{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:46:36Z","timestamp":1774442796390,"version":"3.50.1"},"reference-count":36,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21606136"],"award-info":[{"award-number":["21606136"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The solubilities of metoprolol succinate (a cardioselective \u03b21 adrenergic receptor) in methanol, ethanol, n-propanol, isopropanol, n-butanol, ethyl acetate, and acetone were measured at temperatures ranging from (278.2 to 318.2) K using a solid\u2013liquid equilibrium method. The solubility of metoprolol succinate increases with increasing temperature. At a fixed temperature, the solubility decreases in the order methanol &gt; ethanol &gt; n-butanol &gt; n-propanol &gt; isopropanol &gt; acetone &gt; ethyl acetate. The enthalpy of fusion and the melting point of metoprolol succinate were determined by differential scanning calorimetry. The thermodynamic properties of the dissolution process, determined by a van\u2019t Hoff analysis, have been obtained and are discussed. The modified Apelblat equation, Wilson model, and non-random two-liquid (NRTL) model were employed to correlate the solubilities of metoprolol succinate in different solvents. Finally, a quantitative structure\u2013property relationship (QSPR) study of physical properties of solvents and density functional theory simulations of hydrogen-bonding structure were carried out to give the explanation for the sequence of solubility in alcohols. The density functional theory (DFT) calculations well illustrated that the solubility of metoprolol succinate in various alcohols can be mainly attributed to the intra- and intermolecular hydrogen bonds in metoprolol succinate-solvent complexes.<\/jats:p>","DOI":"10.3390\/molecules23102469","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T10:39:58Z","timestamp":1537958398000},"page":"2469","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Measurements, Thermodynamic Modeling, and a Hydrogen Bonding Study on the Solubilities of Metoprolol Succinate in Organic Solvents"],"prefix":"10.3390","volume":"23","author":[{"given":"Jian","family":"Shen","sequence":"first","affiliation":[{"name":"School of Materials and Chemical Engineering, Ningbo University of Technology, Ningbo 315016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianrui","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Lei","sequence":"additional","affiliation":[{"name":"School of Materials and Chemical Engineering, Ningbo University of Technology, Ningbo 315016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1524-6175.2006.05247.x","article-title":"Metoprolol succinate, a selective beta-adrenergic blocker, has no effect on insulin sensitivity","volume":"8","author":"Falkner","year":"2006","journal-title":"J. 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