{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:07:30Z","timestamp":1792026450448,"version":"4.4.0"},"reference-count":51,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A facile access to polysubstituted 3-(isoxazol-5-yl)pyrroles was developed through [3+2] cycloaddition of tosylmethyl isocyanide (TosMIC) and styrylisoxazoles. In the presence of KOH, various styrylisoxazoles reacted smoothly with tosylmethyl isocyanide and analogs to deliver a wide range of 3-(isoxazol-5-yl)pyrroles at ambient temperature. This transformation is operationally simple, high-yielding, and displays broad substrate scope.<\/jats:p>","DOI":"10.3390\/molecules22071131","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T10:37:17Z","timestamp":1499423837000},"page":"1131","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["[3+2] Cycloaddition of Tosylmethyl Isocyanide with Styrylisoxazoles: Facile Access to Polysubstituted 3-(Isoxazol-5-yl)pyrroles"],"prefix":"10.3390","volume":"22","author":[{"given":"Xueming","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Chemistry, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxiu","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15233","DOI":"10.1039\/C4RA15710A","article-title":"Pyrrole: A resourceful small molecule in key medicinal hetero-aromatics","volume":"46","author":"Bhardwaj","year":"2015","journal-title":"RSC Adv."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.ejmech.2013.03.029","article-title":"Synthesis and evaluation of novel marine bromopyrrole alkaloidbased hybrids as anticancer agents","volume":"63","author":"Rane","year":"2013","journal-title":"Eur. 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