{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:21:25Z","timestamp":1789881685491,"version":"4.0.1"},"reference-count":32,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Liaoning Provincial Natural Science Foundation of China","award":["201602707"],"award-info":[{"award-number":["201602707"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The selective O-benzylation of 2-oxo-1,2-dihydropyridines plays a critical role in organic synthesis of natural products and biological active molecules. Herein we report a novel ternary system of ZnO, ZnCl2 and N,N-diisopropylethylamine (DIEA), that is highly effective for selective O-benzylation of 2-oxo-1,2-dihydropyridines using abundant substituted benzyl halides and related substituted 2-oxo-1,2-dihydropyridines compounds. This process allows access to a variety of O-benzyl products under mild reaction conditions, which are important synthetic intermediates in the protection of functional groups, and represents a new method toward the development for the O-benzylation of 2-oxo-1,2-dihydropyridines.<\/jats:p>","DOI":"10.3390\/molecules23071784","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T02:10:11Z","timestamp":1532052611000},"page":"1784","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Zinc (II)-Mediated Selective O-Benzylation of 2-Oxo-1,2-Dihydropyridines Systems"],"prefix":"10.3390","volume":"23","author":[{"given":"Qifan","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design &amp; Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyu","family":"Du","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design &amp; Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Liang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design &amp; Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design &amp; Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Fang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design &amp; Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design &amp; Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,7,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.2174\/138527205774610886","article-title":"New synthetic methods to 2-pyridone rings","volume":"9","author":"Mercedes","year":"2005","journal-title":"Curr. 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