{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:14:31Z","timestamp":1760242471587,"version":"build-2065373602"},"reference-count":18,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T00:00:00Z","timestamp":1500422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Dear Editor, We read with great interest the recent article by John I. Toohey entitled \u201cPossible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer\u201d, recently published in Molecules 2017, and we wish to discuss some additional insights raised by this important issue into the nephrological area [1].[...]<\/jats:p>","DOI":"10.3390\/molecules22071216","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T04:28:26Z","timestamp":1500524906000},"page":"1216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Hydrogen Sulfide-Vitamin B12-Folic Acid Axis: An Intriguing Issue in Chronic Kidney Disease. A Comment on Toohey JI: \u201cPossible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer\u201d. Molecules 2017, 22, 582, pii: E582"],"prefix":"10.3390","volume":"22","author":[{"given":"Giuseppe","family":"Cianciolo","sequence":"first","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine (DIMES)\u2014Nephrology, Dialysis and Transplantation Unit, St. Orsola Hospital, University of Bologna, Via G. Massarenti 9 (Pad. 15), 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Cappuccilli","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine (DIMES)\u2014Nephrology, Dialysis and Transplantation Unit, St. Orsola Hospital, University of Bologna, Via G. Massarenti 9 (Pad. 15), 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"La Manna","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine (DIMES)\u2014Nephrology, Dialysis and Transplantation Unit, St. Orsola Hospital, University of Bologna, Via G. Massarenti 9 (Pad. 15), 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,7,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Toohey, J.I. (2017). Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer. Molecules, 22, pii: E582.","DOI":"10.3390\/molecules22040582"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/1755-5922.12064","article-title":"The role of homocysteine-lowering B-vitamins in the primary prevention of cardiovascular disease","volume":"32","author":"Debreceni","year":"2014","journal-title":"Cardiovasc. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1111\/1755-5922.12014","article-title":"Updating the relationship between hyperhomocysteinemia lowering therapy and cardiovascular events","volume":"31","author":"Cheng","year":"2013","journal-title":"Cardiovasc. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1053\/j.ajkd.2013.11.001","article-title":"US Renal Data System 2013 Annual Data Report","volume":"63","author":"Collins","year":"2014","journal-title":"Am. J. Kidney Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1161\/CIR.0b013e3181daa7c9","article-title":"Homocysteine lowering in end-stage renal disease: Is there any cardiovascular benefit?","volume":"121","author":"Hu","year":"2010","journal-title":"Circulation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1053\/j.ajkd.2009.01.266","article-title":"Homocysteine as a risk factor for cardiovascular disease in patients treated by dialysis: A meta-analysis","volume":"54","author":"Heinz","year":"2009","journal-title":"Am. J. Kidney Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1525-139X.2009.00579.x","article-title":"Hyperhomocysteinemia in uremia\u2014A red flag in a disrupted circuit","volume":"22","author":"Perna","year":"2009","journal-title":"Semin. Dial."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1159\/000142363","article-title":"5-methyltetrahydrofolate administration is associated with prolonged survival and reduced inflammation in ESRD patients","volume":"28","author":"Cianciolo","year":"2008","journal-title":"Am. J. Nephrol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Marti, F., Vollenweider, P., Marques-Vidal, P.M., Mooser, V., Waeber, G., Paccaud, F., and Bochud, M. (2011). Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study. BMC Public Health, 11.","DOI":"10.1186\/1471-2458-11-733"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1056\/NEJM199804093381507","article-title":"Homocysteine and atherothrombosis","volume":"338","author":"Welch","year":"1998","journal-title":"N. Engl. J. 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Nephrol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1159\/000368883","article-title":"Correlation of lower concentrations of hydrogen sulfide with atherosclerosis in chronic hemodialysis patients with diabetic nephropathy","volume":"38","author":"Li","year":"2014","journal-title":"Blood Purif."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1159\/000439580","article-title":"Lower Hydrogen Sulfide Is Associated with Cardiovascular Mortality, Which Involves cPKC\u03b2II\/Akt Pathway in Chronic Hemodialysis Patients","volume":"40","author":"Feng","year":"2015","journal-title":"Blood Purif."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1096\/fj.08-120345","article-title":"Mice deficient in PKCbeta and Apolipoprotein E display decreased atherosclerosis","volume":"23","author":"Harja","year":"2009","journal-title":"FASEB J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.yjmcc.2011.08.025","article-title":"Pharmacological inhibition of \u03b2IIPKC is cardioprotective in late-stage hypertrophy","volume":"51","author":"Ferreira","year":"2011","journal-title":"J. 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