{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:42:39Z","timestamp":1778866959724,"version":"3.51.4"},"reference-count":135,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T00:00:00Z","timestamp":1508457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Ebola virus disease (EVD) is a deadly global public health threat, with no currently approved treatments. Traditional drug discovery and development is too expensive and inefficient to react quickly to the threat. We review published research studies that utilize computational approaches to find or develop drugs that target the Ebola virus and synthesize its results. A variety of hypothesized and\/or novel treatments are reported to have potential anti-Ebola activity. Approaches that utilize multi-targeting\/polypharmacology have the most promise in treating EVD.<\/jats:p>","DOI":"10.3390\/molecules22101777","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T04:32:19Z","timestamp":1508733139000},"page":"1777","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["A Systematic Review of Computational Drug Discovery, Development, and Repurposing for Ebola Virus Disease Treatment"],"prefix":"10.3390","volume":"22","author":[{"given":"James","family":"Schuler","sequence":"first","affiliation":[{"name":"Department of Biomedical Informatics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Hudson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram","family":"Samudrala","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,10,20]]},"reference":[{"key":"ref_1","unstructured":"(2017, July 25). 2014 Ebola Outbreak in West Africa\u2014Case Counts, Available online: https:\/\/www.cdc.gov\/vhf\/ebola\/outbreaks\/2014-west-africa\/case-counts.html."},{"key":"ref_2","unstructured":"(2017, August 05). 2017 Democratic Republic of the Congo, Bas U\u00e9l\u00e9 District, Available online: https:\/\/www.cdc.gov\/vhf\/ebola\/outbreaks\/drc\/2017-may.html."},{"key":"ref_3","unstructured":"World Health Organization, and Regional Office for Africa, Health Emergencies Programme (2017). 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