{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:33:31Z","timestamp":1790703211089,"version":"4.1.0"},"reference-count":81,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T00:00:00Z","timestamp":1529280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Arterial hypertension is one of the main risk factors in the development of cardiovascular diseases. Therefore, it is important to look for new drugs to treat hypertension. In this study, we carried out the screening of 19 compounds (triterpenes, diterpenes, sesquiterpenes, lignans, and flavonoids) isolated from 10 plants used in Mexican traditional medicine to determine whether they elicited vascular smooth muscle relaxation and, therefore, could represent novel anti-hypertension drug candidates. The vasorelaxant activity of these compounds was evaluated on the isolated rat aorta assay and the results obtained from this evaluation showed that three compounds induced a significant vasodilatory effect: meso-dihydroguaiaretic acid [half maximal effective concentration (EC50), 49.9 \u00b1 11.2 \u00b5M; maximum effect (Emax), 99.8 \u00b1 2.7%]; corosolic acid (EC50, 108.9 \u00b1 6.7 \u00b5M; Emax, 96.4 \u00b1 4.2%); and 5,8,4\u2032-trihydroxy-3,7-dimethoxyflavone (EC50, 122.3 \u00b1 7.6 \u00b5M; Emax, 99.5 \u00b1 5.4%). Subsequently, involvement of the NO\/cyclic guanosine monophosphate (cGMP) and H2S\/ATP-sensitive potassium channel (KATP) pathways on the vasodilator activity of these compounds was assessed. The results derived from this analysis showed that the activation of both pathways contributes to the vasorelaxant effect of corosolic acid. On the other hand, the vasodilator effect of meso-dihydroguaiaretic acid and 5,8,4\u2032-trihydroxy-3,7-dimethoxyflavone, partly involves stimulation of the NO\/cGMP pathway. However, these compounds also showed an important endothelium-independent vasorelaxant effect, whose mechanism of action remains to be clarified. This study indicates that meso-dihydroguaiaretic acid, corosolic acid, and 5,8,4\u2032-trihydroxy-3,7-dimethoxyflavone could be used as lead compounds for the synthesis of new derivatives with a higher potency to be developed as drugs for the prevention and treatment of cardiovascular diseases.<\/jats:p>","DOI":"10.3390\/molecules23061474","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T10:57:11Z","timestamp":1529319431000},"page":"1474","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Vasodilator Activity of Compounds Isolated from Plants Used in Mexican Traditional Medicine"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8093-7068","authenticated-orcid":false,"given":"Francisco J.","family":"Luna-V\u00e1zquez","sequence":"first","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n Qu\u00edmica y Farmacol\u00f3gica de Productos Naturales, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro, C.P. 76010 Quer\u00e9taro, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Ibarra-Alvarado","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n Qu\u00edmica y Farmacol\u00f3gica de Productos Naturales, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro, C.P. 76010 Quer\u00e9taro, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Rayo","family":"Camacho-Corona","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Facultad de Ciencias Qu\u00edmicas, Ciudad Universitaria, San Nicol\u00e1s de los Garza, CP 66451 Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Rojas-Molina","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n Qu\u00edmica y Farmacol\u00f3gica de Productos Naturales, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro, C.P. 76010 Quer\u00e9taro, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Isela","family":"Rojas-Molina","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n Qu\u00edmica y Farmacol\u00f3gica de Productos Naturales, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro, C.P. 76010 Quer\u00e9taro, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Facultad de Ciencias Qu\u00edmicas, Ciudad Universitaria, San Nicol\u00e1s de los Garza, CP 66451 Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustapha","family":"Bah","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n Qu\u00edmica y Farmacol\u00f3gica de Productos Naturales, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro, C.P. 76010 Quer\u00e9taro, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Prospective Studies Collaboration (2002). 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