{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:19:09Z","timestamp":1781111949515,"version":"3.54.1"},"reference-count":59,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["193512"],"award-info":[{"award-number":["193512"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PFCE","award":["2018"],"award-info":[{"award-number":["2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In Mexico one in 14 deaths are caused by diabetes mellitus (DM) or by the macro and microvascular disorders derived from it. A continuous hyperglycemic state is characteristic of DM, resulting from a sustained state of insulin resistance and\/or a dysfunction of \u03b2-pancreatic cells. Acaciella angustissima is a little studied species showing a significant antioxidant activity that can be used as treatment of this disease or preventive against the complications. The objective of this study was to explore the effect of oral administration of A. angustissima methanol extract on physiological parameters of streptozotocin-induced diabetic rats. The results indicated a significant reduction in blood glucose levels, an increase in serum insulin concentration, a decrease in lipid levels and an improvement in the parameters of kidney damage by applying a concentration of 100 mg\/Kg B.W. However, glucose uptake activity was not observed in the adipocyte assay. Moreover, the extract of A. angustissima displayed potential for the complementary treatment of diabetes and its complications likely due to the presence of bioactive compounds such as protocatechuic acid. This study demonstrated that methanol extract of Acacciella angustissima has an antidiabetic effect by reducing the levels of glucose, insulin and improved physiological parameters, hypolipidemic effect, oxidative stress and renal damage in diabetic rats.<\/jats:p>","DOI":"10.3390\/molecules23112812","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T03:50:56Z","timestamp":1540957856000},"page":"2812","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Timbe (Acaciella angustissima) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats"],"prefix":"10.3390","volume":"23","author":[{"given":"Adriana Jheny","family":"Rodr\u00edguez-M\u00e9ndez","sequence":"first","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma de Quer\u00e9taro, Clavel No 200, Col. Prados de la Capilla, 76176 Quer\u00e9taro, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Carmen-Sandoval","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma de Quer\u00e9taro, Clavel No 200, Col. Prados de la Capilla, 76176 Quer\u00e9taro, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Lomas-Soria","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Estudios de Posgrado, C.A. Ingenier\u00eda de Biosistemas. Facultad de Ingenier\u00eda. Universidad Aut\u00f3noma de Quer\u00e9taro, C. U. Cerro de las Campanas, S\/N, 76010 Quer\u00e9taro, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n G.","family":"Guevara-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Estudios de Posgrado, C.A. Ingenier\u00eda de Biosistemas. Facultad de Ingenier\u00eda. Universidad Aut\u00f3noma de Quer\u00e9taro, C. U. Cerro de las Campanas, S\/N, 76010 Quer\u00e9taro, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosal\u00eda","family":"Reynoso-Camacho","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n y Posgrado en Alimentos, PROPAC, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro, C. U. Cerro de las Campanas, S\/N, 76010 Quer\u00e9taro, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Elena","family":"Villagran-Herrera","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma de Quer\u00e9taro, Clavel No 200, Col. Prados de la Capilla, 76176 Quer\u00e9taro, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6906-4561","authenticated-orcid":false,"given":"Luis","family":"Salazar-Olivo","sequence":"additional","affiliation":[{"name":"Instituto Potosino de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica, IPICYT, camino a la presa san Jos\u00e9 2055, col. Lomas 4 secci\u00f3n, 78216, San Luis Potos\u00ed, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irineo","family":"Torres-Pacheco","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Estudios de Posgrado, C.A. Ingenier\u00eda de Biosistemas. Facultad de Ingenier\u00eda. Universidad Aut\u00f3noma de Quer\u00e9taro, C. U. Cerro de las Campanas, S\/N, 76010 Quer\u00e9taro, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8001-5912","authenticated-orcid":false,"given":"Ana A.","family":"Feregrino-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Estudios de Posgrado, C.A. Ingenier\u00eda de Biosistemas. Facultad de Ingenier\u00eda. Universidad Aut\u00f3noma de Quer\u00e9taro, C. U. Cerro de las Campanas, S\/N, 76010 Quer\u00e9taro, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"key":"ref_1","first-page":"494","article-title":"Phenolic constituents and modulatory effects of Raffia palm leaf (Raphia hookeri) extract on carbohydrate hydrolyzing enzymes linked to type-2 diabetes","volume":"7","author":"Dada","year":"2017","journal-title":"J. Trad Comp. 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