{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T23:31:24Z","timestamp":1775691084263,"version":"3.50.1"},"reference-count":59,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["721613"],"award-info":[{"award-number":["721613"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006310","name":"Medicinska Forskningsr\u00e5det","doi-asserted-by":"publisher","award":["2017-02131"],"award-info":[{"award-number":["2017-02131"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","award":["20180049"],"award-info":[{"award-number":["20180049"]}],"id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["fo2017-0182"],"award-info":[{"award-number":["fo2017-0182"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001858","name":"VINNOVA","doi-asserted-by":"publisher","award":["180164"],"award-info":[{"award-number":["180164"]}],"id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>MYC, originally named c-myc, is an oncogene deregulated in many different forms of cancer. Translocation of the MYC gene to an immunoglobulin gene leads to an overexpression and the development of Burkitt\u2019s lymphoma (BL). Sporadic BL constitutes one subgroup where one of the translocation sites is located at the 5\u2019-vicinity of the two major MYC promoters P1 and P2. A non-B-DNA forming sequence within this region has been reported with the ability to form an intramolecular triplex (H-DNA) or a G-quadruplex. We have examined triplex formation at this site first by using a 17 bp triplex-forming oligonucleotide (TFO) and a double strand DNA (dsDNA) target corresponding to the MYC sequence. An antiparallel purine-motif triplex was detected using electrophoretic mobility shift assay. Furthermore, we probed for H-DNA formation using the BQQ-OP based triplex-specific cleavage assay, which indicated the formation of the structure in the supercoiled plasmid containing the corresponding region of the MYC promoter. Targeting non-B-DNA structures has therapeutic potential; therefore, we investigated their influence on strand-invasion of anti-gene oligonucleotides (ON)s. We show that in vitro, non-B-DNA formation at the vicinity of the ON target site facilitates dsDNA strand-invasion of the anti-gene ONs.<\/jats:p>","DOI":"10.3390\/molecules24051000","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T04:07:37Z","timestamp":1552450057000},"page":"1000","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oligonucleotide Binding to Non-B-DNA in MYC"],"prefix":"10.3390","volume":"24","author":[{"given":"Tea","family":"Umek","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Sollander","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Functional Genomics, Stockholm University, 171 65 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Bergquist","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9835-1009","authenticated-orcid":false,"given":"Jesper","family":"Wengel","sequence":"additional","affiliation":[{"name":"Biomolecular Nanoscale Engineerng Center, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, M5230 Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin E.","family":"Lundin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1907-3392","authenticated-orcid":false,"given":"C.I. Edvard","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rula","family":"Zain","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Huddinge, Sweden"},{"name":"Department of Clinical Genetics, Centre for Rare Diseases, Karolinska University Hospital, SE-171 76 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1073\/pnas.76.1.200","article-title":"Helical repeat of DNA in solution","volume":"76","author":"Wang","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"13448","DOI":"10.1073\/pnas.0405116101","article-title":"Naturally occurring H-DNA-forming sequences are mutagenic in mammalian cells","volume":"101","author":"Guliang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Gabay, M., Li, Y., and Felsher, D.W. (2014). MYC activation is a hallmark of cancer initiation and maintenance. Cold Spring Harb. Perspect. Med., 4.","DOI":"10.1101\/cshperspect.a014241"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Schmitz, R., Ceribelli, M., Pittaluga, S., Wright, G., and Staudt, L.M. (2014). Oncogenic mechanisms in Burkitt lymphoma. Cold Spring Harb. Perspect. Med., 4.","DOI":"10.1101\/cshperspect.a014282"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1634\/theoncologist.11-4-375","article-title":"Burkitt\u2019s Lymphoma: Clinicopathologic Features and Differential Diagnosis","volume":"11","author":"Ferry","year":"2006","journal-title":"Oncologist"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1200\/JCO.2000.18.21.3707","article-title":"Molecular biology of Burkitt\u2019s lymphoma","volume":"18","author":"Hecht","year":"2000","journal-title":"J. Clin. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.beha.2018.07.013","article-title":"Burkitt lymphoma\u2014A rare but challenging lymphoma","volume":"31","author":"Casulo","year":"2018","journal-title":"Best Pract. Res. Clin. Haematol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s11684-018-0650-z","article-title":"The MYC transcription factor network: Balancing metabolism, proliferation and oncogenesis","volume":"12","author":"Carroll","year":"2018","journal-title":"Front. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0065-230X(07)99004-1","article-title":"The c-myc promoter: Still MysterY and challenge","volume":"99","author":"Wierstra","year":"2008","journal-title":"Adv. Cancer Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0092-8674(83)90534-2","article-title":"The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma","volume":"34","author":"Battey","year":"1983","journal-title":"Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7476","DOI":"10.1073\/pnas.80.24.7476","article-title":"Activation of the c- myc gene by translocation: A model for translational control","volume":"80","author":"Saito","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0092-8674(84)90368-4","article-title":"Chromatin structure and protein binding in the putative regulatory region of the c- myc gene in burkitt lymphoma","volume":"37","author":"Siebenlist","year":"1984","journal-title":"Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"8412","DOI":"10.1093\/nar\/17.19.7771","article-title":"A cis-acting transcription element of the c-myc gene can assume an H- DNA conformation","volume":"17","author":"Kinniburgh","year":"1989","journal-title":"Nucleic Acids Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/nar\/25.7.1339","article-title":"Mechanisms of triplex-caused polymerization arrest","volume":"25","author":"Krasilnikov","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Wang, G., and Vasquez, K. (2017). Effects of Replication and Transcription on DNA Structure-Related Genetic Instability. Genes, 8.","DOI":"10.3390\/genes8010017"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.tig.2016.09.004","article-title":"G-Quadruplexes in DNA Replication: A Problem or a Necessity?","volume":"32","author":"Valton","year":"2016","journal-title":"Trends Genet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/gcc.20063","article-title":"Level of MYC overexpression in pediatric Burkitt\u2019s lymphoma is strongly dependent on genomic breakpoint location within the MYC locus","volume":"41","author":"Wilda","year":"2004","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5580","DOI":"10.1038\/sj.onc.1204640","article-title":"Mechanisms of chromosomal translocations in B cell lymphomas","volume":"20","author":"Ralf","year":"2001","journal-title":"Oncogene"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/j.1460-2075.1984.tb01816.x","article-title":"Nucleotide sequence of the human c-myc locus: Provocative open reading frame within the first exon","volume":"3","author":"Gazin","year":"1984","journal-title":"Embo J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev.bb.23.060194.002545","article-title":"H-DNA and Related Structures","volume":"23","author":"Mirkin","year":"1994","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1007\/s00018-003-3046-3","article-title":"Do natural DNA triple-helical structures occur and function in vivo?","volume":"60","author":"Zain","year":"2003","journal-title":"CMLS"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3109\/10409239109081126","article-title":"Local supercoil-stabilized DNA structures","volume":"26","author":"Palecek","year":"1991","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/anie.200300589","article-title":"G-quartets 40 years later: From 5\u2032-GMP to molecular biology and supramolecular chemistry","volume":"43","author":"Davis","year":"2004","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/nrg3296","article-title":"DNA secondary structures: Stability and function of G-quadruplex structures","volume":"13","author":"Matthew","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41557-018-0046-3","article-title":"I-motif DNA structures are formed in the nuclei of human cells","volume":"10","author":"Zeraati","year":"2018","journal-title":"Nat. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1021\/acs.biochem.6b00016","article-title":"Mutually exclusive formation of G-quadruplex and i-motif is a general phenomenon governed by steric hindrance in duplex DNA","volume":"55","author":"Cui","year":"2016","journal-title":"Biochemistry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.biochi.2008.02.011","article-title":"DNA triple helices: Biological consequences and therapeutic potential","volume":"90","author":"Jain","year":"2008","journal-title":"Biochimie"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"12500","DOI":"10.3390\/molecules181012500","article-title":"G-Quadruplexes as Potential Therapeutic Targets for Embryonal Tumors","volume":"18","author":"Shalaby","year":"2013","journal-title":"Molecules"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrd3428","article-title":"Targeting G-quadruplexes in gene promoters: A novel anticancer strategy?","volume":"10","author":"Balasubramanian","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_30","first-page":"20","article-title":"DNA damage and the balance between survival and death in cancer biology","volume":"16","author":"Wynand","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1021\/acs.jmedchem.7b00298","article-title":"Simultaneous Drug Targeting of the Promoter MYC G-Quadruplex and BCL2 i-Motif in Diffuse Large B-Cell Lymphoma Delays Tumor Growth","volume":"60","author":"Kendrick","year":"2017","journal-title":"J. Med. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.sbi.2009.04.001","article-title":"The structures of quadruplex nucleic acids and their drug complexes","volume":"19","author":"Neidle","year":"2009","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3390\/ijms17060779","article-title":"Recent Advances in Developing Small Molecules Targeting Nucleic Acid","volume":"17","author":"Maolin","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/nar\/gkj473","article-title":"Growth inhibition and apoptosis induced by daunomycin-conjugated triplex-forming oligonucleotides targeting the c-myc gene in prostate cancer cells","volume":"34","author":"Napoli","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1093\/nar\/gkf376","article-title":"Design of a novel triple helix-forming oligodeoxyribonucleotide directed to the major promoter of the c-myc gene","volume":"30","author":"McGuffie","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/73745","article-title":"Effects in live cells of a c-myc anti-gene PNA linked to a nuclear localization signal","volume":"18","author":"Giovanna","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/cgt.2009.26","article-title":"PNAEmu can significantly reduce Burkitt\u2019s lymphoma tumor burden in a SCID mice model: Cells dissemination similar to the human disease","volume":"16","author":"Matis","year":"2009","journal-title":"Cancer Gene Ther."},{"key":"ref_38","first-page":"6144","article-title":"Inhibition of the translocated c-myc in Burkitt\u2019s lymphoma by a PNA complementary to the E mu enhancer","volume":"63","author":"Cutrona","year":"2003","journal-title":"Cancer Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.3293213","article-title":"Site-specific oligonucleotide binding represses transcription of the human c- myc gene in vitro","volume":"241","author":"Cooney","year":"1988","journal-title":"Science"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1093\/nar\/gkt007","article-title":"Development of bis- locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA","volume":"41","author":"Moreno","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1093\/nar\/gkw021","article-title":"Next-generation bis-locked nucleic acids with stacking linker and 2\u2032-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes","volume":"44","author":"Geny","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.1962210","article-title":"Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide","volume":"254","author":"Nielsen","year":"1991","journal-title":"Science"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/cbdd.12833","article-title":"Versatility of peptide nucleic acids (PNAs): Role in chemical biology, drug discovery, and origins of life","volume":"89","author":"Sharma","year":"2017","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1038\/nbt1296-1700","article-title":"Enhancement of strand invasion by oligonucleotides through manipulation of backbone charge","volume":"14","author":"Sergey","year":"1996","journal-title":"Nat. Biotechnol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/bc00025a001","article-title":"Peptide nucleic acid ( PNA). A DNA mimic with a peptide backbone","volume":"5","author":"Nielsen","year":"1994","journal-title":"Bioconjug. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1021\/ja953125q","article-title":"Strand displacement binding of a duplex-forming homopurine PNA to a homopyrimidine duplex DNA target","volume":"118","author":"Nielsen","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"10433","DOI":"10.1021\/bi700854r","article-title":"High-affinity homologous peptide nucleic acid probes for targeting a quadruplex-forming sequence from a MYC promoter element","volume":"46","author":"Roy","year":"2007","journal-title":"Biochemistry"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Bergquist, H., Rocha, C.S.J., Alvarez-Asencio, R., Nguyen, C.-H., Rutland, M.W., Smith, C.I.E., Good, L., Nielsen, P.E., and Zain, R. (2016). Disruption of Higher Order DNA Structures in Friedreich\u2019s Ataxia (GAA)n Repeats by PNA or LNA Targeting. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0165788"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1002\/cbic.200400074","article-title":"Triple-Helix Directed Cleavage of Double-Stranded DNA by Benzoquinoquinoxaline-1,10-phenanthroline Conjugates","volume":"5","author":"Zaid","year":"2004","journal-title":"ChemBioChem"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jmb.2005.03.044","article-title":"Benzoquinoquinoxaline Derivatives Stabilize and Cleave H-DNA and Repress Transcription Downstream of a Triplex- forming Sequence","volume":"351","author":"Amiri","year":"2005","journal-title":"J. Mol. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1073\/pnas.95.7.3591","article-title":"Rational design of a triple helix-specific intercalating ligand","volume":"95","author":"Christophe","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S1074-5521(99)80124-0","article-title":"Design of a triple-helix-specific cleaving reagent","volume":"6","author":"Zain","year":"1999","journal-title":"Chem. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1093\/nar\/gkx100","article-title":"Alternative DNA structure formation in the mutagenic human c-MYC promoter","volume":"45","author":"Kerwin","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1146\/annurev-pharmtox-010818-021050","article-title":"Therapeutic Oligonucleotides: State of the Art","volume":"59","author":"Smith","year":"2019","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0006-291X(05)80985-4","article-title":"The identification of a tandem H-DNA structure in the c-MYC nuclease sensitive promoter element","volume":"185","author":"Firulli","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1093\/nar\/26.5.1167","article-title":"DNA tetraplex formation in the control region of c-myc","volume":"26","author":"Simonsson","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"11593","DOI":"10.1073\/pnas.182256799","article-title":"Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription","volume":"99","author":"Adam","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/nar\/gkq835","article-title":"Optimizing anti-gene oligonucleotide \u2018 Zorro- LNA\u2019 for improved strand invasion into duplex DNA","volume":"39","author":"Zaghloul","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.molonc.2013.04.006","article-title":"Erroneous class switching and false VDJ recombination: Molecular dissection of t(8;14)\/MYC-IGHtranslocations in Burkitt-type lymphoblastic leukemia\/B-cell lymphoma","volume":"7","author":"Burmeister","year":"2013","journal-title":"Mol. Oncol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/5\/1000\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:38:19Z","timestamp":1760186299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/5\/1000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,12]]},"references-count":59,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,3]]}},"alternative-id":["molecules24051000"],"URL":"https:\/\/doi.org\/10.3390\/molecules24051000","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,12]]}}}