{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:52:52Z","timestamp":1791942772683,"version":"4.3.4"},"reference-count":92,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T00:00:00Z","timestamp":1536883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is one of the most common neurodegenerative disorders worldwide. Its incidence is gradually increasing because of an aging demographic. Therefore, AD prevention and modification is important to improve the health status of older adults. Oxidative stress is a component of the pathological mechanisms underlying AD. It is caused by a disruption of the balance between reactive oxygen species and antioxidant molecules. This imbalance also causes neuroinflammation. Catechins, which are bioactive components of tea, have antioxidative and anti-inflammatory effects. Moreover, other potential properties related to AD prevention and modification have been reported in in vitro and in vivo studies. Several clinical studies have also been conducted to date. The current review summarizes recent updates and perspectives of the effects of catechins on AD based on the molecular mechanisms and related clinical studies.<\/jats:p>","DOI":"10.3390\/molecules23092357","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T10:57:59Z","timestamp":1536922679000},"page":"2357","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Effects of Tea Catechins on Alzheimer\u2019s Disease: Recent Updates and Perspectives"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6377-1361","authenticated-orcid":false,"given":"Kazuki","family":"Ide","sequence":"first","affiliation":[{"name":"Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto 606-8501, Japan"},{"name":"Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto 606-8501, Japan"},{"name":"Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiro","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Jyoto Hospital, 11-22 Hanatenhigashi 2-chome, Tsurumi-ku Osaka-shi, Osaka 538-0044, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Furushima","sequence":"additional","affiliation":[{"name":"Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7477-4071","authenticated-orcid":false,"given":"Koji","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto 606-8501, Japan"},{"name":"Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto 606-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jalz.2017.02.006","article-title":"Alzheimer\u2019s disease: The next frontier-Special Report 2017","volume":"13","author":"Karlawish","year":"2017","journal-title":"Alzheimers Dement."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.1471-4159.2006.04212.x","article-title":"Alois Alzheimer and Alzheimer\u2019s disease: A centennial perspective","volume":"99","author":"Small","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00406-008-2001-6","article-title":"The work of Emil Kraepelin and his research group in M\u00fcnchen","volume":"258","author":"Hippius","year":"2008","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/S0140-6736(96)10203-8","article-title":"Auguste D and Alzheimer\u2019s disease","volume":"349","author":"Maurer","year":"1997","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Alzheimer\u2019s Association (2017). 2017 Alzheimer\u2019s disease facts and figures. Alzheimers Dement., 13, 325\u2013373.","DOI":"10.1016\/j.jalz.2017.02.001"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jns.2017.06.030","article-title":"Worldwide trends in the prevalence of dementia","volume":"379","author":"Cova","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-med-042915-103753","article-title":"Update on Alzheimer\u2019s disease therapy and prevention strategies","volume":"68","author":"Graham","year":"2017","journal-title":"Annu. Rev. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1749-8546-5-13","article-title":"Beneficial effects of green tea: A literature review","volume":"5","author":"Chacko","year":"2010","journal-title":"Chin. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.bcp.2011.07.093","article-title":"Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications","volume":"82","author":"Singh","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/B978-0-444-64058-1.00005-4","article-title":"Chapter 5-Effects of Bioactive Components of Green Tea on Alzheimer\u2019s Disease","volume":"Volume 56","year":"2018","journal-title":"Studies in Natural Products Chemistry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13027-017-0145-6","article-title":"The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer\u2019s disease: An overview of pre-clinical studies and translational perspectives in clinical practice","volume":"12","author":"Cascella","year":"2017","journal-title":"Inf. Agent Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.freeradbiomed.2011.09.010","article-title":"Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease","volume":"52","author":"Williams","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000464422","article-title":"Molecular pathogenesis of Alzheimer\u2019s disease: An update","volume":"24","year":"2017","journal-title":"Ann. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","article-title":"Alzheimer mechanisms and therapeutic strategies","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12017-009-8104-z","article-title":"An Overview of APP processing enzymes and products","volume":"12","author":"Chow","year":"2010","journal-title":"Neuromol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid \u03b2 deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer\u2019s disease: A prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nn.2583","article-title":"Amyloid-beta-induced neuronal dysfunction in Alzheimer\u2019s disease: From synapses toward neural networks","volume":"13","author":"Palop","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","article-title":"Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer\u2019s amyloid beta-peptide","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2174\/187152709787601867","article-title":"Clearance of amyloid-beta peptide across the blood-brain barrier: Implication for therapies in Alzheimer\u2019s disease","volume":"8","author":"Deane","year":"2009","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3233\/JAD-2010-101248","article-title":"Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-beta is an early biomarker for mild cognitive impairment preceding Alzheimer\u2019s disease","volume":"24","author":"Sagare","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fnagi.2014.00093","article-title":"The low-density lipoprotein receptor-related protein 1 and amyloid-beta clearance in Alzheimer\u2019s disease","volume":"6","author":"Kanekiyo","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3233\/JAD-2010-1221","article-title":"Alzheimer\u2019s disease and the amyloid-\u03b2 peptide","volume":"19","author":"Murphy","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejmech.2017.07.070","article-title":"Tau protein aggregation in Alzheimer\u2019s disease: An attractive target for the development of novel therapeutic agents","volume":"139","author":"Jouanne","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1016\/j.neurobiolaging.2013.03.015","article-title":"Tau phosphorylation affects its axonal transport and degradation","volume":"34","author":"Noble","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3892\/br.2016.630","article-title":"Role of oxidative stress in Alzheimer\u2019s disease","volume":"4","author":"Huang","year":"2016","journal-title":"Biomed. Rep."},{"key":"ref_26","first-page":"99","article-title":"The roles of inflammation and immune mechanisms in Alzheimer\u2019s disease","volume":"2","author":"Carrillo","year":"2016","journal-title":"Alzheimers Dement."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/1873-3468.12902","article-title":"The role of mitochondrial ROS in the aging brain","volume":"592","author":"Stefanatos","year":"2018","journal-title":"FEBS Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molcel.2012.09.025","article-title":"Physiological roles of mitochondrial reactive oxygen species","volume":"48","author":"Sena","year":"2012","journal-title":"Mol. Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1196\/annals.1427.015","article-title":"The role of mitochondria in reactive oxygen species metabolism and signaling","volume":"1147","author":"Starkov","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1365-2990.2012.01307.x","article-title":"Review: Systemic inflammation and Alzheimer\u2019s disease","volume":"39","author":"Holmes","year":"2013","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1212\/WNL.0b013e3181b6bb95","article-title":"Systemic inflammation and disease progression in Alzheimer disease","volume":"73","author":"Holmes","year":"2009","journal-title":"Neurology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1212\/WNL.0b013e318225ae07","article-title":"Proinflammatory cytokines, sickness behavior, and Alzheimer disease","volume":"77","author":"Holmes","year":"2011","journal-title":"Neurology"},{"key":"ref_34","first-page":"4","article-title":"Recent advances in the relationship between obesity, inflammation, and insulin resistance","volume":"17","author":"Bastard","year":"2006","journal-title":"Eur. Cytokine Netw."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1089\/neu.2000.17.185","article-title":"Rapid and widespread microglial activation induced by traumatic brain injury in rat brain slices","volume":"17","author":"Koshinaga","year":"2000","journal-title":"J. Neurotrauma"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ana.22455","article-title":"Inflammation after trauma: Microglial activation and traumatic brain injury","volume":"70","author":"Ramlackhansingh","year":"2011","journal-title":"Ann. Neurol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1586\/ern.12.124","article-title":"Rationale for combining glutamatergic and cholinergic approaches in the symptomatic treatment of Alzheimer\u2019s disease","volume":"12","author":"Francis","year":"2012","journal-title":"Expert Rev. Neurother."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejmech.2013.09.050","article-title":"Acetylcholinesterase inhibitors as Alzheimer therapy: From nerve toxins to neuroprotection","volume":"70","author":"Singh","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/jnc.12304","article-title":"Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer\u2019s disease","volume":"126","author":"Ferreira","year":"2013","journal-title":"J. Neurochem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.psych.48.1.649","article-title":"Central cholinergic systems and cognition","volume":"48","author":"Everitt","year":"1997","journal-title":"Annu. Rev. Psychol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neulet.2004.10.062","article-title":"Evaluation of cholinergic markers in Alzheimer\u2019s disease and in a model of cholinergic deficit","volume":"375","author":"Dominguez","year":"2005","journal-title":"Neurosci. Lett."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0301-0082(02)00079-5","article-title":"Alzheimer\u2019s disease and the basal forebrain cholinergic system: Relations to beta-amyloid peptides, cognition, and treatment strategies","volume":"68","author":"Auld","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1586\/14737175.8.11.1703","article-title":"Cholinergic system during the progression of Alzheimer\u2019s disease: Therapeutic implications","volume":"8","author":"Mufson","year":"2008","journal-title":"Expert Rev. Neurother."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/10408690390826464","article-title":"Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions","volume":"43","author":"Higdon","year":"2003","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1021\/jf980223x","article-title":"Survey of catechins, gallic acid, and methylxanthines in green, oolong, pu-erh, and black teas","volume":"46","author":"Lin","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jnutbio.2004.05.002","article-title":"Neurological mechanisms of green tea polyphenols in Alzheimer\u2019s and Parkinson\u2032s diseases","volume":"15","author":"Weinreb","year":"2004","journal-title":"J. Nutr. Biochem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1755-5949.2008.00060.x","article-title":"Simultaneous manipulation of multiple brain targets by green tea catechins: A potential neuroprotective strategy for Alzheimer and Parkinson diseases","volume":"14","author":"Mandel","year":"2008","journal-title":"CNS Neurosci. Ther."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.phanu.2015.07.001","article-title":"Clinical benefits of green tea consumption for cognitive dysfunction","volume":"3","author":"Ide","year":"2015","journal-title":"PharmaNutrition"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"624","DOI":"10.2174\/1871527315666160321110607","article-title":"In silico analysis of green tea polyphenols as inhibitors of AChE and BChE enzymes in Alzheimer\u2019s disease treatment","volume":"15","author":"Ali","year":"2016","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3233\/JAD-2009-1041","article-title":"Oxidative stress in vascular dementia and Alzheimer\u2019s disease: A common pathology","volume":"17","author":"Bennett","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5607\/en.2015.24.4.325","article-title":"The role of oxidative stress in neurodegenerative diseases","volume":"24","author":"Kim","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1196\/annals.1427.010","article-title":"Evidence of oxidative stress in Alzheimer\u2019s disease brain and antioxidant therapy","volume":"1147","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.jnutbio.2007.08.008","article-title":"Green tea catechins prevent cognitive deficits caused by A\u03b21\u201340 in rats","volume":"19","author":"Haque","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbr.2012.08.039","article-title":"Green tea (\u2212)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia","volume":"236","author":"Biasibetti","year":"2013","journal-title":"Behav. Brain Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1016\/S0968-0896(03)00367-5","article-title":"Chemical studies of the antioxidant mechanism of tea catechins: Radical reaction products of epicatechin with peroxyl radicals","volume":"11","author":"Sang","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1021\/jf052857r","article-title":"Catechin and caffeine content of green tea dietary supplements and correlation with antioxidant capacity","volume":"54","author":"Seeram","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.freeradbiomed.2004.04.012","article-title":"Catechin polyphenols: Neurodegeneration and neuroprotection in neurodegenerative diseases","volume":"37","author":"Mandel","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s12263-009-0143-4","article-title":"Neuroprotective molecular mechanisms of (\u2212)-epigallocatechin-3-gallate: A reflective outcome of its antioxidant, iron chelating and neuritogenic properties","volume":"4","author":"Weinreb","year":"2009","journal-title":"Genes Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(14)70117-6","article-title":"The role of iron in brain ageing and neurodegenerative disorders","volume":"13","author":"Ward","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fncel.2014.00112","article-title":"Neuroinflammation in the pathogenesis of Alzheimer\u2019s disease. A rational framework for the search of novel therapeutic approaches","volume":"8","author":"Morales","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jnutbio.2012.06.011","article-title":"Epigallocatechin-3-gallate prevents systemic inflammation-induced memory deficiency and amyloidogenesis via its anti-neuroinflammatory properties","volume":"24","author":"Lee","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"163106","DOI":"10.1155\/2012\/163106","article-title":"Green tea extract ameliorates learning and memory deficits in ischemic rats via its active component polyphenol epigallocatechin-3-gallate by modulation of oxidative stress and neuroinflammation","volume":"2012","author":"Wu","year":"2012","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1128\/MCB.17.8.4346","article-title":"Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade","volume":"17","author":"Berra","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.tips.2006.12.002","article-title":"PKC signaling deficits: A mechanistic hypothesis for the origins of Alzheimer\u2019s disease","volume":"28","author":"Alkon","year":"2007","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1096\/fj.02-0881fje","article-title":"Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (\u2212)-epigallocatechin-3-gallate","volume":"17","author":"Levites","year":"2003","journal-title":"FASEB J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bandc.2007.10.003","article-title":"Effects of green tea extract on learning, memory, behavior and acetylcholinesterase activity in young and old male rats","volume":"67","author":"Kaur","year":"2008","journal-title":"Brain Cogn."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1271\/bbb.68.1977","article-title":"Effects of green tea polyphenol on cognitive and acetylcholinesterase activities","volume":"68","author":"Kim","year":"2004","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.neuint.2012.02.005","article-title":"Impact of epigallo catechin-3-gallate on acetylcholine-acetylcholine esterase cycle in aged rat brain","volume":"60","author":"Srividhya","year":"2012","journal-title":"Neurochem. Int."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/ajcn\/83.2.355","article-title":"Green tea consumption and cognitive function: A cross-sectional study from the Tsurugaya Project 1","volume":"83","author":"Kuriyama","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/ajcn\/88.1.224","article-title":"Tea consumption and cognitive impairment and decline in older Chinese adults","volume":"88","author":"Ng","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3945\/jn.108.095182","article-title":"Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance","volume":"139","author":"Nurk","year":"2009","journal-title":"J. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s12603-010-0095-9","article-title":"Cognitive function and tea consumption in community dwelling older Chinese in Singapore","volume":"14","author":"Feng","year":"2010","journal-title":"J. Nutr. Health Aging"},{"key":"ref_73","unstructured":"Gu, Y.J., He, C.H., Li, S., Zhang, S.Y., Duan, S.Y., Sun, H.P., Shen, Y.P., Xu, Y., Yin, J.Y., and Pan, C.W. (2017). Tea consumption is associated with cognitive impairment in older Chinese adults. Aging Ment. Health, 1\u20137."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Shen, W., Xiao, Y.Y., Ying, X.H., Li, S.T., Zhai, Y.J., Shang, X.P., Li, F.D., Wang, X.Y., He, F., and Lin, J.F. (2015). Tea consumption and cognitive impairment: A cross-sectional study among Chinese elderly. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0140739"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/WNN.0b013e3181b2790b","article-title":"Association of cognitive impairment with smoking, alcohol consumption, tea consumption, and exercise among Chinese nonagenarians\/centenarians","volume":"22","author":"Huang","year":"2009","journal-title":"Cogn. Behav. Neurol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1007\/s12603-012-0077-1","article-title":"Tea drinking and cognitive function in oldest-old Chinese","volume":"16","author":"Feng","year":"2012","journal-title":"J. Nutr. Health Aging"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Noguchi-Shinohara, M., Yuki, S., Dohmoto, C., Ikeda, Y., Samuraki, M., Iwasa, K., Yokogawa, M., Asai, K., Komai, K., and Nakamura, H. (2014). Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096013"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3233\/JAD-2011-110431","article-title":"Gender differences in tea, coffee, and cognitive decline in the elderly: The Cardiovascular Health Study","volume":"27","author":"Arab","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3233\/JAD-2009-0920","article-title":"Midlife coffee and tea drinking and the risk of late-life dementia: A population-based CAIDE study","volume":"16","author":"Eskelinen","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"43306","DOI":"10.18632\/oncotarget.17429","article-title":"Association between tea consumption and risk of cognitive disorders: A dose-response meta-analysis of observational studies","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1089\/jmf.2009.1374","article-title":"A Combination of green tea extract and L-theanine improves memory and attention in subjects with mild cognitive impairment: A double-blind placebo-controlled study","volume":"14","author":"Park","year":"2011","journal-title":"J. Med. Food"},{"key":"ref_82","first-page":"17","article-title":"Preventive effect of green tea containing theanine at a high concentration on dementia in aged volunteers","volume":"15","author":"Kataoka","year":"2009","journal-title":"J. Jpn. Mibyou Syst. Assoc."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.3390\/nu6104032","article-title":"Green tea consumption affects cognitive dysfunction in the elderly: A pilot study","volume":"6","author":"Ide","year":"2014","journal-title":"Nutrients"},{"key":"ref_84","first-page":"1","article-title":"Effects of green tea consumption on cognitive dysfunction in an elderly population: A randomized placebo-controlled study","volume":"15","author":"Ide","year":"2016","journal-title":"Nutr. J."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.nbd.2008.12.001","article-title":"Cerebrospinal fluid antibodies to oxidized LDL are increased in Alzheimer\u2019s disease","volume":"33","author":"Kankaanpaa","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3177\/jnsv.43.679","article-title":"Absorption and distribution of tea catechin, (\u2212)-epigallocatechin-3-gallate, in the rat","volume":"43","author":"Nakagawa","year":"1997","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1039\/C0FO00100G","article-title":"Insights into the putative catechin and epicatechin transport across blood-brain barrier","volume":"2","author":"Faria","year":"2011","journal-title":"Food Funct."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"9377","DOI":"10.1021\/jf301787f","article-title":"Pharmacokinetics and blood\u2013brain barrier penetration of (+)-catechin and (\u2212)-epicatechin in rats by microdialysis sampling coupled to high-performance liquid chromatography with chemiluminescence detection","volume":"60","author":"Wu","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1700294","DOI":"10.1002\/mnfr.201700294","article-title":"Blood-brain barrier permeability of green tea catechin metabolites and their neuritogenic activity in human neuroblastoma SH-SY5Y cells","volume":"61","author":"Unno","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodchem.2004.02.010","article-title":"Determination of low molecular weight polyphenolic constituents in grape (Vitis vinifera sp.) seed extracts: Correlation with antiradical activity","volume":"89","author":"Guendez","year":"2005","journal-title":"Food Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1002\/jnr.21706","article-title":"Novel regimen through combination of memantine and tea polyphenol for neuroprotection against brain excitotoxicity","volume":"86","author":"Chen","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1179\/147683009X423283","article-title":"Green tea polyphenol (\u2212)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin","volume":"12","author":"Zhang","year":"2009","journal-title":"Nutr. Neurosci."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/9\/2357\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:20:33Z","timestamp":1760196033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/9\/2357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,14]]},"references-count":92,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9]]}},"alternative-id":["molecules23092357"],"URL":"https:\/\/doi.org\/10.3390\/molecules23092357","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,14]]}}}