{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:10:27Z","timestamp":1780060227065,"version":"3.54.0"},"reference-count":28,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T00:00:00Z","timestamp":1549152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The study was aimed to determine whether treatment with oat oligopeptides (OOPs) could modulate hyperglycemia related to type 2 diabetes mellitus (T2DM) in Sprague\u2013Dawley (SD) rats. Diabetic SD rats modeling by a joint effect of high-calorie diet for 45 days and twice intraperitoneal injection of 30 mg\/kg streptozotocin at one-week interval were observed with or without OOPs administration (0.25, 0.50, 1.00, and 2.00 g\/kg Body Weight) for 12 weeks. Fasting blood glucose (FBG), oral glucose test tolerance (OGTT), serum insulin, level of antioxidant, and hepatic enzymes were measured. In addition, frequency of micturition was recorded in this study for the first time. It was observed that the administration of OOPs (2.00 g\/kg Body Weight) resulted in a significant decrease (p &lt; 0.05) in FBG since 6th week and a significant decrease (p &lt; 0.05) in the OGTT-AUC on 6th and 10th week. In addition, the administration of OOPs (2.00 g\/kg Body Weight) reduced HOMA-IR index and 24-h urine volume significantly (p &lt; 0.05) whereas increased SOD activity significantly (p &lt; 0.05). These results suggested that OOPs may have a hypoglycemic effect in diabetic rats.<\/jats:p>","DOI":"10.3390\/molecules24030558","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T11:31:07Z","timestamp":1549366267000},"page":"558","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Hypoglycemic Effects of Oat Oligopeptides in High-Calorie Diet\/STZ-Induced Diabetic Rats"],"prefix":"10.3390","volume":"24","author":[{"given":"Jun-bo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-ran","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-xue","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-juan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3914-5840","authenticated-orcid":false,"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","article-title":"IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045","volume":"138","author":"Cho","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/S0140-6736(14)60613-9","article-title":"Prevention and management of type 2 diabetes: Dietary components and nutritional strategies","volume":"383","author":"Ley","year":"2014","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"B32","DOI":"10.1016\/j.numecd.2011.03.009","article-title":"The role of diet in the prevention of type 2 diabetes","volume":"21","author":"Ros","year":"2011","journal-title":"Nutr. Metab. Cardiovasc. Diseases"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1094\/CCHEM-87-4-0315","article-title":"REVIEW: Oat and Rye \u03b2-Glucan: Properties and Function","volume":"87","author":"Wood","year":"2010","journal-title":"Cereal Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1024\/0300-9831.77.5.347","article-title":"Effects of high-fiber oat and wheat cereals on postprandial glucose and lipid responses in healthy men","volume":"77","author":"Maki","year":"2007","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/jsfa.7236","article-title":"Effects of dietary oat proteins on cholesterol metabolism of hypercholesterolaemic hamsters","volume":"96","author":"Tong","year":"2016","journal-title":"J. Sci. Food Agric."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"10369","DOI":"10.3390\/nu7125536","article-title":"The Metabolic Effects of Oats Intake in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis","volume":"7","author":"Hou","year":"2015","journal-title":"Nutrients"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1017\/S0007114514000889","article-title":"Effect of oat intake on glycaemic control and insulin sensitivity: A meta-analysis of randomised controlled trials","volume":"112","author":"Bao","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1039\/C5FO01364J","article-title":"The difference between oats and beta-glucan extract intake in the management of HbA1c, fasting glucose and insulin sensitivity: A meta-analysis of randomized controlled trials","volume":"7","author":"He","year":"2016","journal-title":"Food Funct."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1039\/C7FO01658A","article-title":"Anti-fatigue effects of small-molecule oligopeptides isolated from Panax quinquefolium L. in mice","volume":"9","author":"Li","year":"2018","journal-title":"Food Funct."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1620\/tjem.236.71","article-title":"Hypoglycemic, hypolipidemic and antioxidant effects of peptides from red deer antlers in streptozotocin-induced diabetic mice","volume":"236","author":"Jiang","year":"2015","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4314\/sajas.v44i2.12","article-title":"Chemical composition of hulled, dehulled and naked oat grains","volume":"2014","author":"Biel","year":"2014","journal-title":"S. Afr. J. Anim. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.2527\/1990.68124253x","article-title":"Nutritive value of oat flour and oat bran","volume":"68","author":"Hahn","year":"1990","journal-title":"J. Anim. Sci."},{"key":"ref_14","first-page":"18","article-title":"Quality characteristics of oat cultivars and cluster analysis","volume":"10","author":"Ni","year":"2016","journal-title":"J. Chin. Cereals Oils Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1365-2621.1976.tb01099.x","article-title":"Protein content and amino acid composition in groats and hulls of developing oats (Avena sativa)","volume":"41","author":"Pomeranz","year":"2010","journal-title":"J. Food Sci."},{"key":"ref_16","unstructured":"Yang, J.L., Guo, L.I., You-Pin, L., Zhang, F.L., Cui, J.L., Zhang, D., Zhou, W.Z., and Luo, M. (2003). Establishing a Rat Model Similar to the Adult Patient of the General Type 2 Diabetes by Long-Term Fat-Enriched Fed and Lower Dose of Streptozocin-Treated Rats. Acta Laboratorium Animalis Scientia Sinica, Chinese Society of Laboratory Animals."},{"key":"ref_17","first-page":"169","article-title":"Six week follow-up of metabolic effects induced by a high-fat diet and streptozotocin in a rodent model of type 2 diabetes mellitus","volume":"35","author":"Atanasovska","year":"2014","journal-title":"Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)"},{"key":"ref_18","first-page":"1115","article-title":"Biochemical and pathological analysis of mice with type 2 diabetes mellitus induced by high-fat diet and low-dose streptozotocin injections","volume":"34","author":"Zeng","year":"2014","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.diabres.2016.06.007","article-title":"Identifying hyperinsulinaemia in the absence of impaired glucose tolerance: An examination of the Kraft database","volume":"118","author":"Crofts","year":"2016","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.diabres.2009.11.011","article-title":"Development and validation of a risk-score model for subjects with impaired glucose tolerance for the assessment of the risk of type 2 diabetes mellitus-The STOP-NIDDM risk-score","volume":"87","author":"Tuomilehto","year":"2010","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1177\/147323001204000408","article-title":"Relationship between Fasting and 2-hour Postprandial Plasma Glucose Levels and Vascular Complications in Patients with Type 2 Diabetes Mellitus","volume":"40","author":"Tanaka","year":"2012","journal-title":"J. Int. Med. Res."},{"key":"ref_22","first-page":"5","article-title":"Postprandial peaks as a risk factor for cardiovascular disease: Epidemiological perspectives","volume":"129","author":"Bonora","year":"2002","journal-title":"Int. J. Clin. Pract."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.52.1.1","article-title":"Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?","volume":"52","author":"JL","year":"2003","journal-title":"Diabetes"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Du, Y., Esfandi, R., Willmore, W.G., and Tsopmo, A. (2016). Antioxidant Activity of Oat Proteins Derived Peptides in Stressed Hepatic HepG2 Cells. Antioxidants, 5.","DOI":"10.3390\/antiox5040039"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e000097","DOI":"10.1136\/bmjdrc-2015-000097","article-title":"Lower urinary pH is useful for predicting renovascular disorder onset in patients with diabetes","volume":"3","author":"Ogawa","year":"2015","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/1476-511X-13-182","article-title":"The cholesterol-lowering effects of oat varieties based on their difference in the composition of proteins and lipids","volume":"13","author":"Guo","year":"2014","journal-title":"Lipids Health Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jcjd.2016.10.009","article-title":"Influence of Amino Acids in Dairy Products on Glucose Homeostasis: The Clinical Evidence","volume":"41","author":"Chartrand","year":"2017","journal-title":"Can. J. Diabetes"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/ejcn.2013.201","article-title":"Effects of Avena nuda L. on metabolic control and cardiovascular disease risk among Chinese patients with diabetes and meeting metabolic syndrome criteria: Secondary analysis of a randomized clinical trial","volume":"67","author":"Ma","year":"2013","journal-title":"Eur. J. Clin. Nutr."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/3\/558\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:30:52Z","timestamp":1760185852000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/3\/558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,3]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,2]]}},"alternative-id":["molecules24030558"],"URL":"https:\/\/doi.org\/10.3390\/molecules24030558","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,3]]}}}