{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:07:10Z","timestamp":1791220030067,"version":"4.1.0"},"reference-count":28,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T00:00:00Z","timestamp":1549584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 105-2632-M-126-001"],"award-info":[{"award-number":["MOST 105-2632-M-126-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 106-2632-M-126-001"],"award-info":[{"award-number":["MOST 106-2632-M-126-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 107-2632-M-126-001"],"award-info":[{"award-number":["MOST 107-2632-M-126-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Resveratrol (tran-3,5,4\u2032-trihydroxystibene, RSV) is a kind of polyphenol which has anti-inflammatory, antioxidant, anti-allergy, and anti-cancer properties, as well as being a scavenger of free radicals and preventing cardiovascular diseases. However, it is quite unstable in light, heat, and other conditions, and decays easily due to environmental factors. For these reasons, this study used a new type of carrier, transfersome, to encapsulate RSV. Transfersome consists of phosphatidyl choline (PC) from a liposomal system and non-ionic edge activators (EA). EA are an important ingredient in the formulation of transfersome; they can enhance the flexibility of the lipid bimolecular membrane of transfersome. Due to its ultradeformability, it also allows drugs to penetrate the skin, even through the stratum corneum. We hope that this new encapsulation technique will improve the stability and enhance the permeability of RSV. Concluding all the tested parameters, the best production condition was 5% PC\/EA (3:1) and 5% ethanol in distilled water, with an ultrasonic bath and stirring at 500 rpm, followed by high pressure homogenization. The optimal particle size was 40.13 \u00b1 0.51 nm and the entrapment efficiency (EE) was 59.93 \u00b1 0.99%. The results of antioxidant activity analysis showed that transfersomes were comparable to the RSV group (unencapsulated). During in vitro transdermal delivery analysis, after 6 h, D1-20(W) increased 27.59% by accumulation. Cell viability assay showed that the cytotoxicity of D3-80(W) was reduced by 34.45% compared with the same concentration of RSV. Therefore, we successfully prepared RSV transfersomes and also improved the stability, solubility, and safety of RSV.<\/jats:p>","DOI":"10.3390\/molecules24030600","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T03:26:01Z","timestamp":1549855561000},"page":"600","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Preparation and Evaluation of Novel Transfersomes Combined with the Natural Antioxidant Resveratrol"],"prefix":"10.3390","volume":"24","author":[{"given":"Pey-Shiuan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cosmetic Science, Providence University, Taichung 43301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Syuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Science, Providence University, Taichung 43301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ching","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Science, Providence University, Taichung 43301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suh-Jen Jane","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, Providence University, Taichung 43301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4664-2995","authenticated-orcid":false,"given":"Chih-Chien","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Science, Providence University, Taichung 43301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2174\/092986712799945085","article-title":"Resveratrol in medicinal chemistry: A critical review of its pharmacokinetics, drug-delivery, and membrane interactions","volume":"19","author":"Lucio","year":"2012","journal-title":"Curr. 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