{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T18:50:17Z","timestamp":1785005417276,"version":"3.55.0"},"reference-count":60,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A new series of coumarin-1,2,3-triazole conjugates with varied alkyl, phenyl and heterocycle moieties at C-4 of the triazole nucleus were synthesized using a copper(I)-catalysed Huisgen 1,3-dipolar cycloaddition reaction of corresponding O-propargylated coumarin (3) or N-propargylated coumarin (6) with alkyl or aryl azides. Based on their minimal inhibitory concentrations (MICs) against selected microorganisms, six out of twenty-six compounds showed significant antibacterial activity towards Enterococcus faecalis (MIC = 12.5\u201350 \u00b5g\/mL). Moreover, the synthesized triazoles show relatively low toxicity against human erythrocytes.<\/jats:p>","DOI":"10.3390\/molecules23010199","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T12:19:48Z","timestamp":1516277988000},"page":"199","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Synthesis and Antimicrobial Activity of 4-Substituted 1,2,3-Triazole-Coumarin Derivatives"],"prefix":"10.3390","volume":"23","author":[{"given":"Priscila","family":"L\u00f3pez-Rojas","sequence":"first","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez (CIBICAN), Departamento de Qu\u00edmica Org\u00e1nica, Universidad de La Laguna, Avda. Astrof\u00edsico Fco. S\u00e1nchez 2, 38206 La Laguna, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Janeczko","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, The John Paul II Catholic University of Lublin, ul. Konstantyn\u00f3w 1i, 20-708 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6870-845X","authenticated-orcid":false,"given":"Konrad","family":"Kubi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, The John Paul II Catholic University of Lublin, ul. Konstantyn\u00f3w 1i, 20-708 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Amesty","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez (CIBICAN), Departamento de Qu\u00edmica Org\u00e1nica, Universidad de La Laguna, Avda. Astrof\u00edsico Fco. S\u00e1nchez 2, 38206 La Laguna, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Mas\u0142yk","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, The John Paul II Catholic University of Lublin, ul. Konstantyn\u00f3w 1i, 20-708 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5279-7099","authenticated-orcid":false,"given":"Ana","family":"Est\u00e9vez-Braun","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez (CIBICAN), Departamento de Qu\u00edmica Org\u00e1nica, Universidad de La Laguna, Avda. Astrof\u00edsico Fco. S\u00e1nchez 2, 38206 La Laguna, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"ref_1","unstructured":"Holpuch, A. (2016). 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