{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:24:25Z","timestamp":1789806265277,"version":"4.0.1"},"reference-count":23,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004225","name":"Petrobras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004225","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ag\u00eancia Nacional do Petr\u00f3leo, G\u00e1s Natural e Biocombust\u00edveis (ANP)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>To avoid gas hydrate formation during oil and gas production, companies usually employ thermodynamic inhibitors consisting of hydroxyl compounds, such as monoethylene glycol (MEG). However, these inhibitors may cause other types of fouling during production such as inorganic salt deposits (scale). Calcium carbonate is one of the main scaling salts and is a great concern, especially for the new pre-salt wells being explored in Brazil. Hence, it is important to understand how using inhibitors to control gas hydrate formation may be interacting with the scale formation process. Multiple regression and design of experiments were used to mathematically model the calcium carbonate scaling process and its evolution in the presence of MEG. It was seen that MEG, although inducing the precipitation by increasing the supersaturation ratio, actually works as a scale inhibitor for calcium carbonate in concentrations over 40%. This effect was not due to changes in the viscosity, as suggested in the literature, but possibly to the binding of MEG to the CaCO3 particles\u2019 surface. The interaction of the MEG inhibition effect with the system\u2019s variables was also assessed, when temperature\u2019 and calcium concentration were more relevant.<\/jats:p>","DOI":"10.3390\/molecules23040860","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T13:06:08Z","timestamp":1523365568000},"page":"860","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Application of Multiple Regression and Design of Experiments for Modelling the Effect of Monoethylene Glycol in the Calcium Carbonate Scaling Process"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0261-9811","authenticated-orcid":false,"given":"Vinicius","family":"Kartnaller","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica, P\u00f3lo de Xistoqu\u00edmica, Universidade Federal do Rio de Janeiro (UFRJ), Rua H\u00e9lio de Almeida 40, Cidade Universit\u00e1ria, Rio de Janeiro 21941-614, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcio","family":"Ven\u00e2ncio","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, P\u00f3lo de Xistoqu\u00edmica, Universidade Federal do Rio de Janeiro (UFRJ), Rua H\u00e9lio de Almeida 40, Cidade Universit\u00e1ria, Rio de Janeiro 21941-614, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"F. do Ros\u00e1rio","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas e Desenvolvimento Leopoldo Am\u00e9rico Miguez de Mello, PETROBRAS, Cidade Universit\u00e1ria, Rio de Janeiro 21040-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Cajaiba","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, P\u00f3lo de Xistoqu\u00edmica, Universidade Federal do Rio de Janeiro (UFRJ), Rua H\u00e9lio de Almeida 40, Cidade Universit\u00e1ria, Rio de Janeiro 21941-614, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Frenier, W.W., and Ziauddin, M. 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