{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:43:00Z","timestamp":1790916180235,"version":"4.1.0"},"reference-count":64,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T00:00:00Z","timestamp":1539907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>One of the advantages of using biodiesel and its blends with diesel oil is the lower levels of emissions of particulate matter, sulfur dioxide, carbon monoxide, among others, making it less harmful to the environment and to humans. However, this biofuel is susceptible to microbial contamination and biodeterioration. In this sense, studies on the use of effective low toxicity biocides are being carried out, and this work aims to present the latest information (2008\u20132018) available in the scientific databases, on the use of biocides in biodiesel, mainly concerning their toxicity to the environment and public health. The results showed that in relation to the control of microbial contamination, the current scenario is limited, with seven publications, in which the most studied additives were isothiazolinones, oxazolidines, thiocyanates, morpholines, oxaborinanes, thiocarbamates and phenolic antioxidants. Studies regarding direct experiments with humans have not been found, showing the need for more studies in this area, since the potential growth of biodiesel production and consumption in the world is evident. Thus, there are need for more studies on antimicrobial products for use in biodiesel, with good broad-spectrum activity (bactericidal and fungicidal), and further toxicological tests to ensure no or little impact on the environment.<\/jats:p>","DOI":"10.3390\/molecules23102698","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T10:08:02Z","timestamp":1539943682000},"page":"2698","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Biocides Used as Additives to Biodiesels and Their Risks to the Environment and Public Health: A Review"],"prefix":"10.3390","volume":"23","author":[{"given":"Gl\u00e9cia V. S.","family":"Luz","sequence":"first","affiliation":[{"name":"Postgraduate Program in Biomedical Engineering, Campus Gama (FGA), University of Bras\u00edlia (UnB), Bras\u00edlia 72.444-240, Brazil"},{"name":"Nanotechnology Laboratory, University of Bras\u00edlia at Gama (NANOTEC-FGA\/UnB), Bras\u00edlia 72.444-240, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breno A. S. M.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Nanotechnology Laboratory, University of Bras\u00edlia at Gama (NANOTEC-FGA\/UnB), Bras\u00edlia 72.444-240, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adevilton V.","family":"Guedes","sequence":"additional","affiliation":[{"name":"Nanotechnology Laboratory, University of Bras\u00edlia at Gama (NANOTEC-FGA\/UnB), Bras\u00edlia 72.444-240, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristine C.","family":"Barreto","sequence":"additional","affiliation":[{"name":"Biotechnology Laboratory, Catholic University of Bras\u00edlia, Bras\u00edlia 70790-160, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes M.","family":"Brasil","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biomedical Engineering, Campus Gama (FGA), University of Bras\u00edlia (UnB), Bras\u00edlia 72.444-240, Brazil"},{"name":"Nanotechnology Laboratory, University of Bras\u00edlia at Gama (NANOTEC-FGA\/UnB), Bras\u00edlia 72.444-240, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s00204-011-0689-y","article-title":"Effects of 5-chloro-2-methyl-4-isothiazolin-3-one and other candidate biodiesel biocides on rat alveolar macrophages and NR8383 cells","volume":"85","author":"Poon","year":"2011","journal-title":"Arch. 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