{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:03:53Z","timestamp":1790805833248,"version":"4.1.0"},"reference-count":147,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tenovus Scotland","award":["Moulton-Barrett Schloarship"],"award-info":[{"award-number":["Moulton-Barrett Schloarship"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Neurodegenerative disorders, including Alzheimer\u2019s disease, Parkinson\u2019s disease and Huntington\u2019s disease, present a major health issue and financial burden for health care systems around the world. The impact of these diseases will further increase over the next decades due to increasing life expectancies. No cure is currently available for the treatment of these conditions; only drugs, which merely alleviate the symptoms. Oxidative stress has long been associated with neurodegeneration, whether as a cause or as part of the downstream results caused by other factors. Thus, the use of antioxidants to counter cellular oxidative stress within the nervous system has been suggested as a potential treatment option for neurological disorders. Over the last decade, significant research has focused on the potential use of natural antioxidants to target oxidative stress. However, clinical trial results have lacked success for the treatment of patients with neurological disorders. The knowledge that natural extracts show other positive molecular activities in addition to antioxidant activity, however, has led to further research of natural extracts for their potential use as prevention or treatment\/management of neurodegenerative diseases. This review will cover several in vitro and in vivo research studies, as well as clinical trials, and highlight the potential of natural antioxidants.<\/jats:p>","DOI":"10.3390\/molecules23123283","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T03:27:49Z","timestamp":1544585269000},"page":"3283","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":252,"title":["The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention\/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials"],"prefix":"10.3390","volume":"23","author":[{"given":"Franziska","family":"Pohl","sequence":"first","affiliation":[{"name":"School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen AB10 7GJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kong Thoo Lin","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen AB10 7GJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5607\/en.2015.24.4.325","article-title":"The role of oxidative stress in neurodegenerative diseases","volume":"24","author":"Kim","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0140-6736(09)61460-4","article-title":"Ageing populations: The challenges ahead","volume":"374","author":"Christensen","year":"2009","journal-title":"Lancet"},{"key":"ref_3","unstructured":"Prince, M., Guerchet, M., and Prina, M. (2013). World Alzheimer Report 2013, Alzheimer\u2019s Disease International."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1212\/01.wnl.0000247740.47667.03","article-title":"Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030","volume":"68","author":"Dorsey","year":"2007","journal-title":"Neurology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1021\/np200906s","article-title":"Natural products as sources of new drugs over the 30 years from 1981 to 2010","volume":"75","author":"Newman","year":"2012","journal-title":"J. Nat. Prod."},{"key":"ref_6","unstructured":"Prince, M., and Jackson, J. (2009). World Alzheimer Report, Alzheimer\u2019s Disease International."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Rafii, M.S., and Aisen, P.S. (2009). Recent developments in Alzheimer\u2019s disease therapeutics. BMC Med., 7.","DOI":"10.1186\/1741-7015-7-7"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/alzrt269","article-title":"Alzheimer\u2019s disease drug-development pipeline: Few candidates, frequent failures","volume":"6","author":"Cummings","year":"2014","journal-title":"Alzheimers Res. Ther."},{"key":"ref_9","unstructured":"Dunn, W.H. (2018, December 08). (FDA) Namzaric Drug Approval (NDA 206439) 2014, Available online: https:\/\/www.accessdata.fda.gov\/scripts\/cder\/daf\/in."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.bmc.2005.09.011","article-title":"The benefits of the multi-target approach in drug design and discovery","volume":"14","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"ref_11","unstructured":"(2018, November 08). CenterWatch FDA Approved Drugs by Medical Condition. Available online: https:\/\/www.centerwatch.com\/drug-information\/fda-approved-drugs\/medical-conditions\/."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev-pharmtox-010617-052745","article-title":"Toward therapy of human prion diseases","volume":"58","author":"Aguzzi","year":"2018","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2174\/138161211795049732","article-title":"Antiapoptotic drugs: A therapautic strategy for the prevention of neurodegenerative diseases","volume":"17","author":"Sureda","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1016\/j.ddtec.2012.02.002","article-title":"Alzheimer\u2019s disease drug discovery: in vivo screening using Caenorhabditis elegans as a model for \u03b2-amyloid peptide-induced toxicity","volume":"10","author":"Lublin","year":"2013","journal-title":"Drug Discov. Today Technol."},{"key":"ref_15","first-page":"1893","article-title":"Multipotent cholinesterase\/monoamine oxidase inhibitors for the treatment of Alzheimer\u2019s disease: Design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids","volume":"8","author":"Esteban","year":"2014","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/157015909787602823","article-title":"Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options","volume":"7","author":"Uttara","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Laher, I. (2014). Flavones from the root of Scutellaria baicalensis Georgi\u2014drug of the future in neurodegeneration and neuroprotection?. Systems Biology of Free Radicals and Antioxidants, Springer.","DOI":"10.1007\/978-3-642-30018-9"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1080\/14728222.2016.1182990","article-title":"Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases","volume":"20","author":"Zhang","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/nm1066","article-title":"Protein aggregation and neurodegenerative disease","volume":"10","author":"Ross","year":"2004","journal-title":"Nat. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neuron.2017.12.012","article-title":"Reversible conformational conversion of \u03b1-synuclein into toxic assemblies by glucosylceramide","volume":"97","author":"Zunke","year":"2018","journal-title":"Neuron"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sharma, N.K., Mathur, D., Vinish, M., Sharma, R., Bhatia, K., Pannu, V., and Anand, A. (2017). Hype and hopes of stem cell research in neurodegenerative diseases. Regenerative Medicine: Laboratory to Clinic, Springer.","DOI":"10.1007\/978-981-10-3701-6_13"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1001\/jamaneurol.2015.4321","article-title":"Safety and clinical effects of mesenchymal stem cells secreting neurotrophic factor transplantation in patients with amyotrophic lateral sclerosis","volume":"73","author":"Petrou","year":"2016","journal-title":"JAMA Neurol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nm1239","article-title":"A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease","volume":"11","author":"Tuszynski","year":"2005","journal-title":"Nat. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/geronj\/11.3.298","article-title":"Aging: A theory based on free radical and radiation chemistry","volume":"11","author":"Harman","year":"1956","journal-title":"J. Gerontol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"S357","DOI":"10.3233\/JAD-2010-100498","article-title":"Reactive oxygen species: Stuck in the middle of neurodegeneration","volume":"20","author":"Patten","year":"2010","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_26","first-page":"331","article-title":"Free radicals: Their history and current status in aging and disease","volume":"28","author":"Knight","year":"1998","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00415-010-5741-y","article-title":"A brief history of levodopa","volume":"257","author":"Hornykiewicz","year":"2010","journal-title":"J. Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4236\/pp.2013.43A003","article-title":"The success of natural products in drug discovery","volume":"4","author":"Lahlou","year":"2013","journal-title":"Pharmacol. Pharm."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"956792","DOI":"10.1155\/2013\/956792","article-title":"Achieving the balance between ROS and antioxidants: When to use the synthetic antioxidants","volume":"2013","author":"Poljsak","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"428010","DOI":"10.1155\/2012\/428010","article-title":"Mechanism of oxidative stress in neurodegeneration","volume":"2012","author":"Gandhi","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2005.06.026","article-title":"Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production","volume":"519","author":"Tang","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.brainresbull.2011.11.014","article-title":"Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer\u2019s disease","volume":"87","author":"Choi","year":"2012","journal-title":"Brain Res. Bull."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2014.00089","article-title":"Caenorhabditis elegans: A model to investigate oxidative stress and metal dyshomeostasis in Parkinson\u2019s disease","volume":"6","author":"Chege","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0028-3908(01)00019-3","article-title":"Oxidative stress induced-neurodegenerative diseases: The need for antioxidants that penetrate the blood brain barrier","volume":"40","author":"Melamed","year":"2001","journal-title":"Neuropharmacology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.3109\/10715762.2010.508495","article-title":"Natural and synthetic antioxidants: An updated overview","volume":"44","author":"Augustyniak","year":"2010","journal-title":"Free Radic. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.fct.2012.09.021","article-title":"A review on antioxidants, prooxidants and related controversy: Natural and synthetic compounds, screening and analysis methodologies and future perspectives","volume":"51","author":"Carocho","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","article-title":"Natural products as sources of new drugs from 1981 to 2014","volume":"79","author":"Newman","year":"2016","journal-title":"J. Nat. Prod."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd4510","article-title":"The re-emergence of natural products for drug discovery in the genomics era","volume":"14","author":"Harvey","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3892\/br.2017.909","article-title":"Drug development: Lessons from nature","volume":"6","author":"Mathur","year":"2017","journal-title":"Biomed. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Wink, M. (2010). Introduction: Biochemistry, physiology and ecological functions of secondary metabolites. Annual Plant Reviews Volume 40 Biochemistry of Plant Secondary Metabolites, Wiley-Blackwell.","DOI":"10.1002\/9781444318876.ch1"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.foodres.2011.03.009","article-title":"Stability of phytochemicals as sources of anti-inflammatory nutraceuticals in beverages\u2014A review","volume":"50","author":"Harbourne","year":"2013","journal-title":"Food Res. Int."},{"key":"ref_42","first-page":"232","article-title":"Anti-inflammatory and acetylcholinesterase inhibition activities of Globularia Alypum","volume":"2","author":"Khlifi","year":"2013","journal-title":"J. Med. Bioeng."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1007\/s11064-011-0533-z","article-title":"Protective effects of walnut extract against amyloid beta peptide-induced cell death and oxidative stress in PC12 cells","volume":"36","author":"Muthaiyah","year":"2011","journal-title":"Neurochem. Res."},{"key":"ref_44","first-page":"2700","article-title":"Importance of Brassica napus as a medicinal food plant","volume":"6","author":"Saeidnia","year":"2012","journal-title":"J. Med. Plants Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"918","DOI":"10.12691\/jfnr-2-12-10","article-title":"Nutritional and antioxidant properties of rapeseed (Brassica Napus) cultivars with high and low erucic acid content","volume":"2","author":"Yue","year":"2014","journal-title":"J. Food Nutr. Res."},{"key":"ref_46","unstructured":"Preedy, V.R. (2013). Epigallocatechin gallate (EGCG) from green tea (Camellia sinensis) and other natural products mediate stress resistance and slows down aging processes in caenorhabditis elegans. Tea in Health and Disease Prevention, Elsevier Science Publishing Co., Inc."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1365-2621.2010.02499.x","article-title":"The development of fruit-based functional foods targeting the health and wellness market: A review","volume":"46","year":"2011","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"8987","DOI":"10.1021\/jf402586f","article-title":"Grape pomace as a sustainable source of bioactive compounds: Extraction, characterization, and biotechnological applications of phenolics","volume":"61","author":"Fontana","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jpba.2013.03.007","article-title":"Isolation and characterization of bioactive compounds from plant resources: The role of analysis in the ethnopharmacological approach","volume":"87","author":"Brusotti","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"504253","DOI":"10.1155\/2015\/504253","article-title":"Role of polyphenols and other phytochemicals on molecular signaling","volume":"2015","author":"Upadhyay","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.phytochem.2011.01.014","article-title":"Phytochemicals of Brassicaceae in plant protection and human health--influences of climate, environment and agronomic practice","volume":"72","author":"Klingen","year":"2011","journal-title":"Phytochemistry"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1242\/dmm.030205","article-title":"Neurodegenerative disease: Models, mechanisms, and a new hope","volume":"10","author":"Gitler","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnmol.2017.00050","article-title":"Modeling human neurological and neurodegenerative diseases: From induced pluripotent stem cells to neuronal differentiation and its applications in neurotrauma","volume":"10","author":"Bahmad","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/adhm.201700723","article-title":"Three-dimensional models of the human brain development and diseases","volume":"7","author":"Jorfi","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.stem.2016.07.017","article-title":"Neural differentiation in the third dimension: Generating a human midbrain","volume":"19","author":"Marton","year":"2016","journal-title":"Cell. Stem Cell."},{"key":"ref_56","unstructured":"Amini, S., and White, K.M. (USA 2013). Considerations for the use of SH-SY5Y neuroblastoma cells in neurobiology. Neuronal Cell Culture: Methods and Protocols, Springer Science + Business Media."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-62703-640-5_1","article-title":"General overview of neuronal cell culture","volume":"1078","author":"Gordon","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/13880209.2016.1251468","article-title":"Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans","volume":"55","author":"Cheon","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.foodchem.2010.03.007","article-title":"Antioxidant activity and cell toxicity of pressurised liquid extracts from 20 selected plant species in Jeju, Korea","volume":"122","author":"Kim","year":"2010","journal-title":"Food Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2495624","DOI":"10.1155\/2016\/2495624","article-title":"Allium cepa extract and quercetin protect neuronal cells from oxidative stress via PKC-\u03b5 inactivation\/ERK1\/2 activation","volume":"2016","author":"Lee","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Fredotov\u00edc, \u017d., \u0160prung, M., Soldo, B., Ljubenkov, I., Budi\u0107-Leto, I., Bilu\u0161i\u0107, T., Cike\u0161-\u010culi\u0107, V., and Puizina, J. (2017). Chemical composition and biological activity of allium cepa L. and Allium \u00d7 cornutum (Clementi ex Visiani 1842) methanolic extracts. Molecules, 22.","DOI":"10.20944\/preprints201701.0084.v1"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1089\/jmf.2008.1400","article-title":"Neuroprotective effects of onion extract and quercetin against ischemic neuronal damage in the gerbil hippocampus","volume":"12","author":"Hwang","year":"2009","journal-title":"J. Med. Food"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"374","DOI":"10.4103\/0974-8490.75460","article-title":"A comparative profile of methanol extracts of Allium cepa and Allium sativum in diabetic neuropathy in mice","volume":"2","author":"Bhanot","year":"2010","journal-title":"Pharmacogn. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1002\/jsfa.6620","article-title":"Onion extract (Allium cepa L.), quercetin and catechin up-regulate paraoxonase 1 activity with concomitant protection against low-density lipoprotein oxidation in male Wistar rats subjected to oxidative stress","volume":"94","author":"Jaiswal","year":"2014","journal-title":"J. Sci. Food Agric."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/cns.12659","article-title":"Anthoxanthin polyphenols attenuate a \u03b2 oligomer-induced neuronal responses associated with Alzheimer\u2019s disease","volume":"23","author":"Pate","year":"2017","journal-title":"CNS Neurosci. Ther."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/bdd.1956","article-title":"Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin","volume":"36","author":"Fuentes","year":"2015","journal-title":"Biopharm. Drug Dispos."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.fitote.2011.01.018","article-title":"Antioxidant and prooxidant properties of flavonoids","volume":"82","year":"2011","journal-title":"Fitoterapia"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/acn3.282","article-title":"Antioxidants inhibit neuronal toxicity in Parkinson\u2019s disease-linked LRRK2","volume":"3","author":"Angeles","year":"2016","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mrrev.2011.11.001","article-title":"Biological activity of piceatannol: Leaving the shadow of resveratrol","volume":"750","author":"Piotrowska","year":"2012","journal-title":"Mutat. Res. Mutat. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1559325818761455","DOI":"10.1177\/1559325818761455","article-title":"The neuroprotective effects of thymoquinone: A review","volume":"16","author":"Farkhondeh","year":"2018","journal-title":"Dose. Response"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3746\/pnf.2014.19.4.321","article-title":"Analysis and distribution of esculetin in plasma and tissues of rats after oral administration","volume":"19","author":"Kim","year":"2014","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1021\/jf030319d","article-title":"Inhibition of peroxynitrite-mediated reactions by vanillin","volume":"52","author":"Kumar","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bbagen.2010.11.004","article-title":"Evaluation of antioxidant activity of vanillin by using multiple antioxidant assays","volume":"1810","author":"Tai","year":"2011","journal-title":"Biochim. Biophys. Acta\u2014Gen. Subj."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.ejmech.2017.11.072","article-title":"Novel vanillin derivatives: Synthesis, anti-oxidant, DNA and cellular protection properties","volume":"143","author":"Scipioni","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1124\/jpet.109.152835","article-title":"Vanillin improves and prevents trinitrobenzene sulfonic acid-induced colitis in mice","volume":"330","author":"Wu","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"626028","DOI":"10.1155\/2015\/626028","article-title":"Neurosupportive role of vanillin, a natural phenolic compound, on rotenone induced neurotoxicity in SH-SY5Y neuroblastoma cells","volume":"2015","author":"Dhanalakshmi","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1534\/genetics.115.179457","article-title":"Drosophila as an in vivo model for human neurodegenerative disease","volume":"201","author":"McGurk","year":"2015","journal-title":"Genetics"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuroscience.2015.02.048","article-title":"Attenuation of neuromotor deficits by natural antioxidants of Decalepis hamiltonii in transgenic Drosophila model of Parkinson\u2019s disease","volume":"293","author":"Jahromi","year":"2015","journal-title":"Neuroscience"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.lwt.2005.07.005","article-title":"Antioxidant activity of the roots of Decalepis hamiltonii (Wight & Arn.)","volume":"39","author":"Srivastava","year":"2006","journal-title":"LWT\u2014Food Sci. Technol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.foodchem.2006.08.010","article-title":"Isolation of ellagic acid from the aqueous extract of the roots of Decalepis hamiltonii: Antioxidant activity and cytoprotective effect","volume":"103","author":"Srivastava","year":"2007","journal-title":"Food Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neulet.2016.11.058","article-title":"Extracts from two ubiquitous Mediterranean plants ameliorate cellular and animal models of neurodegenerative proteinopathies","volume":"638","author":"Briffa","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_82","first-page":"6","article-title":"Cactus (Opuntia ficus-indica): A review on its antioxidants properties and potential pharmacological use in chronic diseases","volume":"2","year":"2014","journal-title":"Nat. Prod. Chem. Res."},{"key":"ref_83","first-page":"42","article-title":"Antioxidant and antifungal activities of Padina Pavonica and Sargassum Vulgare from the Lebanese Mediterranean coast","volume":"6","author":"Khaled","year":"2012","journal-title":"Adv. Environ. Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fgene.2014.00279","article-title":"Use of Caenorhabditis elegans as a model to study Alzheimer\u2019s disease and other neurodegenerative diseases","volume":"5","author":"Alexander","year":"2014","journal-title":"Front. Genet."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13065-015-0143-y","article-title":"Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases","volume":"9","author":"Chen","year":"2015","journal-title":"Chem. Cent. J."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"10701","DOI":"10.1021\/jf503192x","article-title":"Antioxidant activity, delayed aging, and reduced amyloid-\u03b2 toxicity of methanol extracts of tea seed pomace from Camellia tenuifolia","volume":"62","author":"Wei","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.foodchem.2017.06.129","article-title":"Revalorisation of rapeseed pomace extracts: An in vitro study into its anti-oxidant and DNA protective properties","volume":"239","author":"Pohl","year":"2018","journal-title":"Food Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"E59","DOI":"10.1017\/S0029665116000495","article-title":"Study into the polyphenol content and antioxidant activity of rapeseed pomace extracts","volume":"75","author":"Pohl","year":"2016","journal-title":"Proc. Nutr. Soc."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s00335-017-9687-6","article-title":"Bridging the gap: Large animal models in neurodegenerative research","volume":"28","author":"Eaton","year":"2017","journal-title":"Mamm. Genome"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/s41593-018-0236-8","article-title":"Animal models of neurodegenerative diseases","volume":"21","author":"Dawson","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/j.1742-4658.2012.08491.x","article-title":"Animal models of Parkinson\u2019s disease","volume":"279","author":"Blandini","year":"2012","journal-title":"FEBS J."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.brainresbull.2011.07.016","article-title":"Genetically engineered mouse models of the trinucleotide-repeat spinocerebellar ataxias","volume":"88","author":"Ingram","year":"2012","journal-title":"Brain Res. Bull."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnsys.2016.00069","article-title":"Putting the \u201cbiology\u201d back into \u201cneurobiology\u201d: The strength of diversity in animal model systems for neuroscience research","volume":"10","author":"Keifer","year":"2016","journal-title":"Front. Syst. Neurosci."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Ali, T., Kim, T., Rehman, S.U., Khan, M.S., Amin, F.U., Khan, M., Ikram, M., and Kim, M.O. (2017). Natural dietary supplementation of anthocyanins via PI3K\/Akt\/Nrf2\/HO-1 pathways mitigate oxidative stress, neurodegeneration, and memory impairment in a mouse model of Alzheimer\u2019s disease. Mol. Neurobiol., 1\u201318.","DOI":"10.1007\/s12035-017-0798-6"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Gengler, S., Hamilton, A., and H\u00f6lscher, C. (2010). Synaptic plasticity in the hippocampus of a APP\/PS1 mouse model of Alzheimer\u2019s disease is impaired in old but not young mice. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0009764"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s13197-011-0493-y","article-title":"Identification of anthocyanins in black soybean (Glycine max (L.) Merr.) varieties","volume":"51","author":"Koh","year":"2014","journal-title":"J. Food Sci. Technol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ifset.2009.07.002","article-title":"Antioxidant properties of resveratrol: A structure\u2013activity insight","volume":"11","year":"2010","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"11445","DOI":"10.1038\/ncomms11445","article-title":"Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway","volume":"7","author":"Carmona","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/392169","article-title":"Resveratrol: A focus on several neurodegenerative diseases","volume":"2015","author":"Tellone","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"11310","DOI":"10.1074\/jbc.M116.762658","article-title":"Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer\u2019s disease","volume":"292","author":"Mori","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"7509","DOI":"10.1021\/acs.jafc.7b02503","article-title":"Comparison of antioxidant evaluation assays for investigating antioxidative activity of gallic acid and its alkyl esters in different food matrices","volume":"65","author":"Phonsatta","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Szwajgier, D., Borowiec, K., and Pustelniak, K. (2017). The neuroprotective effects of phenolic acids: Molecular mechanism of action. Nutrients, 9.","DOI":"10.3390\/nu9050477"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1021\/jf011348w","article-title":"Antioxidant properties of ferulic acid and its related compounds","volume":"50","author":"Kikuzaki","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"5499","DOI":"10.2147\/DDDT.S90616","article-title":"Neuroprotective potential of ferulic acid in the rotenone model of Parkinson\u2019s disease","volume":"9","author":"Haque","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Chen, C. (2015). Sinapic acid and its derivatives as medicine in oxidative stress-induced diseases and aging. Oxid. Med. Cell. Longev., 1\u201310.","DOI":"10.1155\/2016\/3571614"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11011-014-9604-6","article-title":"The neuroprotective potential of sinapic acid in the 6-hydroxydopamine-induced hemi-parkinsonian rat","volume":"30","author":"Zare","year":"2015","journal-title":"Metab. Brain Dis."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/1533317514542645","article-title":"Sulforaphane ameliorates neurobehavioral deficits and protects the brain from amyloid \u03b2 deposits and peroxidation in mice with Alzheimer-like lesions","volume":"30","author":"Zhang","year":"2015","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2017.00121","article-title":"Beneficial effects of sulforaphane treatment in Alzheimer\u2019s disease may be mediated through reduced HDAC1\/3 and increased P75NTR expression","volume":"9","author":"Zhang","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/jnc.12647","article-title":"Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington\u2019s disease","volume":"129","author":"Liu","year":"2014","journal-title":"J. Neurochem."},{"key":"ref_110","first-page":"1","article-title":"Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2, and autophagy pathways","volume":"6","author":"Zhou","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Petrillo, S., Piermarini, E., Pastore, A., Vasco, G., Schirinzi, T., Carrozzo, R., Bertini, E., and Piemonte, F. (2017). Nrf2-inducers counteract neurodegeneration in frataxin-silenced motor neurons: Disclosing new therapeutic targets for Friedreich\u2019s Ataxia. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18102173"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/7857186","article-title":"Sulforaphane and other nutrigenomic Nrf2 activators: Can the Clinician\u2019s expectation be matched by the reality?","volume":"2016","author":"Houghton","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Visalli, G., Facciol\u00e0, A., Bertuccio, M.P., Picerno, I., and Di Pietro, A. (2017). In vitro assessment of the indirect antioxidant activity of Sulforaphane in redox imbalance vanadium-induced. Nat. Prod. Res., 1\u20139.","DOI":"10.1080\/14786419.2017.1286485"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"685909","DOI":"10.1155\/2013\/685909","article-title":"Neuroprotective effects of a variety of pomegranate juice extracts against MPTP-induced cytotoxicity and oxidative stress in human primary neurons","volume":"2013","author":"Braidy","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"11641","DOI":"10.1038\/s41598-017-11839-0","article-title":"Treatment with caffeic acid and resveratrol alleviates oxidative stress induced neurotoxicity in cell and drosophila models of spinocerebellar ataxia type3","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.3390\/md13042250","article-title":"Neuroprotective effects of the cultivated chondrus crispus in a C. elegans model of Parkinson\u2019s disease","volume":"13","author":"Liu","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1177\/0963689717738785","article-title":"Neuroprotective effects of betulin in pharmacological and transgenic Caenorhabditis elegans models of Parkinson\u2019s disease","volume":"26","author":"Tsai","year":"2017","journal-title":"Cell. Transplant."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.pbb.2012.08.015","article-title":"Neuroprotective effect of sinapic acid in a mouse model of amyloid \u03b2(1\u201342) protein-induced Alzheimer\u2019s disease","volume":"103","author":"Lee","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1248\/bpb.30.514","article-title":"Cerebral protective and cognition-improving effects of sinapic acid in rodents","volume":"30","author":"Karakida","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3233\/JAD-2010-101074","article-title":"Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer\u2019s disease","volume":"22","author":"Wang","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.3945\/jn.117.255034","article-title":"Epigallocatechin gallate has a neurorescue effect in a mouse model of parkinson disease","volume":"147","author":"Xu","year":"2017","journal-title":"J. Nutr."},{"key":"ref_122","unstructured":"(2018, June 09). National Center for Complementary and Integrative Health (NIH) New NCCIH Funding Opportunities for Natural Product Clinical Trials Webinar Summary|NCCIH. Available online: https:\/\/nccih.nih.gov\/news\/events\/telecon\/natural-product-CT-webinar."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1212\/WNL.0000000000004568","article-title":"Caffeine as symptomatic treatment for Parkinson disease (Caf\u00e9-PD): A randomized trial","volume":"89","author":"Postuma","year":"2017","journal-title":"Neurology"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.neurobiolaging.2013.11.004","article-title":"Reducing iron in the brain: A novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer\u2019s disease","volume":"35","author":"Huang","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2014.00216","article-title":"Huperzine A: Is it an effective disease-modifying drug for Alzheimer\u2019s disease?","volume":"6","author":"Qian","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1212\/WNL.0b013e318216eb7b","article-title":"A phase II trial of huperzine A in mild to moderate Alzheimer disease","volume":"76","author":"Rafii","year":"2011","journal-title":"Neurology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/cns.12270","article-title":"Systematic review of clinical trials assessing pharmacological properties of Salvia species on memory, cognitive impairment and Alzheimer\u2019s disease","volume":"20","author":"Miroddi","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2174\/1389450003349380","article-title":"Ginkgo biloba extract (EGb 761) and CNS functions: Basic studies and clinical applications","volume":"1","author":"DeFeudis","year":"2000","journal-title":"Curr. Drug Targets"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s40262-013-0074-5","article-title":"Ginkgo biloba extracts: A review of the pharmacokinetics of the active ingredients","volume":"52","author":"Ude","year":"2013","journal-title":"Clin. Pharmacokinet."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0006-8993(00)03131-0","article-title":"The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from \u03b2-amyloid-induced cell death by inhibiting the formation of \u03b2-amyloid-derived diffusible neurotoxic ligands","volume":"889","author":"Yao","year":"2001","journal-title":"Brain Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/(SICI)1099-1573(199903)13:2<160::AID-PTR402>3.0.CO;2-H","article-title":"Additional information to the in vitro antioxidant activity of Ginkgo biloba L.","volume":"13","author":"Lugasi","year":"1999","journal-title":"Phyther. Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/0006-2952(95)00089-I","article-title":"Peroxyl radical scavenging activity of Ginkgo biloba extract EGb 761","volume":"49","author":"Maitra","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0367-326X(02)00306-4","article-title":"Investigation of the free radical scavenging activity of Ginkgo biloba L. leaves","volume":"74","author":"Kasprzak","year":"2003","journal-title":"Fitoterapia"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"13102","DOI":"10.1523\/JNEUROSCI.3448-06.2006","article-title":"Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans","volume":"26","author":"Wu","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3233\/JAD-2003-5404","article-title":"Elevation of oxidative free radicals in Alzheimer\u2019s disease models can be attenuated by Ginkgo biloba extract EGb 761","volume":"5","author":"Smith","year":"2003","journal-title":"J. Alzheimers Dis."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbi.2015.01.011","article-title":"Long-term treatment with Ginkgo biloba extract EGb 761 improves symptoms and pathology in a transgenic mouse model of Alzheimer\u2019s disease","volume":"46","author":"Liu","year":"2015","journal-title":"Brain. Behav. Immun."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s00508-012-0307-x","article-title":"Ginkgo biloba extract EGb 761\u00ae in the treatment of dementia: A pharmacoeconomic analysis of the Austrian setting","volume":"125","author":"Rainer","year":"2013","journal-title":"Wien. Klin. Wochenschr."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jpsychires.2012.03.003","article-title":"Ginkgo biloba extract EGb 761\u00ae in dementia with neuropsychiatric features: A randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg","volume":"46","author":"Herrschaft","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/OAJCT.S93531","article-title":"Neuropsychiatric symptoms in dementia and the effects of Ginkgo biloba extract EGb 761\u00ae treatment: Additional results from a 24-week randomized, placebo-controlled trial","volume":"8","author":"Hoerr","year":"2016","journal-title":"Open Access J. Clin. Trials"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1001\/jama.2008.683","article-title":"Ginkgo evaluation of memory (GEM) study investigators Ginkgo biloba for prevention of dementia: A randomized controlled trial","volume":"300","author":"DeKosky","year":"2008","journal-title":"JAMA"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3233\/JAD-140837","article-title":"Efficacy and adverse effects of Ginkgo biloba for cognitive impairment and dementia: A systematic review and meta-analysis","volume":"43","author":"Tan","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.indcrop.2015.01.025","article-title":"Synergistic, additive and antagonistic effects of Potentilla fruticosa combined with EGb761 on antioxidant capacities and the possible mechanism","volume":"67","author":"Wang","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jfca.2014.06.013","article-title":"Investigation of the potential synergistic effect of resveratrol with other phenolic compounds: A case of binary phenolic mixtures","volume":"38","author":"Skroza","year":"2015","journal-title":"J. Food Compos. Anal."},{"key":"ref_144","first-page":"1","article-title":"The therapeutic potential of resveratrol: A review of clinical trials","volume":"35","author":"Berman","year":"2017","journal-title":"NPJ Precis. Oncol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.drudis.2013.01.008","article-title":"Shifting from the single to the multitarget paradigm in drug discovery","volume":"18","author":"Giulianotti","year":"2013","journal-title":"Drug Discov. Today"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Admasu, T.D., Chaithanya Batchu, K., Barardo, D., Ng, L.F., Lam, V.Y.M., Xiao, L., Cazenave-Gassiot, A., Wenk, M.R., Tolwinski, N.S., and Gruber, J. (2018). Drug synergy slows aging and improves healthspan through IGF and SREBP lipid signaling. Dev. Cell, 1\u201313.","DOI":"10.1016\/j.devcel.2018.09.001"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1021\/jm901902w","article-title":"Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyidine derivatives","volume":"53","author":"Egea","year":"2010","journal-title":"J. Med. Chem."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/12\/3283\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:33:15Z","timestamp":1760196795000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/23\/12\/3283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,11]]},"references-count":147,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["molecules23123283"],"URL":"https:\/\/doi.org\/10.3390\/molecules23123283","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,11]]}}}