{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:25:42Z","timestamp":1778891142475,"version":"3.51.4"},"reference-count":41,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004504","name":"Lietuvos Mokslo Taryba","doi-asserted-by":"publisher","award":["LAT-02\/2016"],"award-info":[{"award-number":["LAT-02\/2016"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Treatment of bacteria-associated infections is complicated and antibiotic treatment alone is often inadequate to overcome biofilm infections. Physical methods allow overcoming this problem and propose solutions that are non-dependent on drug resistance. In this work, we investigated the feasibility of pulsed electric fields for sensitization of MRSA to common antibiotics. We analyzed the efficacy of inactivation of methicillin-resistant Staphylococcus aureus in 5\u201320 kV\/cm electric field separately and in combination with gentamicin, doxycycline, ciprofloxacin, sulfamethoxazole, and vancomycin. Combined treatment allowed using up to 1000-fold smaller concentrations of antibiotics to induce the same inactivation of S. aureus.<\/jats:p>","DOI":"10.3390\/molecules23071799","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T03:24:27Z","timestamp":1532316267000},"page":"1799","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Induction of Different Sensitization Patterns of MRSA to Antibiotics Using Electroporation"],"prefix":"10.3390","volume":"23","author":[{"given":"Vitalij","family":"Novickij","sequence":"first","affiliation":[{"name":"Institute of High Magnetic Fields, Vilnius Gediminas Technical University, Naugarduko st. 41, 03227 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurgita","family":"\u0160vedien\u0117","sequence":"additional","affiliation":[{"name":"Laboratory of Biodeterioration Research, Nature Research Centre, Akademijos st. 2, 08412 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Algimantas","family":"Pa\u0161kevi\u010dius","sequence":"additional","affiliation":[{"name":"Laboratory of Biodeterioration Research, Nature Research Centre, Akademijos st. 2, 08412 Vilnius, Lithuania"},{"name":"Laboratory of Microbiology of the Centre of Laboratory Medicine, Vilnius University Hospital Santari\u0161ki\u0173 Clinics, Santariskiu g. 2, 08406 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Markovskaja","sequence":"additional","affiliation":[{"name":"Laboratory of Mycology, Nature Research Centre, \u017dali\u0173j\u0173 e\u017eer\u0173 st. 49, 08406 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egl\u0117","family":"Lastauskien\u0117","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biotechnology, Vilnius University, Sauletekio al. 7, 10257 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Auks\u0117","family":"Zinkevi\u010dien\u0117","sequence":"additional","affiliation":[{"name":"State Research Institute Centre for Innovative Medicine, Department of Immunology, Santari\u0161ki\u0173 st. 5, 08406 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3659-3202","authenticated-orcid":false,"given":"Irut\u0117","family":"Girkontait\u0117","sequence":"additional","affiliation":[{"name":"State Research Institute Centre for Innovative Medicine, Department of Immunology, Santari\u0161ki\u0173 st. 5, 08406 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurij","family":"Novickij","sequence":"additional","affiliation":[{"name":"Institute of High Magnetic Fields, Vilnius Gediminas Technical University, Naugarduko st. 41, 03227 Vilnius, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,7,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrmicro2200","article-title":"Waves of Resistance: Staphylococcus aureus in the Antibiotic Era","volume":"7","author":"Chambers","year":"2010","journal-title":"Nat. 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