{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:57:24Z","timestamp":1787029044805,"version":"build-2736575974"},"reference-count":38,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The antibacterial effects against Staphylococcus epidermidis of five silver carboxylate complexes with anti-inflammatory ligands were studied in order to analyze and compare them in terms of stability (in solution and after exposure to UV light), and their antibacterial and morphological differences. Four effects of the Ag-complexes were evidenced by transmission electronic microscopy (TEM) and scanning electronic microscopy (SEM): DNA condensation, membrane disruption, shedding of cytoplasmic material and silver compound microcrystal penetration of bacteria. 5-Chlorosalicylic acid (5Cl) and sodium 4-aminosalicylate (4A) were the most effective ligands for synthesizing silver complexes with high levels of antibacterial activity. However, Ag-5Cl was the most stable against exposure UV light (365 nm). Cytotoxic effects were tested against two kinds of eukaryotic cells: murine fibroblast cells (T10 1\/2) and human epithelial ovarian cancer cells (A2780). The main objective was to identify changes in their antibacterial properties associated with potential decomposition and the implications for clinical applications.<\/jats:p>","DOI":"10.3390\/molecules23071629","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T12:23:02Z","timestamp":1530706982000},"page":"1629","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects"],"prefix":"10.3390","volume":"23","author":[{"given":"Maialen","family":"Aldabaldetrecu","sequence":"first","affiliation":[{"name":"Faculty of Chemistry and Biology, University of Santiago de Chile, Av. Bernardo \u00d3 Higgins 3363, Casilla 40, Correo 33, Estaci\u00f3n Central, 9170022 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1159-5305","authenticated-orcid":false,"given":"Laura","family":"Tamayo","sequence":"additional","affiliation":[{"name":"Facultad de Ingenier\u00eda, Instituto de Ciencias Qu\u00edmicas Aplicadas, Polymers and Macromolecules Center, Universidad Aut\u00f3noma de Chile, El Llano Subercaseaux 2801, San Miguel, 9170022 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Alarcon","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Biology, University of Santiago de Chile, Av. Bernardo \u00d3 Higgins 3363, Casilla 40, Correo 33, Estaci\u00f3n Central, 9170022 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Walter","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Biology, University of Santiago de Chile, Av. Bernardo \u00d3 Higgins 3363, Casilla 40, Correo 33, Estaci\u00f3n Central, 9170022 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edison","family":"Salas-Huenuleo","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Farmacol\u00f3gica y Toxicol\u00f3gica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile, 9170022 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo J.","family":"Kogan","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Farmacol\u00f3gica y Toxicol\u00f3gica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile, 9170022 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9827-5162","authenticated-orcid":false,"given":"Juan","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Biology, University of Santiago de Chile, Av. Bernardo \u00d3 Higgins 3363, Casilla 40, Correo 33, Estaci\u00f3n Central, 9170022 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maritza","family":"Paez","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Biology, University of Santiago de Chile, Av. Bernardo \u00d3 Higgins 3363, Casilla 40, Correo 33, Estaci\u00f3n Central, 9170022 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1098-4659","authenticated-orcid":false,"given":"Manuel I.","family":"Az\u00f3car","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Biology, University of Santiago de Chile, Av. Bernardo \u00d3 Higgins 3363, Casilla 40, Correo 33, Estaci\u00f3n Central, 9170022 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"ref_1","first-page":"349","article-title":"Silver coordination compounds: A new horizon in medicine","volume":"327\u2013328","author":"Serenella","year":"2016","journal-title":"Coord. Chem. Rev."},{"key":"ref_2","first-page":"23","article-title":"Review: Antibacterial behavior of carboxylate silver(I) complexes","volume":"67","author":"Paez","year":"2014","journal-title":"J. Coord. Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jinorgbio.2003.07.002","article-title":"Synthesis and structural characterization of silver(I), aluminium(III) and cobalt(II) complexes with 4-isopropyltropolone (hinokitiol) showing noteworthy biological activities. Action of silver(I)-oxygen bonding complexes on the antimicrobial activities","volume":"98","author":"Nomiya","year":"2004","journal-title":"J. Inorg. Biochem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1002\/ejic.201402251","article-title":"Synthesis, Properties, and Applications of Light-Insensitive Silver(I) Cyanoximates","volume":"2014","author":"Gerasimchuk","year":"2014","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9863","DOI":"10.1021\/ic100830x","article-title":"Light Insensitive Silver(I) Cyanoximates As Antimicrobial Agents for Indwelling Medical Devices","volume":"49","author":"Gerasimchuk","year":"2010","journal-title":"Inorg. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.molstruc.2017.07.072","article-title":"Synthesis, structural analyses and antimicrobial activity of the water soluble 1D coordination polymer [Ag(3-aminopyridine)]ClO4","volume":"1149","author":"Soliman","year":"2017","journal-title":"J. Mol. Struct."},{"key":"ref_7","first-page":"19","article-title":"Synthesis and characterization of silver(I) complexes with ligands having anti-inflammatory properties","volume":"1","author":"Azocar","year":"2013","journal-title":"Commun. Inorg. Synth."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-62703-736-5_2","article-title":"Staphylococcus epidermidis pathogenesis","volume":"1106","author":"Fey","year":"2014","journal-title":"Staphylococcus Epidermidis: Methods in Molecular Biology (Methods and Protocols)"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1128\/IAI.02177-14","article-title":"Accumulation-associated protein enhances Staphylococcus epidermidis biofilm formation under dynamic conditions and is required for infection in a rat catheter model","volume":"83","author":"Schaeffer","year":"2015","journal-title":"Infect. Immun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1080\/00958972.2016.1234610","article-title":"Correlating light and thermal stability of silver carboxylate complexes by infrared and 13C NMR spectroscopy","volume":"69","author":"Aldabaldetrecu","year":"2016","journal-title":"J. Coord. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5453","DOI":"10.1021\/acs.inorgchem.6b00495","article-title":"Linkage Isomerism in Silver Acylpyrazolonato Complexes and Correlation with Their Antibacterial Activity","volume":"55","author":"Marchetti","year":"2016","journal-title":"Inorg. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.molstruc.2016.10.026","article-title":"Synthesis, characterization, photoluminescent properties and antimicrobial activities of two novel polymeric silver(I) complexes with diclofenac","volume":"1130","author":"Sevim","year":"2017","journal-title":"J. Mol. Struct."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1039\/b913433f","article-title":"Drug-containing coordination and hydrogen bonding networks obtained mechanochemically","volume":"11","author":"Braga","year":"2009","journal-title":"CrystEngComm"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S1387-7003(02)00457-4","article-title":"Synthesis and crystal structure of a novel two-dimensional corrugated coordination polymer","volume":"5","author":"Wang","year":"2002","journal-title":"Inorg. Chem. Commun."},{"key":"ref_15","unstructured":"Brauer, G. (1963). Silver Oxide. Handbook of Preparative Inorganic Chemistry, Academic Press."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cej.2010.04.020","article-title":"Factors affecting diclofenac decomposition in water by UV-A\/TiO2 photocatalysis","volume":"161","author":"Antigoni","year":"2010","journal-title":"Chem. Eng. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/jps.2600741207","article-title":"Mechanism of Decarboxylation of p-Aminosalicylic Acid","volume":"74","author":"Jivani","year":"1985","journal-title":"J. Pharm. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0378-5173(88)90141-X","article-title":"Kinetics and mechanisms of the autoxidation of ketorolac tromethamine in aqueous solution","volume":"41","author":"Leo","year":"1988","journal-title":"Int. J. Pharm."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0378-5173(88)90142-1","article-title":"Light degradation of ketorolac tromethamine","volume":"41","author":"Leo","year":"1988","journal-title":"Int. J. Pharm."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/jps.2600510408","article-title":"Stability of metal complexes of nuclear-substituted salicylic acids: Correlation with biological effects","volume":"51","author":"Foye","year":"1962","journal-title":"J. Pharm. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.ijbiomac.2013.09.021","article-title":"Salicylic acid and some of its derivatives as antibacterial agents for viscose fabric","volume":"62","author":"Kantouch","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1021\/es9035557","article-title":"Ion Release Kinetics and Particle Persistence in Aqueous Nano-Silver Colloids","volume":"44","author":"Liu","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1128\/AAC.5.6.582","article-title":"Mechanism of Silver Sulfadiazine Action on Burn Wound Infections","volume":"5","author":"Fox","year":"1974","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.msec.2014.01.033","article-title":"Antibacterial, kinetics and bacteriolytic properties of silver(I) pyridinedicarboxylate compounds","volume":"37","author":"Azocar","year":"2014","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/cjoc.201100666","article-title":"Antibacterial behavior of Pyridinecarboxylatesilver(I) complexes","volume":"30","author":"Abarca","year":"2012","journal-title":"Chin. J. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"9788","DOI":"10.1021\/ic100581k","article-title":"Synthesis, Crystal Structure, Quantum Chemical Calculations, DNA Interactions, and Antimicrobial Activity of [Ag(2-amino-3-methylpyridine)2]NO3 and [Ag(pyridine-2-carboxaldoxime)NO3]","volume":"49","author":"Soliman","year":"2010","journal-title":"Inorg. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Abu-Youssef, M.A.M., Langer, V., and Ohrstrom, L. (2006). Synthesis, a case of isostructural packing, and antimicrobial activity of silver(I)quinoxaline nitrate, silver(I)(2,5-dimethylpyrazine) nitrate and two related silver aminopyridine compounds. Dalton Trans., 2542\u20132550.","DOI":"10.1039\/B516723J"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ccr.2014.09.005","article-title":"DNA condensation induced by metal complexes","volume":"281","author":"Li","year":"2014","journal-title":"Coord. Chem. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1007\/s11051-014-2465-4","article-title":"A systematic study of antibacterial silver nanoparticles: Efficiency, enhanced permeability, and cytotoxic effects","volume":"16","author":"Tamayo","year":"2014","journal-title":"J. Nanopart. Res."},{"key":"ref_30","unstructured":"Allison, D.G., Maira-Litran, T., and Gilbert, P. (2000). Antimicrobial Resistance of Biofilms, Harwood Academic."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0966-842X(00)01913-2","article-title":"Mechanisms of biofilm resistance to antimicrobial agents","volume":"9","author":"Mah","year":"2001","journal-title":"Trends Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.1128\/AAC.49.12.4853-4859.2005","article-title":"Role of silver ions in destabilization of intermolecular adhesion forces measured by atomic force microscopy in Staphylococcus epidermidis biofilms","volume":"49","author":"Chaw","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1128\/AAC.45.4.999-1007.2001","article-title":"Riddle of Biofilm Resistance","volume":"45","author":"Lewis","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0305-4179(99)00116-3","article-title":"A historical review of the use of silver in the treatment of burns. II. Renewed interest for silver","volume":"26","author":"Klasen","year":"2000","journal-title":"Burns"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1128\/AAC.43.11.2819","article-title":"Role of Silver Ions in Destabilization of Intermolecular Adhesion Forces Measured by Atomic Force Microscopy in Staphylococcus epidermidis Biofilms","volume":"43","author":"Schierholz","year":"1999","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_36","first-page":"23","article-title":"A comprehensive in vitro biological investigation of metal complexes of tolfenamic acid","volume":"54","author":"Mazumder","year":"2017","journal-title":"Alex. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3349\/ymj.2016.57.3.588","article-title":"Tolfenamic Acid Inhibits the Proliferation, Migration, and Invasion of Nasopharyngeal Carcinoma: Involvement of p38-Mediated Down-Regulation of Slug","volume":"57","author":"Jittreetat","year":"2016","journal-title":"Yonsei Med. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.msec.2014.03.037","article-title":"Release of silver and copper nanoparticles from polyethylene nanocomposites and their penetration into Listeria monocytogenes","volume":"40","author":"Tamayo","year":"2014","journal-title":"Mater. Sci. Eng. C"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/7\/1629\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:11:15Z","timestamp":1760195475000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/7\/1629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,4]]},"references-count":38,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7]]}},"alternative-id":["molecules23071629"],"URL":"https:\/\/doi.org\/10.3390\/molecules23071629","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,4]]}}}