{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:50:15Z","timestamp":1789480215999,"version":"build-2803163510"},"reference-count":49,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573602"],"award-info":[{"award-number":["81573602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673600"],"award-info":[{"award-number":["81673600"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673559"],"award-info":[{"award-number":["81673559"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503331"],"award-info":[{"award-number":["81503331"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Opening Project of Zhejiang Provincial First-rate Subject (Traditional Chinese Medicine), Zhejiang Chinese Medical University","award":["Ya2017004"],"award-info":[{"award-number":["Ya2017004"]}]},{"name":"Opening Project of Zhejiang Provincial First-rate Subject (Traditional Chinese Medicine), Zhejiang Chinese Medical University","award":["2017005"],"award-info":[{"award-number":["2017005"]}]},{"name":"Public Welfare Application Project of Zhejiang Province","award":["2017C33174"],"award-info":[{"award-number":["2017C33174"]}]},{"name":"Traditional Chinese Medicine Key Scientific Research Fund Project of Zhejiang Province","award":["2018ZY004"],"award-info":[{"award-number":["2018ZY004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Baizhu Shaoyao San (BSS) is a crucial traditional Chinese medicinal formula widely applied for the treatment of painful diarrhea, diarrhea-predominant irritable bowel syndrome, ulcerative colitis, and some other gastrointestinal diseases. Corresponding to the clinical medication, the three medicinal herbs (Atractylodis Macrocephalae Rhizoma, Paeoniae Radix Alba, and Citri Reticulatae Pericarpium) included in BSS should be processed using some specific methods of stir-frying. To find the underlying correlations between serum chemical profiles and curative effects of crude and processed BSS on ulcerative colitis rats, and further explore for the effective material basis of processing, an UHPLC\/Q-TOF-MS\/MS technique coupled with gray correlation analysis (GCA) was developed. A total of 134 compounds were identified in rat sera after oral administration of BSS, among which 24 compounds were prototypes and 110 compounds were metabolites. Meanwhile, an ulcerative colitis model was established in rats by enema with 2,4,6-trinitrobenzene sulfonic acid, and the pharmacodynamic indicators for drug efficacies were evaluated as well. According to the results, processed BSS showed better efficacy than crude BSS. The top 10 potential effective components with high degree of correlation were identified based on GCA results, which were thought to be the crucial compounds that contributed to the enhancement of therapeutic effects in BSS after processing.<\/jats:p>","DOI":"10.3390\/molecules24050940","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T04:58:35Z","timestamp":1552021115000},"page":"940","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Investigation on Spectrum-Effect Correlation between Constituents Absorbed into Blood and Bioactivities of Baizhu Shaoyao San before and after Processing on Ulcerative Colitis Rats by UHPLC\/Q-TOF-MS\/MS Coupled with Gray Correlation Analysis"],"prefix":"10.3390","volume":"24","author":[{"given":"Hao","family":"Cai","sequence":"first","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-6727","authenticated-orcid":false,"given":"Yangyang","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Duan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Niu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China"},{"name":"Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Pei","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical and Food Engineering, Shanxi University of Traditional Chinese Medicine, Taiyuan 030024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"ref_1","first-page":"856","article-title":"Research progress of Baizhu Shaoyao powder in treating ulcerative colitis","volume":"42","author":"Xu","year":"2017","journal-title":"China J. Chin. Mater. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hu, X.G., Zhang, X.J., Han, B., and Bei, W.J. (2013). The inhibitory effect of tongxieyaofang on rats with post infectious irritable bowel syndrome through regulating colonic par-2 receptor. BMC Complement. Altern. Med., 13.","DOI":"10.1186\/1472-6882-13-246"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/aps.2014.170","article-title":"Herbal prescription Chang\u2019an II repairs intestinal mucosal barrier in rats with post-inflammation irritable bowel syndrome","volume":"36","author":"Wang","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_4","first-page":"S38","article-title":"A novel drug discovery strategy inspired by traditional medicine philosophies","volume":"347","author":"Zhao","year":"2015","journal-title":"Science"},{"key":"ref_5","first-page":"S74","article-title":"Drug discovery in traditional Chinese medicine: From herbal fufang to combinatory drugs","volume":"350","author":"He","year":"2015","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jpba.2016.07.021","article-title":"Comparison of fresh, dried and stir-frying gingers in decoction with blood stasis syndrome in rats based on a GC-TOF\/MS metabolomics approach","volume":"129","author":"Han","year":"2016","journal-title":"J. Pharm. Biomed."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1002\/jssc.201400473","article-title":"Effect of wine processing and acute blood stasis on the serum pharmacochemistry of rhubarb: A possible explanation for processing mechanism","volume":"37","author":"Wang","year":"2014","journal-title":"J. Sep. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1039\/C1AN15833C","article-title":"Metabolomics study on Fuzi and its processed products using ultra-performance liquid-chromatography\/electrospray-ionization synapt high-definition mass spectrometry coupled with pattern recognition analysis","volume":"137","author":"Sun","year":"2012","journal-title":"Analyst"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.jpba.2009.10.002","article-title":"A novel strategy to rapidly explore potential chemical markers for the discrimination between raw and processed Radix Rehmanniae by UHPLC-TOFMS with multivariate statistical analysis","volume":"51","author":"Li","year":"2010","journal-title":"J. Pharm. Biomed."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/jssc.201301376","article-title":"Chemical differentiation of volatile compounds in crude and processed Atractylodis Macrocephalae Rhizoma by using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry combined with multivariate data analysis","volume":"37","author":"Cao","year":"2014","journal-title":"J. Sep. Sci."},{"key":"ref_11","first-page":"3493","article-title":"Verification of processing theory of \u201creducing ketone and dryness, and increasing ester and effect\u201d for bran-fried atractylodes","volume":"38","author":"Zhao","year":"2013","journal-title":"China J. Chin. Mater. Med."},{"key":"ref_12","first-page":"1317","article-title":"Effect of different Paeony processed products on primary dysmenorrhea","volume":"22","author":"Jiang","year":"2011","journal-title":"Lishizhen Med. Mat. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"171987","DOI":"10.1098\/rsos.171987","article-title":"Discrimination of volatiles in herbal formula Baizhu Shaoyao San before and after processing using needle trap device with multivariate data analysis","volume":"5","author":"Xu","year":"2018","journal-title":"R. Soc. Open Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jchromb.2018.03.003","article-title":"Profiling and analysis of multiple constituents in Baizhu Shaoyao San before and after processing by stir-frying using UHPLC\/Q-TOF-MS\/MS coupled with multivariate statistical analysis","volume":"1083","author":"Xu","year":"2018","journal-title":"J. Chromatogr. B"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.trac.2014.05.013","article-title":"UHPLC-MS for the analytical characterization of traditional Chinese medicines","volume":"63","author":"Wang","year":"2014","journal-title":"TrAC Trend. Anal. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7367","DOI":"10.1007\/s00216-014-8169-x","article-title":"Integrated plasma and urine metabolomics coupled with HPLC\/QTOF-MS and chemometric analysis on potential biomarkers in liver injury and hepatoprotective effects of Er-Zhi-Wan","volume":"406","author":"Yao","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jpba.2013.04.019","article-title":"Chemical differentiation of Da-Cheng-Qi-Tang, a Chinese medicine formula, prepared by traditional and modern decoction methods using UPLC\/Q-TOFMS-based metabolomics approach","volume":"83","author":"Wan","year":"2013","journal-title":"J. Pharm. Biomed."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"17897","DOI":"10.3390\/molecules191117897","article-title":"Spectrum-effect relationships as a systematic approach to traditional Chinese medicine research: Current status and future perspectives","volume":"19","author":"Xu","year":"2014","journal-title":"Molecules"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Shi, M.J., Zhang, Y., Song, M.M., Sun, Y., Li, C.Q., and Kang, W.Y. (2018). Screening the marker components in Psoralea corylifolia L. with the aids of spectrum-effect relationship and component knock-out by UPLC-MS. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113439"},{"key":"ref_20","first-page":"40","article-title":"Constructing a competitiveness evaluation system of listed Chinese medicine enterprises based on grey correlation","volume":"27","author":"Zhu","year":"2015","journal-title":"J. Grey Syst."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1080\/14786410801931629","article-title":"Anti-inflammatory components isolated from Atractylodes macrocephala Koidz","volume":"22","author":"Dong","year":"2008","journal-title":"Nat. Prod. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"363076","DOI":"10.1155\/2013\/363076","article-title":"Evaluation of In vitro anti-inflammatory activities and protective effect of fermented preparations of Rhizoma Atractylodis Macrocephalae on intestinal barrier function against lipopolysaccharide insult","volume":"2013","author":"Bose","year":"2013","journal-title":"Evid-Based Complement. Altern. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1016\/j.vaccine.2009.02.002","article-title":"Enhancement of the immune responses to vaccination against foot-and-mouth disease in mice by oral administration of an extract made from Rhizoma Atractylodis Macrocephalae (RAM)","volume":"27","author":"Li","year":"2009","journal-title":"Vaccine"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3923\/ijp.2016.108.115","article-title":"Bidirectional effective components of Atractylodis Macrocephalae Rhizoma on gastrointestinal peristalsis","volume":"12","author":"Chen","year":"2016","journal-title":"Int. J. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jchromb.2015.05.006","article-title":"Simultaneous determination and pharmacokinetic study of atractylenolide I, II and III in rat plasma after intragastric administration of Baizhufuling extract and Atractylodis extract by UPLC-MS\/MS","volume":"993\u2013994","author":"Yan","year":"2015","journal-title":"J. Chromatogr. B"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jpba.2011.09.023","article-title":"Quantitative analysis of atractylenolide I in rat plasma by LC-MS\/MS method and its application to pharmacokinetic study","volume":"58","author":"Li","year":"2012","journal-title":"J. Pharm. Biomed."},{"key":"ref_27","first-page":"366","article-title":"Albiflorin attenuates inflammatory injury by regulating the TLR4 signaling pathway and its negative regulating factor Tollip in experimental models of ulcerative colitis","volume":"25","author":"Fang","year":"2016","journal-title":"J. Chin. Pharm. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.phymed.2009.02.021","article-title":"Modulating effect of hesperidin on experimental murine colitis induced by dextran sulfate sodium","volume":"16","author":"Xu","year":"2009","journal-title":"Phytomedicine"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/mnfr.201400614","article-title":"Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function","volume":"59","author":"Xiong","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_30","first-page":"527","article-title":"Tangeretin inhibits IL-12 expression and NF-kappa B activation in dendritic cells and attenuates colitis in mice","volume":"83","author":"Eun","year":"2017","journal-title":"Planta Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1248\/bpb.b18-00059","article-title":"The effect of prim-O-glucosylcimifugin on tryptase-induced intestinal barrier dysfunction in Caco-2 cells","volume":"41","author":"Xu","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"ref_32","first-page":"3327","article-title":"Theoretical model for compatibility of medicinal property combination of traditional Chinese medicines","volume":"40","author":"Sun","year":"2015","journal-title":"China J. Chin. Mater. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/j.1440-1681.2009.05158.x","article-title":"Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers","volume":"36","author":"Chen","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_34","first-page":"994","article-title":"Mining core herbs and their combination rules using effect degree","volume":"7","author":"Zhou","year":"2013","journal-title":"J. Front. Comp. Sci. Technol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/ptr.5285","article-title":"Inhibitory mechanisms of human CYPs by three alkaloids isolated from traditional Chinese herbs","volume":"29","author":"Zhao","year":"2015","journal-title":"Phytother. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jpba.2016.07.043","article-title":"Bioactivity evaluation-based ultra high-performance liquid chromatography coupled with electrospray ionization tandem quadrupole-time-of-flight mass spectrometry and novel distinction of multi-subchemome compatibility recognition strategy with Astragali Radix-Fructus Corni herb-pair as a case study","volume":"129","author":"Duan","year":"2016","journal-title":"J. Pharm. Biomed."},{"key":"ref_37","first-page":"637","article-title":"Chemical mechanism during Chinese medicine processing","volume":"24","author":"Cai","year":"2012","journal-title":"Prog. Chem."},{"key":"ref_38","first-page":"1504","article-title":"Optimization of extraction process for Baizhu Shaoyao San by multi-index orthogonal experiment","volume":"38","author":"Zheng","year":"2013","journal-title":"China J. Chin. Mater. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1021\/pr9008223","article-title":"Metabonomics in ulcerative colitis: Diagnostics, biomarker identification, and insight into the pathophysiology","volume":"9","author":"Bjerrum","year":"2010","journal-title":"J. Proteome Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"170959","DOI":"10.1155\/2014\/170959","article-title":"Investigation of the chemical changes from crude and processed Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma herbal pair extracts by using Q exactive high-performance benchtop quadrupole-orbitrap LC-MS\/MS","volume":"2014","author":"Cao","year":"2014","journal-title":"Evid-Based Complement. Altern. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jpba.2008.11.007","article-title":"Chemical profiling of Radix Paeoniae evaluated by ultra-performance liquid chromatography\/photo-diode-array\/quadrupole time-of-flight mass spectrometry","volume":"49","author":"Li","year":"2009","journal-title":"J. Pharm. Biomed."},{"key":"ref_42","first-page":"1762","article-title":"Qualitative and quantitative analysis of major constituents of Paeoniae Radix Alba and Paeoniae Radix Rubra by HPLC-DAD-Q-TOF-MS\/MS","volume":"40","author":"Liu","year":"2015","journal-title":"China J. Chin. Mater. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1007\/s12161-016-0690-4","article-title":"Characterization of polymethoxylated flavonoids in the peels of Chinese wild mandarin (Citrus reticulata Blanco) by UPLC-Q-TOF-MS\/MS","volume":"10","author":"Ke","year":"2017","journal-title":"Food Anal. Method"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.foodchem.2012.08.040","article-title":"Rapid resolution liquid chromatography-electrospray ionisation tandem mass spectrometry method for identification of chemical constituents in Citri Reticulatae Pericarpium","volume":"136","author":"Zheng","year":"2013","journal-title":"Food Chem."},{"key":"ref_45","first-page":"255","article-title":"Saposhnikoviae divaricata: A phytochemical, pharmacological, and pharmacokinetic review","volume":"15","author":"Kreiner","year":"2017","journal-title":"Chin. J. Nat. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/chromsci\/bms111","article-title":"High-performance liquid chromatography-electrospray Ionization time-of-flight mass spectrometry analysis of Radix Saposhnikoviae for metabolomic research","volume":"51","author":"Li","year":"2013","journal-title":"J. Chromatogr. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1046\/j.1365-2249.2000.01183.x","article-title":"Therapeutic effect of intracolonically administered nuclear factor kappa B (p65) antisense oligonucleotide on mouse dextran sulphate sodium (DSS)-induced colitis","volume":"120","author":"Murano","year":"2000","journal-title":"Clin. Exp. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.jep.2010.11.010","article-title":"Anti-inflammatory effects of iridoid glycosides fraction of Folium syringae leaves on TNBS-induced colitis in rats","volume":"133","author":"Liu","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"ref_49","first-page":"3390","article-title":"Spectrum-effect relationship for inhibitory action of Wuji Pills on pepsin based on grey incidence degree method","volume":"48","author":"Qing","year":"2017","journal-title":"Chin. Tradit. Herb. Drugs"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/5\/940\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:37:06Z","timestamp":1760186226000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/5\/940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,7]]},"references-count":49,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,3]]}},"alternative-id":["molecules24050940"],"URL":"https:\/\/doi.org\/10.3390\/molecules24050940","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,7]]}}}