{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:12:03Z","timestamp":1780459923000,"version":"3.54.1"},"reference-count":22,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T00:00:00Z","timestamp":1520208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21372183"],"award-info":[{"award-number":["21372183"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program for Innovative Teams of Outstanding Young and Middle\u2013agedResearchers in the Higher Education Institutions of Hubei Province","award":["T201702"],"award-info":[{"award-number":["T201702"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Increasing interests have been invested in the development of synthetic strategies toward the construction of spiro[pyrrolidine-2,3\u2032-oxindole], which is the core structural skeleton in some compounds with diverse biological activities. In this work, an efficient diastereoselective 1,3-dipolar cycloaddition reaction of azomethine ylides generated in situ from 3-amino oxindoles and aldehydes with maleimides has been described. The protocol provides a facile and efficient access to structurally diverse succinimide-fused spiro[pyrrolidine-2,3\u2032-oxindole] compounds in good to high yields (up to 93%) with moderate to excellent diastereoselectivities (up to &gt;95:5). The relative stereochemistry of cycloaddition products has been assigned by X-ray diffraction analysis.<\/jats:p>","DOI":"10.3390\/molecules23030582","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T07:37:25Z","timestamp":1520321845000},"page":"582","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Facile One-Pot Construction of Succinimide-Fused Spiro[Pyrrolidine-2,3\u2032-Oxindoles] via 1,3-Dipolar Cycloaddition Involving 3-Amino Oxindoles and Maleimides"],"prefix":"10.3390","volume":"23","author":[{"given":"Lunqiang","family":"Jin","sequence":"first","affiliation":[{"name":"The State Key Laboratory of Refractories and Metallurgy, Coal Conversion and New Carbon Materials Hubei Key Laboratory, School of Chemistry & Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3974-2621","authenticated-orcid":false,"given":"Feng","family":"Liang","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Refractories and Metallurgy, Coal Conversion and New Carbon Materials Hubei Key Laboratory, School of Chemistry & Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9735","DOI":"10.1016\/j.tet.2014.08.005","article-title":"Recent advances in the synthesis of biologically active spirooxindoles","volume":"70","author":"Santos","year":"2014","journal-title":"Tetrahedron"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11030-015-9629-8","article-title":"Molecular diversity of spirooxindoles. 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These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk\/data_request\/cif."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/3\/582\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:57:37Z","timestamp":1760194657000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/3\/582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,5]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3]]}},"alternative-id":["molecules23030582"],"URL":"https:\/\/doi.org\/10.3390\/molecules23030582","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,5]]}}}