{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:59:27Z","timestamp":1793422767349,"version":"4.5.0"},"reference-count":162,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A pretreatment of lignocellulosic biomass to produce biofuels, polymers, and other chemicals plays a vital role in the biochemical conversion process toward disrupting the closely associated structures of the cellulose-hemicellulose-lignin molecules. Various pretreatment steps alter the chemical\/physical structure of lignocellulosic materials by solubilizing hemicellulose and\/or lignin, decreasing the particle sizes of substrate and the crystalline portions of cellulose, and increasing the surface area of biomass. These modifications enhance the hydrolysis of cellulose by increasing accessibilities of acids or enzymes onto the surface of cellulose. However, lignocellulose-derived byproducts, which can inhibit and\/or deactivate enzyme and microbial biocatalysts, are formed, including furan derivatives, lignin-derived phenolics, and carboxylic acids. These generation of compounds during pretreatment with inhibitory effects can lead to negative effects on subsequent steps in sugar flat-form processes. A number of physico-chemical pretreatment methods such as steam explosion, ammonia fiber explosion (AFEX), and liquid hot water (LHW) have been suggested and developed for minimizing formation of inhibitory compounds and alleviating their effects on ethanol production processes. This work reviews the physico-chemical pretreatment methods used for various biomass sources, formation of lignocellulose-derived inhibitors, and their contributions to enzymatic hydrolysis and microbial activities. Furthermore, we provide an overview of the current strategies to alleviate inhibitory compounds present in the hydrolysates or slurries.<\/jats:p>","DOI":"10.3390\/molecules23020309","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T04:20:50Z","timestamp":1517545250000},"page":"309","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":430,"title":["Physico-Chemical Conversion of Lignocellulose: Inhibitor Effects and Detoxification Strategies: A Mini Review"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6675-5084","authenticated-orcid":false,"given":"Daehwan","family":"Kim","sequence":"first","affiliation":[{"name":"Laboratory of Renewable Resources Engineering, Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0960-8524(01)00212-7","article-title":"Hydrolysis of lignocellulosic materials for ethanol production: A review","volume":"83","author":"Sun","year":"2002","journal-title":"Bioresour. Technol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1754-6834-1-7","article-title":"A short review on SSF\u2014An interesting process option for ethanol production from lignocellulosic feedstocks","volume":"1","author":"Olofsson","year":"2008","journal-title":"Biotechnol. Biofuels"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.tibtech.2006.10.004","article-title":"Bio-ethanol\u2014The fuel of tomorrow from the residues of today","volume":"24","author":"Galbe","year":"2006","journal-title":"Trends Biotechnol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1126\/science.1114736","article-title":"The Path Forward for Biofuels and Biomaterials","volume":"311","author":"Ragauskas","year":"2006","journal-title":"Science"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1016\/j.biortech.2009.10.079","article-title":"Bioethanol production from rice straw: An overview","volume":"101","author":"Binod","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_6","first-page":"8","article-title":"Bioconversion of pentose sugars into ethanol: A review and future directions","volume":"6","author":"Chandel","year":"2011","journal-title":"Biotechnol. Mol. Biol. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nature07190","article-title":"Genomics of cellulosic biofuels","volume":"454","author":"Rubin","year":"2008","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1016\/j.biortech.2010.01.088","article-title":"Hemicelluloses for fuel ethanol: A review","volume":"101","author":"Fonseca","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.biombioe.2012.04.020","article-title":"Review of pretreatment processes for lignocellulosic ethanol production, and development of an innovative method","volume":"46","author":"Chiaramonti","year":"2012","journal-title":"Biomass Bioenergy"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"270","DOI":"10.15376\/biores.3.1.270-294","article-title":"Feedstock pretreatment strategies for producing ethanol from wood, bark, and forest residues","volume":"3","author":"Hu","year":"2008","journal-title":"BioResources"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.rser.2014.04.047","article-title":"Importance of chemical pretreatment for bioconversion of lignocellulosic biomass","volume":"36","author":"Behera","year":"2014","journal-title":"Renew. Sustain. Energy Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1754-6834-6-16","article-title":"Bioconversion of lignocellulose: Inhibitors and detoxification","volume":"6","author":"Alriksson","year":"2013","journal-title":"Biotechnol. Biofuels"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.biortech.2015.10.009","article-title":"Pretreatment of lignocellulose: Formation of inhibitory by-products and strategies for minimizing their effects","volume":"199","year":"2016","journal-title":"Bioresour. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"9054","DOI":"10.1021\/jf100807b","article-title":"Compositional analysis of lignocellulosic feedstocks. 2. Method uncertainties","volume":"58","author":"Templeton","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s10295-010-0812-8","article-title":"Composition of sugar cane, energy cane, and sweet sorghum suitable for ethanol production at Louisiana sugar mills","volume":"38","author":"Kim","year":"2011","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5694","DOI":"10.1016\/j.biortech.2007.10.055","article-title":"Bioethanol production from barley hull using SAA (soaking in aqueous ammonia) pretreatment","volume":"99","author":"Kim","year":"2008","journal-title":"Bioresour. Technol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.biortech.2004.06.025","article-title":"Features of promising technologies for pretreatment of lignocellulosic biomass","volume":"96","author":"Mosier","year":"2005","journal-title":"Bioresour. Technol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.biortech.2017.08.156","article-title":"Cellulose conversion of corn pericarp without pretreatment","volume":"245","author":"Kim","year":"2017","journal-title":"Bioresour. Technol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.biortech.2016.05.086","article-title":"Maleic acid treatment of biologically detoxified corn stover liquor","volume":"216","author":"Kim","year":"2016","journal-title":"Bioresour. Technol."},{"key":"ref_20","first-page":"129","article-title":"Ethanol production from steam-explosion pretreated wheat straw","volume":"129","author":"Ballesteros","year":"2006","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Ximenes, E., Kim, Y., and Ladisch, M.R. (2013). Biological Conversion of Plants to Fuels and Chemicals and the Effects of Inhibitors. Aqueous Pretreatment Plant Biomass Biological Chemical Conversion Fuels Chemicals, John Wiley & Sons, Ltd.","DOI":"10.1002\/9780470975831.ch4"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1016\/j.biortech.2010.11.052","article-title":"Pretreatment efficiency and structural characterization of rice straw by an integrated process of dilute-acid and steam explosion for bioethanol production","volume":"102","author":"Chen","year":"2011","journal-title":"Bioresour. Technol."},{"key":"ref_23","first-page":"1608","article-title":"Effect of ozonolysis pretreatment on enzymatic digestibility of sugarcane bagasse","volume":"100","author":"Indacoechea","year":"2009","journal-title":"Agric. Eng. Int. CIGR J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1016\/j.biortech.2009.10.066","article-title":"Comparison of dilute acid and ionic liquid pretreatment of switchgrass: Biomass recalcitrance, delignification and enzymatic saccharification","volume":"101","author":"Li","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.enzmictec.2006.07.015","article-title":"Wet oxidation as a pretreatment method for enhancing the enzymatic convertibility of sugarcane bagasse","volume":"40","author":"Klinke","year":"2007","journal-title":"Enzym. Microb. Technol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.biortech.2009.09.044","article-title":"Process optimization to convert forage and sweet sorghum bagasse to ethanol based on ammonia fiber expansion (AFEX) pretreatment","volume":"101","author":"Li","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.fuel.2007.05.008","article-title":"Production of fuel ethanol from steam-explosion pretreated olive tree pruning","volume":"87","author":"Cara","year":"2008","journal-title":"Fuel"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1016\/j.biortech.2009.01.075","article-title":"Physical and chemical characterizations of corn stover and poplar solids resulting from leading pretreatment technologies","volume":"100","author":"Kumar","year":"2009","journal-title":"Bioresour. Technol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/bit.22829","article-title":"Effect of varying feedstock-pretreatment chemistry combinations on the formation and accumulation of potentially inhibitory degradation products in biomass hydrolysates","volume":"107","author":"Du","year":"2010","journal-title":"Biotechnol. Bioeng."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4914","DOI":"10.1016\/j.biortech.2009.08.100","article-title":"Pretreatment of spruce and oak by N-methylmorpholine-N-oxide (NMMO) for efficient conversion of their cellulose to ethanol","volume":"101","author":"Shafiei","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1754-6834-3-10","article-title":"Cellulose crystallinity index: Measurement techniques and their impact on interpreting cellulase performance","volume":"3","author":"Park","year":"2010","journal-title":"Biotechnol. Biofuels"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/bit.260261010","article-title":"Effect of crystallinity and degree of polymerization of cellulose on enzymatic saccharification","volume":"26","author":"Puri","year":"1984","journal-title":"Biotechnol. Bioeng."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/bit.25349","article-title":"Effect of liquid hot water pretreatment severity on properties of hardwood lignin and enzymatic hydrolysis of cellulose","volume":"112","author":"Ko","year":"2015","journal-title":"Biotechnol. Bioeng."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/bit.25359","article-title":"Adsorption of enzyme onto lignins of liquid hot water pretreated hardwoods","volume":"112","author":"Ko","year":"2015","journal-title":"Biotechnol. Bioeng."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1021\/bm800528f","article-title":"Coniferyl ferulate incorporation into lignin enhances the alkaline delignification and enzymatic degradation of cell walls","volume":"9","author":"Grabber","year":"2008","journal-title":"Biomacromolecules"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.biortech.2008.05.027","article-title":"Pretreatments to enhance the digestibility of lignocellulosic biomass","volume":"100","author":"Hendriks","year":"2009","journal-title":"Bioresour. Technol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/btpr.153","article-title":"Access of cellulase to cellulose and lignin for poplar solids produced by leading pretreatment technologies","volume":"25","author":"Kumar","year":"2009","journal-title":"Biotechnol. Prog."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/bit.22068","article-title":"Effect of enzyme supplementation at moderate cellulase loadings on initial glucose and xylose release from corn stover solids pretreated by leading technologies","volume":"102","author":"Kumar","year":"2009","journal-title":"Biotechnol. Bioeng."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13068-016-0485-2","article-title":"Inhibition of lignin-derived phenolic compounds to cellulase","volume":"9","author":"Qin","year":"2016","journal-title":"Biotechnol. Biofuels"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/bbb.4","article-title":"Enzymatic conversion of lignocellulose into fermentable sugars: Challenges and opportunities","volume":"1","author":"Kristensen","year":"2007","journal-title":"Biofuels Bioprod. Biorefin."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/bit.25465","article-title":"Hydrolysis-determining substrate characteristics in liquid hot water pretreated hardwood","volume":"112","author":"Kim","year":"2015","journal-title":"Biotechnol. Bioeng."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10570-004-5840-y","article-title":"The degree of disorder in hardwood kraft pulps studied by means of LODP","volume":"12","author":"Ahlgren","year":"2005","journal-title":"Cellulose"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"10925","DOI":"10.1039\/c2ra22045h","article-title":"Chemical transformations of Populus trichocarpa during dilute acid pretreatment","volume":"2","author":"Cao","year":"2012","journal-title":"RSC Adv."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1016\/j.biortech.2009.11.093","article-title":"Pretreatment technologies for an efficient bioethanol production process based on enzymatic hydrolysis: A review","volume":"101","author":"Alvira","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.biombioe.2010.07.023","article-title":"Changes in lignocellulosic supramolecular and ultrastructure during dilute acid pretreatment of Populus and switchgrass","volume":"34","author":"Foston","year":"2010","journal-title":"Biomass Bioenergy"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.enzmictec.2010.09.006","article-title":"Deactivation of cellulases by phenols","volume":"48","author":"Ximenes","year":"2011","journal-title":"Enzym. Microb. Technol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.enzmictec.2009.11.001","article-title":"Inhibition of cellulases by phenols","volume":"46","author":"Ximenes","year":"2010","journal-title":"Enzym. Microb. Technol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1385\/ABAB:84-86:1-9:5","article-title":"Fundamental Factors Affecting Biomass Enzymatic Reactivity","volume":"84","author":"Chang","year":"2000","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/bit.22981","article-title":"Enhancing the enzymatic hydrolysis of lignocellulosic biomass by increasing the carboxylic acid content of the associated lignin","volume":"108","author":"Nakagame","year":"2011","journal-title":"Biotechnol. Bioeng."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1016\/j.biortech.2010.12.082","article-title":"The isolation, characterization and effect of lignin isolated from steam pretreated Douglas-fir on the enzymatic hydrolysis of cellulose","volume":"102","author":"Nakagame","year":"2011","journal-title":"Bioresour. Technol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1139\/v79-187","article-title":"Characterization of autohydrolysis aspen (P. tremuloides) lignins. Part 1. Composition and molecular weight distribution of extracted autohydrolysis lignin","volume":"57","author":"Chua","year":"1979","journal-title":"Can. J. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1016\/j.biortech.2006.10.018","article-title":"Lignin depolymerization\/repolymerization and its critical role for delignification of aspen wood by steam explosion","volume":"98","author":"Li","year":"2007","journal-title":"Bioresour. Technol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1007\/s00253-015-6595-0","article-title":"Compounds inhibiting the bioconversion of hydrothermally pretreated lignocellulose","volume":"99","author":"Ko","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1021\/jf062131a","article-title":"Porosity and its effect on the digestibility of dilute sulfuric acid pretreated corn stover","volume":"55","author":"Ishizawa","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1515\/HF.2006.062","article-title":"Effect of acetyl groups on enzymatic hydrolysis of cellulosic substrates","volume":"60","author":"Pan","year":"2006","journal-title":"Holzforschung"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1754-6834-5-8","article-title":"The impacts of deacetylation prior to dilute acid pretreatment on the bioethanol process","volume":"5","author":"Chen","year":"2012","journal-title":"Biotechnol. Biofuels"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10570-009-9322-0","article-title":"The impact of cell wall acetylation on corn stover hydrolysis by cellulolytic and xylanolytic enzymes","volume":"16","author":"Selig","year":"2009","journal-title":"Cellulose"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1754-6834-6-15","article-title":"Assessing the molecular structure basis for biomass recalcitrance during dilute acid and hydrothermal pretreatments","volume":"6","author":"Pu","year":"2013","journal-title":"Biotechnol. Biofuels"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0961-9534(97)10043-5","article-title":"Steam-assisted biomass fractionation. I. Process considerations and economic evaluation","volume":"14","author":"Avellar","year":"1998","journal-title":"Biomass Bioenergy"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1385\/ABAB:124:1-3:1069","article-title":"Strategies to Enhance the Enzymatic Hydrolysis of Pretreated Softwood with High Residual Lignin Content","volume":"124","author":"Pan","year":"2005","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biortech.2006.11.039","article-title":"Steam pretreatment of H2SO4-impregnated Salix for the production of bioethanol","volume":"99","author":"Sassner","year":"2008","journal-title":"Bioresour. Technol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"6312","DOI":"10.1016\/j.biortech.2009.06.097","article-title":"Impact of impregnation time and chip size on sugar yield in pretreatment of softwood for ethanol production","volume":"100","author":"Monavari","year":"2009","journal-title":"Bioresour. Technol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.biombioe.2007.09.013","article-title":"Steam pretreatment of dilute H2SO4-impregnated wheat straw and SSF with low yeast and enzyme loadings for bioethanol production","volume":"32","author":"Linde","year":"2008","journal-title":"Biomass Bioenergy"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.biortech.2015.08.029","article-title":"Various pretreatments of lignocellulosics","volume":"199","author":"Rabemanolontsoa","year":"2016","journal-title":"Bioresour. Technol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.15376\/biores.7.2.2051-2074","article-title":"Mild steam explosion and chemical pre-treatment of Norway spruce","volume":"7","author":"Jedvert","year":"2012","journal-title":"BioResources"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/sj.jim.7000054","article-title":"Comparison of SHF and SSF processes for the bioconversion of steam-exploded wheat straw","volume":"25","author":"Alfani","year":"2000","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/07388559709146606","article-title":"Xylanolytic Enzymes from Fungi and Bacteria","volume":"17","author":"Sunna","year":"1997","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1754-6834-6-11","article-title":"Ethanol and biogas production after steam pretreatment of corn stover with or without the addition of sulphuric acid","volume":"6","author":"Bondesson","year":"2013","journal-title":"Biotechnol. Biofuels"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.biortech.2006.02.029","article-title":"Unpolluted fractionation of wheat straw by steam explosion and ethanol extraction","volume":"98","author":"Hongzhang","year":"2007","journal-title":"Bioresour. Technol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1016\/j.biortech.2007.11.013","article-title":"Trends in biotechnological production of fuel ethanol from different feedstocks","volume":"99","author":"Cardona","year":"2008","journal-title":"Bioresour. Technol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1385\/ABAB:125:2:077","article-title":"Industrial scale-up of pH-controlled liquid hot water pretreatment of corn fiber for fuel ethanol production","volume":"125","author":"Mosier","year":"2005","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/btpr.137","article-title":"Enzymatic digestion of liquid hot water pretreated hybrid poplar","volume":"25","author":"Kim","year":"2009","journal-title":"Biotechnol. Prog."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1016\/j.biortech.2005.01.013","article-title":"Optimization of pH controlled liquid hot water pretreatment of corn stover","volume":"96","author":"Mosier","year":"2005","journal-title":"Bioresour. Technol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.15376\/biores.6.2.1576-1598","article-title":"Impact of hot compressed water pretreatment on the structural changes of woody biomass for bioethanol production","volume":"6","author":"Xiao","year":"2011","journal-title":"BioResources"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1385\/ABAB:124:1-3:1081","article-title":"Understanding factors that limit enzymatic hydrolysis of biomass","volume":"124","author":"Teymouri","year":"2005","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_76","first-page":"51","article-title":"Overview of biomass pretreatment for cellulosic ethanol production","volume":"2","author":"Zheng","year":"2009","journal-title":"Int. J. Agric. Biol. Eng."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1016\/j.biortech.2005.01.016","article-title":"Optimization of the ammonia fiber explosion (AFEX) treatment parameters for enzymatic hydrolysis of corn stover","volume":"96","author":"Teymouri","year":"2005","journal-title":"Bioresour. Technol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"8429","DOI":"10.1016\/j.biortech.2008.02.059","article-title":"Recent process improvements for the ammonia fiber expansion (AFEX) process and resulting reductions in minimum ethanol selling price","volume":"99","author":"Sendich","year":"2008","journal-title":"Bioresour. Technol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.biombioe.2008.02.013","article-title":"Comparison of crop and animal simulation options for integration with the biorefinery","volume":"32","author":"Sendich","year":"2008","journal-title":"Biomass Bioenergy"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/j.biortech.2005.01.010","article-title":"Coordinated development of leading biomass pretreatment technologies","volume":"96","author":"Wyman","year":"2005","journal-title":"Bioresour. Technol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1754-6834-3-12","article-title":"Enzymatic digestibility and ethanol fermentability of AFEX-treated starch-rich lignocellulosics such as corn silage and whole corn plant","volume":"3","author":"Shao","year":"2010","journal-title":"Biotechnol. Biofuels"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"7849","DOI":"10.1016\/j.biortech.2010.04.076","article-title":"Effect of primary degradation-reaction products from Ammonia Fiber Expansion (AFEX)-treated corn stover on the growth and fermentation of Escherichia coli KO11","volume":"101","author":"Lau","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"8171","DOI":"10.1016\/j.biortech.2010.06.026","article-title":"Two-step SSCF to convert AFEX-treated switchgrass to ethanol using commercial enzymes and Saccharomyces cerevisiae 424A(LNH-ST)","volume":"101","author":"Jin","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.biortech.2015.04.064","article-title":"Bioabatement with hemicellulase supplementation to reduce enzymatic hydrolysis inhibitors","volume":"190","author":"Cao","year":"2015","journal-title":"Bioresour. Technol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.biortech.2013.07.112","article-title":"Biological abatement of cellulase inhibitors","volume":"146","author":"Cao","year":"2013","journal-title":"Bioresour. Technol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.enzmictec.2011.01.007","article-title":"Soluble inhibitors\/deactivators of cellulase enzymes from lignocellulosic biomass","volume":"48","author":"Kim","year":"2011","journal-title":"Enzym. Microb. Technol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.biortech.2012.10.130","article-title":"Fractionation of cellulase and fermentation inhibitors from steam pretreated mixed hardwood","volume":"135","author":"Kim","year":"2013","journal-title":"Bioresour. Technol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0960-8524(99)00160-1","article-title":"Fermentation of lignocellulosic hydrolysates. I: Inhibition and detoxification","volume":"74","author":"Palmqvist","year":"2000","journal-title":"Bioresour. Technol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0960-8524(99)00161-3","article-title":"Fermentation of lignocellulosic hydrolysates. II: Inhibitors and mechanisms of inhibition","volume":"74","author":"Palmqvist","year":"2000","journal-title":"Bioresour. Technol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1021\/bp9900864","article-title":"Substrate and enzymatic characteristics that limit cellulose hydrolysis","volume":"15","author":"Mansfield","year":"1999","journal-title":"Biotechnol. Prog."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/bit.20282","article-title":"Toward an aggregated understanding of enzymatic hydrolysis of cellulose: Noncomplexed cellulase systems","volume":"88","author":"Zhang","year":"2004","journal-title":"Biotechnol. Bioeng."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1002\/bit.260381108","article-title":"Saccharification of steam-exploded poplar wood","volume":"38","author":"Excoffier","year":"1991","journal-title":"Biotechnol. Bioeng."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"7850","DOI":"10.1016\/j.biortech.2011.05.043","article-title":"Removal of enzymatic and fermentation inhibitory compounds from biomass slurries for enhanced biorefinery process efficiencies","volume":"102","author":"Gurram","year":"2011","journal-title":"Bioresour. Technol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00253-004-1642-2","article-title":"Inhibition of ethanol-producing yeast and bacteria by degradation products produced during pre-treatment of biomass","volume":"66","author":"Klinke","year":"2004","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.biortech.2015.08.120","article-title":"Effect of phenolic compounds from pretreated sugarcane bagasse on cellulolytic and hemicellulolytic activities","volume":"199","author":"Michelin","year":"2016","journal-title":"Bioresour. Technol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1098\/rsta.1987.0029","article-title":"Fractionation of lignocellulosics by steam\u2014Aqueous pretreatments","volume":"321","author":"Overend","year":"1987","journal-title":"Philos. Trans. R. Soc. Lond. A"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-chembioeng-061010-114205","article-title":"Deconstruction of Lignocellulosic Biomass to Fuels and Chemicals","volume":"2","author":"Chundawat","year":"2011","journal-title":"Annu. Rev. Chem. Biomol. Eng."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s13205-013-0167-8","article-title":"An overview of key pretreatment processes employed for bioconversion of lignocellulosic biomass into biofuels and value added products","volume":"3","author":"Chaturvedi","year":"2013","journal-title":"3 Biotech"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/btpr.160","article-title":"Enzymatic digestibility and pretreatment degradation products of AFEX-treated hardwoods (Populus nigra)","volume":"25","author":"Balan","year":"2009","journal-title":"Biotechnol. Prog."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1002\/bit.21373","article-title":"Butanol production from agricultural residues: Impact of degradation products on Clostridium beijerinckii growth and butanol fermentation","volume":"97","author":"Ezeji","year":"2007","journal-title":"Biotechnol. Bioeng."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12934-015-0338-x","article-title":"Catabolism of coniferyl aldehyde, ferulic acid and p-coumaric acid by Saccharomyces cerevisiae yields less toxic products","volume":"14","author":"Adeboye","year":"2015","journal-title":"Microb. Cell Fact."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2672.2004.02275.x","article-title":"Mode of antimicrobial of vanillin against Escherichia coli, Lactobacillus plantarum and Listeria innocua","volume":"97","author":"Fitzgerald","year":"2004","journal-title":"J. Appl. Microbiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1389-1723(99)89007-0","article-title":"Conversion of furfural in aerobic and anaerobic batch fermentation of glucose by Saccharomyces cerevisiae","volume":"87","author":"Taherzadeh","year":"1999","journal-title":"J. Biosci. Bioeng."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0032-9592(91)80003-8","article-title":"Utilization of sugar cane bagasse hemicellulosic hydrolysate by pichia stipitis for the production of ethanol","volume":"26","author":"Roberto","year":"1991","journal-title":"Process Biochem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0168-1656(00)00385-0","article-title":"Ethanol production from wheat straw hemicellulose hydrolysate by Pichia stipitis","volume":"87","author":"Nigam","year":"2001","journal-title":"J. Biotechnol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00253-011-3167-9","article-title":"Molecular mechanisms of yeast tolerance and in situ detoxification of lignocellulose hydrolysates","volume":"90","author":"Liu","year":"2011","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/(SICI)1097-0290(19991005)65:1<24::AID-BIT4>3.0.CO;2-2","article-title":"Effect of Selected Aldehydes on the Growth and Fermentation of Ethanologeic Escherichia coli","volume":"65","author":"Zaldivar","year":"1999","journal-title":"Biotechnol. Bioeng."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0165-7992(89)90125-5","article-title":"Specificity of the interaction of furfural with DNA","volume":"225","author":"Hadi","year":"1989","journal-title":"Mutat. Res. Lett."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.1016\/j.biortech.2007.12.047","article-title":"Characterization of dilute acid pretreatment of silvergrass for ethanol production","volume":"99","author":"Guo","year":"2008","journal-title":"Bioresour. Technol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1754-6834-3-2","article-title":"Furfural induces reactive oxygen species accumulation and cellular damage in Saccharomyces cerevisiae","volume":"3","author":"Allen","year":"2010","journal-title":"Biotechnol. Biofuels"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Liu, Z.L., and Blaschek, H.P. (2010). Biomass Conversion Inhibitors and In Situ Detoxification. Biomass to Biofuels: Strategies for Global Industries, John Wiley & Sons, Ltd.","DOI":"10.1002\/9780470750025.ch12"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"472","DOI":"10.15376\/biores.2.3.472-499","article-title":"Acid-Based Hydrolysis Processes For Ethanol From Lignocellulosic Materials: A Review","volume":"2","author":"Taherzadeh","year":"2015","journal-title":"Bioresources"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/BF00270792","article-title":"Combined effect of acetic acid, pH and ethanol on intracellular pH of fermenting yeast","volume":"31","author":"Pampulha","year":"1989","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_114","first-page":"405","article-title":"Energetics of Saccharomyces cerevisiae in anaerobic glucose-limited chemostat cultures","volume":"136","author":"Verduyn","year":"1990","journal-title":"Biotechnol. Bioeng."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1385\/ABAB:77:1-3:133","article-title":"Dilute acid hydrolysis of softwoods","volume":"77","author":"Nguyen","year":"1999","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/bit.260470103","article-title":"Transport of lactate and acetate through the energized cytoplasmic membrane of Escherichia coli","volume":"47","author":"Axe","year":"1995","journal-title":"Biotechnol. Bioeng."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/bit.260190703","article-title":"Cellobiase from Trichoderma viride: Purification, Properties, Kinetics, and Mechanism","volume":"19","author":"Gong","year":"1977","journal-title":"Biotechnol. Bioleng."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1002\/bit.260231212","article-title":"Combined product and substrate inhibition equation for cellobiase","volume":"23","author":"Hong","year":"1981","journal-title":"Biotechnol. Bioeng."},{"key":"ref_119","first-page":"663","article-title":"A Theoretical Analysis of Cellulase Product Inhibition: Effect of Cellulase Binding Constant, Enzyme\/Substrate Ratio, Inhibition Pattern T1","volume":"40","author":"Gusakov","year":"1992","journal-title":"Biotechnology"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/bit.260360310","article-title":"Inhibition of Trichoderma reesei cellulase by sugars and solvents","volume":"36","author":"Holtzapple","year":"1990","journal-title":"Biotechnol. Bioeng."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/bit.260410903","article-title":"Study of the enzymatic hydrolysis of cellulose for production of fuel ethanol by the simultaneous saccharification and fermentation process","volume":"41","author":"Philippidis","year":"1993","journal-title":"Biotechnol. Bioeng."},{"key":"ref_122","unstructured":"Ladisch, M.R., Gong, C.S., and Tsao, G.T. (1997). Corn Crop Residues as a Potential Source of Single Cell Protein Kinetics of Trichoderma Viride Cellobiase Action, Developments in Industrial Microbilogy."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"9624","DOI":"10.1016\/j.biortech.2010.06.137","article-title":"Xylooligomers are strong inhibitors of cellulose hydrolysis by enzymes","volume":"101","author":"Qing","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1080\/10408398.2011.561379","article-title":"Advance in Dietary Polyphenols as \u03b1-Glucosidases Inhibitors: A Review on Structure-Activity Relationship Aspect","volume":"53","author":"Xiao","year":"2013","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1754-6834-4-18","article-title":"Supplementation with xylanase and \u03b2-xylosidase to reduce xylo-oligomer and xylan inhibition of enzymatic hydrolysis of cellulose and pretreated corn stover","volume":"4","author":"Qing","year":"2011","journal-title":"Biotechnol. Biofuels"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.biortech.2012.04.037","article-title":"Pseudo-lignin formation and its impact on enzymatic hydrolysis","volume":"117","author":"Hu","year":"2012","journal-title":"Bioresour. Technol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.1073\/pnas.1009252108","article-title":"Lignin content in natural Populus variants affects sugar release","volume":"108","author":"Studer","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.biombioe.2012.03.033","article-title":"Inbicon makes lignocellulosic ethanol a commercial reality","volume":"46","author":"Larsen","year":"2012","journal-title":"Biomass Bioenergy"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1754-6834-3-27","article-title":"Lignin monomer composition affects Arabidopsis cell-wall degradability after liquid hot water pretreatment","volume":"3","author":"Li","year":"2010","journal-title":"Biotechnol. Biofuels"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1039\/c3gc42422g","article-title":"Engineering plant cell walls: Tuning lignin monomer composition for deconstructable biofuel feedstocks or resilient biomaterials","volume":"16","author":"Ciesielski","year":"2014","journal-title":"Green Chem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.biortech.2010.08.037","article-title":"Improving the fermentability of enzymatic hydrolysates of lignocellulose through chemical in-situ detoxification with reducing agents","volume":"102","author":"Alriksson","year":"2011","journal-title":"Bioresour. Technol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1385\/ABAB:130:1:599","article-title":"Optimal Conditions for Alkaline Detoxification of Dilute-Acid Lignocellulose Hydrolysates","volume":"130","author":"Alriksson","year":"2006","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.apenergy.2014.07.038","article-title":"PEI detoxification of pretreated spruce for high solids ethanol fermentation","volume":"132","author":"Cannella","year":"2014","journal-title":"Appl. Energy"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"7545","DOI":"10.1016\/j.biortech.2010.04.097","article-title":"Fermentation of bioenergy crops into ethanol using biological abatement for removal of inhibitors","volume":"101","author":"Nichols","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1385\/ABAB:121:1-3:0379","article-title":"Bioabatement to remove inhibitors from biomass-derived sugar hydrolysates","volume":"121\u2013124","author":"Nichols","year":"2005","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.enzmictec.2008.02.008","article-title":"Fungal metabolism of fermentation inhibitors present in corn stover dilute acid hydrolysate","volume":"42","author":"Nichols","year":"2008","journal-title":"Enzym. Microb. Technol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1754-6834-5-32","article-title":"Evolutionary engineering strategies to enhance tolerance of xylose utilizing recombinant yeast to inhibitors derived from spruce biomass","volume":"5","author":"Koppram","year":"2012","journal-title":"Biotechnol. Biofuels"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1002\/bit.24938","article-title":"Evolutionary engineering of Saccharomyces cerevisiae for enhanced tolerance to hydrolysates of lignocellulosic biomass","volume":"110","author":"Almario","year":"2013","journal-title":"Biotechnol. Bioeng."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1128\/AEM.67.3.1163-1170.2001","article-title":"Development of a Saccharomyces cerevisiae Strain with Enhanced Resistance to Phenolic Fermentation Inhibitors in Lignocellulose Hydrolysates by Heterologous Expression of Laccase","volume":"67","author":"Larsson","year":"2001","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1073\/pnas.1217958110","article-title":"Engineering furfural tolerance in Escherichia coli improves the fermentation of lignocellulosic sugars into renewable chemicals","volume":"110","author":"Wang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"7917","DOI":"10.1016\/j.biortech.2011.06.028","article-title":"Repeated-batch fermentation of lignocellulosic hydrolysate to ethanol using a hybrid Saccharomyces cerevisiae strain metabolically engineered for tolerance to acetic and formic acids","volume":"102","author":"Sanda","year":"2011","journal-title":"Bioresour. Technol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1073\/pnas.1100310108","article-title":"Genetic manipulation of lignin reduces recalcitrance and improves ethanol production from switchgrass","volume":"108","author":"Fu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s10570-009-9309-x","article-title":"Role of pretreatment and conditioning processes on toxicity of lignocellulosic biomass hydrolysates","volume":"16","author":"Pienkos","year":"2009","journal-title":"Cellulose"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1385\/ABAB:77:1-3:91","article-title":"Comparison of Different Methods for the Detoxification of Lignocellulose Hydrolyzates of Spruce","volume":"77","author":"Larsson","year":"1999","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/btpr.2282","article-title":"Acetic acid removal from corn stover hydrolysate using ethyl acetate and the impact on Saccharomyces cerevisiae bioethanol fermentation","volume":"32","author":"Aghazadeh","year":"2016","journal-title":"Biotechnol. Prog."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0141-0229(02)00134-5","article-title":"Mechanism of surfactant effect in enzymatic hydrolysis of lignocellulose","volume":"31","author":"Eriksson","year":"2002","journal-title":"Enzym. Microb. Technol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.biortech.2011.09.091","article-title":"The lignin present in steam pretreated softwood binds enzymes and limits cellulose accessibility","volume":"103","author":"Kumar","year":"2012","journal-title":"Bioresour. Technol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.enzmictec.2010.05.010","article-title":"Hydrolysis efficiency and enzyme adsorption on steam-pretreated spruce in the presence of poly(ethylene glycol)","volume":"47","author":"Sipos","year":"2010","journal-title":"Enzym. Microb. Technol."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Silva, A., Sampaio-Marques, B., Fernandes, \u00c2., Carreto, L., Rodrigues, F., Holcik, M., Santos, M.A.S., and Ludovico, P. (2013). Involvement of Yeast HSP90 Isoforms in Response to Stress and Cell Death Induced by Acetic Acid. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0071294"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1021\/ef5019274","article-title":"Techno-economic and environmental analysis of ethanol production from 10 agroindustrial residues in Colombia","volume":"29","author":"Duque","year":"2015","journal-title":"Energy Fuels"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.biombioe.2014.04.026","article-title":"Biological abatement of inhibitors in rice hull hydrolyzate and fermentation to ethanol using conventional and engineered microbes","volume":"67","author":"Nichols","year":"2014","journal-title":"Biomass Bioenergy"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00253-003-1401-9","article-title":"Isolation of microorganisms for biological detoxification of lignocellulosic hydrolysates","volume":"64","author":"Moreno","year":"2004","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez, D.J., Hector, R.E., Riley, R., Lipzen, A., Kuo, R.C., Amirebrahimi, M., Barry, K.W., Grigoriev, I.V., Van Elsas, J.D., and Nichols, N. (2017). Draft Genome Sequence of Coniochaeta ligniaria NRRL 30616, a Lignocellulolytic Fungus for Bioabatement of Inhibitors in Plant Biomass Hydrolysates. Genome Announc., 5.","DOI":"10.1128\/genomeA.01476-16"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s00284-005-4485-x","article-title":"Functional expression of bacterial Zymobacter palmae pyruvate decarboxylase gene in Lactococcus lactis","volume":"50","author":"Liu","year":"2005","journal-title":"Curr. Microbiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1385\/ABAB:78:1-3:455","article-title":"Bioconversion of mixed solids waste to ethanol","volume":"77\u201379","author":"Nguyen","year":"1999","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1754-6834-6-168","article-title":"Exploring grape marc as trove for new thermotolerant and inhibitor-tolerant Saccharomyces cerevisiae strains for second-generation bioethanol production","volume":"6","author":"Favaro","year":"2013","journal-title":"Biotechnol. Biofuels"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jbiosc.2013.07.007","article-title":"Co-expression of TAL1 and ADH1 in recombinant xylose-fermenting Saccharomyces cerevisiae improves ethanol production from lignocellulosic hydrolysates in the presence of furfural","volume":"117","author":"Hasunuma","year":"2014","journal-title":"J. Biosci. Bioeng."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1128\/MMBR.00025-07","article-title":"Progress in Metabolic Engineering of Saccharomyces cerevisiae","volume":"72","author":"Nevoigt","year":"2008","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpls.2016.00520","article-title":"Identification and Overexpression of a Knotted1-Like Transcription Factor in Switchgrass (Panicum virgatum L.) for Lignocellulosic Feedstock Improvement","volume":"7","author":"Wuddineh","year":"2016","journal-title":"Front. Plant Sci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/pbi.12458","article-title":"Overexpression of GA20-OXIDASE1 impacts plant height, biomass allocation and saccharification efficiency in maize","volume":"14","author":"Voorend","year":"2016","journal-title":"Plant Biotechnol. J."},{"key":"ref_161","unstructured":"Yang, B., and Wyman, E.C. (2013). Lignin Blockers and Uses Thereof. (US8580541 B2), U.S. Patant."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bej.2009.10.013","article-title":"Synergism between hydrophobic proteins of corn stover and cellulase in lignocellulose hydrolysis","volume":"48","author":"Han","year":"2010","journal-title":"Biochem. Eng. J."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/2\/309\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:53:24Z","timestamp":1760194404000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/2\/309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,1]]},"references-count":162,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2]]}},"alternative-id":["molecules23020309"],"URL":"https:\/\/doi.org\/10.3390\/molecules23020309","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,1]]}}}