{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:04:33Z","timestamp":1781622273799,"version":"3.54.5"},"reference-count":60,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T00:00:00Z","timestamp":1534118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006070","name":"Universidad de los Andes","doi-asserted-by":"publisher","award":["the number does not exist"],"award-info":[{"award-number":["the number does not exist"]}],"id":[{"id":"10.13039\/501100006070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this work, six complexes (2\u20137) of Cr(III) and Co(II) transition metals with triazole ligands were synthesized and characterized. In addition, a new ligand, 3,5-bis(1,2,4-triazol-1-ylmethyl)toluene (1), was synthesized and full characterized. The complexes were obtained as air-stable solids and characterized by melting point, electrical conductivity, thermogravimetric analysis, and Raman, infrared and ultraviolet\/visible spectroscopy. The analyses and spectral data showed that complexes 3\u20137 had 1:1 (M:L) stoichiometries and octahedral geometries, while 2 had a 1:2 (M:L) ratio, which was supported by DFT calculations. The complexes and their respective ligands were evaluated against bacterial and fungal strains with clinical relevance. All the complexes showed higher antibacterial and antifungal activities than the free ligands. The complexes were more active against fungi than against bacteria. The activities of the chromium complexes against Candida tropicalis are of great interest, as they showed minimum inhibitory concentration 50 (MIC50) values between 7.8 and 15.6 \u03bcg mL\u22121. Complexes 5 and 6 showed little effect on Vero cells, indicating that they are not cytotoxic. These results can provide an important platform for the design of new compounds with antibacterial and antifungal activities.<\/jats:p>","DOI":"10.3390\/molecules23082013","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T11:27:13Z","timestamp":1534159633000},"page":"2013","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes: Synthesis and Biological Activity Evaluations"],"prefix":"10.3390","volume":"23","author":[{"given":"Ricardo A.","family":"Murcia","sequence":"first","affiliation":[{"name":"Departament of Chemistry, Universidad de los Andes, Carrera 1 No. 18A-12, 111711 Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0120-8060","authenticated-orcid":false,"given":"Sandra M.","family":"Leal","sequence":"additional","affiliation":[{"name":"Programa de Bacteriolog\u00eda y Laboratorio Cl\u00ednico, Facultad de Ciencias de la Salud, Universidad de Santander, 680002 Bucaramanga, Colombia"},{"name":"Programa de Maestr\u00eda en Investigaci\u00f3n en Enfermedades Infecciosas, Facultad de Ciencias de la Salud, Universidad de Santander, 680002 Bucaramanga, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4588-0681","authenticated-orcid":false,"given":"Martha V.","family":"Roa","sequence":"additional","affiliation":[{"name":"Programa de Bacteriolog\u00eda y Laboratorio Cl\u00ednico, Facultad de Ciencias de la Salud, Universidad de Santander, 680002 Bucaramanga, Colombia"},{"name":"Programa de Maestr\u00eda en Investigaci\u00f3n en Enfermedades Infecciosas, Facultad de Ciencias de la Salud, Universidad de Santander, 680002 Bucaramanga, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Nagles","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Naturales y Matem\u00e1ticas, Universidad de Ibagu\u00e9, Carrera 22 Calle 67, 730001 Ibagu\u00e9, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Mu\u00f1oz-Castro","sequence":"additional","affiliation":[{"name":"Grupo de Qu\u00edmica Inorg\u00e1nica y Materiales Moleculares, Universidad Autonoma de Chile, El Llano Subercaseaux, 2801 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-9719","authenticated-orcid":false,"given":"John J.","family":"Hurtado","sequence":"additional","affiliation":[{"name":"Departament of Chemistry, Universidad de los Andes, Carrera 1 No. 18A-12, 111711 Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,13]]},"reference":[{"key":"ref_1","unstructured":"O\u2019Neill, J. 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