{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:35:31Z","timestamp":1782747331769,"version":"3.54.5"},"reference-count":38,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T00:00:00Z","timestamp":1539907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["CTQ2017-88091-P"],"award-info":[{"award-number":["CTQ2017-88091-P"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gobierno de Arag\u00f3n-Fondo Social Europeo","award":["Research Group E07_17R"],"award-info":[{"award-number":["Research Group E07_17R"]}]},{"DOI":"10.13039\/501100007041","name":"Universidad de Zaragoza","doi-asserted-by":"publisher","award":["JIUZ-2017-CIE-05"],"award-info":[{"award-number":["JIUZ-2017-CIE-05"]}],"id":[{"id":"10.13039\/501100007041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Preliminary results concerning the first asymmetric synthesis of highly functionalized 1-benzamido-1,4-dihydropyridine derivatives via the reaction of hydrazones with alkylidenemalononitriles in the presence of \u03b2-isocupreidine catalyst are reported. The moderate, but promising, enantioselectivity observed (40\u201354% ee), opens the door to a new area of research for the asymmetric construction of new chiral 1,4-dihydropyridine derivatives, whose enantioselective catalytic preparation are still very limited. Moreover, the use of hydrazones for the enantioselective construction of chiral 1,4-dihydropyridines has been overlooked in the literature so far. Therefore, our research represents a pivotal example in this field which remains still unexplored.<\/jats:p>","DOI":"10.3390\/molecules23102692","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T10:08:02Z","timestamp":1539943682000},"page":"2692","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["First Organocatalytic Asymmetric Synthesis of 1-Benzamido-1,4-Dihydropyridine Derivatives"],"prefix":"10.3390","volume":"23","author":[{"given":"Fernando","family":"Auria-Luna","sequence":"first","affiliation":[{"name":"Laboratorio de Organocat\u00e1lisis Asim\u00e9trica, Departamento de Qu\u00edmica Org\u00e1nica, Instituto de S\u00edntesis Qu\u00edmica y Cat\u00e1lisis Homog\u00e9nea (ISQCH) CSIC-Universidad de Zaragoza, C\/Pedro Cerbuna 12, E-50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6832-8983","authenticated-orcid":false,"given":"Eugenia","family":"Marqu\u00e9s-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Laboratorio de Organocat\u00e1lisis Asim\u00e9trica, Departamento de Qu\u00edmica Org\u00e1nica, Instituto de S\u00edntesis Qu\u00edmica y Cat\u00e1lisis Homog\u00e9nea (ISQCH) CSIC-Universidad de Zaragoza, C\/Pedro Cerbuna 12, E-50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-9569","authenticated-orcid":false,"given":"Raquel","family":"P. Herrera","sequence":"additional","affiliation":[{"name":"Laboratorio de Organocat\u00e1lisis Asim\u00e9trica, Departamento de Qu\u00edmica Org\u00e1nica, Instituto de S\u00edntesis Qu\u00edmica y Cat\u00e1lisis Homog\u00e9nea (ISQCH) CSIC-Universidad de Zaragoza, C\/Pedro Cerbuna 12, E-50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/cr60275a001","article-title":"The chemistry of dihydropyridines","volume":"72","author":"Eisner","year":"1972","journal-title":"Chem. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1021\/cr00048a004","article-title":"Recent advances in the chemistry of dihydropyridines","volume":"82","author":"Stout","year":"1982","journal-title":"Chem. 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