{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:58:53Z","timestamp":1777442333844,"version":"3.51.4"},"reference-count":43,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>We studied effects of NO-donor iron nitrosyl complex with N-ethylthiourea ligand (ETM) on normal or tumor-derived cell lines. ETM was mildly toxic to most cell lines studied except the human glioma cell line A172 that proved to be highly sensitive to the complex and underwent cell death after ETM exposure. The high susceptibility of A172 cells to ETM was attributed to its NO-donor properties since no toxicity was detected for the N-ethylthiourea ligand.<\/jats:p>","DOI":"10.3390\/molecules22091426","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T10:39:15Z","timestamp":1504003155000},"page":"1426","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["NO-Donor Iron Nitrosyl Complex with N-Ethylthiourea Ligand Exhibits Selective Toxicity to Glioma A172 Cells"],"prefix":"10.3390","volume":"22","author":[{"given":"Nataliya","family":"Sanina","sequence":"first","affiliation":[{"name":"Institute of Problems of Chemical Physics RAS, Chernogolovka 142432, Russia"},{"name":"Medicinal Chemistry Research and Education Center, Moscow Region State University, Moscow 105005, Russia"},{"name":"Faculty of Fundamental Physical and Chemical Engineering, M.V. Lomonosov Moscow State University, Moscow 119991, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natal\u2019ya","family":"Shmatko","sequence":"additional","affiliation":[{"name":"Institute of Problems of Chemical Physics RAS, Chernogolovka 142432, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiyana","family":"Stupina","sequence":"additional","affiliation":[{"name":"Institute of Problems of Chemical Physics RAS, Chernogolovka 142432, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasiya","family":"Balakina","sequence":"additional","affiliation":[{"name":"Institute of Problems of Chemical Physics RAS, Chernogolovka 142432, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexei","family":"Terent\u2019ev","sequence":"additional","affiliation":[{"name":"Institute of Problems of Chemical Physics RAS, Chernogolovka 142432, Russia"},{"name":"Medicinal Chemistry Research and Education Center, Moscow Region State University, Moscow 105005, Russia"},{"name":"Faculty of Fundamental Physical and Chemical Engineering, M.V. Lomonosov Moscow State University, Moscow 119991, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"C254","DOI":"10.1152\/ajpcell.00315.2016","article-title":"Nitric oxide: What\u2019s new to NO?","volume":"312","author":"Ghimire","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.freeradbiomed.2008.03.020","article-title":"The chemical biology of nitric oxide: Implications in cellular signaling","volume":"45","author":"Thomas","year":"2008","journal-title":"Free Radic. Biol. 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