{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:17:43Z","timestamp":1790774263423,"version":"4.1.0"},"reference-count":36,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T00:00:00Z","timestamp":1550361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Artemisia integrifolia L. (Compositae) is a medicinal and edible plant. To investigate its antihyperlipidemic effect, a crude lipophilic extract and the composing compounds were isolated and fractioned from the petroleum ether extract of aerial parts of A. integrifolia using column chromatography on silica gel. The anti-hyperlipidemia effect was studied in a rat model of acute hyperlipidemia, which was induced by triton WR-1339. A new compound, integrinol (4), together with nine known compounds, namely chamazulene (1), acetylenes (E)-2 (2), acetylenes (E)-3 (3), eugenol (5), palmitic acid (6), oleic acid (7), linoleic acid (8), linolenic acid (9) and 12,13-epoxylinolenic acid were isolated from the crude lipophilic extract of A. integrifolia. The LD50 value of the crude extract was more than 4 g\/kg. In Triton WR-1339-induced acute hyperlipidemia model, the crude lipophilic extract (200 mg\/kg) significantly reduced total cholesterol (TC) by 70% (p \u2264 0.01) and triglycerides (TGs) by 94% (p \u2264 0.001). The fractioned compounds, such as chamazulene (1), acetylene-2 (2), and linolenic acid (9), used at 4 mg\/kg dose, also significantly decreased the concentrations of TC (32%, 33% and 64%, respectively) and TGs (48%, 33% and 93%, respectively). These compounds (i.e., chamazulene, acetylenes (E)-2, and linolenic acid) were considered to be responsible for the bioactive antihyperlipidemic effect. In conclusion, the crude lipid extract of Artemisia integrifolia L. could be used as a potential treatment to avert hyperlipidemia. Further studies to confirm these results in other models of hyperlipidemia (e.g., diet-induced obesity) are warranted.<\/jats:p>","DOI":"10.3390\/molecules24040725","type":"journal-article","created":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T22:11:50Z","timestamp":1550441510000},"page":"725","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Antihyperlipidemic Effect, Identification and Isolation of the Lipophilic Components from Artemisia integrifolia"],"prefix":"10.3390","volume":"24","author":[{"given":"Yanhua","family":"Xu","sequence":"first","affiliation":[{"name":"College of Traditional Mongolian Medicine, Inner Mongolia Uaniversity for Nationalities, Tongliao 028000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghu","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Traditional Mongolian Medicine, Inner Mongolia Uaniversity for Nationalities, Tongliao 028000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Bao","sequence":"additional","affiliation":[{"name":"College of Traditional Mongolian Medicine, Inner Mongolia Uaniversity for Nationalities, Tongliao 028000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biligetu","family":"Pa","sequence":"additional","affiliation":[{"name":"College of Traditional Mongolian Medicine, Inner Mongolia Uaniversity for Nationalities, Tongliao 028000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18S","DOI":"10.1016\/S0002-9343(98)00184-3","article-title":"Biologic markers as predictors of cardiovascular disease","volume":"104","author":"Frishman","year":"1998","journal-title":"Am. 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