{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:11:14Z","timestamp":1777554674406,"version":"3.51.4"},"reference-count":73,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Selective inhibition of tumor-associated carbonic anhydrase (CA; EC 4.2.1.1) isoforms IX and XII is a crucial prerequisite to develop successful anticancer therapeutics. Herein, we confirmed the efficacy of the 3-nitrobenzoic acid substructure in the design of potent and selective carboxylic acid derivatives as CAs inhibitors. Compound 10 emerged as the most potent inhibitor of the tumor-associated hCA IX and XII (Ki = 16 and 82.1 nM, respectively) with a significant selectivity with respect to the wide spread hCA II. Other 3-nitrobenzoic acid derivatives showed a peculiar CA inhibition profile with a notable potency towards hCA IX.<\/jats:p>","DOI":"10.3390\/molecules23010017","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T05:50:19Z","timestamp":1513921819000},"page":"17","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII"],"prefix":"10.3390","volume":"23","author":[{"given":"Ylenia","family":"Cau","sequence":"first","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, Universit\u00e0 degli Studi di Siena, via Aldo Moro 2, I-53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Vullo","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Universit\u00e0 degli Studi di Firenze, Polo Scientifico, Via della Lastruccia 3, 50019 Sesto Fiorentino (Firenze), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Mori","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, Universit\u00e0 degli Studi di Siena, via Aldo Moro 2, I-53100 Siena, Italy"},{"name":"Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, viale Regina Elena 291, I-00161 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8987-940X","authenticated-orcid":false,"given":"Elena","family":"Dreassi","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, Universit\u00e0 degli Studi di Siena, via Aldo Moro 2, I-53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu","family":"Supuran","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Universit\u00e0 degli Studi di Firenze, Polo Scientifico, Via della Lastruccia 3, 50019 Sesto Fiorentino (Firenze), Italy"},{"name":"Dipartimento NEUROFARBA, Sezione di Scienze Farmaceutiche, Universit\u00e0 degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Firenze), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Botta","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie, Chimica e Farmacia, Universit\u00e0 degli Studi di Siena, via Aldo Moro 2, I-53100 Siena, Italy"},{"name":"Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Building, Suite 333, 1900 N 12th Street, Philadelphia, PA 19122, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lomelino, C.L., Supuran, C.T., and McKenna, R. 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