{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:00:10Z","timestamp":1789596010825,"version":"build-2803163510"},"reference-count":184,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T00:00:00Z","timestamp":1524182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish National Science Centre project","award":["2016\/21\/D\/NZ9\/02597"],"award-info":[{"award-number":["2016\/21\/D\/NZ9\/02597"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Mycotoxins are secondary fungal metabolites, toxic to humans, animals and plants. Under the influence of various factors, mycotoxins may undergo modifications of their chemical structure. One of the methods of mycotoxin modification is a transformation occurring in plant cells or under the influence of fungal enzymes. This paper reviews the current knowledge on the natural occurrence of the most important trichothecenes and zearalenone in cereals\/cereal products, their metabolism, and the potential toxicity of the metabolites. Only very limited data are available for the majority of the identified mycotoxins. Most studies concern biologically modified trichothecenes, mainly deoxynivalenol-3-glucoside, which is less toxic than its parent compound (deoxynivalenol). It is resistant to the digestion processes within the gastrointestinal tract and is not absorbed by the intestinal epithelium; however, it may be hydrolysed to free deoxynivalenol or deepoxy-deoxynivalenol by the intestinal microflora. Only one zearalenone derivative, zearalenone-14-glucoside, has been extensively studied. It appears to be more reactive than deoxynivalenol-3-glucoside. It may be readily hydrolysed to free zearalenone, and the carbonyl group in its molecule may be easily reduced to \u03b1\/\u03b2-zearalenol and\/or other unspecified metabolites. Other derivatives of deoxynivalenol and zearalenone are poorly characterised. Moreover, other derivatives such as glycosides of T-2 and HT-2 toxins have only recently been investigated; thus, the data related to their toxicological profile and occurrence are sporadic. The topics described in this study are crucial to ensure food and feed safety, which will be assisted by the provision of widespread access to such studies and obtained results.<\/jats:p>","DOI":"10.3390\/molecules23040963","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T04:29:17Z","timestamp":1524457757000},"page":"963","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Modified Fusarium Mycotoxins in Cereals and Their Products\u2014Metabolism, Occurrence, and Toxicity: An Updated Review"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1855-3610","authenticated-orcid":false,"given":"Marcin","family":"Bry\u0142a","sequence":"first","affiliation":[{"name":"Department of Food Analysis, Prof. Waclaw Dabrowski Institute of Agricultural and Food Biotechnology, Rakowiecka 36, 02-532 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Wa\u015bkiewicz","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Poznan University of Life Sciences, Wojska Polskiego 75, 60-625 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edyta","family":"Ksieniewicz-Wo\u017aniak","sequence":"additional","affiliation":[{"name":"Department of Food Analysis, Prof. Waclaw Dabrowski Institute of Agricultural and Food Biotechnology, Rakowiecka 36, 02-532 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystyna","family":"Szymczyk","sequence":"additional","affiliation":[{"name":"Department of Food Analysis, Prof. Waclaw Dabrowski Institute of Agricultural and Food Biotechnology, Rakowiecka 36, 02-532 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"J\u0119drzejczak","sequence":"additional","affiliation":[{"name":"Department of Food Analysis, Prof. Waclaw Dabrowski Institute of Agricultural and Food Biotechnology, Rakowiecka 36, 02-532 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,4,20]]},"reference":[{"key":"ref_1","unstructured":"Buzby, J. (2003). Mycotoxin hazards and regulations: Impacts on food and animal feed crop trade, International Trade and Food Safety: Economic Theory and Case Studies, Agricultural Economic Report No. 828."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3389\/fmicb.2014.00269","article-title":"Potential of essential oils for protection of grains contaminated by aflatoxin produced by Aspergillus flavus","volume":"5","author":"Esper","year":"2014","journal-title":"Front. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jcs.2013.10.005","article-title":"Reducing the incidence of cereal head infection and mycotoxins in small grain cereal species","volume":"59","author":"Terzi","year":"2014","journal-title":"J. Cereal Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3389\/fmicb.2016.00395","article-title":"Functional agents to biologically control deoxynivalenol in cereal grains","volume":"7","author":"Tian","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1541-4337.2009.00094.x","article-title":"Mycotoxins in food and feed: Present status and future concerns","volume":"9","author":"Bhat","year":"2010","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cofs.2017.09.008","article-title":"Biocontrol of mycotoxins: Dynamics and mechanisms of action","volume":"17","author":"Medina","year":"2017","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1515\/aucft-2015-0005","article-title":"Occurence of Fusarium Mycotoxins in Wheat from Europe\u2014A Review","volume":"19","author":"Stanciu","year":"2015","journal-title":"Acta Univ. Cibiniensis Ser. E Food Technol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.fbr.2017.04.002","article-title":"Climate change, food security and mycotoxins: Do we know enough?","volume":"31","author":"Medina","year":"2017","journal-title":"Fungal Biol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.foodcont.2011.10.028","article-title":"Co-occurrence of type-A and type-B trichothecenes in barley from a northern region of Spain","volume":"25","author":"Lizarraga","year":"2012","journal-title":"Food Control"},{"key":"ref_10","unstructured":"(2018, April 19). Commission Regulation (EC) No 1881\/2006 of 19 December 2006 Setting Maximum Levels for Certain Contaminants in Foodstuffs. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/ALL\/?uri=CELEX%3A32006R1881."},{"key":"ref_11","unstructured":"(2018, April 19). Commission Recommendation No 2013\/165\/EU of 27 March 2013 on the Presence of T-2 and HT-2 Toxin in Cereals and Cereal Products. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=CELEX%3A32013H0165."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s12550-014-0203-5","article-title":"Proposal of a comprehensive definition of modified and other forms of mycotoxins including \u201cmasked\u201d mycotoxins","volume":"30","author":"Rychlik","year":"2014","journal-title":"Mycotoxin Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.tifs.2017.10.012","article-title":"Deoxynivalenol and its masked forms: Characteristics, incidence, control and fate during wheat and wheat based products processing\u2014A review","volume":"71","author":"Khaneghah","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1439-0450.1990.tb01052.x","article-title":"Cleavage of zearalenone-glycoside, a \u201cmasked\u201d mycotoxin, during digestion in swine","volume":"37","author":"Gareis","year":"1990","journal-title":"J. Vet. Med. B"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/mnfr.201100764","article-title":"Masked mycotoxins: A review","volume":"57","author":"Berthiller","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.fct.2015.02.015","article-title":"Modified Fusarium mycotoxins unmasked: From occurrence in cereals to animal and human excretion","volume":"80","author":"Broekaert","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1360-1385(97)01019-4","article-title":"Detoxification of xenobiotics by plants: Chemical modification and vacuolar compartmentation","volume":"2","author":"Coleman","year":"1997","journal-title":"Trends Plant Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10658-014-0498-2","article-title":"Biotic stresses in the anthropogenic hybrid triticale (\u00d7Triticosecale Wittmack): Current knowledge and breeding challenges","volume":"140","author":"Audenaert","year":"2014","journal-title":"Eur. J. Plant. Pathol."},{"key":"ref_19","first-page":"1553","article-title":"Structure elucidation of a novel trichothecene glycoside using 1H and 13C nuclear magnetic resonance spectroscopy","volume":"1","author":"Steyn","year":"1985","journal-title":"J. Chem. Soc. Perkin Trans."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1093\/jxb\/ers141","article-title":"Transgenic Arabidopsis thaliana expressing a barley UDP-glucosyltransferase exhibit resistance to the mycotoxin deoxynivalenol","volume":"63","author":"Shin","year":"2012","journal-title":"J. Exp. Bot."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1094\/MPMI-23-7-0977","article-title":"Validation of a candidate deoxynivalenol-inactivating UDP-glucosyltransferase from barley by heterologous expression in yeast","volume":"23","author":"Schweiger","year":"2010","journal-title":"Mol. Plant Microbe Interact."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.3390\/toxins5122522","article-title":"Analysis of deoxynivalenol and deoxynivalenol-3-glucoside in hard red spring wheat inoculated with Fusarium graminearum","volume":"5","author":"Ozsisli","year":"2013","journal-title":"Toxins"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Gratz, S.W. (2017). Do Plant-Bound Masked Mycotoxins Contribute to Toxicity?. Toxins, 9.","DOI":"10.3390\/toxins9030085"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.fct.2017.11.021","article-title":"Modified mycotoxins: An uptake review on their formation, detection, occurrence and toxic effects","volume":"111","author":"Freire","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1021\/jf047798g","article-title":"Masked mycotoxins: Determination of a deoxynivalenol glucoside in artificially and naturally contaminated wheat by liquid chromatography-tandem mass spectrometry","volume":"53","author":"Berthiller","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3390\/toxins6010081","article-title":"Durum wheat (Triticum Durum Desf.) lines show different abilities to form masked mycotoxins under greenhouse conditions","volume":"6","author":"Cirlini","year":"2014","journal-title":"Toxins"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1021\/jf803749u","article-title":"Occurence of Deoxynivalenol and its major conjugate, deoxynivalenol-3-glucoside, in beer and some brewing intermediate","volume":"57","author":"Kostelanska","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.foodcont.2014.03.037","article-title":"Fate of deoxynivalenol and deoxynivalenol-3-glucoside during wheat milling and Chinese steamed bread processing","volume":"44","author":"Zhang","year":"2014","journal-title":"Food Control"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.toxlet.2014.06.032","article-title":"Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in pigs","volume":"229","author":"Nagl","year":"2014","journal-title":"Toxicol. Lett."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.toxlet.2011.08.006","article-title":"Hydrolytic fate of deoxynivalenol-3-glucoside during digestion","volume":"206","author":"Berthiller","year":"2011","journal-title":"Toxicol. Lett."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1021\/tx300438c","article-title":"Masked mycotoxins are efficiently hydrolyzed by human colonic microbiota releasing their aglycones","volume":"26","author":"Cirlini","year":"2013","journal-title":"Chem. Res. Toxicol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1094\/MPMI-23-7-0962","article-title":"Transcriptome analysis of the barley-deoxynivalenol interaction: Evidence for a role of glutathione in deoxynivalenol detoxification","volume":"23","author":"Gardiner","year":"2010","journal-title":"Mol. Plant Microbe Interact."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.1007\/s00216-012-6483-8","article-title":"Stable isotopic labelling-assisted untargeted metabolic profiling reveals novel conjugates of the mycotoxin deoxynivalenol in wheat","volume":"405","author":"Kluger","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1065\/espr2006.10.352","article-title":"How plants cope with foreign compounds\u2014Translocation of xenobiotic glutathione conjugates in roots of barley (Hordeum vulgare)","volume":"14","author":"Schroder","year":"2007","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"38640","DOI":"10.1038\/srep38640","article-title":"Aphids transform and detoxify the mycotoxin deoxynivalenol via a type II biotransformation mechanism yet unknown in animals","volume":"6","author":"Audenaert","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3920\/WMJ2014.1840","article-title":"Developments in mycotoxin analysis: An update for 2013\u20132014","volume":"8","author":"Berthiller","year":"2015","journal-title":"World Mycotoxin J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00216-014-8340-4","article-title":"Deoxynivalenol-sulfates: Identification and quantification of novel conjugated (masked) mycotoxins in wheat","volume":"407","author":"Warth","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Kluger, B., Bueschl, C., Lemmens, M., Michlmayr, H., Malachova, A., Koutnik, A., Maloku, I., Berthiller, F., Adam, G., and Krska, R. (2015). Biotransformation of the mycotoxin deoxynivalenol in Fusarium resistant and susceptible near isogenic wheat lines. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0119656"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Uhlig, S., Stanic, A., Hofgaard, I.S., Kluger, B., Schuhmacher, R., and Miles, C.O. (2016). Glutathione-conjugates of deoxynivalenol in naturally contaminated grain are primarily linked via the epoxide group. Toxins, 11.","DOI":"10.3390\/toxins8110329"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.3390\/toxins7083112","article-title":"The metabolic fate of deoxynivalenol and its acetylated derivatives in a wheat suspension culture: Identification and detection of DON-15-O-glucoside, 15-acetyl-DON-3-O-glucoside and 15-acetyl-DON-3-sulfate","volume":"7","author":"Schmeitzl","year":"2015","journal-title":"Toxins"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3390\/toxins3121554","article-title":"Observation of T-2 toxin and HT-2 toxin glucosides from Fusarium sporotrichioides by liquid chromatography coupled to tandem mass spectrometry (LC-MS\/MS)","volume":"3","author":"Busman","year":"2011","journal-title":"Toxins"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3920\/WMJ2012.1453","article-title":"Occurrence of mono- and di-glycosylated conjugates of T-2 and HT-2 toxins in naturally contaminated cereals","volume":"5","author":"Veprikova","year":"2012","journal-title":"World Mycotoxin J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/jms.2980","article-title":"Identification and characterization of new Fusarium masked mycotoxins, T2 and HT2 glycosyl derivatives, in naturally contaminated wheat and oats by liquid chromatography\u2013high-resolution mass spectrometry","volume":"47","author":"Lattanzio","year":"2012","journal-title":"J. Mass Spectrom."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1080\/19440049.2012.740776","article-title":"Fate of deoxynivalenol, T-2 and HT-2 toxins and their glucoside conjugates from flour to bread: An investigation by high-performance liquid chromatography high-resolution mass spectrometry","volume":"30","author":"Monaci","year":"2013","journal-title":"Food Addit. Contam."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3390\/toxins5030590","article-title":"Detection of type A trichothecene di-glucosides produced in corn by high-resolution liquid chromatography-orbitrap mass spectrometry","volume":"5","author":"Nakagawa","year":"2013","journal-title":"Toxins"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/jms.3289","article-title":"Mycotoxin profile of Fusarium langsethiae isolated from wheat in Italy: Production of type-A trichothecenes and relevant glucosyl derivatives","volume":"48","author":"Lattanzio","year":"2013","journal-title":"J. Mass Spectrom."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1021\/jf504737f","article-title":"Anomericity of T-2 toxin-glucoside: Masked mycotoxin in cereal crops","volume":"63","author":"McCormick","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3920\/WMJ2014.1717","article-title":"Detached leaf in vitro model for masked mycotoxin biosynthesis and subsequent analysis of unknown conjugates","volume":"7","author":"Vanheule","year":"2014","journal-title":"World Mycotoxin J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"8694","DOI":"10.1128\/AEM.02391-12","article-title":"Glucosylation and other biotransformations of T-2 toxin by yeasts of the Trichomonascus Clade","volume":"78","author":"McCormick","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"7862","DOI":"10.1021\/acs.jafc.5b02697","article-title":"Metabolism of the Fusarium mycotoxins T-2 toxin and HT-2 toxin in wheat","volume":"63","author":"Nathanail","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8019","DOI":"10.1007\/s00216-015-8975-9","article-title":"Tracing the metabolism of HT-2 toxin and T-2 toxin in barley by isotope-assisted untargeted screening and quantitative LC-HRMS analysis","volume":"407","author":"Varga","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Meng-Reiterer, J., Bueschl, C., Rechthaler, J., Berthiller, F., Lemmens, M., and Schuhmacher, R. (2016). Metabolism of HT-2 toxin and T-2 toxin in oats. Toxins, 8.","DOI":"10.3390\/toxins8120364"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0890-6238(02)00141-7","article-title":"Influence of the mycotoxins a- and b- zearalenol and deoxynivalenol on the cell cycle of cultured porcine endometrial cells","volume":"17","author":"Tiemann","year":"2003","journal-title":"Reprod. Toxicol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0377-8401(99)00059-0","article-title":"Fusarium mycotoxins: A review of global implications for animal health, welfare and productivity","volume":"80","author":"Placinta","year":"1999","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/BF00367324","article-title":"Transformation of the Fusarium mycotoxin zearalenone in maize cell suspension cultures","volume":"75","author":"Engelhardt","year":"1988","journal-title":"Naturwissenschaften"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.fct.2016.11.013","article-title":"Assessing the hydrolytic fate of the masked mycotoxin zearalenone-14-glucoside\u2014A warning light for the need to look at the \u201cmaskedome\u201d","volume":"99","author":"Dellafiora","year":"2017","journal-title":"Food Chem Toxicol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1021\/jf010802t","article-title":"Occurrence of zearalenone-4-\u03b2-d-glucopyranoside in wheat","volume":"50","author":"Schneeweis","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4404","DOI":"10.1128\/AEM.02544-05","article-title":"Heterologous expression of Arabidopsis UDP-glucosyltransferases in Saccharomyces cerevisiae for production of zearalenone-4-O-glucoside","volume":"72","author":"Poppenberger","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF02946045","article-title":"Production of zearalenone-4-glucoside, a-zearalenol-4-glucoside and \u00df-zearalenol-4-glucoside","volume":"23","author":"Krenn","year":"2007","journal-title":"Mycotoxin Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/02652030802399034","article-title":"Preparation and characterization of the conjugated Fusarium mycotoxins zearalenone-4-O-\u03b2-d-glucopyranoside, \u03b1-zearalenol-4-O-\u03b2-d-glucopyranoside and \u03b2-zearalenol-4-O-\u03b2-d-glucopyranoside by MS\/MS and two-dimensional NMR","volume":"26","author":"Berthiller","year":"2009","journal-title":"Food Addit. Contam."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1080\/02652030600778728","article-title":"Liquid chromatography coupled to tandem mass spectrometry (LC-MS\/MS) determination of phase II metabolites of the mycotoxin zearalenone in the model plant Arabidopsis thaliana","volume":"23","author":"Berthiller","year":"2006","journal-title":"Food Addit. Contam."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1021\/jf405627d","article-title":"Zearalenone-16-O-glucoside: A new masked mycotoxin","volume":"62","author":"Kovalsky","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Michlmayr, H., Varga, E., Lupi, F., Malachov\u00e1, A., Hametner, C., Berthiller, F., and Adam, G. (2017). Synthesis of mono- and di-glucosides of zearalenone and \u03b1-\/\u03b2-zearalenol by recombinant barley glucosyltransferase HvUGT14077. Toxins, 9.","DOI":"10.3390\/toxins9020058"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1128\/aem.57.1.146-150.1991","article-title":"Isolation and characterization of zearalenone sulfate produced by Fusarium spp.","volume":"57","author":"Plasencia","year":"1991","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3920\/WMJ2012.1410","article-title":"Natural occurrence of mycotoxins and their masked forms in food and feed products","volume":"5","author":"Landschoot","year":"2012","journal-title":"World Mycotoxin J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1080\/19440041003801166","article-title":"Occurrence of free and conjugated Fusarium mycotoxins in cereal-based food","volume":"27","author":"Vendl","year":"2010","journal-title":"Food Addit. Contam."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3920\/WMJ2013.1638","article-title":"Evaluation of zearalenone, \u03b1-zearalenol, \u03b2-zearalenol, zearalenone 4-sulfate and \u03b2-zearalenol 4-glucoside levels during the ensiling process","volume":"7","author":"Sulyok","year":"2014","journal-title":"World Mycotoxin J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1128\/aem.57.2.549-552.1991","article-title":"Microbial transformation of zearalenone to a zearalenone sulfate","volume":"57","author":"Selim","year":"1991","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3920\/WMJ2009.1184","article-title":"Transformation of zearalenone to zearalenone-sulfate by Aspergillus spp.","volume":"3","author":"Jard","year":"2010","journal-title":"World Mycotoxin J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/1574-6968.12586","article-title":"Biotransformation of the mycotoxin zearalenone by fungi of the genera Rhizopus and Aspergillus","volume":"359","author":"Brodehl","year":"2014","journal-title":"Microbiol. Lett."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/BF02946028","article-title":"Short review: Metabolism of the Fusarium mycotoxins deoxynivalenol and zearalenone in plants","volume":"23","author":"Berthiller","year":"2007","journal-title":"Mycotoxin Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"29105","DOI":"10.1038\/srep29105","article-title":"Microbial biotransformation of DON: Molecular basis for reduced toxicity","volume":"6","author":"Pierron","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3109\/03602530903125807","article-title":"Metabolic pathways of trichothecenes","volume":"42","author":"Wu","year":"2010","journal-title":"Drug Metab. Rev."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Guevara-Gonzalez, R.G. (2011). Panneerselvam, A. Panneerselvam, aflatoxins and aflatoxicosis in human and animals. Aflatoxins\u2014Biochemistry and Molecular Biology, InTech.","DOI":"10.5772\/896"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1039\/c5tx00293a","article-title":"Mycotoxins: Cytotoxicity and biotransformation in animal cells","volume":"5","author":"Wen","year":"2016","journal-title":"Toxicol. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.1021\/jf100892v","article-title":"Determinants of urinary deoxynivalenol and de-epoxy deoxynivalenol in male farmers from Normandy, France","volume":"58","author":"Turner","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1021\/jf304655d","article-title":"Enzyme-assisted synthesis and structural characterization of the 3-, 8-, and 15-glucuronides of deoxynivalenol","volume":"61","author":"Uhlig","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"10170","DOI":"10.1021\/jf302571y","article-title":"HT-2 toxin 4-glucuronide as new T-2 toxin metabolite: Enzymatic synthesis, analysis, and species specific formation of T-2 and HT-2 toxin glucuronides by rat, mouse, pig, and human liver microsomes","volume":"60","author":"Welsch","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s12550-010-0057-4","article-title":"Blood plasma levels of deoxynivalenol and its de-epoxy metabolite in broilers after a single oral dose of the toxin","volume":"26","author":"Yunus","year":"2010","journal-title":"Mycotoxin Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1021\/jf4047946","article-title":"Metabolism, distribution, and excretion of deoxynivalenol with combined techniques of radiotracing, high-performance liquid chromatography ion trap time-of-flight mass spectrometry, and online radiometric detection","volume":"62","author":"Wan","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3920\/WMJ2014.1843","article-title":"Toxicokinetic study and oral bioavailability of DON in turkey poults, and comparative biotransformation between broilers and turkeys","volume":"8","author":"Devreese","year":"2015","journal-title":"World Mycotoxin J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00204-014-1286-7","article-title":"In vitro glucuronidation kinetics of deoxynivalenol by human and animal microsomes and recombinant human UGT enzymes","volume":"89","author":"Maul","year":"2015","journal-title":"Arch. Toxicol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2520\/myco.66.21","article-title":"Research on mycotoxin glucosides (masked mycotoxins)","volume":"66","author":"Nakagawa","year":"2016","journal-title":"JSM Mycotoxins"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cropro.2015.02.025","article-title":"Management of Fusarium head blight of wheat and barley","volume":"73","author":"Wegulo","year":"2015","journal-title":"Crop Prot."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Wu, L., Qiu, L., Zhang, H., Sun, J., Hu, X., and Wang, B. (2017). Optimization for the production of deoxynivalenol and zearalenone by Fusarium graminearum using response surface methodology. Toxins, 9.","DOI":"10.3390\/toxins9020057"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.foodcont.2012.01.056","article-title":"Analysis of deoxynivalenol and deoxynivalenol-3-glucoside in wheat","volume":"26","author":"Simsek","year":"2012","journal-title":"Food Control"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1515\/jppr-2015-0038","article-title":"Fusarium head blight (FHB) and Fusarium spp. on grain of spring wheat cultivars grown in Poland","volume":"55","author":"Lenc","year":"2015","journal-title":"J. Plant Prot. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.3390\/toxins4111157","article-title":"Factors influencing deoxinivalenol accumulation in small grain cereals","volume":"4","author":"Wegulo","year":"2012","journal-title":"Toxins"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.3390\/toxins5122656","article-title":"Occurrence of deoxynivalenol and deoxynivalenol-3-glucoside in hard red spring wheat grown in the USA","volume":"5","author":"Simsek","year":"2013","journal-title":"Toxins"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.1007\/s11033-012-1823-5","article-title":"Identification, characterization and mapping of differentially expressed genes in a winter wheat cultivar (Centenaire) resistant to Fusarium graminearum infection","volume":"39","author":"Muhovski","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fm.2013.10.009","article-title":"Influence of temperature on infection, growth, and mycotoxin production by Fusarium langsethiae and F. sporotrichioides in durum wheat","volume":"39","author":"Nazari","year":"2014","journal-title":"Food Microbiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ijfoodmicro.2013.07.002","article-title":"Deoxynivalenol and other selected Fusarium toxins in Swedish wheat\u2014Occurrence and correlation to specific Fusarium species","volume":"167","author":"Lindblad","year":"2013","journal-title":"Int. J. Food Microbiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ijfoodmicro.2012.03.020","article-title":"Molecular studies to identify the Fusarium species responsible for HT-2 and T-2 mycotoxins in UK oats","volume":"156","author":"Edwards","year":"2012","journal-title":"Int. J. Food Microbiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ijfoodmicro.2010.07.021","article-title":"Comparisons of water activity and temperature impacts on growth of Fusarium langsethiae strains from northern Europe on oat-based media","volume":"142","author":"Medina","year":"2010","journal-title":"Int. J. Food Microbiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.anifeedsci.2014.10.002","article-title":"Fusarium mycotoxin contamination of cereals and bedding straw at Swedish pig farms","volume":"198","author":"Nordkvist","year":"2014","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1080\/19440049.2012.689996","article-title":"Mycotoxin contamination of cereal grain commodities in relation to climate in North West Europe","volume":"29","author":"Klemsdal","year":"2012","journal-title":"Food Addit. Contam. A"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.fm.2010.09.012","article-title":"Temperature and water activity effects on production of T-2 and HT-2 by Fusarium langsethiae strains from north European countries","volume":"28","author":"Medina","year":"2011","journal-title":"Food Microbiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1080\/19440049.2010.487498","article-title":"Influence of barley malting operating parameters on T-2 and HT-2 toxinogenesis of Fusarium langsethiae, a worrying contaminant of malting barley in Europe","volume":"27","author":"Strub","year":"2010","journal-title":"Food Addit. Contam."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ijfoodmicro.2010.07.015","article-title":"Mycotoxin production of selected Fusarium species at different culture conditions","volume":"143","author":"Kokkonen","year":"2010","journal-title":"Int. J. Food Microbiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jph.12036","article-title":"Fusarium langsethiae\u2014A HT-2 and T-2 toxins producer that needs more attention","volume":"161","author":"Imathiu","year":"2013","journal-title":"J. Phytopathol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2478\/10004-1254-63-2012-2259","article-title":"The impact of mycotoxicoses on human history","volume":"63","author":"Peraica","year":"2012","journal-title":"Arh. Hig. Rada Toksikol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s10681-015-1550-9","article-title":"Novel QTL associated with the Fusarium head blight resistance in Truman soft red winter wheat","volume":"207","author":"Islam","year":"2016","journal-title":"Euphytica"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.cofs.2017.01.011","article-title":"Prevalence of mycotoxins in food and decontamination","volume":"14","author":"Patriarca","year":"2017","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_104","first-page":"566","article-title":"Antioxidant secondary metabolites in cereals: Potential involvement in resistance to Fusarium and mycotoxin accumulation","volume":"22","author":"Barreau","year":"2016","journal-title":"Front Microbiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.foodchem.2017.02.115","article-title":"Formulation and processing factors affecting trichothecene mycotoxins within industrial biscuit-making","volume":"229","author":"Generotti","year":"2017","journal-title":"Food Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/j.foodchem.2010.12.008","article-title":"The study of deoxynivalenol and its masked metabolites fate during the brewing process realised by UPLC\u2013TOFMS method","volume":"126","author":"Kostelanska","year":"2011","journal-title":"Food Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"9280","DOI":"10.1021\/jf302069z","article-title":"Deoxynivalenol oligoglycosides: New \u201cmasked\u201d Fusarium toxins occurring in malt, beer, and breadstuff","volume":"60","author":"Zachariasova","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1080\/02652030701779625","article-title":"Transfer of Fusarium mycotoxins and \u2018masked\u2019 deoxynivalenol (deoxynivalenol-3-glucoside) from field barley through malt to beer","volume":"25","author":"Lancova","year":"2008","journal-title":"Food Addit. Contam."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.3390\/toxins7082773","article-title":"Deoxynivalenol and deoxynivalenol-3-glucoside mitigation through bakery production strategies: Effective experimental dising within industrial rusk-making technology","volume":"7","author":"Generotti","year":"2015","journal-title":"Toxins"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Dall\u2019Asta, C., and Berthiller, F. (2015). Transformation of mycotoxins upon food processing: Masking, binding and degradation phenomena. Masked Mycotoxins in Food: Formation, Occurrence and Toxicological Relevance, RSC Publishing.","DOI":"10.1039\/9781782622574"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s12550-016-0257-7","article-title":"Impact of food processing and detoxification treatments on mycotoxin contamination","volume":"32","author":"Karlovsky","year":"2016","journal-title":"Mycotoxin Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s12550-016-0263-9","article-title":"Fate of deoxynivalenol and deoxynivalenol-3-glucoside during cereal-based thermal food processing: A review study","volume":"33","author":"Wu","year":"2017","journal-title":"Mycotoxin Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"9303","DOI":"10.1021\/jf202428f","article-title":"Effects of milling and baking technologies on levels of deoxynivalenol and its masked form deoxynivalenol-3-glucoside","volume":"59","author":"Kostelanska","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.foodchem.2016.04.003","article-title":"Enzyme bread improvers affect the stability of deoxynivalenol and deoxynivalenol-3-glucoside during breadmaking","volume":"208","author":"Vidal","year":"2016","journal-title":"Food Chem."},{"key":"ref_115","unstructured":"(2018, April 19). Commission Recommendation (EU) No 2016\/1319 of 29 July 2016 Amending Recommendation 2006\/576\/EC as Regards Deoxynivalenol, Zearalenone and Ochratoxin A in Pet Food. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=uriserv:OJ.L_.2016.208.01.0058.01.ENG&toc=OJ:L:2016:208:FULL."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"EFSA (2014). Scientific Opinion on the risk for human and animal health related to the presence of modified forms of certain mycotoxins in food and feed. EFSA J., 12, 3916.","DOI":"10.2903\/j.efsa.2014.3916"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1080\/19440049.2012.656707","article-title":"Development and validation of an LC-MS\/MS method for the simultaneous determination of deoxynivalenol, zearalenone, T-2-toxin and some masked metabolites in different cereals and cereal-derived food","volume":"29","author":"Maene","year":"2012","journal-title":"Food Addit. Contam."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s12550-012-0133-z","article-title":"Occurrence of different trichothecenes and deoxynivalenol-3-\u03b2-d-glucoside in naturally and artificially contaminated Danish cereal grains and whole maize plants","volume":"28","author":"Rasmussen","year":"2012","journal-title":"Mycotoxin Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jchromb.2014.05.053","article-title":"Simultaneous determination of major type B trichothecenes and deoxynivalenol-3-glucoside in animal feed and raw materials using improved DSPE combined with LC-MS\/MS","volume":"963","author":"Zhao","year":"2014","journal-title":"J. Chromatogr. B"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3920\/WMJ2013.1608","article-title":"Occurrence and within field variability of Fusarium mycotoxins and their masked forms in maize crops in Belgium","volume":"7","author":"Landschoot","year":"2014","journal-title":"World Mycotoxin J."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"11638","DOI":"10.1021\/jf3038133","article-title":"Simultaneous determination of masked deoxynivalenol and some important type B trichothecenes in Chinese corn kernels and corn-based products by ultra-performance liquid chromatography-tandem mass spectrometry","volume":"60","author":"Wei","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Kovalsky, P., Kos, G., N\u00e4hrer, K., Schwab, C., Jenkins, T., Schatzmayr, G., Sulyok, M., and Krska, R. (2016). Co-occurrence of regulated, masked and emerging mycotoxins and secondary metabolites in finished feed and maize-an extensive survey. Toxins, 8.","DOI":"10.3390\/toxins8120363"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1007\/s00216-015-8676-4","article-title":"Simultaneous determination of major type A and B trichothecenes, zearalenone and certain modified metabolites in Finnish cereal grains with a novel liquid chromatography-tandem mass spectrometric method","volume":"407","author":"Nathanail","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Bry\u0142a, M., Wa\u015bkiewicz, A., Podolska, G., Szymczyk, K., J\u0119drzejczak, R., Damaziak, K., and Su\u0142ek, A. (2016). Occurrence of 26 mycotoxins in the grain of cereals cultivated in Poland. Toxins, 8.","DOI":"10.3390\/toxins8060160"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Bry\u0142a, M., Ksieniewicz-Wo\u017aniak, E., Wa\u015bkiewicz, A., Szymczyk, K., and J\u0119drzejczak, R. (2018). Natural occurrence of nivalenol, deoxynivalenol, and deoxynivalenol-3-glucoside in Polish winter wheat. Toxins, 10.","DOI":"10.3390\/toxins10020081"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1007\/s12161-016-0450-5","article-title":"Simultaneous determination of deoxynivalenol, deoxynivalenol-3-glucoside and nivalenol in wheat grains by HPLC-PDA with immunoaffinity column cleanup","volume":"9","author":"Trombete","year":"2016","journal-title":"Food Anal. Methods"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.foodcont.2017.09.002","article-title":"Production of deoxynivalenol (DON) and DON-3Glucoside during the malting of Fusarium infected hard red spring wheat","volume":"85","author":"Jin","year":"2018","journal-title":"Food Control"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.foodchem.2017.03.085","article-title":"Occurrence of deoxynivalenol and deoxynivalenol-3-glucoside in durum wheat from Argentina","volume":"230","author":"Palacios","year":"2017","journal-title":"Food Chem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"12990","DOI":"10.1021\/jf203391x","article-title":"Deoxynivalenol, deoxynivalenol-3-glucoside, and enniatins: The major mycotoxins found in cereal-based products on the Czech market","volume":"59","author":"Malachova","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1080\/19393210.2016.1154109","article-title":"Mycotoxins in wheat flour and intake assessment in Shandong province of China","volume":"9","author":"Li","year":"2016","journal-title":"Food Addit. Contam. B"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.aca.2008.07.014","article-title":"Deoxynivalenol and its conjugates in beer: A critical assessment of data obtained by enzyme-linked immunosorbent assay and liquid chromatography coupled to tandem mass spectrometry","volume":"625","author":"Zachariasova","year":"2008","journal-title":"Anal. Chim. Acta"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/19440049.2012.726745","article-title":"Survey of deoxynivalenol and its conjugates deoxynivalenol-3-glucoside and 3-acetyl-deoxynivalenol in 374 beer samples","volume":"30","author":"Varga","year":"2013","journal-title":"Food Addit. Contam. A"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1080\/19440049.2015.1048750","article-title":"Study of the natural occurrence of T-2 and HT-2 toxins and their glucosyl derivatives from field barley to malt by high-resolution Orbitrap mass spectrometry","volume":"32","author":"Lattanzio","year":"2015","journal-title":"Food Addit. Contam. A"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.fct.2017.07.062","article-title":"Molecular insights on xenoestrogenic potential of zearalenone-14-glucoside through a mixed in vitro\/in silico approach","volume":"108","author":"Dellafiora","year":"2017","journal-title":"Food Chem Toxicol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3920\/WMJ2011.1366","article-title":"Synthesis of deoxynivalenol-3-\u00df-D-O-glucuronide for its use as biomarker for dietary deoxynivalenol exposure","volume":"5","author":"Fruhmann","year":"2012","journal-title":"World Mycotoxin J."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.3762\/bjoc.10.112","article-title":"Synthesis of zearalenone-16-\u03b2,d-glucoside and zearalenone-16-sulfate: A tale of protecting resorcylic acid lactones for regiocontrolled conjugation","volume":"10","author":"Mikula","year":"2014","journal-title":"Beilstein J. Org. Chem."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Habler, K., Frank, O., and Rychlik, M. (2016). Chemical Synthesis of Deoxynivalenol-3-\u03b2-d-[13C6]-glucoside and Application in Stable Isotope Dilution Assays. Molecules, 21.","DOI":"10.3390\/molecules21070838"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.3389\/fmicb.2016.01229","article-title":"Comparative analysis of deoxynivalenol biosynthesis related gene expression among different chemotypes of Fusarium graminearum in spring wheat","volume":"7","author":"Amarasinghe","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Schmeitzl, C., Varga, E., Warth, B., Kugler, K.G., Malachov\u00e1, A., Michlmayr, H., Wiesenberger, G., Mayer, K.F.X., Mewes, H.W., and Krska, R. (2016). Identification and characterization of carboxylesterases from brachypodium distachyon deacetylating trichothecene mycotoxins. Toxins, 8.","DOI":"10.3390\/toxins8010006"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1094\/PHYTO-100-4-0328","article-title":"Population genetic analyses of Fusarium asiaticum populations from barley suggest a recent shift favoring 3AcDON producers in southern China","volume":"100","author":"Zhang","year":"2010","journal-title":"Phytopathology"},{"key":"ref_141","unstructured":"(2018, April 19). Evaluations of the Joint FAO\/WHO Expert Committee on Food Additives (JECFA). Available online: http:\/\/apps.who.int\/food-additives-contaminants-jecfa-database\/chemical.aspx?chemID=2947."},{"key":"ref_142","unstructured":"EFSA (2017). Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed. EFSA J., 15, 1\u2013345."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/toxsci\/kfs239","article-title":"Toxicity of deoxynivalenol and its acetylated derivatives on the intestine: Differential effects on morphology, barrier function, tight junction proteins, and mitogen-activated protein kinases","volume":"130","author":"Pinton","year":"2012","journal-title":"Toxicol. Sci."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Suzuki, T., and Iwahashi, Y. (2016). Acetylated deoxynivalenol generates differences of gene expression that discriminate trichothecene toxicity. Toxins, 8.","DOI":"10.3390\/toxins8020042"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.fct.2016.06.012","article-title":"Comparative in vitro cytotoxicity of modified deoxynivalenol on porcine intestinal epithelial cells","volume":"95","author":"Broekaert","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Alizadeh, A., Braber, S., Akbari, P., Kraneveld, A., Garssen, J., and Fink-Gremmels, J. (2016). Deoxynivalenol and its modified forms: Are there major differences?. Toxins, 8.","DOI":"10.3390\/toxins8110334"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature13737","article-title":"Structural basis for the inhibition of the eukaryotic ribosome","volume":"513","author":"Prokhorova","year":"2014","journal-title":"Nature"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2174\/1389200211314060002","article-title":"Trichothecenes: Structure-toxic activity relationships","volume":"14","author":"Wu","year":"2013","journal-title":"Curr. Drug Metab."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1128\/AEM.02987-12","article-title":"The human fecal microbiota metabolizes deoxynivalenol and deoxynivalenol-3-glucoside and may be responsible for urinary deepoxy-deoxynivalenol","volume":"79","author":"Gratz","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1128\/AEM.02106-17","article-title":"Porcine small and large intestinal microbiota rapidly hydrolyze the masked mycotoxin deoxynivalenol-3-glucoside and release deoxynivalenol in spiked batch cultures in vitro","volume":"84","author":"Gratz","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3920\/WMJ2012.1430","article-title":"Digestibility and absorption of deoxynivalenol-3-\u03b2-glucoside in in vitro models","volume":"5","author":"Portier","year":"2012","journal-title":"World Mycotoxin J."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.foodcont.2014.03.032","article-title":"Investigation on the stability of deoxynivalenol and DON-3 glucoside during gastro-duodenal in vitro digestion of a naturally contaminated bread model food","volume":"43","author":"Monaci","year":"2014","journal-title":"Food Control"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3390\/toxins7010187","article-title":"Low toxicity of deoxynivalenol-3-glucoside in microbial cells","volume":"7","author":"Suzuki","year":"2015","journal-title":"Toxins"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1007\/s00204-015-1592-8","article-title":"Intestinal toxicity of the masked mycotoxin deoxynivalenol-3-\u03b2-d-glucoside","volume":"90","author":"Pierron","year":"2016","journal-title":"Arch. Toxicol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cofs.2015.08.001","article-title":"Deoxynivalenol and its masked forms in food and feed","volume":"5","author":"Nagl","year":"2015","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Tian, Y., Tan, Y., Liu, N., Yan, Z., Liao, Y., Chen, J., de Saeger, S., Yang, H., Zhang, Q., and Wu, A. (2016). Detoxification of deoxynivalenol via glycosylation represents novel insights on antagonistic activities of Trichoderma when confronted with Fusarium graminearum. Toxins, 8.","DOI":"10.3390\/toxins8110335"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s11259-006-3325-1","article-title":"Hydroxysteroid dehydrogenases in bovine and porcine granulosa cells convert zearalenone into its hydroxylated metabolites alpha-zearalenol and beta-zearalenol","volume":"30","author":"Malekinejad","year":"2006","journal-title":"Vet. Res. Commun."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1016\/j.fct.2008.07.011","article-title":"Metabolism and transfer of the mycotoxin zearalenone in human intestinal Caco-2 cells","volume":"46","author":"Videmann","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jchromb.2014.05.019","article-title":"Validation of a UHPLC-MS\/MS method for quantification of zearalenone, \u03b1-zearalenol, \u03b2-zearalenol, \u03b1-zearalanol, \u03b2-zearalanol and zearalanone in human urine","volume":"962","author":"Belhassen","year":"2014","journal-title":"J. Chromatogr. B"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.tox.2008.07.065","article-title":"Cytotoxicity effects induced by zearalenone metabolites, \u03b1 zearalenol and \u03b2 zearalenol, on cultured Vero cells","volume":"252","author":"Othmen","year":"2008","journal-title":"Toxicology"},{"key":"ref_161","first-page":"18","article-title":"Structure\u2013activity relationships among zearalenone and its derivatives based on bovine neutrophil chemiluminescence","volume":"45","author":"Murata","year":"2003","journal-title":"Vet. Hum. Toxicol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.tiv.2006.06.006","article-title":"Interactive effects of fumonisin B1 and alpha-zearalenol on proliferation and cytokine expression in Jurkat T cells","volume":"20","author":"Luongo","year":"2006","journal-title":"Toxicol. In Vitro"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/jbt.20284","article-title":"Comparative study of toxic effects of zearalenone and its two major metabolites alpha-zearalenol and beta-zearalenol on cultured human Caco-2 cells","volume":"23","author":"Bouaziz","year":"2009","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.theriogenology.2009.09.023","article-title":"Effects of in vitro exposure to natural levels of zearalenone and its derivatives on chromatin structure stability in equine spermatozoa","volume":"73","author":"Minervini","year":"2010","journal-title":"Theriogenology"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mrgentox.2011.08.003","article-title":"In vitro and in vivo induction of chromosome aberrations by alpha- and beta-zearalenols: Comparison with zearalenone","volume":"276","author":"Ayed","year":"2011","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tiv.2013.06.025","article-title":"Interactive effects of zearalenone and its metabolites on cytotoxicity and metabolization in ovarian CHO-K1 cells","volume":"28","author":"Tatay","year":"2014","journal-title":"Toxicol. In Vitro"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.3390\/toxins7061979","article-title":"Food contaminant zearalenone and its metabolites affect cytokine synthesis and intestinal epithelial integrity of porcine cells","volume":"7","author":"Marin","year":"2015","journal-title":"Toxins"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.neuro.2015.11.004","article-title":"Activation of ER stress and apoptosis by \u03b1- and \u03b2-zearalenol in HCT116 cells, protective role of Quercetin","volume":"53","author":"Prola","year":"2016","journal-title":"NeuroToxicology"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1021\/tx500312g","article-title":"In vitro phase I metabolism of cis-zearalenone","volume":"27","author":"Drzymala","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.toxlet.2011.07.015","article-title":"Endocrine disrupting effects of zearalenone, alpha- and beta-zearalenol at the level of nuclear receptor binding and steroidogenesis","volume":"206","author":"Frizzell","year":"2011","journal-title":"Toxicol. Lett."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.fct.2014.10.008","article-title":"Assessment of estrogenic and anti-androgenic activities of the mycotoxin zearalenone and its metabolites using in vitro receptor-specific bioassays","volume":"74","author":"Real","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.tiv.2015.01.006","article-title":"Biotransformation of zearalenone and zearalenols to their major glucuronide metabolites reduces estrogenic activity","volume":"29","author":"Frizzell","year":"2015","journal-title":"Toxicol. In Vitro"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3920\/WMJ2010.1244","article-title":"Zearalenone and its metabolites as endocrine disrupting chemicals","volume":"3","author":"Metzler","year":"2010","journal-title":"World Mycotoxin J."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.toxicon.2015.08.027","article-title":"Estrogenicity of novel phase i and phase ii metabolites of zearalenone and cis-zearalenone","volume":"105","author":"Drzymala","year":"2015","journal-title":"Toxicon"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.toxicon.2016.01.053","article-title":"On the masked mycotoxin zearalenone-14-glucoside. Does the mask truly hide?","volume":"111","author":"Dellaflora","year":"2016","journal-title":"Toxicon"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.fct.2016.11.003","article-title":"Study on the uptake and deglycosylation of the masked forms of zearalenone in human intestinal Caco-2 cell","volume":"98","author":"Cirlini","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1017\/S095442241200008X","article-title":"The role of biomarkers in evaluating human health concerns from fungal contaminants in food","volume":"25","author":"Turner","year":"2012","journal-title":"Nutr. Res. Rev."},{"key":"ref_178","first-page":"139","article-title":"In vivo contribution of deoxynivalenol-3-\u03b2-d-glucoside to deoxynivalenol exposure in broiler chickens and pigs: Oral bioavailability, hydrolysis and toxicokinetics","volume":"111","author":"Broekaert","year":"2016","journal-title":"Arch. Toxicol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.3390\/toxins7114706","article-title":"Metabolism of deoxynivalenol and deepoxy-deoxynivalenol in broiler chickens, pullets, roosters and turkeys","volume":"7","author":"Fruhmann","year":"2015","journal-title":"Toxins"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3920\/WMJ2012.1411","article-title":"Simultaneous determination of masked forms of deoxynivalenol and zearalenone after oral dosing in rats by LC-MS\/MS","volume":"5","author":"Versilovskis","year":"2012","journal-title":"World Mycotoxin J."},{"key":"ref_181","first-page":"367","article-title":"Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in rats Toxicol","volume":"213","author":"Nagl","year":"2013","journal-title":"Lett."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"EFSA (2017). Risks for animal health related to the presence of zearalenone and its modified forms in feed. EFSA J., 15, 4851.","DOI":"10.2903\/j.efsa.2017.4851"},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Binder, S.B., Schwartz-Zimmermann, H.E., Varga, E., Bichl, G., Michlmayr, H., Adam, G., and Berthiller, F. (2017). Metabolism of zearalenone and its major modified forms in pigs. Toxins, 9.","DOI":"10.3390\/toxins9020056"},{"key":"ref_184","unstructured":"Broekaert, N., Devreese, M., De Mil, T., Fraeyman, S., De Boevre, M., De Saeger, S., De Backer, P., and Croubels, S. (2015, January 1\u20133). In vivo hydrolysis and toxicokinetics of T-2 toxin and T2-glucoside in broiler chickens. Proceedings of the 37th Mycotoxin Workshop, Bratislava, Slovakia."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/4\/963\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:01:30Z","timestamp":1760194890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/4\/963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,20]]},"references-count":184,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4]]}},"alternative-id":["molecules23040963"],"URL":"https:\/\/doi.org\/10.3390\/molecules23040963","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,20]]}}}