{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:40:33Z","timestamp":1760985633200,"version":"build-2065373602"},"reference-count":46,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"KU Research Professor Program of Konkuk University"},{"name":"National Research Foundation of Korea (NRF) funded by the Ministry of Education","award":["NRF-2015R1D1A1A01058686"],"award-info":[{"award-number":["NRF-2015R1D1A1A01058686"]}]},{"name":"Bio &amp; Medical Technology Development Program of the NRF funded by the Korean government","award":["MSIP (2015M3A9B8031831)"],"award-info":[{"award-number":["MSIP (2015M3A9B8031831)"]}]},{"name":"NRF funded by the Ministry of Science, ICT, &amp; Future Planning","award":["NRF-2015R1C1A1A02037375"],"award-info":[{"award-number":["NRF-2015R1C1A1A02037375"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The poor water solubility of paclitaxel causes significant problems in producing cancer therapeutic formulations. Here, we aimed to solubilize paclitaxel using biocompatible cyclic carbohydrates. Generally recognized as safe, labeled \u03b2-cyclodextrin (\u03b2-CD), a cyclic \u03b1-1,4-glucan consisting of seven glucoses, was prepared, and bio-sourced cyclosophoraoses (CyS), which are unbranched cyclic \u03b2-1,2-glucans with 17\u201323 glucose units, were purified using various chromatographic methods from Rhizobium leguminosarum cultural broth. For effective targeting, CyS and \u03b2-CD were modified with a biotinyl moiety in a reaction of mono-6-amino CyS and mono-6-amino-\u03b2-CD with N-hydroxysuccinimide ester of biotinamidohexanoic acid. Interestingly, the aqueous solubility of paclitaxel was enhanced 10.3- and 3.7-fold in the presence of biotinyl CyS and biotinyl \u03b2-CD, respectively. These findings suggest that biotin-appended cyclooligosaccharides can be applied to improve the delivery of paclitaxel.<\/jats:p>","DOI":"10.3390\/molecules23010090","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T12:00:06Z","timestamp":1514980806000},"page":"90","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Biotinylated Cyclooligosaccharides for Paclitaxel Solubilization"],"prefix":"10.3390","volume":"23","author":[{"given":"Eunae","family":"Cho","sequence":"first","affiliation":[{"name":"Institute for Ubiquitous Information Technology and Applications (UBITA) &amp; Center for Biotechnology Research in UBITA (CBRU), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seunho","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Microbial Carbohydrate Resource Bank (MBRC) &amp; Center for Biotechnology Research in UBITA (CBRU), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/anie.199400151","article-title":"Chemistry and biology of taxol","volume":"33","author":"Nicolaou","year":"1994","journal-title":"Angew. 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