{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:12:01Z","timestamp":1791655921804,"version":"4.3.4"},"reference-count":26,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Diabetes mellitus (DM) is a disease that is caused by a malfunction of carbohydrate metabolism, which plays an important role in the development of long-term diabetic complications. The excess glucose can be transformed to methylglyoxal (MG), a potential precursor of glycation. Glycation is a spontaneous non-enzymatic reaction that initially yields advanced glycation end-products (AGEs), which ultimately triggers several severe complications. Therefore, the inhibition of AGEs formation is the imperative approach for alleviating diabetic complications. The aim of this research was to investigate the glycation and \u03b1-glucosidase inhibitory abilities of compounds isolated from fingerroot. The dichloromethane extract afforded three flavanones, two chalcones, two dihydrochalcones, and one kavalactone. Most of the isolated compounds showed higher inhibition effect against AGEs formation than aminoguanidine (AG). Subsequent evaluation in MG-trapping assay indicated that their trapping potency was relatively comparable to AG. Their structure-activity relationships (SAR) of MG-trapping activity were investigated using the comparison of the structures of flavonoids. In addition, pinocembrin displayed moderate \u03b1-glucosidase inhibition against both maltase and sucrose, with IC50 values of 0.35 \u00b1 0.021 and 0.39 \u00b1 0.020 mM, respectively.<\/jats:p>","DOI":"10.3390\/molecules23123365","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T12:12:44Z","timestamp":1545221564000},"page":"3365","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Identification of Pinocembrin as an Anti-Glycation Agent and \u03b1-Glucosidase Inhibitor from Fingerroot (Boesenbergia rotunda): The Tentative Structure\u2013Activity Relationship towards MG-Trapping Activity"],"prefix":"10.3390","volume":"23","author":[{"given":"Thammatee","family":"Potipiranun","sequence":"first","affiliation":[{"name":"Program of Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand"},{"name":"Center of Excellence in Natural Products, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirichai","family":"Adisakwattana","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wisuttaya","family":"Worawalai","sequence":"additional","affiliation":[{"name":"Center of Excellence in Natural Products, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rico","family":"Ramadhan","sequence":"additional","affiliation":[{"name":"Center of Excellence in Natural Products, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand"},{"name":"Department of Chemistry, Faculty of Science and Technology, Airlangga University, Surabaya 60115, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preecha","family":"Phuwapraisirisan","sequence":"additional","affiliation":[{"name":"Center of Excellence in Natural Products, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"ref_1","first-page":"190","article-title":"Evolution of diabetes management in the 21st century: The contribution of quality of life measurement in asians","volume":"24","author":"Goh","year":"2015","journal-title":"Asia Pac. 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