{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:13:32Z","timestamp":1783606412275,"version":"3.55.0"},"reference-count":23,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T00:00:00Z","timestamp":1549843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Peptic ulcers are currently treated with various drugs, all having serious side effects. The aim of this study was to evaluate the gastroprotective activity of calein D (from Calea urticifolia), a sesquiterpene lactone with a germacrane skeleton. Gastric lesions were induced in mice by administering ethanol (0.2 mL) after oral treatment with calein D at 3, 10 and 30 mg\/kg, resulting in 13.15 \u00b1 3.44%, 77.65 \u00b1 7.38% and 95.76 \u00b1 2.18% gastroprotection, respectively, to be compared with that of the control group. The effect found for 30 mg\/kg of calein D was not reversed by pretreatment with NG-nitro-l-arginine methyl ester (l-NAME, 70 mg\/kg, ip), indomethacin (10 mg\/kg, sc) or N-ethylmaleimide (NEM, 10 mg\/kg, sc). Hence, the mechanism of action of calein D does not involve NO, prostaglandins or sulfhydryl compounds. Calein D was more potent than carbenoxolone, the reference drug. The findings for the latter are in agreement with previous reports.<\/jats:p>","DOI":"10.3390\/molecules24030622","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T03:18:20Z","timestamp":1549941500000},"page":"622","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Gastroprotection of Calein D against Ethanol-Induced Gastric Lesions in Mice: Role of Prostaglandins, Nitric Oxide and Sulfhydryls"],"prefix":"10.3390","volume":"24","author":[{"given":"Mar\u00eda Elena","family":"S\u00e1nchez-Mendoza","sequence":"first","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Santo Tom\u00e1s, Delegaci\u00f3n Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaraset","family":"L\u00f3pez-Lorenzo","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Santo Tom\u00e1s, Delegaci\u00f3n Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Cruz-Antonio","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Superiores Zaragoza, UNAM. Av. Guelatao No. 66, Colonia Ej\u00e9rcito de Oriente Iztapalapa, Ciudad de M\u00e9xico 09230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audif\u00e1s-Salvador","family":"Matus-Meza","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"S\u00e1nchez-Mendoza","sequence":"additional","affiliation":[{"name":"Unidad de Medicina Familiar No. 49, Instituto Mexicano del Seguro Social, Ciudad de M\u00e9xico 06600, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Arrieta","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n, Colonia Santo Tom\u00e1s, Delegaci\u00f3n Miguel Hidalgo, Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1136\/gutjnl-2014-307595","article-title":"The stomach in health and disease","volume":"64","author":"Hunt","year":"2015","journal-title":"BMJ Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1248\/bpb.24.1","article-title":"Recent advances in gastrointestinal pathophysiology: Role of heat shock proteins in mucosal defense and ulcer healing","volume":"24","author":"Tsukimi","year":"2001","journal-title":"Biol. 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