{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:38:49Z","timestamp":1789835929446,"version":"4.0.1"},"reference-count":116,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Neurodegenerative diseases are normally distinguished as disorders with loss of neurons. Various compounds are being tested to treat neurodegenerative diseases (NDs) but they possess solitary symptomatic advantages with numerous side effects. Accumulative studies have been conducted to validate the benefit of phytochemicals to treat neurodegenerative diseases including Alzheimer\u2019s disease (AD) and Parkinson\u2019s disease (PD). In this present review we explored the potential efficacy of phytochemicals such as epigallocatechin-3-galate, berberin, curcumin, resveratrol, quercetin and limonoids against the most common NDs, including Alzheimer\u2019s disease (AD) and Parkinson\u2019s disease (PD). The beneficial potentials of these phytochemicals have been demonstrated by evidence-based but more extensive investigation needs to be conducted for reducing the progression of AD and PD.<\/jats:p>","DOI":"10.3390\/molecules23102485","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T02:54:54Z","timestamp":1538103294000},"page":"2485","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":149,"title":["Neuroprotective Role of Phytochemicals"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4786-9913","authenticated-orcid":false,"given":"Bharath Kumar","family":"Velmurugan","sequence":"first","affiliation":[{"name":"Toxicology and Biomedicine Research Group, Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2676-7379","authenticated-orcid":false,"given":"Baskaran","family":"Rathinasamy","sequence":"additional","affiliation":[{"name":"Graduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharathi Priya","family":"Lohanathan","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei 10617, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varadharajan","family":"Thiyagarajan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Anatomy and Cell biology, Thomas Jefferson University, Philadelphia, PA 19107, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Feng","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.bbadis.2015.12.009","article-title":"Vascular cognitive impairment: Modeling a critical neurologic disease in vitro and in vivo","volume":"1862","author":"Helman","year":"2016","journal-title":"Biochim. 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