{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T17:27:42Z","timestamp":1788715662661,"version":"build-2803163510"},"reference-count":220,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T00:00:00Z","timestamp":1522627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Neurodegeneration is a progressive loss of neuronal cells in certain regions of the brain. Most of the neurodegenerative disorders (NDDs) share the communal characteristic such as damage or reduction of various cell types typically including astrocytes and microglial activity. Several compounds are being trialed to treat NDDs but they possess solitary symptomatic advantages along with copious side effects. The finding of more enthralling and captivating compounds to suspend and standstill the pathology of NDDs will be considered as a hallmark of present times. Phytochemicals possess the potential to alternate the synthetic line of therapy against NDDs. The present review explores the potential efficacy of plant-derived flavonoids against most common NDDs including Alzheimer\u2019s disease (AD) and Parkinson\u2019s disease (PD). Flavonoids are biologically active phytochemicals which possess potential pharmacological effects, including antiviral, anti-allergic, antiplatelet, anti-inflammatory, anti-tumor, anti-apoptotic and anti-oxidant effects and are able to attenuate the pathology of various NDDs through down-regulating the nitric oxide (NO) production, by reducing the tumor necrosis factor-\u03b1 (TNF-\u03b1), by reducing the excitotoxicity of superoxide as well as acting as tyrosine kinase (TK) and monoamine oxidase (MAO) inhibiting enzyme.<\/jats:p>","DOI":"10.3390\/molecules23040814","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T12:32:20Z","timestamp":1522672340000},"page":"814","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Role of Plant-Derived Flavonoids and Their Mechanism in Attenuation of Alzheimer\u2019s and Parkinson\u2019s Diseases: An Update of Recent Data"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9090-7789","authenticated-orcid":false,"given":"Ghulam","family":"Hussain","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9669-7364","authenticated-orcid":false,"given":"Azhar","family":"Rasul","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haseeb","family":"Anwar","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Sohail","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aroona","family":"Razzaq","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimra","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asghar","family":"Shabbir","sequence":"additional","affiliation":[{"name":"Department of Biosciences, COMSATS Institute of Information Technology, Islamabad 44000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Sun","sequence":"additional","affiliation":[{"name":"Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,4,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.3390\/12071455","article-title":"Bin The anti-apoptosis effects of daidzein in the brain of d-galactose treated mice","volume":"12","author":"Mao","year":"2007","journal-title":"Molecules"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hussain, G., Schmitt, F., Henriques, A., Lequeu, T., Rene, F., Bindler, F., Dirrig-Grosch, S., Oudart, H., Palamiuc, L., and Metz-Boutigue, M.-H. (2013). Systemic down-regulation of delta-9 desaturase promotes muscle oxidative metabolism and accelerates muscle function recovery following nerve injury. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064525"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3389\/fncel.2013.00144","article-title":"Fatting the brain: A brief of recent research","volume":"7","author":"Hussain","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fncel.2014.00025","article-title":"A plural role for lipids in motor neuron diseases: Energy, signaling and structure","volume":"8","author":"Schmitt","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"7390","DOI":"10.1093\/hmg\/ddv439","article-title":"Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase","volume":"24","author":"Henriques","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/acn3.179","article-title":"Endplate denervation correlates with Nogo-A muscle expression in amyotrophic lateral sclerosis patients","volume":"2","author":"Bruneteau","year":"2015","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.nbd.2003.07.006","article-title":"Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer\u2019s disease","volume":"14","author":"Zhao","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1568-1637(03)00026-6","article-title":"Caspases, apoptosis and aging","volume":"2","author":"Zhang","year":"2003","journal-title":"Ageing Res. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.molbrainres.2004.02.003","article-title":"Age-related alterations in cytochrome c-mediated caspase activation in rhesus macaque monkey (Macaca mulatta) brains","volume":"123","author":"Zhang","year":"2004","journal-title":"Mol. Brain Res."},{"key":"ref_10","first-page":"78","article-title":"Current concepts of neurodegenerative diseases","volume":"1","author":"Kovacs","year":"2014","journal-title":"EMJ Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2478\/v10136-011-0013-4","article-title":"Neurodegenerative diseases and neuroprotection: Current views and prospects","volume":"9","author":"Nieoullon","year":"2011","journal-title":"J. Appl. Biomed."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/0973-7847.99898","article-title":"Neuroprotective potential of phytochemicals","volume":"6","author":"Kumar","year":"2012","journal-title":"Pharmacogn. Rev."},{"key":"ref_13","first-page":"3","article-title":"Neurological disorder burden in Faisalabad, Punjab-Pakistan: Data from the major tertiary care centers of the city","volume":"12","author":"Hussain","year":"2017","journal-title":"Pakistan J. Neurol. Sci."},{"key":"ref_14","first-page":"52","article-title":"Epidemiological Data of Neurological Disorders in Pakistan and Neighboring Countries: A Review","volume":"12","author":"Hussain","year":"2017","journal-title":"Pakistan J. Neurol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejphar.2006.06.025","article-title":"Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: A review of their intracellular targets","volume":"545","author":"Ramassamy","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"9382","DOI":"10.3390\/molecules18089382","article-title":"Reactive Oxygen Species Mediate Isoalantolactone-Induced Apoptosis in Human Prostate Cancer Cells","volume":"18","author":"Rasul","year":"2013","journal-title":"Molecules"},{"key":"ref_17","first-page":"1219","article-title":"Xanthoxyletin, a coumarin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells","volume":"12","author":"Rasul","year":"2011","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.yexcr.2017.07.003","article-title":"CD147-induced cell proliferation is associated with Smad4 signal inhibition","volume":"358","author":"Qin","year":"2017","journal-title":"Exp. Cell Res."},{"key":"ref_19","first-page":"1481","article-title":"Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy","volume":"27","author":"Rasul","year":"2012","journal-title":"Oncol. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"533","DOI":"10.7150\/ijbs.3753","article-title":"Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells","volume":"8","author":"Khan","year":"2012","journal-title":"Int. J. Biol. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.3892\/ijo.2011.1277","article-title":"Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K\/Akt signaling pathways","volume":"40","author":"Rasul","year":"2012","journal-title":"Int. J. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4269868","DOI":"10.1155\/2017\/4269868","article-title":"Fraxinus: A Plant with Versatile Pharmacological and Biological Activities","volume":"2017","author":"Sarfraz","year":"2017","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"341","DOI":"10.7150\/ijbs.23247","article-title":"Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders","volume":"14","author":"Hussain","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"314560","DOI":"10.1155\/2015\/314560","article-title":"Protective Mechanisms of Flavonoids in Parkinson\u2019s Disease","volume":"2015","author":"Magalingam","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.2147\/NDT.S114846","article-title":"Role of berberine in Alzheimer\u2019s disease","volume":"12","author":"Cai","year":"2016","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.freeradbiomed.2010.07.007","article-title":"Caffeine protects against oxidative stress and Alzheimer\u2019s disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet","volume":"49","author":"Prasanthi","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Zhu, F., Wu, F., Ma, Y., Liu, G., Li, Z., Sun, Y., and Pei, Z. (2011). Decrease in the production of beta-amyloid by berberine inhibition of the expression of beta- secretase in HEK293 cells. BMC Neurosci., 12.","DOI":"10.1186\/1471-2202-12-125"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1586\/14737175.7.5.473","article-title":"Neuropathology and treatment of Alzheimer disease: Did we lose the forest for the trees?","volume":"7","author":"Castellani","year":"2007","journal-title":"Expert Rev. Neurother."},{"key":"ref_29","first-page":"5710","article-title":"Advanced Maillard reaction end products are associated with Alzheimer disease pathology","volume":"91","author":"Smith","year":"1994","journal-title":"Neurobiology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3233\/JAD-2010-1239","article-title":"Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment","volume":"19","author":"Smith","year":"2010","journal-title":"J. Alzheimers Dis. JAD"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/biof.5520330308","article-title":"Oxidative stress related changes in the brain of hypercholesterolemic rabbits","volume":"33","author":"Aytan","year":"2008","journal-title":"Biofactors"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00417-008-0770-2","article-title":"Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells","volume":"246","author":"He","year":"2008","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_33","unstructured":"Prince, M., Bryce, R., and Ferri, C. (2011). World Alzheimer Report\u2014The Benefits of Early Diagnosis and Intervention World Alzheimer Report, Alzheimer\u2019s Disease International."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41531-017-0015-3","article-title":"Integrated molecular landscape of Parkinson\u2019s disease","volume":"3","author":"Klemann","year":"2017","journal-title":"NPJ Park. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/jnc.13691","article-title":"The clinical symptoms of Parkinson\u2019s disease","volume":"1","author":"Sveinbjornsdottir","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2008.07.003","article-title":"Proteomics in animal models of Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"8","author":"Sowell","year":"2009","journal-title":"Ageing Res. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"II3","DOI":"10.1007\/PL00007758","article-title":"Pathoanatomy of Parkinson\u2019s disease","volume":"247","author":"Braak","year":"2000","journal-title":"J. Neurol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev-pathol-011110-130242","article-title":"Parkinson\u2019s disease: Genetics and pathogenesis","volume":"6","author":"Shulman","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0301-0082(97)00052-X","article-title":"Microglia as effector cells in brain damage and repair: Focus on prostanoids and nitric oxide","volume":"54","author":"Minghetti","year":"1998","journal-title":"Prog. Neurobiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.expneurol.2010.01.004","article-title":"Transient elevation of adult hippocampal neurogenesis after dopamine depletion","volume":"222","author":"Park","year":"2010","journal-title":"Exp. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/ajcn\/78.3.517S","article-title":"Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals","volume":"78","author":"Liu","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"287","DOI":"10.4103\/0973-1296.58146","article-title":"Phytochemical study and evaluation of antioxidant, neuroprotective and acetylcholinesterase inhibitor activities of Galeopsis ladanum L. extracts","volume":"5","author":"Calvo","year":"2009","journal-title":"Pharmacogn. Mag."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10059-013-0164-0","article-title":"Enzymatic Synthesis of Apigenin Glucosides by Glucosyltransferase (YjiC) from Bacillus licheniformis DSM 13","volume":"36","author":"Gurung","year":"2013","journal-title":"Mol. Cells"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Rendeiro, C., Vauzour, D., Rattray, M., Waffo-T\u00e9guo, P., M\u00e9rillon, J.M., Butler, L.T., Williams, C.M., and Spencer, J.P.E. (2013). Dietary Levels of Pure Flavonoids Improve Spatial Memory Performance and Increase Hippocampal Brain-Derived Neurotrophic Factor. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0063535"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3945\/an.114.007500","article-title":"Flavonoid-Based Therapies in the Early Management of Neurodegenerative Diseases","volume":"6","author":"Solanki","year":"2015","journal-title":"Adv. Nutr. Int. Rev. J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.phytochem.2013.03.024","article-title":"Phytochemistry Classification of flavonoid compounds by using entropy of information theory","volume":"93","author":"Castellano","year":"2013","journal-title":"Phytochemistry"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"A202","DOI":"10.1051\/ocl\/2017008","article-title":"Polyphenols and brain health","volume":"24","author":"Vauzour","year":"2017","journal-title":"OCL"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mam.2011.10.016","article-title":"Neuroinflammation: Modulation by flavonoids and mechanisms of action","volume":"33","author":"Spencer","year":"2012","journal-title":"Mol. Aspects Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1093\/jn\/136.9.2291","article-title":"Bioavailability of Isoflavones after Ingestion of Soy Beverages in Healthy Adults","volume":"136","author":"Kano","year":"2006","journal-title":"J. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1207\/s15327914nc5001_1","article-title":"Dietary flavonoids and cancer risk: Evidence from human population studies","volume":"50","author":"Neuhouser","year":"2004","journal-title":"Nutr. Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2174\/156800908786241050","article-title":"Luteolin, a flavonoid with potential for cancer prevention and therapy","volume":"8","author":"Lin","year":"2008","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1021\/jf000892m","article-title":"Flavonoid (myrcetin, quercetin, kaempferol, luteolin, and apigein) content of edible tropical plants","volume":"49","author":"Miean","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s11095-010-0089-7","article-title":"Apigenin: A promising molecule for cancer prevention","volume":"27","author":"Shukla","year":"2010","journal-title":"Pharm. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1248\/bpb.b12-00127","article-title":"Acacetin Protects Dopaminergic Cells against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Neuroinflammation in Vitro and in Vivo","volume":"35","author":"Kim","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1007\/s11064-012-0751-z","article-title":"Acacetin attenuates neuroinflammation via regulation the response to LPS stimuli in Vitro and in Vivo","volume":"37","author":"Ha","year":"2012","journal-title":"Neurochem. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/ptr.1074","article-title":"Chemistry and pharmacology of the Citrus bioflavonoid hesperidin","volume":"15","author":"Garg","year":"2001","journal-title":"Phyther. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1383-5718(02)00111-0","article-title":"The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: A micronucleus study","volume":"519","author":"Jagetia","year":"2002","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.appet.2011.11.016","article-title":"Acute neurocognitive effects of epigallocatechin gallate (EGCG)","volume":"58","author":"Scholey","year":"2012","journal-title":"Appetite"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.1523\/JNEUROSCI.0914-07.2007","article-title":"Plant-Derived Flavanol (\u2212)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice","volume":"27","author":"Lucero","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1093\/jn\/137.11.2405","article-title":"Quercetin reduces blood pressure in hypertensive subjects","volume":"137","author":"Edwards","year":"2007","journal-title":"J. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1093\/jn\/138.9.1615","article-title":"Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans","volume":"138","author":"Egert","year":"2008","journal-title":"J. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/ajcn\/76.6.1191","article-title":"Beneficial role of dietary phytoestrogens in obesity and diabetes","volume":"76","author":"Bhathena","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1080\/01635580802143836","article-title":"Dietary flavonoid sources in Australian adults","volume":"60","author":"Somerset","year":"2008","journal-title":"Nutr. Cancer"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Hamuel, J. (2012). Phytochemicals: Extraction Methods, Basic Structures and Mode of Action as Potential Chemotherapeutic Agents. Phytochemicals\u2014A Global Perspective of Their Role in Nutrition and Health, InTech.","DOI":"10.5772\/26052"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1300\/J492v05n03_10","article-title":"Compositional and Functional Properties of Saskatoon Berry and Blueberry","volume":"5","author":"Mazza","year":"2005","journal-title":"Int. J. Fruit Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.foodchem.2007.08.038","article-title":"The polyphenolic profiles of common bean (Phaseolus vulgaris L.)","volume":"107","author":"Lin","year":"2008","journal-title":"Food Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1523\/JNEUROSCI.21-06-01809.2001","article-title":"Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia","volume":"21","author":"Vegeto","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/00001756-200502280-00013","article-title":"Genistein protects dopaminergic neurons by inhibiting microglial activation","volume":"16","author":"Wang","year":"2005","journal-title":"Neuroreport"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1006\/bbrc.1999.0577","article-title":"Genistein Is Neuroprotective in Murine Models of Familial Amyotrophic Lateral Sclerosis and Stroke","volume":"258","author":"Trieu","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.neuro.2003.11.001","article-title":"The soy isoflavone, genistein, protects human cortical neuronal cells from oxidative stress","volume":"25","author":"Sonee","year":"2004","journal-title":"Neurotoxicology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1093\/brain\/awn054","article-title":"Cognitive deficits and striato-frontal dopamine release in Parkinson\u2019s disease","volume":"131","author":"Sawamoto","year":"2008","journal-title":"Brain"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1046\/j.1471-4159.2002.00928.x","article-title":"Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: Relevance to Parkinson\u2019s disease","volume":"81","author":"Gao","year":"2002","journal-title":"J. Neurochem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-10422-x","article-title":"Diversity of Amyloid-beta Proteoforms in the Alzheimer\u2019s Disease Brain","volume":"7","author":"Wildburger","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The Amyloid Hypothesis of Alzheimer\u2019s Disease: Progress and Problems on the Road to Therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0304-3940(01)01659-7","article-title":"Neuroprotective effects of estrogen against beta-amyloid toxicity are mediated by estrogen receptors in cultured neuronal cells","volume":"302","author":"Kim","year":"2001","journal-title":"Neurosci. Lett."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.nbd.2003.12.017","article-title":"Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity","volume":"16","author":"Bang","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/bcpt.12009","article-title":"The Effect of Genistein on the Content and Activity of \u03b1- and \u03b2-Secretase and Protein Kinase C in A\u03b2-Injured Hippocampal Neurons","volume":"112","author":"Liao","year":"2013","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ijdevneu.2010.03.003","article-title":"Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by \u03b2-amyloid peptides 25\u201335 in PC12 cells","volume":"28","author":"Ma","year":"2010","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Devi, K.P., Shanmuganathan, B., Manayi, A., Nabavi, S.F., and Nabavi, S.M. (2016). Molecular and Therapeutic Targets of Genistein in Alzheimer\u2019s Disease. Mol. Neurobiol., 1\u201314.","DOI":"10.1007\/s12035-016-0215-6"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/72671","article-title":"Identification and expression of isoflavone synthase, the key enzyme for biosynthesis of isoflavones in legumes","volume":"18","author":"Jung","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0367-326X(00)00129-5","article-title":"Isoflavonoid production by callus cultures of Maackia amurensis","volume":"71","author":"Fedoreyev","year":"2000","journal-title":"Fitoterapia"},{"key":"ref_83","first-page":"635694","article-title":"Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects: A Development of Potential Health Products and Therapeutic Drugs against Alzheimer\u2018s Disease","volume":"2013","author":"Choi","year":"2013","journal-title":"Hindawi"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s002239900378","article-title":"In vitro and in vivo effects of ipriflavone on bone formation and bone biomechanics","volume":"61","author":"Civitelli","year":"1997","journal-title":"Calcif. Tissue Int."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0006-291X(91)91423-A","article-title":"Genistein inhibition of the growth of human breast cancer cells: Independence from estrogen receptors and the multi-drug resistance gene","volume":"179","author":"Peterson","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mce.2004.12.006","article-title":"Transcriptional regulation by phytoestrogens in neuronal cell lines","volume":"231","author":"Schreihofer","year":"2005","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1210\/endo.139.10.6216","article-title":"Interaction of estrogenic chemicals and pytoestrogens with estrogen receptor beta","volume":"139","author":"Kuiper","year":"1998","journal-title":"Endocrinology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12640-012-9328-5","article-title":"Anti-inflammatory role of the isoflavone diadzein in lipopolysaccharide- stimulated microglia: Implications for parkinson\u2019s disease","volume":"23","author":"Chinta","year":"2013","journal-title":"Neurotox. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.phymed.2008.04.007","article-title":"The phytoestrogenic isoflavones from Trifolium pratense L. (Red clover) protects human cortical neurons from glutamate toxicity","volume":"15","author":"Occhiuto","year":"2008","journal-title":"Phytomedicine"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ejphar.2006.05.020","article-title":"The prooxidant, rather than antioxidant, acts of daidzein in vivo and in vitro: Daidzein suppresses glutathione metabolism","volume":"542","author":"Choi","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/jn\/132.3.370","article-title":"The phytoestrogen daidzein affects the antioxidant enzyme system of rat hepatoma H4IIE cells","volume":"132","author":"Ohler","year":"2002","journal-title":"J. Nutr."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1021\/jf000524i","article-title":"Oxidative in vitro metabolism of the soy phytoestrogens daidzein and genistein","volume":"48","author":"Kulling","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2016.07.005","article-title":"Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson\u2019s disease and Alzheimer\u2019s disease","volume":"147","author":"Jiang","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1523\/JNEUROSCI.0060-08.2008","article-title":"Microglia Cells Protect Neurons by Direct Engulfment of Invading Neutrophil Granulocytes: A New Mechanism of CNS Immune Privilege","volume":"28","author":"Neumann","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0031-9422(00)00235-1","article-title":"Advances in flavonoid research since 1992","volume":"55","author":"Harborne","year":"2000","journal-title":"Phytochemistry"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.nutr.22.111401.144957","article-title":"Dietary flavonoids: Bioavailability, metabolic effects, and safety","volume":"22","author":"Ross","year":"2002","journal-title":"Annu. Rev. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1742-2094-7-3","article-title":"Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype","volume":"7","author":"Dirscherl","year":"2010","journal-title":"J. Neuroinflamm."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.neuroscience.2009.05.009","article-title":"The anti-amnesic effects of luteolin against amyloid \u03b225\u201335 peptide-induced toxicity in mice involve the protection of neurovascular unit","volume":"162","author":"Liu","year":"2009","journal-title":"Neuroscience"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pbb.2014.09.005","article-title":"Protective role of luteolin against cognitive dysfunction induced by chronic cerebral hypoperfusion in rats","volume":"126","author":"Fu","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1582-4934.2008.00344.x","article-title":"Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer\u2019s disease \u03b2-amyloid production","volume":"13","author":"Bai","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.3892\/mmr.2016.5052","article-title":"Ameliorating effect of luteolin on memory impairment in an Alzheimer\u2019s disease model","volume":"13","author":"Wang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3390\/ijms15010895","article-title":"Luteolin reduces Alzheimer\u2019s disease pathologies induced by traumatic brain injury","volume":"15","author":"Sawmiller","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.102.035048","article-title":"Role of microglia in inflammation-mediated neurodegenerative diseases: Mechanisms and strategies for therapeutic intervention","volume":"304","author":"Liu","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.mad.2005.06.012","article-title":"Involvement of proinflammatory factors, apoptosis, caspase-3 activation and Ca2+ disturbance in microglia activation-mediated dopaminergic cell degeneration","volume":"126","author":"Wang","year":"2005","journal-title":"Mech. Ageing Dev."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuint.2006.07.014","article-title":"Di Parkinson disease IgG and C5a-induced synergistic dopaminergic neurotoxicity: Role of microglia","volume":"50","author":"Wang","year":"2007","journal-title":"Neurochem. Int."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1523\/JNEUROSCI.20-16-06309.2000","article-title":"Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: Role of microglia","volume":"20","author":"Kim","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neulet.2008.10.046","article-title":"Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation","volume":"448","author":"Chen","year":"2008","journal-title":"Neurosci. Lett."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s10571-007-9175-8","article-title":"A neuroprotective herbal mixture inhibits caspase-3-independent apoptosis in retinal ganglion cells","volume":"28","author":"Cheung","year":"2008","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1146\/annurev.nutr.21.1.381","article-title":"Inhibition of carcinogenesis by dietary polyphenolic compounds","volume":"21","author":"Yang","year":"2001","journal-title":"Annu. Rev. Nutr."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neuint.2010.05.006","article-title":"Apigenin protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis","volume":"57","author":"Choi","year":"2010","journal-title":"Neurochem. Int."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Balez, R., Steiner, N., Engel, M., Mu\u00f1oz, S.S., Lum, J.S., Wu, Y., Wang, D., Vallotton, P., Sachdev, P., and Connor, M.O. (2016). Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer\u2019s disease. Sci. Rep., 1\u201316.","DOI":"10.1038\/srep31450"},{"key":"ref_112","first-page":"a006304","article-title":"Presenilins and gamma-secretase: Structure, function, and role in Alzheimer Disease","volume":"2","author":"Iwatsubo","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer\u2019s disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.brainres.2012.11.019","article-title":"Apigenin attenuates copper-mediated \u03b2-amyloid neurotoxicity through antioxidation, mitochondrion protection and MAPK signal inactivation in an AD cell model","volume":"1492","author":"Zhao","year":"2013","journal-title":"Brain Res."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Zhang, X., Wang, G., Gurley, E.C., and Zhou, H. (2014). Flavonoid apigenin inhibits lipopolysaccharide-induced inflammatory response through multiple mechanisms in Macrophages. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107072"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1016\/j.bmcl.2004.02.003","article-title":"Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cells","volume":"14","author":"Kang","year":"2004","journal-title":"Bioorgan. Med. Chem. Lett."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cbi.2017.03.016","article-title":"Protective role of apigenin on rotenone induced rat model of Parkinson\u2019s disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis","volume":"269","author":"Anusha","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1136\/jnnp.2007.131045","article-title":"Parkinson\u2019s disease: Clinical features and diagnosis","volume":"79","author":"Jankovic","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.neuint.2012.12.016","article-title":"Neuroinflammation and oxidative stress: Co-conspirators in the pathology of Parkinson\u2019s disease","volume":"62","author":"Taylor","year":"2013","journal-title":"Neurochem. Int."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nrd3430","article-title":"Priorities in Parkinson\u2019s disease research","volume":"10","author":"Meissner","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.neuropharm.2014.07.012","article-title":"Neuroprotective and neurotrophic effects of Apigenin and Luteolin in MPTP induced parkinsonism in mice","volume":"86","author":"Patil","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1742-2094-5-41","article-title":"Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression","volume":"5","author":"Ehrhart","year":"2008","journal-title":"J. Neuroinflamm."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Chen, H.L., Lee, H.J., Huang, W.J., Chou, J.F., Fan, P.C., Du, J.C., Ku, Y.L., and Chiou, L.C. (2012). Clerodendrum inerme leaf extract alleviates animal behaviors, hyperlocomotion, and prepulse inhibition disruptions, mimicking tourette syndrome and schizophrenia. Evid. Based Complement. Altern. Med., 2012.","DOI":"10.1155\/2012\/284301"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s11010-009-0229-8","article-title":"Acacetin, a flavonoid, inhibits the invasion and migration of human prostate cancer DU145 cells via inactivation of the p38 MAPK signaling pathway","volume":"333","author":"Shen","year":"2010","journal-title":"Mol. Cell Biochem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1016-8478(23)10760-6","article-title":"Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria-mediated death signaling and SAPK\/JNK1\/2-c-Jun activation","volume":"24","author":"Shim","year":"2007","journal-title":"Mol. Cells"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.bcp.2006.07.039","article-title":"Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice","volume":"72","author":"Pan","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/glia.10161","article-title":"Microglia as a source and target of cytokines","volume":"40","author":"Hanisch","year":"2002","journal-title":"Glia"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev.neuro.22.1.219","article-title":"Microglia as Mediators of Inflammatory and Degenerative Diseases","volume":"22","author":"Baltuch","year":"1999","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-kappaB: A key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/glia.20173","article-title":"c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia","volume":"50","author":"Waetzig","year":"2005","journal-title":"Glia"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2174\/1568026054985902","article-title":"The biology of p38 kinase: A central role in inflammation","volume":"5","author":"Schieven","year":"2005","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3233\/JAD-160763","article-title":"Role of Glutamate and NMDA Receptors in Alzheimer\u2019s Disease","volume":"57","author":"Wang","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Lin, T.Y., Huang, W.J., Wu, C.C., Lu, C.W., and Wang, S.J. (2014). Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088644"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1080\/10715760410001713844","article-title":"Hesperetin: A potent antioxidant against peroxynitrite","volume":"38","author":"Kim","year":"2004","journal-title":"Free Radic. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ptr.5256","article-title":"Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: An updated review of their molecular mechanisms and experimental models","volume":"29","author":"Parhiz","year":"2015","journal-title":"Phyther. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"9078","DOI":"10.1523\/JNEUROSCI.1071-09.2009","article-title":"Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin","volume":"29","author":"Ma","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/BF02968255","article-title":"Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin","volume":"29","author":"Cho","year":"2006","journal-title":"Arch. Pharm. Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/mnfr.201100682","article-title":"Cytoprotective effects of hesperetin and hesperidin against amyloid \u03b2-induced impairment of glucose transport through downregulation of neuronal autophagy","volume":"56","author":"Huang","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/758706","article-title":"Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo","volume":"2015","author":"Yin","year":"2015","journal-title":"Stem Cells Int."},{"key":"ref_140","first-page":"493","article-title":"Systematic analysis of main constituents in rat biological samples after oral administration of the methanol extract of fructus aurantii by HPLC-ESI-MS\/MS","volume":"13","author":"Zhang","year":"2014","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1017\/S0007114512005405","article-title":"Drynaria fortunei-derived total flavonoid fraction and isolated compounds exert oestrogen-like protective effects in bone","volume":"110","author":"Wong","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s12031-015-0547-0","article-title":"Naringin Abrogates Cisplatin-Induced Cognitive Deficits and Cholinergic Dysfunction Through the Down-Regulation of AChE Expression and iNOS Signaling Pathways in Hippocampus of Aged Rats","volume":"56","author":"Chtourou","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"5576","DOI":"10.3390\/ijms14035576","article-title":"Naringin enhances CaMKII activity and improves long-term memory in a mouse model of Alzheimer\u2019s disease","volume":"14","author":"Wang","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"8809","DOI":"10.1021\/jf300669s","article-title":"Citrus flavanones: What is their role in cardiovascular protection?","volume":"60","author":"Chanet","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"124","DOI":"10.5607\/en.2014.23.2.124","article-title":"Naringin: A Protector of the Nigrostriatal Dopaminergic Projection","volume":"23","author":"Jung","year":"2014","journal-title":"Exp. Neurobiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1002\/jnr.22318","article-title":"Prothrombin Kringle-2 induces death of mesencephalic dopaminergic neurons in vivo and in vitro via microglial activation","volume":"88","author":"Kim","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/WNR.0000000000000122","article-title":"Inhibition of prothrombin kringle-2-induced inflammation by minocycline protects dopaminergic neurons in the substantia nigra in vivo","volume":"25","author":"Nam","year":"2014","journal-title":"Neuroreport"},{"key":"ref_148","first-page":"2410","article-title":"Flavonoid naringin inhibits microglial activation and exerts neuroprotection against deltamethrin induced neurotoxicity through Nrf2\/ARE signaling in the cortex and hippocampus of rats","volume":"3","author":"Vinayagam","year":"2015","journal-title":"World J. Pharm. Sci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/jnc.12742","article-title":"Enteric GFAP expression and phosphorylation in Parkinson\u2019s disease","volume":"130","author":"Clairembault","year":"2014","journal-title":"J. Neurochem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuroscience.2012.07.060","article-title":"Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway","volume":"227","author":"Gopinath","year":"2012","journal-title":"Neuroscience"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.jnutbio.2014.03.006","article-title":"Naringin protects the nigrostriatal dopaminergic projection through induction of GDNF in a neurotoxin model of parkinson\u2019s disease","volume":"25","author":"Leem","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1089\/jmf.2009.1251","article-title":"Protective effect of naringin, a citrus flavonoid, against colchicine-induced cognitive dysfunction and oxidative damage in rats","volume":"13","author":"Kumar","year":"2010","journal-title":"J. Med. Food"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/jnr.20193","article-title":"Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils","volume":"77","author":"Lee","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/01635589609514488","article-title":"Prevention of photocarcinogenesis by topical administration of pure epigallocatechin gallate isolated from green tea","volume":"26","author":"Gensler","year":"1996","journal-title":"Nutr. Cancer Int. J."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/jcb.240590822","article-title":"Polyphenols as cancer chemopreventive agents","volume":"59","author":"Stoner","year":"1995","journal-title":"J. Cell. Biochem."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1093\/carcin\/19.10.1771","article-title":"Wide distribution of [3H](\u2212)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue","volume":"19","author":"Suganuma","year":"1998","journal-title":"Carcinogenesis"},{"key":"ref_157","first-page":"189","article-title":"The antioxidative property of green tea against iron-induced oxidative stress in rat brain","volume":"41","author":"Lin","year":"1998","journal-title":"Chin. J. Physiol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0301-0082(00)00015-0","article-title":"The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer\u2019s disease","volume":"62","author":"Miranda","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0047-6374(00)00172-X","article-title":"\u03b2-Amyloid-induced activation of Caspase-3 in primary cultures of rat neurons","volume":"119","author":"Romero","year":"2000","journal-title":"Mech. Ageing Dev."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0024-3205(01)01438-2","article-title":"The green tea polyphenol (\u2212)-epigallocatechin gallate attenuates \u03b2-amyloid-induced neurotoxicity in cultured hippocampal neurons","volume":"70","author":"Choi","year":"2001","journal-title":"Life Sci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1073\/pnas.0510168103","article-title":"(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans","volume":"103","author":"Schroeter","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0891-5849(02)01137-1","article-title":"Uptake and metabolism of epicatechin and its access to the brain after oral ingestion","volume":"33","author":"Kuhnle","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12035-013-8483-x","article-title":"The Role of inflammatory and oxidative stress mechanisms in the pathogenesis of parkinson\u2019s disease: Focus on astrocytes","volume":"49","author":"Niranjan","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s12017-014-8294-x","article-title":"Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson\u2019s disease","volume":"16","author":"Gaki","year":"2014","journal-title":"Neuromol. Med."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0161-813X(02)00079-7","article-title":"Prevention of nitric oxide-mediated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson\u2019s disease in mice by tea phenolic epigallocatechin 3-gallate","volume":"23","author":"Choi","year":"2002","journal-title":"Neurotoxicology"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.biopsych.2007.04.020","article-title":"Protective Effects of Green Tea Polyphenols in the 6-OHDA Rat Model of Parkinson\u2019s Disease Through Inhibition of ROS-NO Pathway","volume":"62","author":"Guo","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1053\/apmr.2002.34623","article-title":"The effect of spasticity on cortical somatosensory-evoked potentials: Changes of cortical somatosensory-evoked potentials after botulinum toxin type A injection","volume":"83","author":"Park","year":"2002","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.lfs.2010.07.004","article-title":"Quercetin: A potential drug to reverse multidrug resistance","volume":"87","author":"Chen","year":"2010","journal-title":"Life Sci."},{"key":"ref_169","first-page":"361","article-title":"Quercetin","volume":"10","author":"Chalcone","year":"2002","journal-title":"Altern. Med. Rev. Monogr."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.nutres.2004.07.005","article-title":"Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology","volume":"24","author":"Erlund","year":"2004","journal-title":"Nutr. Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/jn\/137.5.1208","article-title":"Quercetin Inhibits TNF-Induced NF-kB Transcription Factor Recruitment to Proinflammatory Gene Promoters in Murine Intestinal Epithelial Cells 1,2","volume":"137","author":"Ruiz","year":"2007","journal-title":"J. Nutr."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/0748233713504810","article-title":"Neuroprotective effect of quercetin against oxidative damage and neuronal apoptosis caused by cadmium in hippocampus","volume":"32","author":"Kanter","year":"2016","journal-title":"Toxicol. Ind. Health"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4068\/cmj.2014.50.2.45","article-title":"Effects of Flavonoid Compounds on beta-amyloid-peptide-induced Neuronal Death in Cultured Mouse Cortical Neurons","volume":"50","author":"Choi","year":"2014","journal-title":"Chonnam Med. J."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"7630","DOI":"10.1021\/jf303387d","article-title":"Quercetin protects mouse brain against lead-induced neurotoxicity","volume":"61","author":"Liu","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.freeradbiomed.2004.01.001","article-title":"Flavonoids: Antioxidants or signalling molecules?","volume":"36","author":"Williams","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1254\/jphs.FP0070247","article-title":"Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats","volume":"104","author":"Pu","year":"2007","journal-title":"J. Pharmacol. Sci."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Sabogal-Gu\u00e1queta, A.M., Mu\u00f1oz-Manco, J.I., Ram\u00edrez-Pineda, J.R., Lamprea-Rodriguez, M., Osorio, E., and Cardona-G\u00f3mez, G.P. (2015). The Flavonoid Quercetin Ameliorates Alzheimer\u2019s Disease Pathology and Protects Cognitive and Emotional Function in Aged Triple Transgenic Alzheimer\u2019s Disease Model Mice, Elsevier Ltd.","DOI":"10.1016\/j.neuropharm.2015.01.027"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"7514","DOI":"10.1021\/jf049243r","article-title":"Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration","volume":"52","author":"Heo","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jnutbio.2008.03.002","article-title":"Protective effect of quercetin in primary neurons against A\u03b2(1\u201342): Relevance to Alzheimer\u2019s disease","volume":"20","author":"Ansari","year":"2009","journal-title":"J. Nutr. Biochem."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Zuk, M., Kulma, A., Dymi\u0144ska, L., Szo\u0142tysek, K., Prescha, A., Hanuza, J., and Szopa, J. (2011). Flavonoid engineering of flax potentiate its biotechnological application. BMC Biotechnol., 11.","DOI":"10.1186\/1472-6750-11-10"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0891-5849(00)00415-9","article-title":"Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein","volume":"29","author":"Schroeter","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1042\/bj3580547","article-title":"Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3","volume":"358","author":"Schroeter","year":"2001","journal-title":"Biochem. J."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0891-5849(00)00498-6","article-title":"Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms","volume":"30","author":"Ishige","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.neurobiolaging.2010.05.021","article-title":"Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: Possible implications for Parkinson\u2019s disease","volume":"33","author":"Filomeni","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"ref_185","first-page":"RA17","article-title":"Mechanisms of MPTP toxicity and their implications for therapy of Parkinson\u2019s disease","volume":"11","author":"Watanabe","year":"2005","journal-title":"Med. Sci. Monit."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S1474-4422(06)70521-X","article-title":"Continuous dopamine-receptor treatment of Parkinson\u2019s disease: Scientific rationale and clinical implications","volume":"5","author":"Olanow","year":"2006","journal-title":"Lancet Neurol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1211\/0022357001774075","article-title":"Identification of Kaempferol as a Monoamine Oxidase Inhibitor and Potential Neuroprotectant in Extracts of Ginkgo Biloba Leaves","volume":"52","author":"Sloley","year":"2000","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1248\/bpb.34.1291","article-title":"Neuroprotective Effect of Kaempferol against a 1-Methyl-4-phenyl-1, 2, 3, 6- tetrahydropyridine-Induced Mouse Model of Parkinson\u2019s Disease","volume":"34","author":"Shen","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.1021\/jf010567e","article-title":"Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.)","volume":"49","author":"Asano","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4196\/kjpp.2011.15.6.353","article-title":"The neuroprotective potential of cyanidin-3-glucoside fraction extracted from mulberry following oxygen-glucose deprivation","volume":"15","author":"Bhuiyan","year":"2011","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Liang, T., Guan, R., Shen, H., Xia, Q., and Liu, M. (2017). Optimization of conditions for cyanidin-3-O-glucoside (C3G) nanoliposome production by response surface methodology and cellular uptake studies in caco-2 cells. Molecules, 22.","DOI":"10.3390\/molecules22030457"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1097\/WNR.0b013e32830fe4b8","article-title":"Cyanidin 3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity","volume":"19","author":"Tarozzi","year":"2008","journal-title":"Neuroreport"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neulet.2007.07.017","article-title":"Neuroprotective effects of anthocyanins and their in vivo metabolites in SH-SY5Y cells","volume":"424","author":"Tarozzi","year":"2007","journal-title":"Neurosci. Lett."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.lfs.2005.12.033","article-title":"Protective effect of anthocyanins in middle cerebral artery occlusion and reperfusion model of cerebral ischemia in rats","volume":"79","author":"Shin","year":"2006","journal-title":"Life Sci."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neuint.2016.09.016","article-title":"Neuroprotective effects of cyanidin against A\u03b2-induced oxidative and ER stress in SK-N-SH cells","volume":"101","author":"Thummayot","year":"2016","journal-title":"Neurochem. Int."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neulet.2010.02.006","article-title":"Neuroprotective effects of cyanidin 3-O-glucopyranoside on amyloid \u03b225\u201335 oligomer-induced toxicity","volume":"473","author":"Tarozzi","year":"2010","journal-title":"Neurosci. Lett."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1747-0285.2005.00318.x","article-title":"Inhibition of amyloid fibril formation by polyphenols: Structural similarity and aromatic interactions as a common inhibition mechanism","volume":"67","author":"Porat","year":"2006","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Rauk, A. (2008). Why is the amyloid beta peptide of Alzheimer\u2019s disease neurotoxic?. Dalton Trans., 1273\u20131282.","DOI":"10.1039\/b718601k"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/10284150500078117","article-title":"Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory","volume":"8","author":"Galli","year":"2005","journal-title":"Nutr. Neurosci."},{"key":"ref_200","first-page":"245","article-title":"Pelargonidin improves passive avoidance task performance in a rat amyloid beta25-35 model of Alzheimer\u2019s disease via estrogen receptor independent pathways","volume":"54","author":"Sohanaki","year":"2016","journal-title":"Acta Med. Iran."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/jn\/138.5.897","article-title":"Anthocyanin Excretion by Humans Increases Linearly with Increasing Strawberry Dose 1","volume":"138","author":"Carkeet","year":"2008","journal-title":"J. Nutr."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1017\/S0029665108007088","article-title":"Food for thought: The role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance","volume":"67","author":"Spencer","year":"2008","journal-title":"Proc. Nutr. Soc."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.jfca.2009.08.012","article-title":"Anthocyanin content, antioxidant, anti-inflammatory and anticancer properties of blackberry and raspberry fruits","volume":"23","author":"Zhang","year":"2010","journal-title":"J. Food Compos. Anal."},{"key":"ref_204","first-page":"33","article-title":"Chronic oral pelargonidin alleviates streptozotocin-induced diabetic neuropathic hyperalgesia in rat: Involvement of oxidative stress","volume":"14","author":"Mirshekar","year":"2010","journal-title":"Iran. Biomed. J."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/0929867321666140815123852","article-title":"Anthocyanins as a potential therapy for diabetic retinopathy","volume":"22","author":"Nabavi","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.thromres.2005.01.002","article-title":"Anthocyanins and colonic metabolites of dietary polyphenols inhibit platelet function","volume":"116","author":"Rechner","year":"2005","journal-title":"Thromb. Res."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.nutres.2017.09.006","article-title":"ScienceDirect Pelargonidin-3-O-glucoside and its metabolites have modest anti-inflammatory effects in human whole blood cultures","volume":"46","author":"Amini","year":"2017","journal-title":"Nutr. Res."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/BF03327433","article-title":"Pharmacological treatment of Alzheimer\u2019s Disease","volume":"18","author":"Bianchetti","year":"2006","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"H\u00e4m\u00e4l\u00e4inen, M., Nieminen, R., Vuorela, P., Heinonen, M., and Moilanen, E. (2007). Anti-inflammatory effects of flavonoids: Genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-\u03baB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-\u03baB activation along with their inhibitory effect on i. Mediat. Inflamm., 2007.","DOI":"10.1155\/2007\/45673"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.brainresbull.2014.09.004","article-title":"Estrogen receptor agonists for attenuation of neuroinflammation and neurodegeneration","volume":"109","author":"Chakrabarti","year":"2014","journal-title":"Brain Res. Bull."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1095\/biolreprod.102.003848","article-title":"Protective effects of estrogen and selective estrogen receptor modulators in the brain","volume":"67","author":"Dhandapani","year":"2002","journal-title":"Biol. Reprod."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.biopha.2016.06.021","article-title":"Pelargonidin improves memory deficit in amyloid \u03b225\u201335 rat model of Alzheimer\u2019s disease by inhibition of glial activation, cholinesterase, and oxidative stress","volume":"83","author":"Sohanaki","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0091-3057(98)00219-6","article-title":"Estrogen improves working but not reference memory and prevents amnestic effects of scopolamine on a radial-arm maze","volume":"62","author":"Fader","year":"1999","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0197-4580(02)00075-1","article-title":"MAPK signaling in neurodegeneration: Influences of flavonoids and of nitric oxide","volume":"23","author":"Schroeter","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson\u2019s Disease: Mechanisms and Models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"723","DOI":"10.2165\/00023210-200519090-00001","article-title":"Treatment of Parkinson\u2019s disease: What\u2019s on the Horizon?","volume":"19","author":"Wu","year":"2005","journal-title":"CNS Drugs"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"7545","DOI":"10.1021\/jf800930s","article-title":"Effects of anthocyanins on psychological stress-induced oxidative stress and neurotransmitter status","volume":"56","author":"Rahman","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.brainresbull.2010.06.004","article-title":"Oral pelargonidin exerts dose-dependent neuroprotection in 6-hydroxydopamine rat model of hemi-parkinsonism","volume":"82","author":"Roghani","year":"2010","journal-title":"Brain Res. Bull."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.freeradbiomed.2003.11.023","article-title":"Flavonoid permeability across an in situ model of the blood-brain barrier","volume":"36","author":"Youdim","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"ref_220","first-page":"51","article-title":"Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats","volume":"95","author":"Marks","year":"2007","journal-title":"Br. J. 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