{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:26:02Z","timestamp":1762507562102,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The influence of ionising radiation on the physicochemical properties of meropenem trihydrate in solid state was studied for doses of e-beam radiation: 25 kGy and 400 kGy. In the first part of our studies, we evaluated the possibility of applying radiosterilization to obtain sterile meropenem. No changes for meropenem irradiated with a dose of 25 kGy, the dose required to attain sterility, was confirmed in the results of spectroscopic (FT-IR), thermal (DSC, TGA) and X-ray powder diffraction (XRPD) studies. The radiation dose of 25 kGy produces no more than about 1500 ppm of radical defects. The chromatographic studies of irradiated meropenem in solutions did not show any chemical degradation. Moreover, the antimicrobial activity of meropenem irradiated with the dose of 25 kGy was unchanged. Based on the received results, we can conclude that radiostelization is a promising, alternative method for obtaining sterile meropenem. In the second part of the research, meropenem was exposed to e-beam radiation at the 400 kGy dose rate. It was confirmed, that reducing of antimicrobial activity could be connected with the degradation of \u03b2-lactam ring and changes in the trans-hydroxyethyl group. Apart from chemical changes, changes in the physical stability of irradiated meropenem (400 kGy) was also observed.<\/jats:p>","DOI":"10.3390\/molecules23112738","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T02:59:40Z","timestamp":1540349980000},"page":"2738","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Radiostability of Meropenem Trihydrate in Solid State"],"prefix":"10.3390","volume":"23","author":[{"given":"Karolina","family":"Kili\u0144ska","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Poznan University of Medical Sciences, \u015awi\u0119cickiego 4, 60-781 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-5419","authenticated-orcid":false,"given":"Judyta","family":"Cielecka-Piontek","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Poznan University of Medical Sciences, \u015awi\u0119cickiego 4, 60-781 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Skibi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daria","family":"Szymanowska","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Food Microbiology, Pozna\u0144 University of Life Sciences, Wojska Polskiego 48, 60-627 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6792-4281","authenticated-orcid":false,"given":"Andrzej","family":"Miklaszewski","sequence":"additional","affiliation":[{"name":"Institute of Material Science and Engineering, Poznan University of Technology, Jana Paw\u0142a II 24, 60-965 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldemar","family":"Bednarski","sequence":"additional","affiliation":[{"name":"Institute of Molecular Physics, Polish Academy of Sciences, Smoluchowskiego 17, 60-179 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-3536","authenticated-orcid":false,"given":"Ewa","family":"Tykarska","sequence":"additional","affiliation":[{"name":"Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Stasi\u0142owicz","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Poznan University of Medical Sciences, \u015awi\u0119cickiego 4, 60-781 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5116-9426","authenticated-orcid":false,"given":"Przemys\u0142aw","family":"Zalewski","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Poznan University of Medical Sciences, \u015awi\u0119cickiego 4, 60-781 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"ref_1","first-page":"35","article-title":"Radiation sterilization of pharmaceuticals and polymers","volume":"12","author":"Gopal","year":"1978","journal-title":"Radiat. 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