{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:22:04Z","timestamp":1790292124850,"version":"4.1.0"},"reference-count":75,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T00:00:00Z","timestamp":1536796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Center for Complementary and Integrated Health of National Institutes of Health","award":["1R01AT007077"],"award-info":[{"award-number":["1R01AT007077"]}]},{"name":"National Center for Complementary and Integrated Health of National Institutes of Health","award":["1R01AT007566-01"],"award-info":[{"award-number":["1R01AT007566-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In diabetes mellitus, the excessive rate of glucose production from the liver is considered a primary contributor for the development of hyperglycemia, in particular, fasting hyperglycemia. In this study, we investigated whether kaempferol, a flavonol present in several medicinal herbs and foods, can be used to ameliorate diabetes in an animal model of insulin deficiency and further explored the mechanism underlying the anti-diabetic effect of this flavonol. We demonstrate that oral administration of kaempferol (50 mg\/kg\/day) to streptozotocin-induced diabetic mice significantly improved hyperglycemia and reduced the incidence of overt diabetes from 100% to 77.8%. This outcome was accompanied by a reduction in hepatic glucose production and an increase in glucose oxidation in the muscle of the diabetic mice, whereas body weight, calorie intake, body composition, and plasma insulin and glucagon levels were not altered. Consistently, treatment with kaempferol restored hexokinase activity in the liver and skeletal muscle of diabetic mice while suppressed hepatic pyruvate carboxylase activity and gluconeogenesis. These results suggest that kaempferol may exert antidiabetic action via promoting glucose metabolism in skeletal muscle and inhibiting gluconeogenesis in the liver.<\/jats:p>","DOI":"10.3390\/molecules23092338","type":"journal-article","created":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T11:46:04Z","timestamp":1536839164000},"page":"2338","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":125,"title":["The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-6349","authenticated-orcid":false,"given":"Hana","family":"Alkhalidy","sequence":"first","affiliation":[{"name":"Department of Human Nutrition, Foods and Exercise, College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA 24060, USA"},{"name":"Department of Nutrition and Food Technology, Faculty of Agriculture, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-3660","authenticated-orcid":false,"given":"Will","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Foods and Exercise, College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA 24060, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Foods and Exercise, College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA 24060, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3211-4331","authenticated-orcid":false,"given":"Jing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Foods and Exercise, College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA 24060, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan P.","family":"McMillan","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Foods and Exercise, College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA 24060, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhen","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Foods and Exercise, College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA 24060, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kequan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, College of Liberal Arts &amp; Sciences, Wayne State University, Detroit, MI 48202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3877-8198","authenticated-orcid":false,"given":"Dongmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Foods and Exercise, College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA 24060, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20080595","article-title":"Glucokinase and molecular aspects of liver glycogen metabolism","volume":"414","author":"Agius","year":"2008","journal-title":"Biochem. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1146\/annurev.ph.54.030192.004215","article-title":"Regulation of net hepatic glucose uptake in vivo","volume":"54","author":"Pagliassotti","year":"1992","journal-title":"Annu. Rev. Physiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.2337\/diabetes.50.8.1872","article-title":"Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism","volume":"50","author":"Edgerton","year":"2001","journal-title":"Diabetes"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2337\/diabetes.47.4.523","article-title":"Basal hepatic glucose production is regulated by the portal vein insulin concentration","volume":"47","author":"Sindelar","year":"1998","journal-title":"Diabetes"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"958","DOI":"10.2337\/diabetes.48.5.958","article-title":"Splanchnic and leg substrate exchange after ingestion of a natural mixed meal in humans","volume":"48","author":"Capaldo","year":"1999","journal-title":"Diabetes"},{"key":"ref_6","first-page":"686","article-title":"Effects of pulsatile delivery of insulin and glucagon in humans","volume":"257","author":"Paolisso","year":"1989","journal-title":"Am. J. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1152\/ajpendo.00492.2002","article-title":"Glucagon and regulation of glucose metabolism","volume":"284","author":"Jiang","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s00018-005-5410-y","article-title":"Anaplerotic roles of pyruvate carboxylase in mammalian tissues","volume":"63","author":"Jitrapakdee","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.biocel.2003.10.002","article-title":"Hepatocytes: Critical for glucose homeostasis","volume":"36","author":"Klover","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.2337\/diabetes.48.5.1198","article-title":"Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo","volume":"48","author":"Cherrington","year":"1999","journal-title":"Diabetes"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1172\/JCI118043","article-title":"Interstitial fluid concentrations of glycerol, glucose, and amino acids in human quadricep muscle and adipose tissue. Evidence for significant lipolysis in skeletal muscle","volume":"96","author":"Maggs","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2337\/dc10-S062","article-title":"Diagnosis and classification of diabetes mellitus","volume":"33","year":"2010","journal-title":"Diabetes Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3109\/07853899009147270","article-title":"Changes in muscle glucose metabolism in type 1 diabetes","volume":"22","author":"Koivisto","year":"1990","journal-title":"Ann. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1089\/10430340260201653","article-title":"Adenovirus-mediated expression of glucokinase in the liver as an adjuvant treatment for type 1 diabetes","volume":"13","author":"Morral","year":"2002","journal-title":"Hum. Gene Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0003-9861(86)90560-6","article-title":"Effect of Streptozotocin-Induced Diabetes and Insulin-Treatment on the Synthesis of Hexokinase-Ii in the Skeletal-Muscle of the Rat","volume":"249","author":"Frank","year":"1986","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1172\/JCI117727","article-title":"Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study","volume":"95","author":"Hwang","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0950-351X(05)80207-1","article-title":"Control of glycaemia","volume":"7","author":"Gerich","year":"1993","journal-title":"Bailliere\u2019s Clin. Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1056\/NEJM197505082921901","article-title":"Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon","volume":"292","author":"Gerich","year":"1975","journal-title":"N. Eng. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2337\/db10-0426","article-title":"Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice","volume":"60","author":"Lee","year":"2011","journal-title":"Diabetes"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0140-6736(13)60591-7","article-title":"Type 1 diabetes","volume":"383","author":"Atkinson","year":"2014","journal-title":"Lancet"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1056\/NEJMoa0805017","article-title":"Continuous glucose monitoring and intensive treatment of type 1 diabetes","volume":"359","author":"Tamborlane","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1021\/jf000892m","article-title":"Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants","volume":"49","author":"Miean","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2174\/138955711795305335","article-title":"A review on the dietary flavonoid kaempferol","volume":"11","year":"2011","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/ptr.2983","article-title":"Kaempferol protects HIT-T15 pancreatic beta cells from 2-deoxy-D-ribose-induced oxidative damage","volume":"24","author":"Lee","year":"2010","journal-title":"Phytother. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1248\/bpb.32.746","article-title":"Kaempferol attenuates 2-deoxy-d-ribose-induced oxidative cell damage in MC3T3-E1 osteoblastic cells","volume":"32","author":"Suh","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"45673","DOI":"10.1155\/2007\/45673","article-title":"Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages","volume":"2007","author":"Hamalainen","year":"2007","journal-title":"Mediators Inflamm."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1017\/S0007114508966083","article-title":"A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cells","volume":"100","author":"Crespo","year":"2008","journal-title":"Br. J. Nutr."},{"key":"ref_28","first-page":"387","article-title":"Kaempferol, but not resveratrol inhibits angiotensin converting enzyme","volume":"59","author":"Olszanecki","year":"2008","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/ptr.2008","article-title":"Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb) (Simaroubaceae)","volume":"21","author":"Loizzo","year":"2007","journal-title":"Phytother. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1248\/bpb.29.2510","article-title":"3-O-beta-d-glucosyl-(1\u21926)-beta-D-glucosyl-kaempferol isolated from Sauropus androgenus reduces body weight gain in Wistar rats","volume":"29","author":"Yu","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"767","DOI":"10.2337\/db06-1488","article-title":"The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation","volume":"56","author":"Harney","year":"2007","journal-title":"Diabetes"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jss.2008.02.036","article-title":"Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells","volume":"148","author":"Zhang","year":"2008","journal-title":"J. Surg. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bbrc.2010.06.038","article-title":"The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions","volume":"398","author":"Mylonis","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1002\/ptr.2913","article-title":"Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells","volume":"24","author":"Kang","year":"2010","journal-title":"Phytother. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.1073\/pnas.77.10.6129","article-title":"Insulin-dependent diabetes mellitus induced by subdiabetogenic doses of streptozotocin: obligatory role of cell-mediated autoimmune processes","volume":"77","author":"Paik","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","article-title":"The mechanisms of alloxan- and streptozotocin-induced diabetes","volume":"51","author":"Lenzen","year":"2008","journal-title":"Diabetologia"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-59745-448-3_1","article-title":"Selecting the \u201cright\u201d mouse model for metabolic syndrome and type 2 diabetes research","volume":"560","author":"Leiter","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"S122","DOI":"10.1055\/s-2001-18575","article-title":"Integration of biochemical and physiologic effects of insulin on glucose metabolism","volume":"109","author":"Newsholme","year":"2001","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0092-8674(89)90968-9","article-title":"Identification of a novel gene encoding an insulin-responsive glucose transporter protein","volume":"57","author":"Birnbaum","year":"1989","journal-title":"Cell"},{"key":"ref_40","first-page":"701","article-title":"Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle","volume":"269","author":"Mandarino","year":"1995","journal-title":"Am. J. Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1042\/bj2570369","article-title":"Effects of hypothyroidism on the sensitivity of glycolysis and glycogen synthesis to insulin in the soleus muscle of the rat","volume":"257","author":"Dimitriadis","year":"1989","journal-title":"Biochem. J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1126\/science.180605","article-title":"Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus","volume":"193","author":"Like","year":"1976","journal-title":"Science"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1126\/science.1089999","article-title":"Glucagon: Role in the hyperglycemia of diabetes mellitus","volume":"187","author":"Dobbs","year":"1975","journal-title":"Science"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0140-6736(75)92375-2","article-title":"The essential role of glucagon in the pathogenesis of diabetes mellitus","volume":"1","author":"Unger","year":"1975","journal-title":"Lancet"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"21824","DOI":"10.1016\/S0021-9258(20)88258-1","article-title":"Transcriptional induction of glucokinase gene by insulin in cultured liver cells and its repression by the glucagon-cAMP system","volume":"264","author":"Iynedjian","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.2337\/db11-0061","article-title":"Elevated glucose represses liver glucokinase and induces its regulatory protein to safeguard hepatic phosphate homeostasis","volume":"60","author":"Arden","year":"2011","journal-title":"Diabetes"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"639469","DOI":"10.1155\/2012\/639469","article-title":"Fisetin inhibits hyperglycemia-induced proinflammatory cytokine production by epigenetic mechanisms","volume":"2012","author":"Kim","year":"2012","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"43806","DOI":"10.18632\/oncotarget.6245","article-title":"Inhibition of p300 lysine acetyltransferase activity by luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model","volume":"6","author":"Selvi","year":"2015","journal-title":"Oncotarget"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"17395","DOI":"10.1038\/srep17395","article-title":"Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity","volume":"5","author":"Park","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41467-017-02537-6","article-title":"Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein","volume":"9","author":"Watanabe","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41467-017-00163-w","article-title":"Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity","volume":"8","author":"Cao","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jnutbio.2017.09.022","article-title":"Vitamin K1 inversely correlates with glycemia and insulin resistance in patients with type 2 diabetes (T2D) and positively regulates SIRT1\/AMPK pathway of glucose metabolism in liver of T2D mice and hepatocytes cultured in high glucose","volume":"52","author":"Dihingia","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1521-690X(03)00036-8","article-title":"Regulation of hepatic and peripheral glucose disposal","volume":"17","author":"Moore","year":"2003","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_54","first-page":"E170","article-title":"A model to measure insulin effects on glucose transport and phosphorylation in muscle: A three-tracer study","volume":"270","author":"Saccomani","year":"1996","journal-title":"Am. J. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1172\/JCI113489","article-title":"Skeletal muscle glycolysis, oxidation, and storage of an oral glucose load","volume":"81","author":"Kelley","year":"1988","journal-title":"J. Clin. Investig."},{"key":"ref_56","first-page":"224","article-title":"Direct Measurement of Change in Muscle Glycogen Concentration after a Mixed Meal in Normal Subjects","volume":"265","author":"Taylor","year":"1993","journal-title":"Am. J. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"12963","DOI":"10.1016\/S0021-9258(18)99969-2","article-title":"Glucose transporters in single skeletal muscle fibers. Relationship to hexokinase and regulation by contractile activity","volume":"269","author":"Kong","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_58","first-page":"E70","article-title":"Overexpression of hexokinase II increases insulinand exercise-stimulated muscle glucose uptake in vivo","volume":"276","author":"Halseth","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0300-2977(94)00048-E","article-title":"Plasma-Lipoprotein Abnormalities in Type-1 (Insulin-Dependent) Diabetes-Mellitus","volume":"46","author":"Dullaart","year":"1995","journal-title":"Neth. J. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/S0140-6736(86)91159-1","article-title":"Lipoprotein abnormalities in insulin-dependent diabetes mellitus","volume":"1","author":"Winocour","year":"1986","journal-title":"Lancet"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1172\/JCI118604","article-title":"Increased atherosclerosis in streptozotocin-induced diabetic mice","volume":"97","author":"Kunjathoor","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1476-511X-12-15","article-title":"Lipoprotein metabolism in patients with type 1 diabetes under intensive insulin treatment","volume":"12","author":"Feitosa","year":"2013","journal-title":"Lipids Health Disease"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s001250050889","article-title":"Effects of dietary cholesterol on plasma lipoproteins and their subclasses in IDDM patients","volume":"41","author":"Romano","year":"1998","journal-title":"Diabetologia"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/BF00400632","article-title":"Excessive glucose production, rather than insulin resistance, accounts for hyperglycaemia in recent-onset streptozotocin-diabetic rats","volume":"38","author":"Burcelin","year":"1995","journal-title":"Diabetologia"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0006-2952(96)00660-0","article-title":"In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase","volume":"53","author":"Bahl","year":"1997","journal-title":"Biochem. Pharmacol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/1357-2725(94)00087-R","article-title":"The structure and the mechanism of action of pyruvate carboxylase","volume":"27","author":"Attwood","year":"1995","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0021-9258(18)69442-6","article-title":"Formation of oxaloacetate from pyruvate and carbon dioxide","volume":"235","author":"Utter","year":"1960","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.bbagen.2015.08.003","article-title":"H2S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells","volume":"1850","author":"Ju","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.2337\/db12-1311","article-title":"Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance","volume":"62","author":"Kumashiro","year":"2013","journal-title":"Diabetes"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"532984","DOI":"10.1155\/2015\/532984","article-title":"Small Molecule Kaempferol Promotes Insulin Sensitivity and Preserved Pancreatic beta -Cell Mass in Middle-Aged Obese Diabetic Mice","volume":"2015","author":"Alkhalidy","year":"2015","journal-title":"J. Diabetes Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/oby.2006.137","article-title":"Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training","volume":"14","author":"Cortright","year":"2006","journal-title":"Obesity"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cmet.2005.09.002","article-title":"Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans","volume":"2","author":"Hulver","year":"2005","journal-title":"Cell Metab."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jnutbio.2018.04.014","article-title":"Kaempferol ameliorates hyperglycemia through suppressing hepatic gluconeogenesis and enhancing hepatic insulin sensitivity in diet-induced obese mice","volume":"58","author":"Alkhalidy","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1099\/00221287-59-1-97","article-title":"Pyruvate carboxylase in Rhodopseudomonas spheroides","volume":"59","author":"Payne","year":"1969","journal-title":"J. Gen. Microbiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1210\/en.2009-1294","article-title":"Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice","volume":"151","author":"Fu","year":"2010","journal-title":"Endocrinology"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/9\/2338\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:20:14Z","timestamp":1760196014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/9\/2338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,13]]},"references-count":75,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9]]}},"alternative-id":["molecules23092338"],"URL":"https:\/\/doi.org\/10.3390\/molecules23092338","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,13]]}}}