{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:22:17Z","timestamp":1789953737960,"version":"4.0.1"},"reference-count":39,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T00:00:00Z","timestamp":1528243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This study was aimed at formulating a bioabsorbable, controlled-release, nanoemulgel of Quercetin, a potent antimicrobial and anti-inflammatory agent for the treatment of periodontitis that could improve its solubility and bioavailability. Screening of components was carried out based on the solubility studies. Nanoemulsion containing cinnamon oil as the oil phase, tween 80 and Carbitol\u00ae as the surfactant-cosurfactant mixture (Smix) and water as the aqueous phase containing 125 \u00b5g\/200 \u00b5L of Quercetin was prepared by using spontaneous emulsification method. Nanoemulgel was prepared using 23% w\/v poloxamer 407 as gel base. Comprehensive evaluation of the formulated nanoemulgel was carried out, and the optimized formulation was studied for drug release using Franz vertical diffusion cells. The formulated nanoemulgelexhibited a remarkable release of 92.4% of Quercetin at the end of 6 h, as compared to that of pure Quercetin-loaded gel (&lt;3% release). The viscosity of the prepared nanoemulgel was found to be 30,647 \u00b1 0.32 cPs at 37 \u00b0C. Also, molecular dynamics (MD) simulation was utilized to understand the gelation process and role of each component in the formulation. The present study revealed that the developed nanoemulgel of Quercetin could be a potential delivery system for clinical testing in periodontitis.<\/jats:p>","DOI":"10.3390\/molecules23061363","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T07:38:15Z","timestamp":1528270695000},"page":"1363","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Localized In Situ Nanoemulgel Drug Delivery System of Quercetin for Periodontitis: Development and Computational Simulations"],"prefix":"10.3390","volume":"23","author":[{"given":"Gururaj C.","family":"Aithal","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1995-3114","authenticated-orcid":false,"given":"Usha Yogendra","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reema","family":"Narayan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratibha","family":"Gopalkrishna","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal 576104, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudharsan","family":"Pandiyan","sequence":"additional","affiliation":[{"name":"Schr\u00f6dinger, Bengaluru, Karnataka 560086, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7253-2629","authenticated-orcid":false,"given":"Sanjay","family":"Garg","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Medical Science, University of South Australia, Adelaide, SA 5000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2174\/156720110793566290","article-title":"Local delivery of minocycline hydrochloride: A therapeutic paradigm in periodontal diseases","volume":"7","author":"Javed","year":"2010","journal-title":"Curr. 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