{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T06:52:53Z","timestamp":1772952773227,"version":"3.50.1"},"reference-count":26,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T00:00:00Z","timestamp":1522195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Most cinnamic acids, their esters, amides, aldehydes, and alcohols present several therapeutic actions through anti-inflammatory, antitumor, and inhibitory activity against a great variety of microorganisms. In this work, eight amines derived from cinnamic acid were synthesized and tested against host cells infected with Toxoplasma gondii and the bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis, and three strains of Staphylococcus aureus. Compounds 3 and 4 showed the best result against intracellular T. gondii, presenting antiparasitic activity at low concentrations (0.38 and 0.77 mM). The antibacterial activity of these compounds was also evaluated by the agar microdilution method, and amides 2 and 5 had a minimum inhibitory concentration of 250 \u00b5g mL\u22121 against two strains of S. aureus (ATCC 25923 and bovine strain LSA 88). These also showed synergistic action along with a variety of antibiotics, demonstrating that amines derived from cinnamic acid have potential as pharmacological agents.<\/jats:p>","DOI":"10.3390\/molecules23040774","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T05:26:37Z","timestamp":1522301197000},"page":"774","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["In Vitro Anti-Toxoplasma gondii and Antimicrobial Activity of Amides Derived from Cinnamic Acid"],"prefix":"10.3390","volume":"23","author":[{"given":"Graziela","family":"Silveira","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Ci\u00eancias Qu\u00edmicas, Centro de Ci\u00eancias e Tecnologia, Universidade Estadual do Norte Fluminense-Darcy Ribeiro, Av. Alberto Lamego, 2000\u2014Parque Calif\u00f3rnia, 28013-602 Campos dos Goytacazes\/RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karoline","family":"Campelo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ci\u00eancias Qu\u00edmicas, Centro de Ci\u00eancias e Tecnologia, Universidade Estadual do Norte Fluminense-Darcy Ribeiro, Av. Alberto Lamego, 2000\u2014Parque Calif\u00f3rnia, 28013-602 Campos dos Goytacazes\/RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gleice","family":"Lima","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ci\u00eancias Qu\u00edmicas, Centro de Ci\u00eancias e Tecnologia, Universidade Estadual do Norte Fluminense-Darcy Ribeiro, Av. Alberto Lamego, 2000\u2014Parque Calif\u00f3rnia, 28013-602 Campos dos Goytacazes\/RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lais","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Celular e Tecidual, Centro de Bioci\u00eancias e Biotecnologia, Universidade Estadual do Norte Fluminense-Darcy Ribeiro, Av. Alberto Lamego, 2000\u2014Parque Calif\u00f3rnia, 28013-602 Campos dos Goytacazes\/RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solange","family":"Samar\u00e3o","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Sanidade Animal, Centro de Ci\u00eancias e Tecnologias Agropecu\u00e1rias, Universidade Estadual do Norte Fluminense-Darcy Ribeiro, Av. Alberto Lamego, 2000\u2014Parque Calif\u00f3rnia, 28013-602 Campos dos Goytacazes\/RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olney","family":"Vieira-da-Motta","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Sanidade Animal, Centro de Ci\u00eancias e Tecnologias Agropecu\u00e1rias, Universidade Estadual do Norte Fluminense-Darcy Ribeiro, Av. Alberto Lamego, 2000\u2014Parque Calif\u00f3rnia, 28013-602 Campos dos Goytacazes\/RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leda","family":"Mathias","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ci\u00eancias Qu\u00edmicas, Centro de Ci\u00eancias e Tecnologia, Universidade Estadual do Norte Fluminense-Darcy Ribeiro, Av. Alberto Lamego, 2000\u2014Parque Calif\u00f3rnia, 28013-602 Campos dos Goytacazes\/RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Matos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ci\u00eancias Qu\u00edmicas, Centro de Ci\u00eancias e Tecnologia, Universidade Estadual do Norte Fluminense-Darcy Ribeiro, Av. Alberto Lamego, 2000\u2014Parque Calif\u00f3rnia, 28013-602 Campos dos Goytacazes\/RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Vieira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ci\u00eancias Qu\u00edmicas, Centro de Ci\u00eancias e Tecnologia, Universidade Estadual do Norte Fluminense-Darcy Ribeiro, Av. Alberto Lamego, 2000\u2014Parque Calif\u00f3rnia, 28013-602 Campos dos Goytacazes\/RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edesio","family":"Melo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Celular e Tecidual, Centro de Bioci\u00eancias e Biotecnologia, Universidade Estadual do Norte Fluminense-Darcy Ribeiro, Av. Alberto Lamego, 2000\u2014Parque Calif\u00f3rnia, 28013-602 Campos dos Goytacazes\/RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmilson","family":"Maria","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ci\u00eancias Qu\u00edmicas, Centro de Ci\u00eancias e Tecnologia, Universidade Estadual do Norte Fluminense-Darcy Ribeiro, Av. Alberto Lamego, 2000\u2014Parque Calif\u00f3rnia, 28013-602 Campos dos Goytacazes\/RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,3,28]]},"reference":[{"key":"ref_1","first-page":"11","article-title":"Cinnamon: It\u2019s Not Just For Making Cinnamon Rolls","volume":"2010","author":"Pittman","year":"2010","journal-title":"Ethnobot. Leafl."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"19292","DOI":"10.3390\/molecules191219292","article-title":"Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity","volume":"19","author":"Guzman","year":"2014","journal-title":"Molecules"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Boudreau, L.H., Maillet, J., LeBlanc, L.M., Jean-Fran\u00e7ois, J., Touaibia, M., Flamand, N., and Surette, M.E. (2012). 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