{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:45:36Z","timestamp":1784951136241,"version":"3.55.0"},"reference-count":51,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,12,9]],"date-time":"2018-12-09T00:00:00Z","timestamp":1544313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["PCCI 52\/2018"],"award-info":[{"award-number":["PCCI 52\/2018"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Five new copper(II) acrylate complexes (acr is the acrylate anion: C3H3O2) with imidazole derivatives (2-methylimidazole\/2-MeIm, 5-methylimidazole\/5-MeIm, 2-ethylimidazole\/2-EtIm) of type: cis-[Cu(2-RIm)2(acr)2]\u00b7xH2O ((1): R = \u2013CH3, x = 2; (4): R = \u2013CH2\u2013CH3, x = 0), trans-[Cu(2-RIm)2(acr)2] ((2): R = \u2013CH3; (5): R = \u2013CH2\u2013CH3) and trans-[Cu(5-RIm)2(acr)2] ((3): R = \u2013CH3) have been prepared and characterized by elemental analysis, Fourier Transform Infrared spectrometry (FTIR), Electron Paramagnetic Resonance (EPR), electronic reflectance spectroscopy, scanning electron microscopy, and mass spectrometry. The single crystal X-ray diffraction study of complexes (2) and (5) reveals that the copper(II) ion is located on an inversion center and show elongated octahedral geometry completed by two coplanar bidentate acrylates and two unidentate imidazole derivatives displayed in trans positions. For complex (4) the single crystal X-ray diffraction shows that the copper(II) ion is in a distorted octahedral environment which can be easily confused with a trigonal prism completed by two bidentate acrylates and two unidentate imidazole derivatives displayed in cis positions. These results indicate the fact that complexes (4) and (5) are the geometric isomers of the same compound bis(acrylate)-bis(2-ethylimidazole)-copper(II). Complexes (1) and (2), as well as (4) and (5), were produced simultaneously in the reaction of the corresponding copper(II) acrylate with imidazole derivatives in methanol solution. Furthermore, in order to be able to formulate potential applications of the obtained compounds, our next goal was to investigate the in vitro antimicrobial activity of the synthesized complexes against Gram-positive and Gram-negative bacteria, as well as fungal strains, of both clinical and ecological importance (biodeterioration of historical buildings). The trans isomers (2) and (5), followed by (4) have shown the broadest range of antimicrobial activity. In case of (1) and (2) isomers, the trans isomer (2) was significantly more active than cis (1), while the cis isomer (4) proved to be more active than trans (5). Taken together, the biological evaluation results indicate that the trans (2) was the most active complex, demonstrating its potential for the development of novel antimicrobial agents, with potential applications in the biomedical and restoration of architectural monuments fields.<\/jats:p>","DOI":"10.3390\/molecules23123253","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T03:36:41Z","timestamp":1544413001000},"page":"3253","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["X-ray Crystal Structure, Geometric Isomerism, and Antimicrobial Activity of New Copper(II) Carboxylate Complexes with Imidazole Derivatives"],"prefix":"10.3390","volume":"23","author":[{"given":"Ioana Dorina","family":"Vlaicu","sequence":"first","affiliation":[{"name":"National Institute of Materials Physics, 405A Atomistilor, 077125 Magurele-Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gheorghe","family":"Borodi","sequence":"additional","affiliation":[{"name":"National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat Avenue, 400293 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina Vasile","family":"Sc\u0103e\u021beanu","sequence":"additional","affiliation":[{"name":"Department of Soil Sciences, University of Agronomical Sciences and Veterinary Medicine, 59 M\u0103r\u0103\u015fti Str., Sector 1, 011464 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-1857","authenticated-orcid":false,"given":"Mariana Carmen","family":"Chifiriuc","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Biology, University of Bucharest, 1\u20133 Aleea Portocalelor Str., 60101 Bucharest, Romania"},{"name":"Life, Environment and Earth Sciences Division, Research Institute of the University of Bucharest (ICUB), Spl. Independentei 91\u201395, 010271 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lumini\u021ba","family":"M\u0103ru\u021bescu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Biology, University of Bucharest, 1\u20133 Aleea Portocalelor Str., 60101 Bucharest, Romania"},{"name":"Life, Environment and Earth Sciences Division, Research Institute of the University of Bucharest (ICUB), Spl. Independentei 91\u201395, 010271 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Popa","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Biology, University of Bucharest, 1\u20133 Aleea Portocalelor Str., 60101 Bucharest, Romania"},{"name":"Life, Environment and Earth Sciences Division, Research Institute of the University of Bucharest (ICUB), Spl. Independentei 91\u201395, 010271 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5272-4770","authenticated-orcid":false,"given":"Mariana","family":"Stefan","sequence":"additional","affiliation":[{"name":"National Institute of Materials Physics, 405A Atomistilor, 077125 Magurele-Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-2919","authenticated-orcid":false,"given":"Ionel Florinel","family":"Mercioniu","sequence":"additional","affiliation":[{"name":"National Institute of Materials Physics, 405A Atomistilor, 077125 Magurele-Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Maurer","sequence":"additional","affiliation":[{"name":"3S-Pharmacological Consultation &amp; Research GmbH, 1 Koenigsbergerstrasse, 27243 Harpstedt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6709-3673","authenticated-orcid":false,"given":"Constantin G.","family":"Daniliuc","sequence":"additional","affiliation":[{"name":"Organisch-Chemisches Institut, Westf\u00e4lische Wilhelms-Universit\u00e4t M\u00fcnster, Corrensstrasse 40, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodica","family":"Olar","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90\u201392 Panduri Str., 050663 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Badea","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90\u201392 Panduri Str., 050663 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0020-1693(00)85052-5","article-title":"Copper(II) carboxylates and their antimicrobial effect","volume":"67","year":"1982","journal-title":"Inorg. 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