRNA levels. Furthermore, compared with the DBDCT treatment group, a special blocking agent of PPAR-\u03bb T0070907 was used to evaluate the relationship between PPAR-\u03bb and its downstream genes. Our studies indicated that DBDCT may serve as a modulator of PPAR-\u03bb, further up-regulating CD36, FABP4 and EHHADH on the PPAR signal pathway.<\/jats:p>","DOI":"10.3390\/molecules22071113","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T10:55:45Z","timestamp":1499338545000},"page":"1113","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Proteomics Analysis Reveals an Important Role for the PPAR Signaling Pathway in DBDCT-Induced Hepatotoxicity Mechanisms"],"prefix":"10.3390","volume":"22","author":[{"given":"Yunlan","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China"},{"name":"Department of Traditional Chinese Medicine, Shanxi University of Traditional Chinese Medicine, Taiyuan 030001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Niu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingshan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China"},{"name":"Department of Traditional Chinese Medicine, Shanxi University of Traditional Chinese Medicine, Taiyuan 030001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1186\/1471-2164-15-839","article-title":"iTRAQ-proteomics and bioinformatics analyses of mammary tissue from cows with clinical mastitis due to natural infection with Staphylococci aureus","volume":"15","author":"Huang","year":"2014","journal-title":"BMC Genom."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/pmic.201000273","article-title":"Proteomic analysis of the anti-inflammatory action of minocycline","volume":"11","author":"Dunston","year":"2011","journal-title":"Proteomics"},{"key":"ref_3","first-page":"92","article-title":"Apoptosis induced neurotoxicity of di-n-butyl-di-(4-chlorobenzohydroxamato) tin (IV) via mitochondria-mediated pathway in PC12 cells","volume":"1","author":"Rui","year":"2013","journal-title":"Toxicol. 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