{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:13:30Z","timestamp":1760242410199,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T00:00:00Z","timestamp":1500249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Widespread concern for the occurrence of resistant strains, along with the avoidance of the use of highly toxic insecticides and their wide environmental dispersal, highlights the need for the development of new and safer pest control agents. Natural products provide inspiration for new chemical entities with biological activities, and their analogues are good lead compounds for the development of new pest control agents. For this purpose, we evaluated the larvicidal and nematicidal activities of 48 3-acylbarbituric acid analogues against the Asian tiger mosquito, Aedes albopictus and the pine wood nematode, Bursaphelenchus xylophilus, organisms of increasing global concern. Among the 48 3-acylbarbituric acid analogues, four compounds\u201410, 14d, 14g and 19b\u2014showed &gt;90% larvicidal activity against Ae. albopictus at 10 \u03bcg\/mL concentration, and one (compound 10) showed the strongest larvicidal activity against Ae. albopictus, with a LC50 value of 0.22 \u03bcg\/mL. Only compound 18 showed strong nematicidal activity against pine wood nematode. Most active compounds possessed similar physicochemical properties; thus, actives typically had ClogP values of around 1.40\u20131.50 and rel-PSA values of 16\u201317% and these similar cheminformatic characteristics reflect their similar structure. This study indicates that active 3-acylbarbituric acids analogues have potential as lead compounds for developing novel mosquito control agents.<\/jats:p>","DOI":"10.3390\/molecules22071196","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T03:45:16Z","timestamp":1500349516000},"page":"1196","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Larvicidal and Nematicidal Activities of 3-Acylbarbituric Acid Analogues against Asian Tiger Mosquito, Aedes albopictus, and Pine Wood Nematode, Bursaphelenchus xylophilus"],"prefix":"10.3390","volume":"22","author":[{"given":"Seon-Mi","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Forest Sciences, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea"},{"name":"Research Institute of Agriculture and Life Science, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Rim","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Forest Sciences, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea"},{"name":"Research Institute of Agriculture and Life Science, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Forest Sciences, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Chul","family":"Jeong","sequence":"additional","affiliation":[{"name":"Chemistry Research Laboratory, University of Oxford, 12 Mansfield Rd, Oxford OS1 3TA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung-Wook","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Bio-Resource and Environmental Center, College of Life Science &amp; Bioengineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Korea"},{"name":"Convergence Research Center for Insect Vector, College of Life Science &amp; Bioengineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9944-7475","authenticated-orcid":false,"given":"Joon-Kwan","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Plant Life and Environmental Sciences, hankyong National University, 327 Jungangro, Anseong, Gyeonggi 17579, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4440-3632","authenticated-orcid":false,"given":"Mark","family":"Moloney","sequence":"additional","affiliation":[{"name":"Chemistry Research Laboratory, University of Oxford, 12 Mansfield Rd, Oxford OS1 3TA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Il-Kwon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Forest Sciences, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea"},{"name":"Research Institute of Agriculture and Life Science, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.pt.2013.07.003","article-title":"The invasive mosquito species Aedes albopictus: Current knowledge and future perspectives","volume":"29","author":"Bonizzoni","year":"2013","journal-title":"Trends Parasitol."},{"key":"ref_2","unstructured":"World Health Organization (2011). 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