{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:49:35Z","timestamp":1789426175900,"version":"build-2803163510"},"reference-count":55,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The introduction and designing of functional thermoresponsive hydrogels have been recommended as recent potential therapeutic approaches for biomedical applications. The development of bioactive materials such as thermosensitive gelatin-incorporated nano-organic materials with a porous structure and photothermally triggerable and cell adhesion properties may potentially achieve this goal. This novel class of photothermal hydrogels can provide an advantage of hyperthermia together with a reversibly transformable hydrogel for tissue engineering. Polypyrrole (Ppy) is a bioorganic conducting polymeric substance and has long been used in biomedical applications owing to its brilliant stability, electrically conductive features, and excellent absorbance around the near-infrared (NIR) region. In this study, a cationic photothermal triggerable\/guidable gelatin hydrogel containing a polyethylenimine (PEI)\u2013Ppy nanocomplex with a porous microstructure was established, and its physicochemical characteristics were studied through dynamic light scattering, scanning electronic microscopy, transmission electron microscopy, an FTIR; and cellular interaction behaviors towards fibroblasts incubated with a test sample were examined via MTT assay and fluorescence microscopy. Photothermal performance was evaluated. Furthermore, the in vivo study was performed on male Wistar rat full thickness excisions model for checking the safety and efficacy of the designed gelatin\u2013PEI\u2013Ppy nanohydrogel system in wound healing and for other biomedical uses in future. This photothermally sensitive hydrogel system has an NIR-triggerable property that provides local hyperthermic temperature by PEI\u2013Ppy nanoparticles for tissue engineering applications. Features of the designed hydrogel may fill other niches, such as being an antibacterial agent, generation of free radicals to further improve wound healing, and remodeling of the promising photothermal therapy for future tissue engineering applications.<\/jats:p>","DOI":"10.3390\/molecules23061256","type":"journal-article","created":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T03:54:21Z","timestamp":1527479661000},"page":"1256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["A Gelatin Hydrogel-Containing Nano-Organic PEI\u2013Ppy with a Photothermal Responsive Effect for Tissue Engineering Applications"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-7928","authenticated-orcid":false,"given":"Mantosh Kumar","family":"Satapathy","sequence":"first","affiliation":[{"name":"Graduate Institute of Biomedical Materials and Tissue Engineering Taipei Medical University and International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"},{"name":"School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batzaya","family":"Nyambat","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Materials and Tissue Engineering Taipei Medical University and International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"},{"name":"School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Wei","family":"Chiang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Materials and Tissue Engineering Taipei Medical University and International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"},{"name":"School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"},{"name":"Bone and Joint Research Center, Department of Orthopedics, Taipei Medical University Hospital, School of Medicine, College of Medicine, Taipei Medical University, No. 252, Wuxing Street, Xinyi District, Taipei 110, Taiwan"},{"name":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Room 410, Barry Lam Hall, No.1, Sec.4, Roosevelt Road, Taipei 10617, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hwa","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Materials and Tissue Engineering Taipei Medical University and International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"},{"name":"School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"},{"name":"Bone and Joint Research Center, Department of Orthopedics, Taipei Medical University Hospital, School of Medicine, College of Medicine, Taipei Medical University, No. 252, Wuxing Street, Xinyi District, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8357-5616","authenticated-orcid":false,"given":"Pei-Chun","family":"Wong","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Materials and Tissue Engineering Taipei Medical University and International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"},{"name":"School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Hsien","family":"Ho","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Materials and Tissue Engineering Taipei Medical University and International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"},{"name":"School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Ru","family":"Jheng","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Materials and Tissue Engineering Taipei Medical University and International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"},{"name":"School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Burnouf","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Materials and Tissue Engineering Taipei Medical University and International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"},{"name":"School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9446-4030","authenticated-orcid":false,"given":"Ching-Li","family":"Tseng","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Materials and Tissue Engineering Taipei Medical University and International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan"},{"name":"School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, No. 250, 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