{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:57:13Z","timestamp":1787029033690,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T00:00:00Z","timestamp":1543449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Radix Codonopsis, derived from the roots of Codonopsis pilosula (Franch.) Nannf., Codonopsis pilosula (Franch.) Nannf. Var. modesta (Nannf.) L.T. Shen and Codonopsis tangshen Oliv., has been used as traditional Chinese medicine for improving poor gastrointestinal function, treating gastric ulcers and chronic gastritis in China. Inulin-type fructans are carbohydrates consisting mainly of \u03b2 (2\u21921) fructosyl-fructose links in chemical structure and exhibit a range of properties such as prebiotic activity, fat substitutes in low-calorie foods and disease-modifying effects. The prebiotic effects of inulin-type fructans are hypothesized to improve gastrointestinal function through alterations to gut microbiota composition and metabolism. In the present study, three inulin-type fructans with high degree of polymerization (DP = 16, 22, and 31) were isolated from the roots of Codonopsis pilosula (Franch.) Nannf. and their structures were confirmed by MALDI-TOF-MS, 1D- and 2D-NMR. The prebiotic activity of these fructans was evaluated by detecting growth stimulation on Bifidobacterium longum. The results demonstrated that three fructans at a concentration of 2.0 g\/L exhibited significant growth stimulation on Bifidobacterium longum in a time-dependent manner (p &lt; 0.01). The data indicated that inulin-type fructans in Radix Codonopsis could be used as potential prebiotics.<\/jats:p>","DOI":"10.3390\/molecules23123123","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T11:47:53Z","timestamp":1543492073000},"page":"3123","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Three Inulin-Type Fructans from Codonopsis pilosula (Franch.) Nannf. Roots and Their Prebiotic Activity on Bifidobacterium longum"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5615-9588","authenticated-orcid":false,"given":"Jiankuan","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China"},{"name":"The Engineering Technology Research Center of Authentic Herbal Material Resources Development of Shanxi Province, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingya","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China"},{"name":"School of Basic Medical Science, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Ji","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China"},{"name":"The Engineering Technology Research Center of Authentic Herbal Material Resources Development of Shanxi Province, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China"},{"name":"The Engineering Technology Research Center of Authentic Herbal Material Resources Development of Shanxi Province, Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jep.2018.02.039","article-title":"Traditional uses, phytochemistry, pharmacology and toxicology of Codonopsis: A review","volume":"219","author":"Gao","year":"2018","journal-title":"J. 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