{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:52:58Z","timestamp":1773841978797,"version":"3.50.1"},"reference-count":56,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Esophageal cancer has a poor prognosis and high mortality rate across the world. The diagnosis and treatment of esophageal cancer are hindered by the limited knowledge about the pathogenesis mechanisms of esophageal cancer. Esophageal cancer has two major subtypes, squamous and adenocarcinoma. In this work, we proposed a method to select candidate biomarkers of esophageal squamous carcinoma based on the topological differential analysis between the gene\u2013gene interaction networks for esophageal squamous carcinoma and normal cells. We established the gene\u2013gene interaction networks for esophageal squamous carcinoma and normal based on the correlation of genes. For each gene, we firstly calculated and compared five centrality measures, which could reflect the topological property of a network. According to five centrality measures, the genes with large differences between the two networks were regarded as candidate biomarkers for esophageal squamous carcinoma. A total of 21 candidate biomarkers were identified for esophageal squamous carcinoma, and seven of them have been confirmed to be biomarkers of esophageal-12 squamous carcinoma by previous research. In addition, six genes (RBPMS2, PDK4, IGK, SBSN, IFIT3 and HSPB6) were likely to be the biomarkers of tumorigenesis for esophageal squamous carcinoma due to the fact that the biological processes in which they participate are closely related with the development of esophageal squamous carcinoma. Statistical analysis indicates that effectiveness of the detected biomarkers of esophageal squamous carcinoma. The proposed method could be extended to other complex diseases for detecting the molecular features of pathopoiesis and targets for targeted therapy.<\/jats:p>","DOI":"10.3390\/molecules23010088","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T12:00:06Z","timestamp":1514980806000},"page":"88","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Network-Based Differential Analysis to Identify Molecular Features of Tumorigenesis for Esophageal Squamous Carcinoma"],"prefix":"10.3390","volume":"23","author":[{"given":"Suxia","family":"Jiang","sequence":"first","affiliation":[{"name":"School of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou 450002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou 450002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yansen","family":"Su","sequence":"additional","affiliation":[{"name":"Institute of Bio-inspired Intelligence and Mining Knowledge, School of Computer Science and Technology, Anhui University, Hefei 230039, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-455X","authenticated-orcid":false,"given":"Linqiang","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou 450002, China"},{"name":"Key Laboratory of Image Processing and Intelligent Control, School of Automation, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global cancer statistics, 2002","volume":"55","author":"Parkin","year":"2005","journal-title":"CA Cancer J. 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