{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:36:03Z","timestamp":1790271363255,"version":"4.1.0"},"reference-count":100,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Several species of berries, such as blueberries (Vaccinium angustifolium) and lingonberries (Vaccinium vitis-idaea L.), have attracted much scientific attention in recent years, especially due to their reported antioxidant and anti-inflammatory properties. Berries, as with other types of plants, have developed metabolic mechanisms to survive various environmental stresses, some of which involve reactive oxygen species. In addition, the fruits and leaves of berries have high amounts of polyphenols, such as flavonoids, which act as potent antioxidants. These compounds could potentially be beneficial for brain aging and neurodegenerative disorders. There are now several studies documenting the beneficial effects of various berries in cell models of neurotoxicity as well as in vivo models of neurodegenerative disease. In the current review, we discuss the metabolic strategies that plants and animals have developed in order to combat reactive oxygen species. We then discuss issues of bioavailability of various compounds in mammals and provide a synopsis of studies demonstrating the neuroprotective ability of berries and polyphenols. We also summarize findings from our own research group. For example, we have detected various polyphenols in samples of blueberries and lingonberries and have found that the leaves have a much higher antioxidant capacity than the fruits. Extracts from these species have also demonstrated neuroprotective effects in cellular models of toxicity and inflammation, which are being further pursued in animal models.<\/jats:p>","DOI":"10.3390\/molecules23010026","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T11:38:04Z","timestamp":1513942684000},"page":"26","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Biochemical Properties and Neuroprotective Effects of Compounds in Various Species of Berries"],"prefix":"10.3390","volume":"23","author":[{"given":"Erin","family":"Kelly","sequence":"first","affiliation":[{"name":"School of Pharmacy, Memorial University of Newfoundland, St. John\u2019s, NL A1B3V6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poorva","family":"Vyas","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Memorial University of Newfoundland, St. John\u2019s, NL A1B3V6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Weber","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Memorial University of Newfoundland, St. John\u2019s, NL A1B3V6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1471-4159.2006.03907.x","article-title":"Oxidative Stress and Neurodegeneration: Where are we Now?","volume":"97","author":"Halliwell","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Inze, D., and Montago, M. (2002). Oxidative stress: An introduction. Oxidative Stress in Plants, Taylor and Francis Publishers.","DOI":"10.1201\/b12593"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1152\/physrev.1994.74.1.139","article-title":"Cellular Defenses against Damage from Reactive Oxygen Species","volume":"74","author":"Yu","year":"1994","journal-title":"Physiol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1104\/pp.106.079129","article-title":"Mitochondrial Reactive Oxygen Species. Contribution to Oxidative Stress and Interorganellar Signaling","volume":"141","author":"Rhoads","year":"2006","journal-title":"Plant Physiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1104\/pp.86.2.626","article-title":"Hydrogen Peroxide Metabolism in Soybean Embryonic Axes at the Onset of Germination","volume":"86","author":"Puntarulo","year":"1988","journal-title":"Plant Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev.pp.43.060192.000503","article-title":"Superoxide Dismutase and Stress Tolerance","volume":"43","author":"Bowler","year":"1992","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1146\/annurev.arplant.52.1.561","article-title":"Plant Mitochondria and Oxidative Stress: Electron Transport, NADPH Turnover, and Metabolism of Reactive Oxygen Species","volume":"52","author":"Moller","year":"2001","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1093\/carcin\/7.11.1849","article-title":"Formation of 8-Hydroxyguanine Moiety in Cellular DNA by Agents Producing Oxygen Radicals and Evidence for its Repair","volume":"7","author":"Kasai","year":"1986","journal-title":"Carcinogenesis"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1399-3054.1997.tb04782.x","article-title":"Ozone-Induced Oxidative Stress: Mechanisms of Action and Reaction","volume":"100","author":"Pell","year":"1997","journal-title":"Physiol. Plant."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.py.06.090168.001121","article-title":"Factors Influencing Expression of Oxidant Damage to Plants","volume":"6","author":"Heck","year":"1968","journal-title":"Annu. Rev. Phytopathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2174\/092986708783497337","article-title":"Antioxidants and Free Radical Scavengers for the Treatment of Stroke, Traumatic Brain Injury and Aging","volume":"15","author":"Slemmer","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0065-2660(08)60223-0","article-title":"Microbial Superoxide Dismutases","volume":"26","author":"Hassan","year":"1989","journal-title":"Adv. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3109\/10409238709083738","article-title":"Aspects of the Structure, Function, and Applications of Superoxide Dismutase","volume":"22","author":"Bannister","year":"1987","journal-title":"CRC Crit. Rev. Biochem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/aob\/mcf118","article-title":"Antioxidants, Oxidative Damage and Oxygen Deprivation Stress: A Review","volume":"91","author":"Blokhina","year":"2003","journal-title":"Ann. Bot."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0031-9422(88)80254-1","article-title":"The Antioxidants of Higher Plants","volume":"27","author":"Larson","year":"1988","journal-title":"Phytochemistry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S1369-5266(00)00069-8","article-title":"Ascorbic Acid: Metabolism and Functions of a Multi-Facetted Molecule","volume":"3","author":"Smirnoff","year":"2000","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/180553a0","article-title":"Missing Step in Man, Monkey and Guinea Pig Required for the Biosynthesis of l-Ascorbic Acid","volume":"180","author":"Burns","year":"1957","journal-title":"Nature"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6377","DOI":"10.1073\/pnas.86.16.6377","article-title":"Ascorbate is an Outstanding Antioxidant in Human Blood Plasma","volume":"86","author":"Frei","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1139\/o90-173","article-title":"Cellular Functions of Ascorbic Acid","volume":"68","author":"Padh","year":"1990","journal-title":"Biochem. Cell Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF00386001","article-title":"The Presence of Glutathione and Glutathione Reductase in Chloroplasts: A Proposed Role in Ascorbic Acid Metabolism","volume":"133","author":"Foyer","year":"1976","journal-title":"Planta"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1042\/bj2100899","article-title":"Glutathione and Ascorbic Acid in Spinach (Spinacia oleracea) Chloroplasts. The Effect of Hydrogen Peroxide and of Paraquat","volume":"210","author":"Law","year":"1983","journal-title":"Biochem. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/0735-260291044179","article-title":"The Function of Tocopherols and Tocotrienols in Plants","volume":"21","author":"Alegre","year":"2002","journal-title":"Crit. Rev. Plant Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1365-3040.1992.tb00988.x","article-title":"The Antioxidant Effects of Thylakoid Vitamin E (\u03b1-Tocopherol)","volume":"15","author":"Fryer","year":"1992","journal-title":"Plant Cell Environ."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1039\/b311404j","article-title":"Anthocyanins and Other Flavonoids","volume":"21","author":"Williams","year":"2004","journal-title":"Nat. Prod. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/jn\/134.4.923","article-title":"Consumption of Foods Rich in Flavonoids is Related to a Decreased Cardiovascular Risk in Apparently Healthy French Women","volume":"134","author":"Mennen","year":"2004","journal-title":"J. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4067\/S0716-97602000000200007","article-title":"Antioxidant Flavonols from Fruits, Vegetables and Beverages: Measurements and Bioavailability","volume":"33","author":"Crozier","year":"2000","journal-title":"Biol. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jfca.2008.12.004","article-title":"Flavonols in Fresh and Processed Brazilian Fruits","volume":"22","author":"Huber","year":"2009","journal-title":"J. Food Compos. Anal."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3136\/fstr.16.395","article-title":"Content of Selected Flavonoids in 100 Edible Vegetables and Fruits","volume":"16","author":"Cao","year":"2010","journal-title":"Food Sci. Technol. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00217-013-2033-7","article-title":"HPLC-DAD Detection of Changes in Phenol Content of Red Berry Skins during Grape Ripening","volume":"237","year":"2013","journal-title":"Eur. Food Res. Technol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0163-7258(02)00298-X","article-title":"The Biochemistry and Medical Significance of the Flavonoids","volume":"96","author":"Havsteen","year":"2002","journal-title":"Pharmacol. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1104\/pp.010675","article-title":"It Takes a Garden. How Work on Diverse Plant Species Has Contributed to an Understanding of Flavonoid Metabolism","volume":"127","year":"2001","journal-title":"Plant Physiol."},{"key":"ref_32","first-page":"335","article-title":"The Flavonoids","volume":"5","author":"Middleton","year":"1984","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0076-6879(90)86128-I","article-title":"Flavonoids as Antioxidants: Determination of Radical-Scavenging Efficiencies","volume":"186","author":"Bors","year":"1990","journal-title":"Methods Enzymol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3177\/jnsv.47.357","article-title":"Antioxidant Ability of various Flavonoids Against DPPH Radicals and LDL Oxidation","volume":"47","author":"Hirano","year":"2001","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S1369-5266(02)00256-X","article-title":"Biosynthesis of Flavonoids and Effects of Stress","volume":"5","year":"2002","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.2307\/3870059","article-title":"Stress-Induced Phenylpropanoid Metabolism","volume":"7","author":"Dixon","year":"1995","journal-title":"Plant Cell"},{"key":"ref_37","first-page":"193","article-title":"Anthocyanins in Foods","volume":"7","author":"Shrikhand","year":"1976","journal-title":"Food Sci. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1021\/jf025551i","article-title":"Antioxidant Activity of Anthocyanins and their Aglycons","volume":"51","author":"Kahkonen","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1021\/jf970234a","article-title":"Anthocyanins as Antioxidants on Human Low-Density Lipoprotein and Lecithin-Liposome Systems","volume":"45","author":"Heinonen","year":"1997","journal-title":"J. Agric. Food Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1021\/jf960421t","article-title":"Oxygen Radical Absorbing Capacity of Anthocyanins","volume":"45","author":"Wang","year":"1997","journal-title":"J. Agric. Food Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0308-8146(96)00065-9","article-title":"Analysis and Health Effects of Flavonoids","volume":"57","author":"Holiman","year":"1996","journal-title":"Food Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/ajcn\/76.3.560","article-title":"Flavonoid Intake and Risk of Chronic Diseases","volume":"76","author":"Knekt","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/jn\/133.1.199","article-title":"Low Intake of Fruits, Berries and Vegetables is Associated with Excess Mortality in Men: The Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study","volume":"133","author":"Rissanen","year":"2003","journal-title":"J. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0031-9422(03)00438-2","article-title":"Analysis and Biological Activities of Anthocyanins","volume":"64","author":"Kong","year":"2003","journal-title":"Phytochemistry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1080\/1071576031000112690","article-title":"Protective Effects of Anthocyanins from Blackberry in a Rat Model of Acute Lung Inflammation","volume":"37","author":"Rossi","year":"2003","journal-title":"Free Radic. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/jsfa.1511","article-title":"Berry Anthocyanins: Isolation, Identification and Antioxidant Activities","volume":"83","author":"Kahkonen","year":"2003","journal-title":"J. Sci. Food Agric."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1021\/jf034785e","article-title":"Protein-Lipid Interactions during Liposome Oxidation with Added Anthocyanin and Other Phenolic Compounds","volume":"52","author":"Viljanen","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Scoggan, H.J. (1979). The Flora of Canada\/Part 4, National Museum of Natural Sciences. [7th ed.].","DOI":"10.5962\/bhl.title.122890"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/pca.1203","article-title":"A RP-HPLC-DAD-APCI\/MSD Method for the Characterisation of Medicinal Ericaceae used by the Eeyou Istchee Cree First Nations","volume":"21","author":"Saleem","year":"2010","journal-title":"Phytochem. Anal."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1139\/b81-287","article-title":"Use of Plants for Food and Medicine by Native Peoples of Eastern Canada","volume":"59","author":"Arnason","year":"1981","journal-title":"Can. J. Bot."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuro.2006.07.015","article-title":"Protective Activities of Vaccinium Antioxidants with Potential Relevance to Mitochondrial Dysfunction and Neurotoxicity","volume":"28","author":"Yao","year":"2007","journal-title":"Neurotoxicology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/mnfr.200700002","article-title":"Berry Anthocyanins as Novel Antioxidants in Human Health and Disease Prevention","volume":"51","author":"Yasmin","year":"2007","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1021\/jf500107j","article-title":"Anthocyanin Metabolites are Abundant and Persistent in Human Urine","volume":"62","author":"Kalt","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1021\/acs.jafc.6b05455","article-title":"Flavonoid Metabolites in Human Urine during Blueberry Anthocyanin Intake","volume":"65","author":"Kalt","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3945\/ajcn.112.049247","article-title":"Human Metabolism and Elimination of the Anthocyanin, Cyanidin-3-Glucoside: A 13C-Tracer Study","volume":"97","author":"Czank","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1021\/jf900894k","article-title":"Urinary Excretion of the Main Anthocyanin in Lingonberry (Vaccinium Vitis-Idaea), Cyanidin 3-O-Galactoside, and its Metabolites","volume":"57","author":"Lehtonen","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1079\/BJN20041126","article-title":"Anthocyanin Metabolites in Human Urine and Serum","volume":"91","author":"Kay","year":"2004","journal-title":"Br. J. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1021\/jf9809582","article-title":"Direct Intestinal Absorption of Red Fruit Anthocyanins, Cyanidin-3-Glucoside and Cyanidin-3,5-Diglucoside, into Rats and Humans","volume":"47","author":"Miyazawa","year":"1999","journal-title":"J. Agric. Food Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"914273","DOI":"10.1155\/2012\/914273","article-title":"Dietary Polyphenols as Modulators of Brain Functions: Biological Actions and Molecular Mechanisms Underpinning their Beneficial Effects","volume":"2012","author":"Vauzour","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1021\/jf2036033","article-title":"Berry Fruit Enhances Beneficial Signaling in the Brain","volume":"60","author":"Miller","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Miller, M.G., Hamilton, D.A., Joseph, J.A., and Shukitt-Hale, B. (2017). Dietary Blueberry Improves Cognition among Older Adults in a Randomized, Double-Blind, Placebo-Controlled Trial. Eur. J. Nutr.","DOI":"10.1096\/fasebj.30.1_supplement.679.18"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.2174\/0929867323666160809094934","article-title":"Flavonoids in Neurodegeneration: Limitations and Strategies to Cross CNS Barriers","volume":"23","author":"Andrade","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/10284150500078117","article-title":"Anthocyanins in Aged Blueberry-Fed Rats are found Centrally and may Enhance Memory","volume":"8","author":"Galli","year":"2005","journal-title":"Nutr. Neurosci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1021\/jf050145v","article-title":"Anthocyanin Metabolism in Rats and their Distribution to Digestive Area, Kidney, and Brain","volume":"53","author":"Talavera","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1079\/BJN20051596","article-title":"Absorption, Tissue Distribution and Excretion of Pelargonidin and its Metabolites Following Oral Administration to Rats","volume":"95","author":"Marks","year":"2006","journal-title":"Br. J. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1021\/jf071998l","article-title":"Identification of Anthocyanins in the Liver, Eye, and Brain of Blueberry-Fed Pigs","volume":"56","author":"Kalt","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1021\/jf903529m","article-title":"Xenobiotic Metabolism and Berry Flavonoid Transport across the Blood-Brain Barrier","volume":"58","author":"Milbury","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Cirmi, S., Ferlazzo, N., Lombardo, G.E., Ventura-Spagnolo, E., Gangemi, S., Calapai, G., and Navarra, M. (2016). Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?. Molecules, 21.","DOI":"10.3390\/molecules21101312"},{"key":"ref_69","first-page":"81","article-title":"Polyphenolic Antioxidants and Neuronal Regeneration","volume":"7","author":"Ataie","year":"2016","journal-title":"Basic Clin. Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.brainres.2014.01.047","article-title":"Neuroprotective Effects of Anthocyanin- and Proanthocyanidin-Rich Extracts in Cellular Models of Parkinson\u2019s Disease","volume":"1555","author":"Strathearn","year":"2014","journal-title":"Brain Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jns.2009.08.034","article-title":"The Epidemiology of Dementia Associated with Parkinson Disease","volume":"289","author":"Aarsland","year":"2010","journal-title":"J. Neurol. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"11456","DOI":"10.1038\/s41598-017-11512-6","article-title":"Polyphenols Journey through Blood-Brain Barrier towards Neuronal Protection","volume":"7","author":"Figueira","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"7769","DOI":"10.1021\/jf401158a","article-title":"Chemical Analysis and Effect of Blueberry and Lingonberry Fruits and Leaves against Glutamate-Mediated Excitotoxicity","volume":"61","author":"Vyas","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s12035-013-8498-3","article-title":"Food, Nutrigenomics, and Neurodegeneration\u2014Neuroprotection by what You Eat!","volume":"48","author":"Virmani","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"636","DOI":"10.3390\/antiox3040636","article-title":"Assessing Antioxidant Capacity in Brain Tissue: Methodologies and Limitations in Neuroprotective Strategies","volume":"3","author":"Slemmer","year":"2014","journal-title":"Antioxidants"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12263-011-0255-5","article-title":"Do Polyphenols Enter the Brain and does it Matter? Some Theoretical and Practical Considerations","volume":"7","author":"Schaffer","year":"2012","journal-title":"Genes Nutr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/ptr.3670","article-title":"Cell-Line Specific Protection by Berry Polyphenols Against Hydrogen Peroxide Challenge and Lack of Effect on Metabolism of Amyloid Precursor Protein","volume":"26","author":"Papandreou","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"8114","DOI":"10.1523\/JNEUROSCI.19-18-08114.1999","article-title":"Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, Or Strawberry Dietary Supplementation","volume":"19","author":"Joseph","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Jurikova, T., Mlcek, J., Skrovankova, S., Balla, S., Sochor, J., Baron, M., and Sumczynski, D. (2016). Black Crowberry (Empetrum nigrum L.) Flavonoids and their Health Promoting Activity. Molecules, 21.","DOI":"10.3390\/molecules21121685"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.neuint.2015.07.003","article-title":"Bioavailability of Dietary Polyphenols: Factors Contributing to their Clinical Application in CNS Diseases","volume":"89","author":"Pandareesh","year":"2015","journal-title":"Neurochem. Int."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Hossain, M.Z., Shea, E., Daneshtalab, M., and Weber, J.T. (2016). Chemical Analysis of Extracts from Newfoundland Berries and Potential Neuroprotective Effects. Antioxidants, 5.","DOI":"10.3390\/antiox5040036"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1021\/jf9029332","article-title":"Blueberry Supplementation Improves Memory in Older Adults","volume":"58","author":"Krikorian","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00394-012-0307-7","article-title":"Neuroprotective Effects of Digested Polyphenols from Wild Blackberry Species","volume":"52","author":"Tavares","year":"2013","journal-title":"Eur. J. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ejphar.2012.01.036","article-title":"Potential Neuroprotective Effects of Oxyresveratrol Against Traumatic Injury","volume":"680","author":"Weber","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2174\/1567202043480134","article-title":"Calcium Homeostasis Following Traumatic Neuronal Injury","volume":"1","author":"Weber","year":"2004","journal-title":"Curr. Neurovasc. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fphar.2012.00060","article-title":"Altered Calcium Signaling Following Traumatic Brain Injury","volume":"3","author":"Weber","year":"2012","journal-title":"Front. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.nbd.2006.03.017","article-title":"Neuroprotection by Two Polyphenols Following Excitotoxicity and Experimental Ischemia","volume":"23","author":"Gottlieb","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1179\/147683009X423292","article-title":"Effects of Blackberries on Motor and Cognitive Function in Aged Rats","volume":"12","author":"Cheng","year":"2009","journal-title":"Nutr. Neurosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.nut.2010.05.001","article-title":"Short-Term Blueberry-Enriched Diet Prevents and Reverses Object Recognition Memory Loss in Aging Rats","volume":"27","author":"Malin","year":"2011","journal-title":"Nutrition"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1515\/pjvs-2017-0038","article-title":"Effect of Feeding with Bilberry Fruit on the Expression Pattern of \u03b1CaMKII in Hippocampal Neurons in Normal and Diabetic Rats","volume":"20","author":"Matysek","year":"2017","journal-title":"Pol. J. Vet. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/10284150400020482","article-title":"Modulation of Hippocampal Plasticity and Cognitive Behavior by Short-Term Blueberry Supplementation in Aged Rats","volume":"7","author":"Casadesus","year":"2004","journal-title":"Nutr. Neurosci."},{"key":"ref_92","first-page":"81","article-title":"Methodologies and Limitations in the Analysis of Potential Neuroprotective Compounds Derived from Natural Products","volume":"2","author":"Weber","year":"2015","journal-title":"New Horiz. Transl. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3109\/09637486.2011.585964","article-title":"In Vitro Neuroprotective Effects of the Leaf and Fruit Extracts of Juglans regia L. (Walnut) through Enzymes Linked to Alzheimer\u2019s Disease and Antioxidant Activity","volume":"62","author":"Orhan","year":"2011","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3109\/09637486.2011.629178","article-title":"Inhibitory Potential of the Leaves and Berries of Myrtus communis L. (Myrtle) Against Enzymes Linked to Neurodegenerative Diseases and their Antioxidant Actions","volume":"63","author":"Tumen","year":"2012","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1039\/C7FO01205E","article-title":"Anthocyanin Profile, Antioxidant Activity and Enzyme Inhibiting Properties of Blueberry and Cranberry Juices: A Comparative Study","volume":"8","author":"Casedas","year":"2017","journal-title":"Food Funct."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1002\/jnr.22679","article-title":"Synaptic Failure and Adenosine Triphosphate Imbalance Induced by Amyloid-\u03b2 Aggregates are Prevented by Blueberry-Enriched Polyphenols Extract","volume":"89","author":"Fuentealba","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.foodres.2015.05.019","article-title":"Partridgeberry Polyphenols Protect Primary Cortical and Hippocampal Neurons against \u03b2-Amyloid Toxicity","volume":"74","author":"Bhullar","year":"2015","journal-title":"Food Res. Int."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1089\/jmf.2013.2881","article-title":"Blueberry (Vaccinium virgatum) Leaf Extracts Protect against A\u03b2-Induced Cytotoxicity and Cognitive Impairment","volume":"16","author":"Jeong","year":"2013","journal-title":"J. Med. Food"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrn2038","article-title":"Microglia-Mediated Neurotoxicity: Uncovering the Molecular Mechanisms","volume":"8","author":"Block","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1021\/acs.jafc.6b04538","article-title":"Neuroprotective Effects of Bioavailable Polyphenol-Derived Metabolites Against Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells","volume":"65","author":"Espin","year":"2017","journal-title":"J. Agric. Food Chem."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/1\/26\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:55:09Z","timestamp":1760208909000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/1\/26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,22]]},"references-count":100,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1]]}},"alternative-id":["molecules23010026"],"URL":"https:\/\/doi.org\/10.3390\/molecules23010026","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,22]]}}}