{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:42:19Z","timestamp":1790800939209,"version":"4.1.0"},"reference-count":78,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T00:00:00Z","timestamp":1536451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Viral diseases, such as human immune deficiency virus (HIV), influenza, hepatitis, and herpes, are the leading causes of human death in the world. The shortage of effective vaccines or therapeutics for the prevention and treatment of the numerous viral infections, and the great increase in the number of new drug-resistant viruses, indicate that there is a great need for the development of novel and potent antiviral drugs. Natural products are one of the most valuable sources for drug discovery. Most natural triterpenoids, such as oleanolic acid (OA), possess notable antiviral activity. Therefore, it is important to validate how plant isolates, such as OA and its analogues, can improve and produce potent drugs for the treatment of viral disease. This article reports a review of the analogues of oleanolic acid and their selected pathogenic antiviral activities, which include HIV, the influenza virus, hepatitis B and C viruses, and herpes viruses.<\/jats:p>","DOI":"10.3390\/molecules23092300","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T10:28:57Z","timestamp":1536575337000},"page":"2300","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Antiviral Activities of Oleanolic Acid and Its Analogues"],"prefix":"10.3390","volume":"23","author":[{"given":"Vuyolwethu","family":"Khwaza","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Opeoluwa O.","family":"Oyedeji","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blessing A.","family":"Aderibigbe","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.biotechadv.2017.12.016","article-title":"In vitro methods for testing antiviral drugs","volume":"36","author":"Ruml","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jpba.2017.06.071","article-title":"Current antiviral drugs and their analysis in biological materials\u2014Part I: Antivirals against respiratory and herpes viruses","volume":"147","author":"Martinec","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_3","unstructured":"(2017, November 05). National Health Laboratory Service. Available online: http:\/\/www.nhls.ac.za\/?page=alerts&id=5&archive=2016&rows=5&pager=5."},{"key":"ref_4","first-page":"14","article-title":"Viral infectious disease and natural products with antiviral activity","volume":"1","author":"Kitazato","year":"2007","journal-title":"Drug Discov. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s13337-015-0276-6","article-title":"Herbal plants and plant preparations as remedial approach for viral diseases","volume":"26","author":"Ganjhu","year":"2015","journal-title":"VirusDisease"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1053\/j.gastro.2009.11.053","article-title":"Silibinin and Related Compounds Are Direct Inhibitors of Hepatitis C","volume":"138","author":"Ahnou","year":"2010","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1053\/j.gastro.2009.09.021","article-title":"Silymarin Inhibits In Vitro T-Cell Proliferation and Cytokine Production in Hepatitis C Virus Infection","volume":"138","author":"Morishima","year":"2010","journal-title":"Gastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1016\/j.bmc.2014.04.061","article-title":"Synthesis of triterpenoid triazine derivatives from allobetulone and betulonic acid with biological activities","volume":"22","author":"Dinh","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/BF02167631","article-title":"The isoprene rule and the biogenesis of terpenic compounds","volume":"9","author":"Ruzicka","year":"1953","journal-title":"Experientia"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/med.21484","article-title":"Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives","volume":"38","author":"Xiao","year":"2018","journal-title":"Med. Res. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"980","DOI":"10.2741\/3730","article-title":"Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer","volume":"16","author":"Bishayee","year":"2011","journal-title":"Front. Biosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.phytochem.2003.11.014","article-title":"On the origins of triterpenoid skeletal diversity","volume":"65","author":"Xu","year":"2004","journal-title":"Phytochemistry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bcp.2016.09.029","article-title":"Antivirals against animal viruses","volume":"133","author":"Villa","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4103\/2225-4110.124335","article-title":"Antiviral Natural Products and Herbal Medicines","volume":"4","author":"Lin","year":"2014","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/281689a0","article-title":"Glycyrrhizic acid inhibits virus growth and inactivates virus particles","volume":"281","author":"Pompei","year":"1979","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1021\/np50081a010","article-title":"Anti-aids agents, 6. salaspermic acid, an anti-HIV principle from tripterygium wilfordii, and the structure-activity correlation with its related compounds","volume":"55","author":"Chen","year":"1992","journal-title":"Prod. J. Nat."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1021\/np50104a008","article-title":"Anti- aids agents, 11 betulinic acid and plantanic acid as anti-HIV principles from syzygium claviflorum, and the anti-HIV activity of structurally relate triterpenoids","volume":"57","author":"Fujioka","year":"1994","journal-title":"J. Nat. Prod."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.antiviral.2013.02.003","article-title":"Oleanolic acid and ursolic acid: Novel hepatitis C virus antivirals that inhibit NS5B activity","volume":"98","author":"Kong","year":"2013","journal-title":"Antiviral Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/8401843","article-title":"Semisynthesis of derivatives of oleanolic acid from Syzygium aromaticum and their antinociceptive and anti-inflammatory properties","volume":"2016","author":"Rali","year":"2016","journal-title":"Mediators Inflamm."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kim, S., Lee, H., Lee, S., Yoon, Y., and Choi, K.H. (2015). Antimicrobial action of oleanolic acid on Listeria monocytogenes, Enterococcus faecium, and Enterococcus faecalis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0118800"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S1631-0748(03)00066-3","article-title":"Antibacterial activities of a few prepared derivatives of oleanolic acid and of other natural triterpenic compounds","volume":"6","author":"Hichri","year":"2003","journal-title":"C. R. Chim."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7599","DOI":"10.1007\/s13277-015-4655-9","article-title":"Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K\/Akt pathway","volume":"37","author":"Li","year":"2016","journal-title":"Tumor Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.indcrop.2016.03.024","article-title":"Regiospecific synthesis, anti-inflammatory and anticancer evaluation of novel 3,5-disubstituted isoxazoles from the natural maslinic and oleanolic acids","volume":"85","author":"Romdhane","year":"2016","journal-title":"Ind. Crops Prod."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.biopha.2016.11.091","article-title":"NOX2-ROS-HIF-1\u03b1 signaling is critical for the inhibitory effect of oleanolic acid on rectal cancer cell proliferation","volume":"85","author":"Guo","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.canlet.2014.01.016","article-title":"Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: Preclinical and clinical evidence","volume":"346","author":"Shanmugam","year":"2014","journal-title":"Cancer Lett."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.biopha.2016.08.030","article-title":"Improvement of ursolic and oleanolic acids\u2032 antitumor activity by complexation with hydrophilic cyclodextrins","volume":"83","author":"Oprean","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bioorg.2016.08.001","article-title":"Bioorganic Chemistry Synthesis of ring-C modified oleanolic acid derivatives and their cytotoxic evaluation","volume":"68","author":"Pattnaik","year":"2016","journal-title":"Bioorg. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.fbp.2012.12.006","article-title":"Extraction optimization of oleanolic and ursolic acids from pomegranate (Punica granatum L.) flowers","volume":"92","author":"Fu","year":"2014","journal-title":"Food Bioprod. Process."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.indcrop.2016.01.031","article-title":"Novel approaches to optimize extraction processes of ursolic, oleanolic and rosmarinic acids from Rosmarinus officinalis leaves","volume":"84","author":"Bernatoniene","year":"2016","journal-title":"Ind. Crops Prod."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.foodchem.2015.03.018","article-title":"Semi-synthesis of new antimicrobial esters from the natural oleanolic and maslinic acids","volume":"183","author":"Chouab","year":"2015","journal-title":"Food Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.phymed.2006.12.013","article-title":"Screening of plant extracts for antimicrobial activity against bacteria and yeasts with dermatological relevance","volume":"14","author":"Weckesser","year":"2007","journal-title":"Phytomedicine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1590\/S0102-695X2011005000185","article-title":"Syzygium aromaticum extracts as good source of betulinic acid and potential anti-breast cancer","volume":"22","author":"Aisha","year":"2012","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_33","first-page":"844","article-title":"Low Dose of Oleanolic Acid Protects against Lithocholic Acid\u2013Induced Cholestasis in Mice: Potential Involvement of Nuclear Factor-E2-Related Factor 2-Mediated Upregulation of Multidrug Resistance-Associated Proteins","volume":"42","author":"Chen","year":"2014","journal-title":"Am. Soc. Pharmacol. Exp. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1039\/c0np00059k","article-title":"Synthesis, biology and clinical significance of pentacyclic triterpenes: A multi-target approach to prevention and treatment of metabolic and vascular diseases","volume":"28","author":"Sheng","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jep.2005.05.024","article-title":"Oleanolic acid and ursolic acid: Research perspectives","volume":"100","author":"Liu","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1093\/pcp\/pcr146","article-title":"CYP716A Subfamily Members are Multifunctional Oxidases in Triterpenoid Biosynthesis","volume":"52","author":"Fukushima","year":"2011","journal-title":"Plant Cell Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Jesus, J.A., Lago, J.H.G., Laurenti, M.D., Yamamoto, E.S., and Passero, L.F.D. (2015). Antimicrobial activity of oleanolic and ursolic acids: An update. Evid.-Based Complement. Altern. Med., 2015.","DOI":"10.1155\/2015\/620472"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.bbrc.2007.06.130","article-title":"Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea","volume":"362","author":"Strehle","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.lfs.2006.03.044","article-title":"Gastroprotective and ulcer-healing activity of oleanolic acid derivatives: In vitro\u2013in vivo relationships","volume":"79","author":"Theoduloz","year":"2006","journal-title":"Life Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1078\/094471103321659807","article-title":"Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental","volume":"10","author":"Somova","year":"2003","journal-title":"Phytomedicine"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.indcrop.2007.09.004","article-title":"Optimizing conditions for oleanolic acid extraction from Lantana camara roots using response surface methodology","volume":"27","author":"Banik","year":"2008","journal-title":"Ind. Crops Prod."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1055\/s-2007-967106","article-title":"Solubility Studies of Oleanolic Acid and Betulinic Acid in Aqueous Solutions and Plant Extracts of Viscum album L.","volume":"73","author":"Winkler","year":"2007","journal-title":"Planta Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jep.2006.04.004","article-title":"Amylase inhibitory activity of some Malaysian plants used to treat diabetes  with particular reference to Phyllanthus amarus","volume":"107","author":"Ali","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1248\/cpb.59.496","article-title":"Triterpenoids and diterpenoids from Viburnum chingii","volume":"59","author":"Chen","year":"2011","journal-title":"Chem. Pharm. Bull."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/BF02977756","article-title":"Potentially cytotoxic triterpenoids from the root bark of Siphonodon celastrineus Griff","volume":"28","author":"Niampoka","year":"2005","journal-title":"Arch. Pharm. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.phytochem.2013.09.027","article-title":"Lupane, friedelane, oleanane, and ursane triterpenes from the stem of Siphonodon celastrineus Griff","volume":"96","author":"Kaweetripob","year":"2013","journal-title":"Phytochemistry"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1016\/j.bmc.2013.03.018","article-title":"Anti-inflammatory secondary metabolites from the leaves of Rosa laevigata","volume":"21","author":"Yan","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1124\/pr.111.004846","article-title":"Synthetic Oleanane Triterpenoids: Multifunctional Drugs with a Broad Range of Applications for Prevention and Treatment of Chronic Disease","volume":"64","author":"Liby","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"ref_49","first-page":"336","article-title":"Advances in Brief A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity","volume":"59","author":"Suh","year":"1999","journal-title":"Cancer Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1016\/j.bmcl.2006.03.009","article-title":"Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase","volume":"16","author":"Chen","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.phytochem.2011.12.022","article-title":"Phytochemistry Oleanolic acid","volume":"77","author":"Pollier","year":"2012","journal-title":"Phytochemistry"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10753-014-0007-y","article-title":"Anti-Inflammatory and Membrane-Stabilizing Properties of Two Semisynthetic Derivatives of Oleanolic Acid","volume":"38","author":"Oyedeji","year":"2015","journal-title":"Inflammation"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3109\/14756366.2011.611134","article-title":"Ionic derivatives of betulinic acid as novel HIV-1 protease inhibitors","volume":"27","author":"Zhao","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.molmed.2004.11.001","article-title":"Betulinic acid derivatives as HIV-1 antivirals","volume":"11","author":"Aiken","year":"2005","journal-title":"Trends Mol. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"657","DOI":"10.2174\/0929867053202214","article-title":"Betulinic Acid and Its Derivatives: A Review on their Biological Properties","volume":"12","author":"Yogeeswari","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1016\/S0960-894X(01)00647-3","article-title":"Synthesis and Anti-HIV Activity of Oleanolic Acid Derivatives","volume":"11","author":"Zhu","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5462","DOI":"10.1021\/jm0601912","article-title":"Anti-AIDS Agents 69. Moronic Acid and Other Triterpene Derivatives as Novel Potent Anti-HIV Agents","volume":"49","author":"Yu","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1021\/np990633v","article-title":"Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives","volume":"63","author":"Kashiwada","year":"2000","journal-title":"J. Nat. Prod."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1021\/np9800710","article-title":"Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids","volume":"61","author":"Kashiwada","year":"1998","journal-title":"J. Nat. Prod."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1080\/14756360701633187","article-title":"Oleanolic acid and related derivatives as medicinally important compounds","volume":"23","author":"Sultana","year":"2008","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4014\/jmb.1210.10074","article-title":"Antiviral Activity of the Plant Extracts from Thuja orientalis, Aster spathulifolius, and Pinus thunbergii against Influenza Virus A\/PR\/8\/34","volume":"23","author":"Lee","year":"2013","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1016\/j.foodchem.2012.04.016","article-title":"Anti-influenza A virus effects of fructan from Welsh onion (Allium fistulosum L.)","volume":"134","author":"Lee","year":"2012","journal-title":"Food Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1271\/bbb.120112","article-title":"Anti-Influenza Virus Effects of Elderberry Juice and Its Fractions","volume":"76","author":"Kinoshita","year":"2012","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.antiviral.2012.02.013","article-title":"Antiviral effects of Psidium guajava Linn. (guava) tea on the growth of clinical isolated H1N1 viruses: Its role in viral hemagglutination and neuraminidase inhibition","volume":"94","author":"Sriwilaijaroen","year":"2012","journal-title":"Antiviral Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ptr.1892","article-title":"Anti-influenza agents from plants and traditional Chinese medicine","volume":"20","author":"Wang","year":"2006","journal-title":"Phyther. Res."},{"key":"ref_66","first-page":"1","article-title":"Molecular docking of potential inhibitors for influenza H7N9","volume":"2015","author":"Liu","year":"2015","journal-title":"Comput. Math. Methods Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.ejmech.2017.10.070","article-title":"Multivalent oleanolic acid human serum albumin conjugate as nonglycosylated neomucin for influenza virus capture and entry inhibition","volume":"143","author":"Yang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1039\/C6MD00292G","article-title":"Design, synthesis and biological activity evaluation of novel conjugated sialic acid and pentacyclic triterpene derivatives as anti-influenza entry inhibitors","volume":"7","author":"Han","year":"2016","journal-title":"MedChemComm"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Han, X., Si, L.L., Shi, Y.Y., Fan, Z.B., Wang, S.X., Tian, Z.Y., Li, M., Sun, J.Q., Jiao, P.X., and Ran, F.X. (2017). Synthesis and in vitro anti-influenza virus evaluation of novel sialic acid (C-5 and C-9)-pentacyclic triterpene derivatives. Molecules, 22.","DOI":"10.3390\/molecules22071018"},{"key":"ref_70","first-page":"116","article-title":"Survey of Anti-HIV and Anti-HCV Compounds from Natural Sources","volume":"1","author":"Hattori","year":"2013","journal-title":"Can. Chem. Trans."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ejmech.2017.05.051","article-title":"Novel thioglycosyl analogs of glycosyltransferase substrates as antiviral compounds against classical swine fever virus and hepatitis C virus","volume":"137","author":"Chaubey","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0166-3542(02)00007-4","article-title":"Antiviral activity of Plantago major extracts and related compounds in vitro","volume":"55","author":"Chiang","year":"2002","journal-title":"Antiviral Res."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Yan, W., Zhang, C., Li, B., Xu, X., Liang, M., Gu, S., Chu, S., Xu, B., Ren, J., and Wang, P. (2016). A Series of Oleanolic Acid Derivatives as Anti-Hepatitis B Virus Agents: Design, Synthesis, and in Vitro and in Vivo Biological Evaluation. Molecules, 21.","DOI":"10.3390\/molecules21040402"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.micres.2012.11.002","article-title":"Anti-herpes virus activities of Achyranthes aspera: An Indian ethnomedicine, and its triterpene acid","volume":"168","author":"Mukherjee","year":"2013","journal-title":"Microbiol. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(00)04638-9","article-title":"Herpes simplex virus infections","volume":"357","author":"Whitley","year":"2001","journal-title":"Lancet"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jcv.2004.02.009","article-title":"Antiviral drugs in current clinical use","volume":"30","year":"2004","journal-title":"J. Clin. Virol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1248\/bpb.28.1779","article-title":"Anti-herpes Virus Type 1 Activity of Oleanane-Type Triterpenoids","volume":"28","author":"Keda","year":"2005","journal-title":"Biol. Pharm. Bull."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jhep.2015.09.011","article-title":"The importance of resistance to direct antiviral drugs in HCV infection in clinical practice","volume":"64","author":"Sarrazin","year":"2016","journal-title":"J. Hepatol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/9\/2300\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:19:34Z","timestamp":1760195974000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/9\/2300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,9]]},"references-count":78,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9]]}},"alternative-id":["molecules23092300"],"URL":"https:\/\/doi.org\/10.3390\/molecules23092300","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,9]]}}}