{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:46:53Z","timestamp":1789008413424,"version":"build-2803163510"},"reference-count":77,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T00:00:00Z","timestamp":1538438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Malaria is an infectious disease caused by a protozoan parasite which is transmitted by female Anopheles mosquitoes around tropical and sub-tropical regions. Half of the world\u2019s population is at risk of being infected by malaria. This mainly includes children, pregnant women and people living with chronic diseases. The main factor that has contributed to the spread of this disease is the increase in the number of drug-resistant parasites. To overcome drug resistance, researchers have developed drug delivery systems from biodegradable polymers for the loading of antimalarials. The drug delivery systems were characterized by distinct features such as good biocompatibility, high percentage drug encapsulation, reduced drug toxicity and targeted drug delivery. In this review article, we highlight the various types of drug delivery systems developed from polymeric nanocarriers used for the delivery of antimalarials.<\/jats:p>","DOI":"10.3390\/molecules23102527","type":"journal-article","created":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T02:19:49Z","timestamp":1538619589000},"page":"2527","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Polymeric Nanocarriers for the Delivery of Antimalarials"],"prefix":"10.3390","volume":"23","author":[{"given":"Zandile","family":"Mhlwatika","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blessing Atim","family":"Aderibigbe","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,2]]},"reference":[{"key":"ref_1","unstructured":"(2016, February 18). WHO Malaria Factsheet updated January 2016. Available online: http:\/\/www.who.int\/mediacentre\/factsheets\/fs094\/en\/."},{"key":"ref_2","unstructured":"(2015, December 09). WHO Factsheet: Malaria Report 2015. Available online: http:\/\/www.who.int\/malaria\/media\/world-malaria-report-2015\/en\/."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1128\/CMR.00074-12","article-title":"Evidence and implications of mortality associated with acute Plasmodium vivax malaria","volume":"26","author":"Baird","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_4","first-page":"11","article-title":"The anaemia of plasmodium vivax malaria","volume":"10","author":"Douglas","year":"2012","journal-title":"Malar. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.4269\/ajtmh.2011.10-0285","article-title":"Doxycycline for malaria chemoprophylaxis and treatment: report from the CDC expert meeting on malaria chemoprophylaxis","volume":"4","author":"Tan","year":"2011","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1179\/146532810X12858955921032","article-title":"The impact of maternal malaria on newborns","volume":"30","author":"Hartman","year":"2010","journal-title":"Ann.Trop. Pediatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1046\/j.1365-3156.2003.01186.x","article-title":"Artemether-lumefantrine for uncomplicated malaria: a systematic review","volume":"9","author":"Omari","year":"2004","journal-title":"Trop. Med. Int. Health."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nri3742","article-title":"Innate sensing of Malaria Parasites","volume":"14","author":"Gazzinelli","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.biocel.2011.03.012","article-title":"The Plasmodium falciparum-infected red blood cell","volume":"43","author":"Tilley","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1056\/NEJMct0709050","article-title":"Artesunate for the Treatment of Severe Falciparum Malaria","volume":"358","author":"Rosenthal","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_11","unstructured":"(2009, February 03). Life Cycle of Malaria Parasite. Available online: http:\/\/encarta.msn.com\/media_461541582\/life cycle of the malaria."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Baer, K., Klotz, C., and Kappe, S.H. (2007). Release of hepatic Plasmodium yoelii merozoites into the pulmonary microvasculature. PLoS Pathog., 3.","DOI":"10.1371\/journal.ppat.0030171"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.febslet.2011.04.042","article-title":"Drug\u2013resistant malaria: Molecular mechanisms and implications for public health","volume":"585","author":"Petersen","year":"2011","journal-title":"FEBS. Lett."},{"key":"ref_14","first-page":"1","article-title":"Antimalarial drugs resistance in Plasmodium falciparum and the current strategies to overcome them. Microbial pathogens and strategies for combating them","volume":"2013. 1","author":"Aminake","year":"2013","journal-title":"Formatex"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S1473-3099(12)70064-6","article-title":"Poor-quality antimalarial drugs in Southeast Asia and sub-Saharan Africa","volume":"12","author":"Nayyar","year":"2012","journal-title":"Lancet Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1126\/science.3317830","article-title":"Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance","volume":"238","author":"Krogstad","year":"1987","journal-title":"Science"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Nqoro, X., Tobeka, N., and Aderibigbe, B.A. (2017). Quinoline-based hybrid compounds with antimalarial activity. Molecules., 22.","DOI":"10.3390\/molecules22122268"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"148","DOI":"10.5897\/AJPPX12.015","article-title":"Antimalarial drugs: Mode of action and status of resistance","volume":"7","author":"Saifi","year":"2013","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.2165\/00003495-200262090-00003","article-title":"Combination therapy for malaria: the way forward","volume":"62","author":"Nosten","year":"2002","journal-title":"Drugs"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0377-1237(16)30022-3","article-title":"WHO Guidelines for the treatment of malaria","volume":"67","author":"Kunte","year":"2016","journal-title":"Med. J. Armed. Forces India"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"East African Network for Monitoring Antimalarial Treatment (EANMAT) (2003). The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: Implications for sub-regional policy. Trop. Med. Int. Health, 8, 860\u2013867.","DOI":"10.1046\/j.1360-2276.2003.01114.x"},{"key":"ref_22","unstructured":"World Health Organization (2004). WHO Information Note on Artemether\/Lumefantrine (Coartem), WHO."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0001-706X(94)90092-2","article-title":"Randomised trial of mefloquine-tetracycline and quinine-tetracycline for acute uncomplicated falciparum malaria","volume":"57","author":"Looareesuwan","year":"1994","journal-title":"Acta Trop."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1517\/17425247.2015.1026893","article-title":"Recent advances in cyclodextrin delivery techniques","volume":"12","author":"Arima","year":"2015","journal-title":"Expert Opin. Drug. Deliv."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2174\/138955708783744092","article-title":"Malaria Combination Therapies: Advantages and Shortcomings","volume":"8","author":"Martinelli","year":"2008","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/1521-3927(20020401)23:5\/6<332::AID-MARC332>3.0.CO;2-I","article-title":"Poly (amidoamine)s: Biomedical Applications","volume":"23","author":"Ferruti","year":"2002","journal-title":"Macromol. Rapid Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1177\/2211068211428189","article-title":"Reservoir-Based Polymer Drug Delivery Systems","volume":"17","author":"Yang","year":"2012","journal-title":"J. Lab. Autom."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.polymer.2008.01.027","article-title":"Hydrogels in drug delivery: Progress and challenges","volume":"49","author":"Hoare","year":"2008","journal-title":"Polymer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5185","DOI":"10.1016\/j.biomaterials.2007.07.044","article-title":"Hydrogel biomaterials: a smart future?","volume":"28","year":"2007","journal-title":"Biomaterials"},{"key":"ref_30","first-page":"1","article-title":"Ciprofloxacin-imprinted hydrogels for drug sustained release in aqueous media","volume":"16","author":"Kioomars","year":"2016","journal-title":"Pharm. Dev. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejpb.2007.06.020","article-title":"A novel thermoresponsive hydrogel based on chitosan","volume":"68","author":"Schuetz","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"17118","DOI":"10.1021\/acsami.6b04424","article-title":"Injectable and pH-responsive silk nanofiber hydrogels for sustained anticancer drug delivery","volume":"8","author":"Wu","year":"2016","journal-title":"ACS Appl. Mater Interfaces"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"41613","DOI":"10.1002\/app.41613","article-title":"Controlled Dual Release Study of Curcumin and a 4-Aminoquinoline Analog from Gum Acacia Containing Hydrogels","volume":"132","author":"Aderibigbe","year":"2015","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_34","first-page":"1","article-title":"Dual release kinetics of antimalarials from soy protein isolate-carbopol-polyacrylamide based hydrogels","volume":"43918","author":"Aderibigbe","year":"2016","journal-title":"Appl. Polym."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.1002\/jps.22191","article-title":"Curcumin-Loaded Hydrogel Nanoparticles: Application in Anti-Malarial Therapy and Toxicological Evaluation","volume":"99","author":"Dandekar","year":"2010","journal-title":"J. Pharm. Sci. Exp. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1063\/1.3681956","article-title":"Chitosan-based nanocarriers for antimalarials","volume":"1425","author":"Dreve","year":"2012","journal-title":"AIP Conf. Proc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41467-017-00144-z","article-title":"Triggerable tough hydrogels for gastric resident dosage forms","volume":"8","author":"Liu","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1081\/JDI-120022543","article-title":"Transdermal delivery of chloroquine by amidated pectin hydrogel matrix patch in the rat","volume":"25","author":"Musabayane","year":"2003","journal-title":"Ren. Fail."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.apjtm.2016.10.008","article-title":"Asiatic acid-pectin hydrogel matrix patch transdermal delivery system influences parasitaemia suppression and inflammation reduction in P. berghei murine malaria infected Sprague\u2013Dawley rats","volume":"9","author":"Mavondo","year":"2016","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_40","unstructured":"Kim, S., and Park, K. (2016, December 23). Polymer Micelles for Drug Delivery. Chapter 19. Available online: http:\/\/kinam. com\/Articles\/PMicelles%20Papers\/Kim,%20SW%2010%20Pol%20Micelle%20BookCh.pdf."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3109\/10837450.2015.1125920","article-title":"Drug-conjugated PLA\u2013PEG\u2013 PLA copolymers: A novel approach for controlled delivery of hydrophilic drugs by micelle formation","volume":"22","author":"Danafar","year":"2017","journal-title":"Pharm. Dev. Technol."},{"key":"ref_42","first-page":"321","article-title":"Polymeric micelles for oral drug delivery: Why and how?","volume":"76","author":"Francis","year":"2004","journal-title":"Int. Res. J. Pure Appl. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/pola.27009","article-title":"Preparation of amphiphilic copolymers for covalent loading of paclitaxel for drug delivery system","volume":"52","author":"Chen","year":"2014","journal-title":"J. Polym. Sci. A Polym. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jconrel.2014.06.042","article-title":"Progress of drug-loaded polymeric micelles into clinical studies","volume":"190","author":"Cabral","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1142411","DOI":"10.1080\/2331205X.2016.1142411","article-title":"MPEG\u2013PCL copolymeric nanomicelles in drug delivery systems","volume":"3","author":"Danafar","year":"2016","journal-title":"Cogent Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1021\/bc0498166","article-title":"Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy","volume":"16","author":"Bae","year":"2005","journal-title":"Bioconjug. Chem."},{"key":"ref_47","first-page":"234","article-title":"Preparation and Physicochemical Characterization of Biodegradable mPEG-PCL Core-Shell Micelles for Delivery of Artemisinin","volume":"22","author":"Manjili","year":"2016","journal-title":"J. Pharm. Sci. Exp. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Ramazani, A., Keramati, M., Malvandi, H., Danafar, H., and Kheiri Manjili, H. (2017). Preparation and in vivo evaluation of anti-plasmodial properties of artemisinin-loaded PCL-PEG-PCL nanoparticles. Pharm. Dev. Technol, 1\u201310.","DOI":"10.1080\/10837450.2017.1372781"},{"key":"ref_49","first-page":"467","article-title":"Pegylated Lysine Based Copolymeric Dendritic Micelles For Solubilization And Delivery Of Artemether","volume":"8","author":"Bhadra","year":"2005","journal-title":"J. Pharm. Pharm. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1080\/21691401.2017.1347880","article-title":"In vitro and in vivo delivery of artemisinin loaded PCL\u2013PEG\u2013PCL micelles and its pharmacokinetic study","volume":"46","author":"Manjili","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Aderibigbe, B.A. (2017). Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives. Molecules, 22.","DOI":"10.3390\/molecules22020323"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Sezer, A.D. (2014). Liposomes as Potential Drug Carrier Systems for Drug Delivery. Nanotechnology and Nanomaterials. Application of Nanotechnology in Drug Delivery, Intech.","DOI":"10.5772\/57028"},{"key":"ref_53","first-page":"297","article-title":"Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential","volume":"1","author":"Immordino","year":"2006","journal-title":"Int. J. Nanomed."},{"key":"ref_54","first-page":"19","article-title":"A Review on Composite Liposomal Technologies for Specialized Drug Delivery","volume":"2011","author":"Mufamadi","year":"2011","journal-title":"J. Drug. Deliv. Sci Technol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0731-7085(01)00611-2","article-title":"Preparation of \u03b2-artemether liposomes, their HPLC-UV evaluation and relevance for clearing recrudescent parasitaemia in Plasmodium chabaudi malaria-infected mice","volume":"28","author":"Chimanuka","year":"2002","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Shakeel, K., Raisuddin, S., Ali, S., Imam, S.S., Rahman, M.A., Jain, G.K., and Ahmad, F.J. (2017). Development and in vitro\/in vivo evaluation of artemether and lumefantrine co-loaded nanoliposomes for parenteral delivery. J. Liposome Res., 1\u20139.","DOI":"10.1080\/08982104.2017.1410173"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.nano.2014.06.002","article-title":"Application of heparin as a dual agent with antimalarial and liposome targeting activities toward Plasmodium-infected red blood cells","volume":"10","author":"Marques","year":"2014","journal-title":"Nanomedicine"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1186\/1556-276X-6-620","article-title":"Study of the efficacy of antimalarial drugs delivered inside targeted immunoliposomal nanovectors","volume":"6","author":"Estelrich","year":"2011","journal-title":"Nanoscale Res. Lett."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1128\/AAC.01796-15","article-title":"Stearylamine Liposomal Delivery of Monensin in combination with free Artemisinin eliminates blood stages of P. falciparum in culture and P. berghei infection in Murine Malaria","volume":"60","author":"Rajendran","year":"2016","journal-title":"Antimicrob Agents. Ch."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.carbpol.2012.06.044","article-title":"Synthesis of a new amphiphilic glycodendrimer with antiviral functionality","volume":"90","author":"Han","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ejps.2009.07.008","article-title":"Dendrimers: Emerging polymers for drug-delivery systems","volume":"38","author":"Nanjwade","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"138491","DOI":"10.1002\/app.34967","article-title":"Investigation of solid supported dendrimers for water disinfection","volume":"124","author":"Gangadharan","year":"2012","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ijpharm.2005.01.026","article-title":"Glycodendrimeric nanoparticulate carriers of primaquine phosphate for liver targeting","volume":"295","author":"Bhadra","year":"2005","journal-title":"Int. J. Pharm."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1016\/j.biomaterials.2007.04.004","article-title":"Glycoconjugated peptide dendrimers-based nanoparticulate system for the delivery of chloroquine phosphate","volume":"28","author":"Agrawal","year":"2007","journal-title":"Biomaterials"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"7940","DOI":"10.1016\/j.biomaterials.2014.05.061","article-title":"Amphiphilic dendritic derivatives as nanocarriers for the targeted delivery of antimalarial drugs","volume":"13","author":"Movellan","year":"2014","journal-title":"Biomaterials"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1021\/cm2031569","article-title":"Polymeric conjugates for drug delivery","volume":"24","author":"Larson","year":"2012","journal-title":"Chem. Mater."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.1002\/anie.200902672","article-title":"Poly (ethylene glycol) in drug delivery: pros and cons as well as potential alternatives","volume":"49","author":"Knop","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1155\/2012\/103973","article-title":"Poly (ethylene glycol)-Prodrug Conjugates: Concept, Design, and Applications","volume":"2012","author":"Banerjee","year":"2012","journal-title":"J. Drug. Deliv."},{"key":"ref_69","first-page":"135","article-title":"Structure and properties of pharmacologically active polymers","volume":"5","author":"Ringsdorf","year":"1975","journal-title":"J. Polym. Sci.: Polym Symposia"},{"key":"ref_70","first-page":"1","article-title":"Polymeric Prodrugs: Recent Achievements and General Strategies","volume":"15","author":"Agrawal","year":"2013","journal-title":"J. Antivir. Antiretrovir"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2147\/IJN.S13482","article-title":"Synthesis, characterization, and biological evaluation of poly (L-\u03b3-glutamyl-glutamine)-paclitaxel nanoconjugate","volume":"5","author":"Van","year":"2010","journal-title":"Int. J. Nanomedicine"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.progpolymsci.2007.05.008","article-title":"Polymer\u2013drug conjugation, recent achievements and general strategies","volume":"32","author":"Pasut","year":"2007","journal-title":"Prog. Polym. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1007\/s00289-016-1886-x","article-title":"Synthesis and characterization of water-soluble polyaspartamides containing platinum (II) complex and bisphosphonate as potential antimalarial drug","volume":"74","author":"Mukaya","year":"2016","journal-title":"Polym. Bull."},{"key":"ref_74","first-page":"123","article-title":"Design, synthesis and evaluation of antimalarial potential of polyphosphazene linked combination therapy of primaquine and dihydroartemisinin","volume":"66C","author":"Kumar","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s10904-011-9616-1","article-title":"Macromolecular conjugates of 4-and 8-aminoquinoline compounds","volume":"22","author":"Aderibigbe","year":"2012","journal-title":"J. Inorg. Organomet. Polym. Mater."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/jbm.a.34866","article-title":"Synthesis, characterization, and antiplasmodial activity of polymer-incorporated aminoquinolines","volume":"102","author":"Aderibigbe","year":"2014","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2478\/v10007-009-0007-x","article-title":"Macromolecular prodrugs. XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation","volume":"59","author":"Rajic","year":"2009","journal-title":"Acta Pharm."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/10\/2527\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:23:48Z","timestamp":1760196228000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/10\/2527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,2]]},"references-count":77,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10]]}},"alternative-id":["molecules23102527"],"URL":"https:\/\/doi.org\/10.3390\/molecules23102527","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,2]]}}}