{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:07:02Z","timestamp":1791090422025,"version":"4.1.0"},"reference-count":39,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["(GRP-74-39)"],"award-info":[{"award-number":["(GRP-74-39)"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A novel series of thiazole-based heterocycles was synthesized using 1,3-dipolar cycloaddition reactions in the presence of chitosan-grafted-poly(vinylpyridine) as an eco-friendly biopolymeric basic catalyst. The molecular structure of the synthesized compounds was illustrated by spectroscopic and elemental analysis. Various in vitro biological assays were performed to explore the potential antitumor, antimicrobial and hepatoprotective activities of the newly synthesized compounds. The cytotoxic activities were assessed against human hepatocellular carcinoma (HepG-2), colorectal carcinoma (HCT-116) and breast cancer (MCF-7) cell lines and results revealed that all compounds displayed antitumor activities with the chlorine-containing derivatives, 11c and 6g, being the most potent. The majority of the tested thiazole derivatives exhibited satisfactory antibacterial activity towards the used gram positive and gram-negative bacterial species. Moreover, many derivatives showed weak hepatoprotective activity against CCl4-induced hepatotoxicity.<\/jats:p>","DOI":"10.3390\/molecules24030539","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T11:19:58Z","timestamp":1549019998000},"page":"539","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Synthesis and Biological Evaluation of Some Novel Thiazole-Based Heterocycles as Potential Anticancer and Antimicrobial Agents"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8949-9204","authenticated-orcid":false,"given":"Sraa","family":"Abu-Melha","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, King Khalid University, Abha 61413, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2301-7652","authenticated-orcid":false,"given":"Mastoura M.","family":"Edrees","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, King Khalid University, Abha 61413, Saudi Arabia"},{"name":"Department of Organic Chemistry, National Organization for Drug Control and Research (NODCAR), Giza 12311, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba H.","family":"Salem","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia"},{"name":"Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila A.","family":"Kheder","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt"},{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7739-2837","authenticated-orcid":false,"given":"Sobhi M.","family":"Gomha","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt"},{"name":"Department of Chemistry, Faculty of Science, Islamic University in Almadinah Almonawara, Almadinah Almonawara 42351, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad R.","family":"Abdelaziz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, MIU University, Cairo 19648, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5464","DOI":"10.1016\/j.bmcl.2009.07.097","article-title":"Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist","volume":"19","author":"Satoh","year":"2009","journal-title":"Bioorg. 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[3rd ed.].","DOI":"10.1093\/oso\/9780199637973.003.0007"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/3\/539\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:30:21Z","timestamp":1760185821000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/3\/539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,1]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,2]]}},"alternative-id":["molecules24030539"],"URL":"https:\/\/doi.org\/10.3390\/molecules24030539","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,1]]}}}