{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:31:01Z","timestamp":1789021861159,"version":"build-2803163510"},"reference-count":14,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T00:00:00Z","timestamp":1533513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Novel 1,4-naphthoquinones possessing indole scaffolds were prepared by the reaction of 2-hydroxy-1,4-naphthoquinone-substituted salicylic aldehydes and indoles using In(OTf)3 as a catalyst. The method has the advantages of simple operation, mild reaction conditions, and friendly environment.<\/jats:p>","DOI":"10.3390\/molecules23081954","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T03:44:18Z","timestamp":1533613458000},"page":"1954","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis of Novel 1,4-Naphthoquinones Possessing Indole Scaffolds Using In(OTf)3 in Solvent-Free Conditions"],"prefix":"10.3390","volume":"23","author":[{"given":"Xiaojuan","family":"Yang","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Xinxiang University, Xinxiang 453003, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiang","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1016\/j.ddtec.2012.10.012","article-title":"Multicomponent reactions\u2014Opportunities for the pharmaceutical industry","volume":"10","author":"Ruijter","year":"2013","journal-title":"Drug Discov. Today Technol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/ol020238n","article-title":"A novel microwave-mediated one-pot synthesis of Indolizines via a three-component reaction","volume":"5","author":"Bora","year":"2003","journal-title":"Org. Lett."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Thompson, R.H. (1997). Naturally Occurring Quinones IV: Recents Advances, Champman & Hall.","DOI":"10.1007\/978-94-009-1551-0"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6052","DOI":"10.1016\/j.ejmech.2010.10.006","article-title":"Biological evaluation of donor-acceptor aminonaphthoquinones as antitumor agents","volume":"45","author":"Benites","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Leyva, E., L\u00f3pez, L., Cruz, R., and Espinosa-Gonz\u00e1lez, C.G. (2016). Synthesis and studies of the antifungal activity of 2-anilino-\/2,3-dianilino-\/2-phenoxy- and 2,3-diphenoxy-1,4-naphthoquinones. Res. Chem. Intermediat., 1\u201315.","DOI":"10.1007\/s11164-016-2732-3"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000075548","article-title":"Inhibitory effects of J78, a newly synthesized 1,4-naphthoquinone derivative, on experimental thrombosis and platelet aggregation","volume":"70","author":"Jin","year":"2004","journal-title":"Pharmacology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1248\/bpb.25.669","article-title":"In vitro antifungal activity of naphthoquinone derivatives","volume":"25","author":"Sasaki","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"ref_8","first-page":"133","article-title":"Radermachera xylocarpa: The high\u0142y efficient source of lapachol and synthesis of its derivatives","volume":"58","author":"Shetgiri","year":"2001","journal-title":"Acta. Pol. Pharm."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1248\/bpb.29.2279","article-title":"Antitumor activity of liposomal naphthoquinone esters isolated from thai medicinal plant: Rhinacanthus nasutus KURZ","volume":"29","author":"Siripong","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1021\/np060587g","article-title":"Unusual naphthoquinone derivatives from the twigs of Avicennia marina","volume":"70","author":"Han","year":"2007","journal-title":"J. Nat. Prod."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3390\/md7020166","article-title":"Aplysinopsins-marine indole alkaloids: Chemistry, bioactivity and ecological significance","volume":"7","author":"Bialonska","year":"2009","journal-title":"Mar. Drugs"},{"key":"ref_12","first-page":"1","article-title":"Indole: The molecule of diverse biological activities","volume":"5","author":"Biswal","year":"2012","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1526-4610.2005.05129a.x","article-title":"Resolution of concentration\u2013response differences in onset of effect between subcutaneous and oral sumatriptan","volume":"45","author":"Fox","year":"2005","journal-title":"Headach. J. Head Face Pain"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1310\/hpj4408-670","article-title":"Off-label drug uses-ondansetron: Postanesthetic shivering","volume":"44","author":"Generali","year":"2009","journal-title":"Hosp. Pharm."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/8\/1954\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:16:45Z","timestamp":1760195805000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/8\/1954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,6]]},"references-count":14,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8]]}},"alternative-id":["molecules23081954"],"URL":"https:\/\/doi.org\/10.3390\/molecules23081954","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,6]]}}}